From Our Family to yours “ Live long and Prosper”.
Medicine can use the 12 step HACCP methodology to effectively deliver an integrated service Here I am with my partner Silas Kanning and Medical Director Terry Grossman who is a practitioner of leading edge integrated medicine
HACCP is not a quality or efficiency system but fully integrates with the Define/Measure/Analyze/Improve/Control cycles Open source access to knowledge Facilitates QA/QC and Lean
You assemble and direct your personal healthspan provider team
What you plan to do with your life will determine the aggressiveness with which to apply your plan
Canterpene Hemp Based Nutraceutical Formulations
REBRANDING HEMPFOR THENUTRACEUTICALMARKETCANTERPENE AS AHEALTHSPAN EXTENSIONSUPPLEMENT
Terry Grossman,M.D. Medical Director Morris Johnson, CTO, Founder Silas Kanning, Co-founders of:Lifespan Pharma Inc.
OUR SHAREHOLDERS HAIL FROM AGRICULTURE, MEDICINE AND PHARMACYMorris/Greg/Leah/Erin Rod Fisher Steve Burnside
REBRANDING HEMP ASCANTERPENE MAKES SENSEFOR THE NATURAL HEALTHPRODUCT / DSHEA FOODSUPPLEMENT MARKETS
35 YEARS AGO RAPESEEDEXPERIENCED THE SAMEPROBLEMS AFFECTING HEMPTODAYGrowers needed to rebrand something that wasassociated with a machine oil regarded as tootoxic for humans to consumeLow Erucic Acid Rapeseed (LEAR)?“CANadian source of OLeic Acid” becameCANOLAIt was promoted as a safe, nutritious, multi-purpose human and animal food ingredient
Hemp is undergoing a similar identity crisis in the minds of many today
When you Google “hemp” you get recreational and medicinal marijuana “Hits” because “pot people” use “hemp” indiscriminately when speaking about “marijuana”
SOME MARIJUANA PRODUCTSassociate cannabis with health benefits and socially “sexy” memes such as organic or chemical free
SOME CANADIAN HEMP PRODUCTSASSOCIATE HEMP WITH MARIJUANA
ASSOCIATING HEMP WITH MARIJUANA IS CREATING CONSUMER CONFUSION• Solutions:• Litigate?• Regulate?• Educate?• Ignore?
AFTER MUCH CONSIDERATION WECONCLUDED NONE OF THE ABOVESOLUTIONS ARE PRACTICAL OR COSTEFFECTIVE Some hemp manufacturers want to capitalize on the science which has popularized the term “Medical Marijuana” The best solution: REBRANDING
REBRAND CANADIAN HEMP AS CANTERPENEWe link Canadian Hemp with the messages:“Extend Health-span and Lifespan naturally with cannabis chemistry”Canterpene expands functional chemistry beyond arginine and omega3’s to include cannabinoids and terpenes
CANADIAN HEMP IS LEGAL AND EXEMPT FROM SCHEDULE 1 REGULATION AS IT IS NEITHER HERBAL MARIJUANA NOR SYNTHETIC THC
WE HAVE PATENTEDCANTERPENE AS APROPRIETARY FORMULATION OFMILLED HEMPSEED
DOES CANTERPENE HAVE A MARKET?-Healthspan and lifespan extension are new unmet needs-Personalized /Individualized Medicine is an emergingIndustry-”Bockbuster” Pharma is migrating towards “Niche” Pharma -Canterpene Cannabis without THC contains phyto-chemistry which scientific research indicates would make it a useful food supplement for the purpose of personalized management of AGING
AGING CAN BE BRUTAL This Becomes This--> All Too Soon
IT IS POSSIBLE TOGROW OLDER WITHOUTAGING AT ANY AGE 60 yrs old 80 yrs old
ANTIAGING IS ANENORMOUS MARKET76 million baby boomers in the US6 million “boomies” in CanadaBoomers now 48 – 64 and have begun toexperience the “aging process” firsthandThis generation has redefined each stage oftheir lives and is currently redefining aging
THIS IS THE NEW VIEW OFAGING Bob Delmonteque, age 84
THE TWO PILLARS OFHEALTHPrevention Early Detection
CANTERPENE CAN HELPAS A PREVENTIVEANTIAGING STRATEGYScience has linked numerous Cannabiscompounds found in Canterpene withbeneficial effects on the diseases resultingfrom “normal” agingCanterpene captures much that otherconventional hemp supplements haveignored
A toolbox for slowing aging & regenerating damage is emerging: e.g. Plastoquinine..targeting oxidative stress p
Food supplements claiming to support stem cell healthspanSTEMCELL100.COM , A NUTRACEUTICALDEVELOPED BY GENESCIENTCLAIMS TO PROMOTE THE STABILITY ANDVITALITY OF ADULT STEM CELLS SO THEYHAVE THE CAPACITY TO DIVIDE WHENTHE BODY SIGNALS A NEED FOR MORESTEM CELLS.CONTAINS:-THEANINE- 5-N-ETHYL-GLUTAMINE FROM CAMELLIASINESIS-OLIGO-PROANTHOCYANIDINS FROM THEPINE BARK OF THE PINUS TREE-PTEROSTILBENE, WHICH IS A LONG HALF-LIFE RESVERATROL ANALOG FROMPTEROCARPUS MARSUPIUM- ASTRAGALOSIDES EXTRACTED FROMASTRAGALUS MEMBRANACEUS
CAN CANTERPENE WORK AS A HEALTHSPAN AND LIFESPANEXTENSION TOOL?
AGING IS NOT LEGALLY CLASSIFIEDAS A DISEASE But….
SOME DISEASES/CONDITIONSASSOCIATED WITH AGING AREOxidative stressArthritisCentral nervous system degenerationParkinson’sAlzheimer’s Cannabidiol (CBD) the major cannabinoid in hemp has been shown to be of benefit in each of these and many other conditions
OXIDATIVE STRESSCBD treatment significantly reduced oxidative stress;decreased the levels of tumor necrosis factor, vascularendothelial growth factor, and intercellular adhesionmolecule-1; and prevented retinal cell death and vascularhyperpermeability in the diabetic retina. Consistent withthese effects, CBD treatment also significantly inhibited p38MAP kinase in the diabetic retina. These results demonstratethat CBD treatment reduces neurotoxicity, inflammation, andBRB breakdown in diabetic animals.EL Remessey AB et al. Neuroprotective and blood-retinalbarrier-preserving effects of cannabidiol in experimentaldiabetes. Am J Pathol. 2006 Jan;168(1):235-44.
ARTHRITISThese potentially anti-inflammatory properties of CBD,together with the lack of psychotropic effect and low toxicityprompted us to test the potential of CBD as a therapeuticagent in collagen-induced arthritis (CIA).RESULTS: “We report that CBD has a beneficial therapeuticaction on established CIA.”Malfait AM et al. The nonpsychoactive cannabis constituentcannabidiol is an oral anti-arthritic therapeutic in murinecollagen-induced arthritis. Proc Natl Acad Sci U S A. 2000Aug 15;97(17):9561-6.
PARKINSON’S DISEASEEvidence suggests that cannabinoids may prove useful inParkinsons disease by inhibiting the excitotoxicneurotransmitter glutamate and counteracting oxidative damageto dopaminergic neuronsCroxford JL. Therapeutic potential of cannabinoids in CNSdisease. CNS Drugs. 2003;17(3):179-202.It seems that cannabinoids could delay or even stop progressivedegeneration of brain dopaminergic systems, a process forwhich there is presently no prevention. In combination withcurrently used drugs, cannabinoids might represent,qualitatively, a new approach to the treatment of PD, making itmore effective.Sevcik J, Masek K Potential role of cannabinoids in Parkinsonsdisease DRUG AGING 16 (6): 391-395 JUN 2000
ALZHEIMER’S DISEASEMemory loss, the first and primary symptom of Alzheimer’sdisease, can be slowed down significantly in mice bycannabidiol.In a study at the Cajal Institute in Madrid, Spain, mice wereinjected with a molecule found in the brain of humans sufferingfrom Alzheimer’s disease, and then treated for one week withcannabidiol.Those mice injected with cannabidiol successfully performedthe task within 25-30 seconds, compared to control mice, whotook almost double the amount of time, 45-50 seconds, tocomplete the task.See also: Iuvone T, Esposito G, Esposito R, et al.Neuroprotective effect of cannabidiol, a non-psychoactivecomponent from Cannabis sativa, on beta-amyloid-inducedtoxicity in PC12 cells J NEUROCHEM 89 (1): 134-141 APR 2004
DSHEA COMPLIANTTARGETS-Optimize the broad spectrum of Canterpene functionalities-Add phytochemistry to enhance each functionality-Utilize ingredients with both ethnobotanical and modern pharmacological support in peer-reviewed , published literature-Proprietary varietal selection and agronomic production practices allow the use of the same Canterpene ingredient for several distinctly different formulations-Formulas can be combined into a systemic therapeutic program to attack a systemic problem, AGING “Medicine without a market benefits no one”
DSHEA COMPLIANT TARGET1- Support for Cancer patients Synergistic with Conventional Meds.- Natural sourced ingredients: 1- 200mg Orange oil a source of limonene and perillic acid 2- 800mg Canterpene Hemp Oil
DSHEA COMPLIANT TARGET 2- Replacement of chemistry deficits caused by aging- Food supplement ingredients:-10 mg DHEA (dehydroepiandrosterone) to replace sex hormones required for sexual function, and lean muscular metabolism lost because of aging.- 200mg Acetyl L Carnitine to replace mental energy and endurance lost because of aging.-750mg Canterpene Hemp Oil to reduce subclinical inflammation associated with aging.-“SEXTROPY 4 U” BRANDING targets sexual health- Complementary to “Viagra” type of products
DSHEA COMPLIANT TARGET3Canterpene “hydrogen water” beverage-Hemp tea saturated with hydrogen gas-hydrogen water has been used therapeutically by several spas where the water has a natural hydrogen content-Malcolm dole detailed the anticancer properties of hydrogen in 1975-hydrogen gas mixtures are used by deep divers-numerous papers detail the universal antioxidant properties of water with a hydrogen content-synergistic with the cannabinoid/terpene chemistry of hemp tea
DSHEA COMPLIANT TARGET 5TELOMERASE MODIFIER ASTROGALOSIDE IV + CANTERPENEIn 2009, Nobel in Medicine and Physiology was awarded to three scientistsfor their research on telomeres and telomerase. Researchers find the shorter your telomeres (the caps at the ends of your chromosomes that keep the strands of your DNA from fraying), the faster you age.So here comes an anti-aging opportunity: increase telomere length.Researchers from UCLA found the extracts from Astragalus can boost production of telomerase, an enzyme that allows for the replacement of short bits of DNA, known as telomeres, that play a key role in cell replication and human aging.By now, Cycloastragenol and Astragaloside IV are the only natural nutraceutical substances verified by a study of a lab of UCLA to activate telomerase in human cells.Cycloastragenol and Astragaloside IV are extracts from a Chinese herbal Astragalus which have been used in China for over 2000 years.
DSHEA COMPLIANT TARGET 5TELOMERASE MODIFIER ASTROGALOSIDE IV + CANTERPENEhttp://www.ncbi.nlm.nih.gov/pubmed/21928670http://www.longwoodherbal.org/astragalus/astragalus.PDFhttp://www.umm.edu/altmed/articles/astragalus-000878.htmhttp://www.astragalusextract.net/astragaloside.htmlhttp://www.cmjournal.org/content/4/1/6/http://www.ncbi.nlm.nih.gov/pubmed/16900242http://www.naturalnews.com/027312_astragalus_research_aging.html
FUTURE RESEARCHTARGETS6-Metabolic syndrome-diabetic process modulation: chelated vanadium flavonoid + fenugreek + Canterpene7-CoQ10+plastoquinone +Canterpene8-Epigenomic primer formula … Folic acid + B12+ Biotin+Canterpene9-Arthritis/joint support formula- vitamin D + Canterpene + hops +MSM10-Cardio support: 400 mg Acetyl-l-Carnitine, 500 mg Canterpene +100mg time released niacin11-Microbiome Management: to enhance your macrocellular microflora to produce beneficial bioactives
GOOD SCIENCE WITHOUT A METHOD TOCOMMERCIALIZE IT WILL NOT BENEFITANYONECANTERPENEAS ANANTIAGINGSTRATEGY
THE BOTTOM LINE AFFORABLE BUT NOT CHEAP MSRP ~ 40.00/ BOTTLE OF 100 750 MG CAPSULES 1-INGREDIENTS – COMPOSITE VALUE OF INGREDIENTS 11.00/BOTTLE = (410.00/GALLON OR 50.00/POUND) -60/GALLON -TO COST OF GROWING CROP -160/GALLON -TO BUILD AND OPERATE AND EXPAND FACILITIES AND EQUIPMENT FLEET TO CONVERT CROP IN THE FIELD TO OIL/EXTRACT/DERIVATIVES -90/GALLON -TO PHYTOCHEMICAL R&D/CLINICAL TRIALS -100/GALLON -TO OVERHEAD/TAXES/RETURN TO INVESTORS2-ENCAPSULATION/PKGING./BOTTELING /LABELING -9.00/BTL 3-MARKETING -15.00/BOTTLE 4-DISTRIBUTION/SHIPPING -5.00/BOTTLE AS WE SCALE UP ,WE WILL FIND MARKETING AND DISTRIBUTION EFFICIENCIES TO PROVIDE INVESTORS WITH A PROPER RETURN ON INVESTMENT ….DETAILS IN OUR BUSINESS PLAN
AGING , A SYSTEMIC DEGENERATIVE SYNDROME WITH MULTIPLE THERAPEUTIC TARGETSHTTP://WWW.YOUTUBE.COM/WATCH?V=GHVXW2EE3-A
CANTERPENE- A “MEDICAL EMANCIPATION” TOOLNUTRACEUTICALS THAT EMPOWER INDIVIDUALS TO PERSONALLY MANAGE THEIR HEALTHSPAN