Weight Loss and Pharmanex TR90: What You Need to Know

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Dr. Cady reviews the science and the facts of weight gain, weight loss, and the new genomically focused weight loss program from Pharmanex: TR90. In this program, Dr. Cady relentlessly dissects the errors of the "low fat" way to eat, targets high glycemic eating and protein deficient diets as the main culprits in our society's weight gain, and proposes a common-sense and rational way to eat to achieve any of the following goals: (a) not gain any more weight, (b) maintain your current weight, (c ) lose weight.

The genomic science behind the technology used by Pharmanex to develop TR-90 is reviewed. TR90 is the only genomically focused, nutritionally sound weight management available for sale today. The genomic science behind this product is established. Multiple scientific papers (one of which is referenced in this presentation) unequivocally show that what you eat in your diet alters gene expression.

As of the release of this slide deck on 4/19/2014, the three month TR90 system will only be available for sale in the US for one day on April 23rd at 11 a.m. CST. It is estimated that the entire manufactured run available for the US will sell out in 60 - 90 minutes. It will not be available for sale in this country for six months after this date. Please contact the office at Cady Wellness Institute if you are interested in securing a three month supply. (812) 429-0772.

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  • The U.S. is a heavyweight champion in fat. It has the most obese population of any industrialized nation.
  • The U.S. is a heavyweight champion in fat. It has the most obese population of any industrialized nation.
  • The U.S. is a heavyweight champion in fat. It has the most obese population of any industrialized nation.
  • This heatmap illustrates gene expression of three groups from a pre-clinical test with one of the ageLOC Vitality ingredients: young (column 1), old (column 2), and old with ageLOC science (column 3). Each row represents one of 52 genes comprising the mitochondrial Youth Gene Cluster (mtYGC). Columns 1 and 2 show that each of the 52 genes became more or less active during the aging process. In column 3, the YGC activity pattern of the old with ageLOC science group has been reset to a gene expression pattern similar to the young group in column 1.1
  • Weight Loss and Pharmanex TR90: What You Need to Know

    1. 1. Louis B. Cady, MD, FAPA – CEO & Founder – Cady Wellness InstituteLouis B. Cady, MD, FAPA – CEO & Founder – Cady Wellness Institute Adjunct Clinical Lecturer – Indiana University School of Medicine Department of Psychiatry Wellness Medicine & Functional Neuropsychiatry – Evansville, Indiana TR 90: A Revolutionary Genomic Based Weight Loss Approach
    2. 2. Focus of this review • What most people do not know about why they are (a) gaining weight and (b) can’t lose weight. • How does this eating and insulin thing work? • Why calorie restriction and typical diets don’t work. • Is the problem “all in your glands”? • “What is TR 90?”
    3. 3. Calorie restriction • The foundational principle of the “yo-yo diet” • The FAILURE of calorie restriction only – Starve yourself – Lose fat and muscle – Go off diet – Put on all the weight, and then some, because of loss of muscle – Repeat ad infinitum. And get bigger and heavier.
    4. 4. Techniques of (net) calorie reduction part I: cut calories • Using diet books, weighing portions, counting calories, increasing activity • Join Weight Watchers. • Diet pills & supplements • Fen-Phen disaster – heart valve abnormalities • Stimulant problems – – Stresses adrenals – Potential for adverse cardiac events • Lap band (surgical complications), muscle with fat loss, toxins
    5. 5. WEIGHT STATS ADULTS 70% OVERWEIGHT CHILDREN 20% OBESE OBESITY IS A KILLER
    6. 6. UP TO 40% OF THE WEIGHT LOSS IN TYPICAL DIETS IS MUSCLE LOSS
    7. 7. M us cl e M us cl e Metab olic Burn Metab olic Burn LEAN MUSCLE = METABOLIC ENGINE • Traditional calorie restricted diet • Lose lean muscle as well as fat • Protein heavy, calorie restricted • Maintain more lean muscle Metabolic burn = rate at which body Mu scl e Mus cle Metabo lic Burn Metab olic Burn
    8. 8. Glycemic index • A measure of how fast a carbohydrate triggers a rise in circulating blood sugar. • The higher the number, the greater the blood sugar response.
    9. 9. Selenium, the Thyroid, and You • “T3” is the ACTIVE form of thyroid • Conversion of T4 to T3 is selenium dependent • LP & LP Nano have 200% of RDA of selenium Se+ 
    10. 10. The Old FDA Food pyramid – R.I.P 2005
    11. 11. June 1, 2011
    12. 12. “Pyramid Power” USDA Food PyramidZone Food Pyramid Vegetables Fruits Low-fat Protein Monounsaturated Fat Grains and Starches (Use in Moderation)
    13. 13. How to lose it?
    14. 14. FAT LOSS SECRET #1 Source: http://win.niddk.nih.gov/statistics/index.htm#overweight
    15. 15. FAT LOSS SECRET #2 Source: http://win.niddk.nih.gov/statistics/index.htm#overweight
    16. 16. FAT LOSS SECRET #3 Source: http://win.niddk.nih.gov/statistics/index.htm#overweight
    17. 17. The top weight loss secret from Tim Ferris “Consume 30 grams of protein within one hour of waking up.”
    18. 18. ageLOC – a novel mechanism to target and reset “youth gene clusters” Old Gene Expression Young Gene Expression TARGET Old Gene Expression RESET 1 Transcriptional Biomarkers of Mitochondrial Aging and Modulation by Cordyceps Sinensis Cs-4. Gordon Research Conference, Biology of Aging, Determinants of Health-Span: From Cells to Humans, August 22-27, 2010. Les Diablerets Conference Center, Les Diablerets, Switzerland.
    19. 19. “Youth Gene Clusters” – bogus or bonanza? Comparative genomics of fungal allergens and epitopes show widespread distribution of closely related allergen and epitope orthologues. Bower P, et al, BMC Genomics. 2006; 7:251. Yeast species SPECIFIC genes
    20. 20. Prostate Cancer – more relevant? Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention. Ornish, Dean et al. Proc Natl Acad Sci USA 2008 June 17; 105(24):8369-8374 Pre-invention gene expression Post-intervention gene expression TRANSLATION: What you eat talks to your genes and CHANGES THEIR EXPRESSION.
    21. 21. Comparison of Genetic Profiles of Adipose Tissue in Identical Twins Pietiläinen et al. PLoS Med. 2008 Mar 11;5(3):e51. Same DNA Different Expression of Genes Normal Weight Twin Overweight Twin Compared to their normal weight twin, overweight twins exhibited down regulation of gene expression pathways related to: • Fat Regulation (storage versus utilization) • Muscle Protein Synthesis
    22. 22. Ghrelin Leptin Insulin References: Gene Expression relates to the Appetite Control Center of the Brain • Appetite Control • Eating Behavior • Regulation of energy intake 1. Smeets et al. Proceeding of the Nutrition Society. 2012;71:511-520. 2. Guthoff M, et al. J Clin Endocrinol Metab. 2010;95:748-755. 3. De Silva, et al. Cell Metab. 2011;14:700-706. 4. Malik S, et al. Cell Metab. 2008;7:400-409. 5. Farooqi IS, et al. Science. 2007;317:1355 6. Suzuki K, et al. Experimental Diabetes Research. 2012:1-19. 7. Viquerie N, et al. Diabetologia. 2005;48(1):123-131. 8. Mager et al. European Journal of Endocrinology. 2008;158: 9. Mutch DM, et al. Am J Clin Nutr. 2011;94(6):1399-1409.
    23. 23. Carbohydrates (260g) Proteins (90g) Fats (67g) Normal Calorie Diet – 2000 kcal FatBurning Foods FatStoring Foods FatStoring Foods Carbohydrates (260 g) Proteins (90 g) Fats (67 g)
    24. 24. Carbohydrates (260g) Proteins (90g) Fats (67g) Typical Reduced Calorie Diet – 2000 kcal FatBurning Foods FatStoring Foods FatStoring Foods Carbohydrates (180 g) – 1200 kcal Fats (33 g) Proteins (45 g)
    25. 25. Carbohydrates (260g) Proteins (90g) Fats (67g) FatBurning Foods FatStoring Foods FatStoring Foods Carbohydrates (120 g) Fats (40 g) Muscle Retention Eating Plan – 1200 kcal Proteins (90 g)
    26. 26. Eating Most of Your Protein with Only One Meal of the Day Limits Duration of Metabolic Burn FATSTORINGFATSTORINGFATBURNINGFATBURNING Time in Metabolic Burn Zone = Only 3 hours/day Adapted from: 1.Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86. 2.Layman DL. Nutrition and Metabolism, 2009; 6:12. Breakfast Lunch Dinner ZONES
    27. 27. Eating Protein with Each Meal Accelerates Metabolic BurnFATSTORINGFATSTORINGFATBURNINGFATBURNING Adapted from: 1.Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86. 2.Layman DL. Nutrition and Metabolism, 2009; 6:12. Breakfast Lunch Dinner Time in Metabolic Burn Zone = 9 hours/day ZONES
    28. 28. The TR90 Eating Plan Based on: Protein Science & Nutrition Science • Supports metabolically-active lean muscle and inhibits fat storage1 Reference: Wycherley TP, et al. AJCN. 2012;96(6):1281-98. • An eating plan designed to complement the supplements.
    29. 29. Breakfast Snack Lunch Snack Dinner At least 30 Grams of Protein Trim Shake Egg Omelet Vegetable of color (peppers, onions, zucchini, spinach, broccoli, tomatoes, salsa) Berries on the side Yogurt Cottage Cheese At least 30 Grams of Protein Trim Shake Chicken Fish Pork Shrimp Tofu Cottage Cheese Color Food (see guide) Sweet Potato At least 30 Grams of Protein Chicken Fish Pork Tofu Shrimp Vegetable of color (peppers, zucchini, spinach, salsa) Sweet Potato Yogurt Cottage Cheese Nuts (1 oz) Melon Berries Apple Pear Carrots Celery Cucumber Vegetables Greek Yogurt Yogurt Cottage Cheese Nuts (1 oz) Melon Berries Apple Pear Carrots Celery Cucumber Vegetables Greek Yogurt Non-Shake Healthy Meal 30-60 grams protein + 1 Grain 1 Fruit 1 Vegetable 15+ Grams protein from TR90 Shake + (15-45 grams protein from non-shake protein sources) --- previous eating plan, TR 90, Oct 2013 ---
    30. 30. HOW MANY GRAMS?
    31. 31. H - 36 Benefits of low-glycemic eating
    32. 32. 78 pounds gone forever!78 pounds gone forever! TINA CLARK
    33. 33. DENNY PRETZ
    34. 34. October 5th , 2013
    35. 35. TR 90 – a look back October 28, 2013 January 28, 2014 Jan 29, 2014
    36. 36. Withings WS-50 Smart Body Analyzer
    37. 37. (Start weight: 168.5 lbs – Oct 28th ) 10 lbs of total weight loss = 6% body weight
    38. 38. (43.1 lbs – Oct 28th ) 7.7lbs of fat loss 10 lbs of total loss = 77% of weight loss was FAT loss
    39. 39. Pre-TR90 172 -169 Start June 28th -Oct 28th 4 months, 3 lbs= ¾ lb/mo Oct 28th -Jan 28th 3 mo’s, ll lbs = 3.7 lbs / mo = 5 X the wt. loss rate TR90 – (done imperfectly) -169-158 Post TR90 158 to 155 Jan 28th –April 17th 2.75 mo’s, 3lbs = 1.1 lbs/mo “What happens after I finish 3 months of TR-90?”
    40. 40. “When you change the way you look at things, the things that you look at change.” -John Assaraf
    41. 41. Key down-home principles • Jump start your genes. • Eliminate the junk. Pitch it. If you don’t have it, you can’t eat it. • Develop a taste for [low glycemic] fruit. • Ostrich jerky (GNC) or balance protein/carb bars • 30 grams of protein in the a.m. within ½ - 1 hour of awakening • Eat real food • Minimize eating out. • NO FAST FOOD!! NO FAST FOOD!! • Axiom: If you’re full of the good stuff, you won’t crave the bad stuff.
    42. 42. Personal collection Louis B. Cady, M.D.
    43. 43. The Question: What Will You Do About It?

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