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Vet Times 2017 Lipogems Canine Feature - Novel regeneration therapy available for use in UK dogs


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Holly Kernot from Vet Times writes about the launch of Lipogems Canine in the UK with Lead Lipogems Canine Veterinary Surgeon Alistair Cliff from Crown Vets Referrals. The feature outlines how Lipogems Canine can be used in a range of conditions that affect dogs.

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Vet Times 2017 Lipogems Canine Feature - Novel regeneration therapy available for use in UK dogs

  1. 1. NEWS2 veterinary TimesFollow us on Facebook and @vettimesuk If you received a personal copy of Veterinary Times, your details were generated from our Vetfile database. To change your delivery details, email In brief HOT SUMMER:The National Animal Disease Information Service and Merial are warning farmers above average summer temperatures could lead to a rise in parasitic disease in growing animals.They said the timing of worm treatments for grazing lambs will depend on prevailing weather conditions, grazing history, contamination levels and stocking density. Prolonged spring dry weather may have delayed the larval challenge, but infectivity will increase once wetter weather returns and leaves lambs susceptible to parasitic gastroenteritis. VCS GRANT: Cardiologists are being encouraged to apply for a grant offered by theVeterinary Cardiovascular Society to aid research in this area.The society’s research project grant totals £8,000, which will be match-funded by PetSavers.While it is anticipated any one application would not receive more than £8,000, if a particularly relevant proposal is received, the full £16,000 may be awarded.The closing date for applications is 31 August.To apply, visit CATTLE COURSE:The BCVA’s Bull Breeding Soundness Examination (BBSE) course blends theory and practice, and includes demonstrations of examination and semen collection techniques using electroejaculation on bulls in a farm situation. Delegates will also have the opportunity to take part in laboratory-based semen morphology evaluation techniques and get to grips with all the equipment required for BBSEs. For more information or to book, visit SHELTER SAVED: A campaign to prevent the closure of a WorldwideVeterinary Service (WVS) animal shelter in northernThailand has been successful.The international training centre and rehoming shelter cares for animals and trains the next generation of clinicians in surgical sterilisation techniques, shelter medicine and management. Foundation Marchig pledged to helpWVS purchase the shelter and a WVS fund-raising initiative also proved fruitful. CLUB’S MILESTONE: CVS’ Healthy Pet Club has cemented its status as the UK’s largest veterinary loyalty scheme with the acquisition of its 300,000th member. Angie Scullion joined the club at OkefordVeterinary Centre with her border collie Cassie and was awarded a year’s free membership by the practice to celebrate the milestone. CLASS CATS: Blue Cross has teamed up with Moreton Morrell College inWarwick to care for homeless cats and kittens until new homes can be found. Cats will stay in five double pens at the college where students studying courses in animal care and management will look after them while being supervised by the college’s lecturing team. Novel regeneration therapy available for use in UK dogsA CELL transplantation tech- nique, historically used in human medicine with “groundbreaking regenera- tive capabilities”, has been made available to UK vets for the first time to treat a range of canine orthopaedic cases. Originating in the medical world, the Lipogems technique was invented by Carlo Tremo- lada, an Italian maxillofacial plastic surgeon searching for a way to create a smoother, more viscous fat graft for filling defects and creating natural volumetric face enhancement. Unexpectedly, patients given Lipogems experienced a signif- icant decrease in bruising and inflammation normally asso- ciated with these procedures and demonstrated substantial regenerative effects on the underlying tissues. Scientists identified the regenerative characteristics in Lipogems and it received US Food and Drug Administration Federal Food, Drug, and Cos- metic Act (Act) Section 510(k) clearance in 2014. A subse- quent review in 2016 saw it amended to include application in orthopaedic surgerysettings. The closed loop device was initially used only in plastic and reconstructive surgery, but showed benefits for ortho- paedic indications in more than 8,000 cases and 20 clinical studies worldwide. Harvesting fat The Lipogems method is carried out in one surgical step via a single-use kit for the lipoaspi- ration process and deploy- ment of adipose tissue. Micro- fragmenting adipose tissue (harvested from fat) is obtained from lipoaspirates through a non-enzymatic, mechanical process using a closed system and disposable device. Adipose tissue is harvested using a vacuum syringe around the flank of the dog under general anaesthetic, after the region has been anaesthetised by local infiltration with sterile saline and adrenaline. Harvested fat tissue using the Lipogems device is washed in saline and gently agitated so the pericytes detach from small vessels and activate. Cells with the stromalvascularstructure of adipose tissue then act as a local scaffold to maintain regenera- tive activity for many months. Vet Offer Zeira toldVeterinary Times: “To colleagues who ask me, ‘why Lipogems?’, I give them this – the shortest and most truthful answer–whoever deals with regenerative medi- cine uses stem cells; whoever deals with stem cells should use Lipogems. “The longer answer is Lipo- gems is a concept, a method and a device all in one. “Instead of using pure stem cells that should be cultivated and expanded – and, therefore, are high cost –we use a true mini habitat containing a scaffold, stem cell precursors, numer- ous anti-inflammatory factors, trophic mediators and others. “The method uses mild mechanical forces in a com- pletely closed system with no enzymes, additives or other manipulations, which avoids complex regulatory issues.” The single-use medical device for the processing of lipoaspi- rated adipose tissue is very friendly and straightforward. ‘Amazing’results DrZeira said:“I am happyto say, in myhospital, 70 percent to 80 per cent of all cases treated with stem cells have been shifted from bone marrow- cultivated material to Lipo- gems, which we can use imme- diately on patients. “In the case of dogs’muscles, tendons and articular diseases, 100 per cent of the cases are treated by Lipogems. “The results are amazing. Dogs that suffered severe lameness manage to walk with nearly no lameness within five to six days. “Also, the effect’s duration of this treatment is unique – it lasts for 10 to 12 months after a single treatment, sometimes even longer.” Lipogems Canine chief exec- utive Martin ffrench Blake said the objective of the Lipogems product was to favour the natural regenerative process of tissues and was used in numerous pathologies. “The process activates the dog’s own damage response mechanism in a way that has not yet been achieved by any other regenerative treatment options,” he said. “The whole procedure from harvesting to the injection can be completed in less than 40 minutes under general anaesthetic. One of the impor- tant points about this procedure is it is quick to perform and promotes healing as early as 10 days after treatment, and involves very little requirement for drug usage.” Crown Vet Referrals is the only clinic in the UK and Ireland to have staff trained in the Lipo- gems Canine technique. report by Holly Kernot 01733 383562 ONE of East Lothian’s best known vet practices is undergoing a £60,000 revamp and expansion. The redevelopment of Dunedin Vets’ main surgery in Tranent will create more space for its 13-strong team of vets and VNs, with a new vet consult room, an extra dog ward, a larger pharmacy, laboratory, meeting room and additional office space, plus separate cat and dog waiting areas. Dunedin Vets clinical directors Margot Hunter and Chris Monk are overseeing the redevelopment of the surgery, which has seen them expand the premises into a neighbouring flat owned by the practice. Work started in early March and is expected to be completed by August. Mrs Hunter said: “Over the years, we have expanded the practice in phases, but this is the biggest project we have undertaken. We owned the residential flat next door, so we are expanding into that area to create a much more modern, vibrant surgery.” Dunedin Vets has four sites across East Lothian – with its main practice in Tranent and branch surgeries in North Berwick, Prestonpans and Dunbar – and has 21 staff working across the group, including 6 vets, 7 VNs, and 8 reception and admin staff. Major redevelopment at Scottish clinic Margot Hunter and Chris Monk looking over the building plans outside their main Tranent branch. VN struck off for drinking alcohol THE RCVSveterinarynurse disciplinarycommit- tee (VNDC) has struck aVN off the registerafter she was found to have been working under the influence of alcohol. Somerset-basedVN Nicola Buttler– who did not attend her hearing at the college from 19 to 21 June, having stated in advance she was not going to engage with the disciplinary process – was charged with having been under the influence of alcohol while at work on two occasions – while she was working as a locum between 25 and 28 April 2016 in Frome, and from 3 to 4 July 2016 in Salisbury. It was also alleged a prior conviction for drink-driving in November 2013 rendered her unfit to practise. The VNDC heard from five witnesses for the first charge, including three VNs and one vet. They gave testimony they had cause to suspect Ms Buttlerwas under the influence of alcohol due to her demeanour, and recalled her repeatedly retreating upstairs to her accommodation during theworking day. Further, an openwine bottlewas found in Ms Buttler’s accommodation and shewas observed to have been drunk during hershift.The VNDC, therefore, found the first charge proved. With the second charge, the committee heard from four witnesses, two of whom stated they smelled alcohol on Ms Buttler’s breath while on duty, and one of them stating she had slurred speech and a flushed face at the end of a 14-hour shift. The other two witnesses also presented evidence to support the assertion Ms Buttlerwas under the influence. The VNDC also found Ms Buttler to lack credi- bility because she had denied having any alcohol on the premises when originally confronted, yet later admitted in a college email she had had an open bottle of wine in her bag. The committee, therefore, found the second charge proved. Chairing the VNDC, Jane Downes said: “The VNDC noted Ms Buttler said she had worked for 20years without anyproblem and was previously of good character. However, because there was no evidence Ms Buttler would not repeat the conduct with regards to working while under the influence of alcohol, she could continue to pose a risk to animals or the public in the future. The committee, therefore, was bound to consider her removal from the register. “Although it noted from the brief email corre- spondence Ms Buttler had sent to the college she said she did not intend to practise in the future, the VNDC decided, until she had shown insight into her behaviour in 2016, she remained a risk to animals. It therefore decided the pro- portionate action was to instruct the registrar to remove her name from the register of veterinary nurses forthwith.” Ms Buttler can apply for restoration to the register after 10 months. The VNDC’s full findings and decision is the only authoritative document and is available on NEWLY discovered components of the chicken innate immune system suggest poultry may be better equipped to fight viruses than scientists previously thought. The Pirbright Institute researchers investigating chicken immu- nology have discovered a previously unknown interferon (antiviral molecule), which they identified as interferon kappa (IFN-K). The chicken’s innate immune system is generally not well under- stood and Pirbright scientists have used this component to under- stand its particular function in helping chickens combat viruses. This type of interferon has previously only been known in a few species, including humans, bats and mice. To better understand its significance in poultry, scientists undertook a parallel comparison between the chicken and human genomes to explore how IFN-K worked and specific viruses it might protect chickens from. Muhammad Munir, an expert in infection and innate immunity who led the study, said: “Chickens fight viruses differently to humans and the mechanisms of this process are not well under- stood. Interferons were first discovered in chickens in 1957, but 60 years later the full repertoire of interferons in poultry is still not yet fully explored. “The discovery of IFN-K and the information we have been able to gain about its properties and the protection it gives could offer chickens extra defence against some important diseases. What is especially interesting is chickens may already possess the key to conquering some of the most dangerous diseases that affect them. Using genetic modification technology, we can boost their innate ability to fight disease – potentially protecting people, too. “This study highlights how much more there is to learn from the chicken immune system and could be the first important step towards a major breakthrough in the battle against poultry and human disease.” IFN-K found in chickens