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1.0 jean-françois delfraissy intro


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1.0 jean-françois delfraissy intro

  1. 1.   3rd International Research Meeting June 10th, 2011, Hôtel Marigny Introduction Pr Jean-François Delfraissy Institut de Microbiologie et Maladies Infectieuses (IMMI) Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS) CHU Bicetre – Paris XI CEA CHRU CNRS CPU INRA INRIA INSERM INSTITUT PASTEUR IRD
  2. 2. Infectious diseases account for 26% of all deaths worldwide Leading cause of mortality in ressources limited countries Two-thirds of worldwide deaths in children <5 years old The Heavy Burden of Infectious Diseases % of deaths 18% 15% 31% 36% Pneumonia Diarrhoea Other infections Non infectious
  3. 3. « Emergence »: a global threat <ul><ul><li>Newly apparent pathogens: HIV, Ebola, H5N1, H1N1… </li></ul></ul><ul><ul><li>Rapidly increasing in incidence or geographic range : dengue, chikungunya, West Nile </li></ul></ul><ul><ul><li>Multidrug Resistant Pathogens : </li></ul></ul><ul><ul><li>NDM-1, E.Coli (EHEC) </li></ul></ul><ul><ul><li>Importance of zoonosis </li></ul></ul><ul><ul><li>Multidisciplinary approach </li></ul></ul>Vectors Hosts Humans
  4. 4. A new vision of microbiology <ul><li>Discovery of new viruses, new bacteria </li></ul><ul><li>The commensal microbiota : from homeostasis to disease </li></ul><ul><li>New technologies : deep sequencing, omics… </li></ul><ul><li>Molecular basis of host defense </li></ul><ul><li>Host genetic control </li></ul><ul><li>Biomarkers, Point of care, Pharmacogenomics </li></ul>
  5. 5. Medical and Scientific challenges <ul><li>Transmission of infection (mechanisms, nosocomial…) </li></ul><ul><li>Emerging diseases ; zoonosis, human ecology, biodiversity </li></ul><ul><li>Resistance : Tuberculosis, Bacteria, MDR… </li></ul><ul><li>Infectious agents and non infectious diseases : cancer, cardiovascular, obesity, allergy, inflammation,… </li></ul><ul><li>Vaccination : new vaccines, immunity, SHS… </li></ul><ul><li>The big 3 : HIV, Tuberculosis, Malaria </li></ul>
  6. 6. IMMI: French Biomedical research Centers Institut Pasteur Paris Pitié Salpétrière Mondor/Bicêtre/Orsay/CEA/Saclay Bichat/St Louis Cochin/Cordeliers BIOPOLE Lyon-Grenoble IRT Lyon/Pasteur Institut Pasteur Lille Bordeaux Strasbourg INFECTIOPOLE Sud Marseille-Montpellier-Nice IHU
  7. 7. Microbiology and Infectious Diseases Key points: France 2011 <ul><li>Major Institutions : Institut Pasteur, Inserm, CNRS, IRD </li></ul><ul><li>Others : ANRS, CEA, CIRAD, INRA, INVS, Universities </li></ul><ul><li>12% of French research forces : 300 teams, 2000 Scientists & Technical staff </li></ul><ul><li>18% of French biomedical publications : 5000 publications per year </li></ul><ul><li>Translationnal and clinical research: 35 clinical units involved, including HIV and hepatits </li></ul><ul><li>Network of vaccine research centers </li></ul><ul><li>Large research network in ressources limited countries </li></ul>
  8. 8. Scientific Program (1) <ul><li>8.55 -11.30 </li></ul><ul><li>Session 1 : UNDERSTANDING INFECTIOUS DISEASES: NEW MECHANISMS & PARADIGMS </li></ul><ul><li>Session 2 : NEW TARGETS AND TOOLS IN INFECTIOLOGY </li></ul><ul><li>11.30 Transfer to Elysée Palace </li></ul><ul><li>12.15 The President Sarkozy Lecture </li></ul><ul><li>12.45 – 13.45 Buffet-Lunch </li></ul>
  9. 9. Scientific Program (2) <ul><li>14.00 – 14.30 </li></ul><ul><li>Session 3 : NORTH-SOUTH PARTNERSHIPS: </li></ul><ul><li>POWERFUL RESEARCH TOOLS </li></ul><ul><li>14.30 – 17.00 R&D Dating Session : </li></ul><ul><li>Twenty one companies will meet successively with 4 scientific teams representatives </li></ul><ul><li>This very short meeting allows to define whether a future in depth meeting should be scheduled in case of confirmed common interests </li></ul><ul><li>17.15 Conclusion remarks: Pierre TEILLAC – Chairman of ARIIS </li></ul><ul><li>17.45 Allocution by the Minister Mr Eric BESSON </li></ul>