GFS Chemicals Triple Bond Organics

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GFS Chemicals - Innovation and Commercialization through Chemistry - Specialty Organic Chemical Manufacturing

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GFS Chemicals Triple Bond Organics

  1. 1. GFS Chemicals, Inc.<br />Innovation and Commercialization through Chemistry<br />ISO 9001:2008 Certified<br />
  2. 2. GFS Corporate Story<br />Supporting Major Industry Around the Globe<br />Flexible Production Capabilities for over 80 years<br />Batch Manufacturing for R&D through Commercialization<br />Organic and Inorganic Manufacturing Expertise<br />Semi-Custom Chemistry to Meet Customer Specifications<br />Problem Solving Chemists Complement Your Project Team<br />Manufacturing High Quality Chemicals up to metric tons<br />Exceedingly Responsive to Customer Inquiries<br />Achieving Accurate and Reliable Production Deadlines<br />
  3. 3. Steel Hutchinson<br />President, GFS Chemicals<br />
  4. 4. Industries Served<br />Environmental<br />Semiconductor<br />Pharmaceutical<br />Flavor & Fragrance<br />Superconductivity<br />Petrochemical<br />Agricultural<br />Automotive<br />Defense <br />Biotechnology<br />Power and Energy (Fuel Cells, Batteries, etc)<br />
  5. 5. Industries Served<br />Environmental<br />Semiconductor<br />Pharmaceutical<br />Flavor & Fragrance<br />Superconductivity<br />Petrochemical<br />Agricultural<br />Automotive<br />Defense <br />Biotechnology<br />Power and Energy (Fuel Cells, Batteries, etc)<br />
  6. 6. Industries Served<br />Electronics<br />Chemicals<br />Aerospace<br />Polymers<br />Coatings<br />Catalysts<br />Optics<br />Contract Manufacturing<br />Water treatment and Analysis<br />Beverage/Dairy<br />Quality Control Laboratories<br />
  7. 7. Industries Served<br />Electronics<br />Chemicals<br />Aerospace<br />Polymers<br />Coatings<br />Catalysts<br />Optics<br />Contract Manufacturing<br />Water treatment and Analysis<br />Beverage/Dairy<br />Quality Control Laboratories<br />
  8. 8. Innovation and Growth<br />1928 1940’s 1960’s 1970’s 1980’s <br />Founded, Columbus Ohio. Perchlorate salts defined early business<br />Development of trace metal acids (ppt grade acid)<br />Acquisition of Karl Fischer product line<br />Rare Earth products introduced (CAN) Development of heteroaromatic ligands<br />Collaboration on first chrome etchants<br />
  9. 9. Innovation and Growth<br />1990’s 1997 1997 2001 2003<br />Heavy acquisition period includes quaternary salts, sodium biphenyl & Farchan acetylenics<br />Perchloric acid plant built<br />($2.5M US)<br />Aquisition of APS Analytical Standards for turbidimeters, colorimeters and spectrophotomers<br />New organic <br />production facility <br />built ($3.5M US)<br />ISO 9000 certification<br />
  10. 10. Innovation and Growth<br />2004 2007 2008 2009 2010<br />Perchloric Acid expansion<br />Inorganic and Organic research labs built<br />UDRI Chrome IV Replacement Project<br />Purchase of Catalog Distribution Center, Private Labelling Operation and Laboratory Reagents Manufacturing<br />Beta Phase Tri-Calcium Phosphate - Artificial Bone Scaffold<br />SOCMA Chem Steward Tier II Certification Ammonia Borane Manufacturing Partnership<br />
  11. 11. Safety and Environment<br /><ul><li>GFS is a Tier II Chem Stewards organization focused on safety improvement practices and waste minimization, recovery policies and controls
  12. 12. Selected Employees are DOT, IATA and IMO certified to support all modes of material logistics to ensure safe and legal shipments world wide.</li></li></ul><li>Compliance and Quality <br />GFS organic production operations are a zero discharge facility compliant with all local and federal EPA regulations<br />We adhere to ISO 9001:2008 standards for quality practices and have been ISO certified since 1997<br />
  13. 13. Organic Manufacturing<br />Leaders in the development and commercialization of specialty alkynes and derivatives<br />
  14. 14. Product Offering<br />GFS Chemicals remains focused on a core set of synthetic methodologies<br />In support of alkyne production, we offer down stream intermediates such as olefins, heteroaromatics and heterocycles<br />We offer over 2000 organic chemicals in our product base<br />
  15. 15. Core Synthetic Chemistry<br />Na & Li/Liquid Ammonia Chemistry<br /><ul><li>Alkylations
  16. 16. Aminations
  17. 17. Reductions (Birch, trans)
  18. 18. Ethynylations</li></ul>Halogenations<br /><ul><li>Brominations
  19. 19. Chlorinations
  20. 20. Iodinations</li></li></ul><li>Core Synthetic Chemistry<br />Alkyne Chemistry<br />– Eliminations<br /> Ethynylations<br /> Sonogashira<br /> Glaser Coupling<br /> Cadiot-Chodkiewicz<br /> Click Chemistry<br />
  21. 21. Core Synthetic Chemistry<br />Organometallic Chemistry<br />Grignard<br />Alkyl lithium<br />Coupling (Suzuki, Stille, Negishi, Kumada)<br />Heck Reaction<br />LI/NA Amide<br />Cis-reductions<br />
  22. 22. Core Synthetic Structures<br /> Alkynes<br />Aromatic<br />Terminal<br />Internal<br />Alcohols<br />Ketones<br />Acids<br />Conjugated<br /> Olefins<br />Cis/trans<br />En-yne<br />Cyclic<br />Grignards<br />Vinyl<br />Aryl<br />Alkyl<br />
  23. 23. Core Synthetic Structures<br /> Halogenated Organics<br />Alkynes <br />Olefins<br />Alkyl<br />Aromatic<br /><ul><li>Heteroaromatic
  24. 24. Quinolines
  25. 25. Indoles
  26. 26. Pyrimidines
  27. 27. Bipyridines
  28. 28. Phenanthrolines
  29. 29. Terpyridines</li></li></ul><li>Core Synthetic Methodologies<br /><ul><li>Alkyne Chemistry
  30. 30. Birch Reductions
  31. 31. Halogenation
  32. 32. Dehydrohalogenation
  33. 33. Alkylation(NH3 or other)
  34. 34. Sonogashira Reactions
  35. 35. Kumada Couplings
  36. 36. Cadiot-Chodkiewicz
  37. 37. Suzuki Coupling</li></ul>Diels-Alder Synthesis<br />Trans Reductions(NH3)<br />Barbier Reaction<br />Skraup Synthesis<br />Heck Reaction<br />Grignard/Alkyl Lithium Synthesis<br />Finklestein Reaction<br />Phase Transfer<br />
  38. 38. Kilo Lab Operations<br />Multiple bench top operation<br />Glassware up to 72 L scale<br />Distillation support up to 50L scale<br />Short path<br />Bench Strip<br />Rotary Evaporators<br />Long path<br />18” to 48” packed columns<br />Stainless, Hastelloy, Ceramic packing<br />
  39. 39. Pilot Scale Operations<br /><ul><li>10 gal – 100 gal Glass
  40. 40. 10 gal – 200 gal Stainless
  41. 41. Distillation Support
  42. 42. Rotary Evaporator
  43. 43. 30 gal – 50 gal glass lined steel distillation pots
  44. 44. 4’ to 12’ columns
  45. 45. Glass, Stainless & Hastelloy packing</li></li></ul><li>Plant Operations<br /><ul><li>350-500 gal Hastelloy
  46. 46. 100-1000 gal Glass
  47. 47. 200-1000 gal Stainless
  48. 48. Distillation support
  49. 49. Short path
  50. 50. 50 gal-500 gal glass lined
  51. 51. Long path
  52. 52. 4’ to 16’ column
  53. 53. Stainless, Hastelloy, Glass packing
  54. 54. Solids Handling
  55. 55. Hastelloy and Stainless centrifugation</li></li></ul><li>Common Bulk Raw Materials<br /><ul><li>Acetylene
  56. 56. Ammonia,liq.
  57. 57. Alkyllithium
  58. 58. Carbon disulfide
  59. 59. Chloroformates
  60. 60. Chlorosulfonic acid
  61. 61. Epichlorohydrin
  62. 62. Ethylene oxide
  63. 63. Bromine</li></ul>Lithium amide <br />Lithium metal<br />Magnesium<br />Sodium amide<br />Sodium hydride <br />Sodium metal<br />Trialkylsilanes<br />Iodine<br />Hydrogen Chloride<br />
  64. 64. Robust Distillation Capabilities<br />Increased capacity:<br />Single pass distillation<br />Fractional distillation<br />High vacuum capability<br />Wiped film distillation for heat-sensitive compounds<br />Extensive glass equipment for handling corrosives<br />Low trace metal impurities <br />
  65. 65. Inorganic Bulk Manufacturing<br />U.S. Based Inorganic Product Development and Manufacturing <br />
  66. 66. Inorganic Specialties<br />Perchloric acid & Salts<br />Ceric Ammonium Nitrate (Etchants & Catalysis)<br />Purified compounds for metal complexes<br />Ultra dry salts for moisture sensitive applications<br />Rare Earths, Lithium, Sodium and Magnesium salts & solutions<br />Precious metal ion exchange resins<br />
  67. 67. Bulk Inorganic Salts<br />Nitrates <br />Sulfates<br />Chlorides<br />Perchlorates<br />Carbonates<br />Periodates<br />Oxalates<br />Acetates<br />Formates<br />Phosphates<br />Citrates<br />
  68. 68. GFS Catalog Operations<br />70,000 Sq Ft. Operation, Manufacturing and Distribution Center<br />Repack and Fulfillment Center<br />Private Label Operation<br />Amco Clear Water Analysis Division<br />Bottling Operations<br />Quality Control Labs<br />Manufacturing and Sourcing over 4000 Analytical Reagents<br />
  69. 69. Specialty Inorganics<br />Rubrene (OLED & Dye) <br />Anhydrous Cerous Chloride (Fuel Cell & Grignard Initiator)<br />Hydroxyquinoline, Aluminum Salt (OLED)<br />Polyoxometalate complexes <br />
  70. 70. Bulk Inorganics<br />Lithium Perchlorate (Battery Electrolyte & Organic Catalyst)<br />Lithium Carbonate, 99.998% (Lithium Crystals & Organic Catalyst)<br />Lithium Iodide (Battery Electrolyte & Organic Catalyst<br />Precious Metal Salts (Silver Nitrate)<br />Ammonium Borane (OSU & EBA &D)<br />
  71. 71. In-House Quality Control Support<br /><ul><li>Full wet chemistry lab
  72. 72. HPLC
  73. 73. GC (multiple)
  74. 74. GC/MS
  75. 75. UV/Vis
  76. 76. Karl Fischer
  77. 77. FTIR
  78. 78. Melting & Boiling Point
  79. 79. pH & Conductivity
  80. 80. CoulometricKarl Fischer
  81. 81. Volumetric Karl Fischer
  82. 82. Ion Chromatography
  83. 83. ICP
  84. 84. AA</li></li></ul><li>What’s New<br />Expanded Inorganic drying capacity/capability<br />Expanded Organic and Inorganic distillation capacity<br />Development of Organic Iodides/Iodoalkanes<br />High purity organic acids for etchants<br />Acquisition of novel nanosphere polymer technology<br />New Product Development Labs for Inorganic and Organic Compounds <br />FDA inspected production suite<br />R&D Lab expansion<br />Dry Room for ultra low moisture product handling/packaging<br />Specialty Grignard reagents<br />
  85. 85. Dry Room Capabilities<br />< 1% Relative Humidity<br />- 45° C Dew Point<br />Customized anhydrous material handling<br />Custom packaging capabilities<br />Supporting materials < 100 ppm H2O<br />Designed for Battery Grade and Fuel Cell Grade materials<br />
  86. 86. Customer Metrics<br />Inventory Availability <br />Lead Time Accuracy<br />Product Quality<br />Timely Delivery<br />Product Information/Knowledge<br />Customer Satisfaction<br />
  87. 87. International Operations<br />Sourcing Operations in <br /> Beijing China<br />Serving over 80 countries worldwide<br />www.GFSInternational.com<br />Japanese<br />German<br />French<br />Spanish<br />

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