Proteomic biomarker discovery: It’s more than just mass spectrometry In her seminar Ms. Lisandra Santiago talked about the importance of proteomicbiomarkers for decreasing the effects of certain diseases like cancer, and serious skin burnsamong other applications. The objective of her research and her colleagues was to isolateand identify useful proteins to be used as biomarkers. They studied different types ofapproaches like immunoprecipitation, immobilized metal-ion affinity chromatography,specific chemical modification, and metal oxide affinity chromatography. In their variousexperiments they also used a technique called “shotgun proteomics” which is a method ofidentifying proteins in complex mixtures utilizing a combination of high performance liquidchromatography (LC) combined with mass spectrometry (MS). In her conclusions, shepointed out that we cannot rely only on mass spectrometry, that every work must berevised, and that to be able to have a functional proteomic you must have post translationalmodifications in the protein. Ms. Lisandra Santiago has very good pronunciation andvocabulary. It’s an honor that we have scientists like her come and talk to us about theirresearch.