Louis B. Cady, MD – CEO & Founder – Cady Wellness InstituteLouis B. Cady, MD – CEO & Founder – Cady Wellness Institute
Adj...
H - 2
“There are two objects of medical education: to heal
the sick and to advance the science.”
- Dr. Charles H. Mayo, MD...
Disclaimer: Pharmanex
supplementation and the
BioPhotonic Scanner are not
FDA approved for the diagnosis,
treatment, preve...
Learning objectives
• Define a problem: American’s medical and
financial health is declining.
• MD’s and HCP’s are getting...
The health of society & the doctors to
treat it
• Doctors are going to get squeezed: more will quit,
YOUR out of pocket co...
The Problems & The Solution
The good ole days:
•People had jobs
•People had insurance
•Insurance PAID.
•Society was health...
Everett Napier, an unemployed miner, said he pawned various items while he has
been looking for work, including rifles, to...
CURRENT PRACTICE OF MEDICINE:
What a patient had to say about her “specialists”:
“They just monitor my
degeneration.”
www.billfoster.com - Reviving American Manufacturing, accessed 1 27 2014www.billfoster.com - Reviving American Manufacturi...
Unemployment, underemployment are
contemporary problems…
http://www.scdigest.com/assets/newsViews/08-06-12-2.php accessed 01 27 2014http://www.scdigest.com/assets/newsViews/08-06-...
Look out Pharma reps!!
Feb 6, 2014
- The “SGR” cut: 24 – 30% of Medicare fees
- Has been “patched” 15 times since 2002 for c. $140 billion
- Addi...
Business 101 – 3 doctor internal
medicine clinic
INCOME
NET Revenue: $1.5 million
EXPENSES:
Overhead* : $1 million
[suppor...
Business 101 – 3 doctor internal
medicine clinic
INCOME
(prev) Revenue: $1.5 million
Less 24% cut: - $360,000
Total income...
Instant replay
• 24% cut to gross receipts
• 72% cut to doc salaries (from $166,667
down to $46,667
– Working 50 – 60 hour...
Business 101 – 3 doctor internal medicine clinic
– what does this REALLY MEAN?
As your fees stagnate or are cut, and as yo...
Doctors quitting medicine
• Suicide* (2004):
– 1.41 X for male physicians vs. general pop.
• "Half of primary care physici...
“Why I Left Medicine: A Burnt-Out
Doctor’s Decision to Quit”*
• “It may be dramatic
and self-serving to
frame my career
ch...
REASON: “EHR” requirements. “Would
cost too much in his small medical practice.”
“But I’m not a doctor; I’m not going to
have those problems.”
• Dentists, optometrists, DC’s – mixed fee for
service model...
A TALE OF THREE WOMEN
Evansville Courier & Press: May 29,
2006
As of 03/20/2014
Could it happen to you?
What causes oxidative stress?
• Environmental Toxins
– Heavy metals – including Mercury (fillings!)
– Pesticides/herbicide...
Oxidative stress in the BRAIN
Why is the brain so
susceptible to oxidative stress?
• Burns glucose – generates free radicals.
• Uses 20% of total oxygen...
What are some consequences of
oxidative stress?
• Impaired cognitive function
• Decreased memory
• Depressed immune system...
Antioxidant assessment
Reference:
www.cadywellness.com/cadyw
Reference:
www.cadywellness.com/cadyw
Center for Biomedical Optics – Dixon
Laser Institute, University of Utah
• Werner Gellermann, Ph.D. – Research
Professor
•...
(c) 2013 Louis B. Cady, M.D. - all
rights reserved
“A method and apparatus are provided
for the determination of levels of
carotenoids and similar chemical
compounds in biol...
“But is the scanner really valid and
dependable?”
Scientific Validation: Peer-reviewed by the
medical & research communities
• Society of Investigative Dermatology, May 25,...
• “The totality of the evidence supports the use of skin carotenoid
status as an objective biomarker of fruits/vegetable i...
Where to read more…
“The Complete Idiot’s Guide to the
“Cady White Paper”
• Pp 1-3 Patent claim synthesis: assessing
the overall antioxidant s...
Carotenoid correlation with other
antioxidants (pp 4-6)
• Cited: carotenoids as chemopreventive agents*
• Carotenoids as f...
Relationships of carotenoids to other more
conventionally measured antioxidants (p 6 -7)
• Svilaas et al (2004):
– 2, 670 ...
Convenience of carotenoids as antioxidant
measurement (pp 7-11)
• Hata, et al (2000) – correlated skin
carotenoids (Raman)...
The Svilaas/Hata Syllogism:
• Hata (2000) – Raman measurements of
carotenoid == HPLC skin measurements of
carotenoids
• Sv...
Dissolved carotenoids in stratum corneum
27 days
BTW – what does that “SCS” actually
mean in REAL LAB MEASUREMENTS?
• Y = 12703 * X + 5891.7
– Where Y is the SCS, and X is...
“RSS spectroscopy is a reliable
method for non-invasive
measurement of B-carotene
levels in skin, and may be used
as an im...
How are we doing? 2006 Data Histogram:
N =2,591,667
Mean SCS = 26,673
Skin Carotenoid Score
Frequency
5-9 Fruits & Vegetab...
16,103 people – 1994 – 1996.
ZERO got 100% of all required vitamins and
nutrients
- Highest – B12 =- 82.8% got enough
- 66...
What’s New since the “cady
report” (2006 & 2008)?
Lipid peroxidation, antioxidant status
& survival in institutionalized elderly
• Plasma MDA
predicted mortality
independen...
Angela Mastaloudis Ph.D.
Senior Scientist, Global Research &
Development, Pharmanex
“RS accurately measures total carotenoids in human skin
with less intra-individual variability than measurement of
serum c...
Epidemiology of Vascular Aging (EVA)
• Study population:
– N=1,389; age range {59-71 yoa}
– 9 year study
• Relative risks:
– all cause mortality at 2.94X in me...
Vitamin/mineral supplementation & cancer,
cardiovascular, and all-cause mortality
(EPIC-Heidelberg) Li K, Kaaks R., et al....
Antioxidants and brain tumors?
• “free radicals are another etiological factor
of brain tumor and are removed by cellular
...
Conclusions
• “It is concluded that
administration of antioxidants
could reduce the incidence of
brain tumors and probably...
The GREAT news about a BAD study
Conclusions: “In older women, several
commonly used dietary vitamin and mineral
supplemen...
Not so fast!
• 18 year duration; 38,000 “older” white
women in Iowa
• Supplements: MVI’s, A, D, E, Beta-
carotene, B –vita...
A real hatchet job on MVI’s
• Study measured “who dies over 18 years?”
– Average age at start – 61 yoa
– Average age at en...
More hatcheting – poor controls
• Hormones (Premarin/provera)
– 13.5% of supplement users
– 7.2% of non-supplement users
•...
“Pending strong evidence …from randomized trials, it
appears prudent for all adults to take vitamin
supplements.” Fletcher...
44 million inpatients, 460 sites, 2000-2010 = 20%
of all US inpatient episodes (1.6% were on ONS
during the inpatient epis...
So why do you need a
SYSTEM in your vitamin
supplement/mineral
complex?? And what’s a
‘nano’?
What does “Nano” mean?
• Cylcodextrin ring – benign, digestable
• Feeds the gut microflora
How do nano-nutrients work?
Nano-encapsulated nutrients do
not clump; they DISPERSE.
Fat-soluble nutrients like
carotenoid...
The Nanotechnology Differencepmol/mgprotein
γ-cyclodextrin
complex
5-fold increase in absorption!
Adapted from Craft et al...
The train has left the station…
what about other
things besides carotenoids
and “Antioxidants”??
B12, Magnesium, Selenium, Zinc, fish
oil…
vitamins
vitamins
minerals
minerals
Omega-3
Omega-3
fatty acids
fatty acids
Phytonutrients
Phytonutrients
Antioxidants
Ant...
LifePak Nano Contains
• All 8 forms of natural vitamin E
• Buffered vitamin C, Alpha lipoic acid
• Nano Carotenoids:
– as ...
• Irritability
• Apathy
• Personality changes
• Depression
• Memory loss
• Dementia
• Hallucinations
• Violent behavior
• ...
LifePak Nano factoids - % RDA in 2
packets
• B12 - 1,000% (as 60 MICROgrams
cyanocobalamin)
• Magnesium 76% (as 300 Mg ami...
The Effects of high dose B vitamins
on stress at work
• “Occupational stress is increasing in Western societies.”
• 3 mont...
Magnesium mementos
• One of the first minerals to disappear with:
– Processed food
– Stress
• Decreased by EtOH, caffeine,...
Symptoms of Magnesium Deficiency
PSYCHIATRIC ISSUES:
•Difficulty with memory
and concentration
•Depression, apathy
•Emotio...
SELENIUM DEFICIENCY in FASEB:
• “Adaptive dysfunction of
selenoproteins from the
perspective of the ‘triage’
theory: why m...
Negative downstream effects from
selenium deficiency:
“…cancer, heart disease, and
immune dysfunction are
prospectively as...
“the foot soldier”
LifePak Nano has 200% of
RDA of selenium.
Se+

THYROID
HORMONE
Fast food (low Zn) is bad for you.
• Fast food = high energy density = low essential
micronutrient density, ESPECIALLY ZIN...
Special needs - Zinc
• Low Zinc- associated with low testosterone
– Per USDA, 60% of US men between 20 – 49
years of age d...
Essential Fatty Acids – relevant for:
“Psych”
• Depression
• Bipolar depression
• Schizophrenia
• Autism
• AD(H)D
• Learni...
Do YOU Need Fish Oil?
5X reduction
What happens with biotin
deficiency?
“Our results suggest that biotin deficiency
promotes hyperglycemic mechanisms…and
dec...
A personal close
How do you want to age?
Wrapping Up: The “Survival Curve” –
Where Are You?
What can you do at 100?
• Rita Levi Montalcini, MD
• Nobel Prize – Medicine 1986
• Birthday – April 18, 1909
• “At 100, I ...
TR 90 – a look back
October 28, 2013 January 28, 2014
Jan 29, 2014
Success and Failure (Jim Rohn)
What about you? You’ve only got one body.
• “Errors in judgement” - High glycemic eating,
n...
“For me, the practice of medicine has
opened the door to the greatest adventure in
life. Medicine is like a hallway lined ...
Contact information:
Louis B. Cady, M.D.
www.cadywellness.com
www.tmsrelief.com
Office: 812-429-0772
E-mail: lcady@cadywel...
Pharmanex HCP presentation, Provo, Utah 03
Pharmanex HCP presentation, Provo, Utah 03
Pharmanex HCP presentation, Provo, Utah 03
Pharmanex HCP presentation, Provo, Utah 03
Pharmanex HCP presentation, Provo, Utah 03
Pharmanex HCP presentation, Provo, Utah 03
Pharmanex HCP presentation, Provo, Utah 03
Pharmanex HCP presentation, Provo, Utah 03
Pharmanex HCP presentation, Provo, Utah 03
Pharmanex HCP presentation, Provo, Utah 03
Pharmanex HCP presentation, Provo, Utah 03
Pharmanex HCP presentation, Provo, Utah 03
Pharmanex HCP presentation, Provo, Utah 03
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Pharmanex HCP presentation, Provo, Utah 03

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This is the slightly trimmed version of "The Gathering Storm, The Breaking Dawn" talk I previously gave in California, dealing with the failing financial and physical health of the American public (other than the much talked about "1%") as well as the medical care system which is in danger of imploding. The Pharmanex Biophotonic scanner, its validation, and the rationale behind the LifePak supplement line is reviewed.

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  • Speaker note – transition– of tale of three women.
  • FROM WIKIPEDIA - Epidermis
    Epidermis, "epi" coming from the Greek meaning "over" or "upon", is the outermost layer of the skin. It forms the waterproof, protective wrap over the body's surface and is made up of stratified squamous epithelium with an underlying basal lamina.
    The epidermis contains no blood vessels, and cells in the deepest layers are nourished by diffusion from blood capillaries extending to the upper layers of the dermis. The main type of cells which make up the epidermis are Merkel cells, keratinocytes, with melanocytes and Langerhans cells also present. The epidermis can be further subdivided into the following strata (beginning with the outermost layer): corneum, lucidum (only in palms of hands and bottoms of feet), granulosum, spinosum, basale. Cells are formed through mitosis at the basale layer. The daughter cells (see cell division) move up the strata changing shape and composition as they die due to isolation from their blood source. The cytoplasm is released and the protein keratin is inserted. They eventually reach the corneum and slough off (desquamation). This process is called keratinization and takes place within about 27 days. This keratinized layer of skin is responsible for keeping water in the body and keeping other harmful chemicals and pathogens out, making skin a natural barrier to infection. From WIKIpedia
  • Based on clinical studies with the biophotonic scanner, we have identified a number of factors that may influence your score. The average skin carotenoid score for Europeans is 26,673, those who eat the recommended 5-9 fruits and vegetables or take lifepak regularly have even higher scores. What is really exciting is that people with the best lifestyles - eat the recommended 5-9 fruits and vegetables, take LifePak regularly, avoid cigarettes, and so on, have the very highest scores, in the 40,000 range. Therefore, the effects of a good lifestyle are cumulative when it comes to Antioxidant protection.
    The other point I would like to make is that people with known oxidative stress such as smokers, have lower scanner scores, just as we would predict, but people who are overweight or obese tend to have even lower scores than smokers! Thus it appears that obesity depletes antioxidant levels even more than smoking.
  • METHODS:
    In the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg), which was recruited in 1994-1998, 23,943 participants without pre-existing cancer and myocardial infarction/stroke at baseline were included in the analyses. Vitamin/mineral supplementation was assessed at baseline and during follow-up. Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
    RESULTS:
    After an average follow-up time of 11 years, 1,101 deaths were documented (cancer deaths = 513 and cardiovascular deaths = 264). After adjustment for potential confounders, neither any vitamin/mineral supplementation nor multivitamin supplementation at baseline was statistically significantly associated with cancer, cardiovascular, or all-cause mortality. However, baseline users of antioxidant vitamin supplements had a significantly reduced risk of cancer mortality (HR: 0.52; 95% CI: 0.28, 0.97) and all-cause mortality (HR: 0.58; 95% CI: 0.38, 0.88). In comparison with never users, baseline non-users who started taking vitamin/mineral supplements during follow-up had significantly increased risks of cancer mortality (HR: 1.74; 95% CI: 1.09, 2.77) and all-cause mortality (HR: 1.58; 95% CI: 1.17, 2.14).
    CONCLUSIONS:
    Based on limited numbers of users and cases, this cohort study suggests that supplementation of antioxidant vitamins might possibly reduce cancer and all-cause mortality. The significantly increased risks of cancer and all-cause mortality among baseline non-users who started taking supplements during follow-up may suggest a "sick-user effect," which researchers should be cautious of in future observational studies.
  • One study of Swedish women found that vitamin A intake was negatively associated with bone mineral density, and for every one mg increase in daily vitamin A consumption, risk of hip fracture increased by 68 percent. This is because vitamin A is known to counteract the ability of vitamin D and calcium to build bone density, and excess vitamin A leads to bone loss.
    Supplement quality can be compromised at many stages of the production process and the most common problems are contamination and low potency. When companies want to cut cost they use cheaper raw materials, which result in a lower quality product. For example, in the case of magnesium, magnesium oxide is a cheap, small molecule that isn’t absorbed well by the body, whereas magnesium glycinate and citrate are large molecules that are harder to package but much more easily absorbed. This type of magnesium is effective at raising blood serum levels, but it is also more pricey to produce. Low quality supplements like magnesium oxide aren’t absorbed by the body. Rather, they pass right through and can cause negative side effects—magnesium oxide can have a laxative effect.
    These notes quoted from Flawed Iowa Women's Health Study Used to Discredit Supplements: Don't Believe It!
    by Charles Poliquin
  • When repleted - results pretty quickly. “If if spasms, think magnesium” – bowel, bronchial.
  • Pharmanex HCP presentation, Provo, Utah 03

    1. 1. Louis B. Cady, MD – CEO & Founder – Cady Wellness InstituteLouis B. Cady, MD – CEO & Founder – Cady Wellness Institute Adjunct Clinical Lecturer – University of Southern Indiana Adjunct Clinical Lecturer – Indiana University School of Medicine Department of Psychiatry Child, Adolescent, Adult & Forensic Psychiatry – Evansville, Indiana The Gathering Storm, The Breaking Dawn II: New Challenges & Opportunity for the Health of America
    2. 2. H - 2 “There are two objects of medical education: to heal the sick and to advance the science.” - Dr. Charles H. Mayo, MD “The glory of medicine is that it is always moving forward, that there is always more to learn.” - Dr. William J. Mayo
    3. 3. Disclaimer: Pharmanex supplementation and the BioPhotonic Scanner are not FDA approved for the diagnosis, treatment, prevention, or cure of ANY disease or “medical condition.” They ARE appropriate to support the structure and function of the human body.
    4. 4. Learning objectives • Define a problem: American’s medical and financial health is declining. • MD’s and HCP’s are getting squeezed and are dropping out. • Answer the question of “but I just don’t GET it about those antioxidants.” • Answer the objections about the scanner “gizmo.” • Review the literature. Achieve state of the art, up to date knowledge. • Review some personal reflections.
    5. 5. The health of society & the doctors to treat it • Doctors are going to get squeezed: more will quit, YOUR out of pocket costs are going up. • Americans will have less money to pay for bigger health care costs • Average people need to do something NOW to maintain health and minimize costs. And why we should all start paying attention to those “filthy rich doctors” and how they are getting paid.
    6. 6. The Problems & The Solution The good ole days: •People had jobs •People had insurance •Insurance PAID. •Society was healthier. •Doctors were plentiful. •Your healthcare was essentially “free,” no matter how stupidly you behaved. Problems: •2001/2008 recessions •Outsourcing •More medical technology •More activism from groups such that “everything must be covered.” •2013-14: More government interference in free market The RESULTS: •Medical insurance costs more $$$. •Fewer doctors available. • Doctors are quitting. • Insurance companies/ government = defacto RATIONING. •Now, you “gonna have to PAY” for poor health habits, poor nutrition, obesity, smoking, etc.
    7. 7. Everett Napier, an unemployed miner, said he pawned various items while he has been looking for work, including rifles, tools, jewelry and two guitars he used to play at church. 'I just swallowed my pride and quit playing. That's all you can do.' David Stephenson for The Wall Street Journal. November 26, 2013
    8. 8. CURRENT PRACTICE OF MEDICINE: What a patient had to say about her “specialists”: “They just monitor my degeneration.”
    9. 9. www.billfoster.com - Reviving American Manufacturing, accessed 1 27 2014www.billfoster.com - Reviving American Manufacturing, accessed 1 27 2014
    10. 10. Unemployment, underemployment are contemporary problems…
    11. 11. http://www.scdigest.com/assets/newsViews/08-06-12-2.php accessed 01 27 2014http://www.scdigest.com/assets/newsViews/08-06-12-2.php accessed 01 27 2014
    12. 12. Look out Pharma reps!!
    13. 13. Feb 6, 2014 - The “SGR” cut: 24 – 30% of Medicare fees - Has been “patched” 15 times since 2002 for c. $140 billion - Additional source: McDonough J.E. “Health Stew” column 12/22/2013 http://www.boston.com/lifestyle/health/health_stew/2013/12/advice_to_congress_pass_sgr_ accessed 2/7/2014
    14. 14. Business 101 – 3 doctor internal medicine clinic INCOME NET Revenue: $1.5 million EXPENSES: Overhead* : $1 million [support staff salaries, rent, depreciation, malpractice insurance, license fees, “MOC” fees, equipment costs, consumables, cleaning, office supplies, facilities insurance, Workman’s comp, retirement plans for staff and docs, CME, vacation pay, sick pay, insurance plans for staff and docs] Salaries – 3 docs: $500K Total expenses: $1.5 million Income less expenses = ZERO. This balances.
    15. 15. Business 101 – 3 doctor internal medicine clinic INCOME (prev) Revenue: $1.5 million Less 24% cut: - $360,000 Total income now:$1,140,000 EXPENSES: Overhead* : $1 million [support staff salaries, rent, depreciation, malpractice insurance, license fees, “MOC” fees, equipment costs, consumables, cleaning, office supplies, facilities insurance, Workman’s comp, retirement plans for staff and docs, CME, vacation pay, sick pay, insurance plans for staff and docs] (What’s left over for salaries: $140,000) Total expenses: $1.14 million Income less expenses = ZERO. This balances. Salaries – for 3 docs = 46,667 per doc
    16. 16. Instant replay • 24% cut to gross receipts • 72% cut to doc salaries (from $166,667 down to $46,667 – Working 50 – 60 hours per week – Hassled by paperwork, Medicare reviewers, prior authorizations, constant threat of malpractice lawsuits, continued baseline 2% inflation per year and no way to make it up. • WHAT WOULD YOU DO???
    17. 17. Business 101 – 3 doctor internal medicine clinic – what does this REALLY MEAN? As your fees stagnate or are cut, and as your overhead continues to rise, you will: •Pinch pennies on overhead, do 5-7 minutes per patient and try to be cheap. (Unsuccessful). •Work harder and longer hours to keep pace and feed your family (and burn yourself out)… • …And not get to see your kids grow up. • Marital problems; divorce. • You will miss out on life. •Use the “work ‘til you drop” retirement plan. •Or you will quit if you’ve made enough and either retire or do something else.
    18. 18. Doctors quitting medicine • Suicide* (2004): – 1.41 X for male physicians vs. general pop. • "Half of primary care physicians in survey would leave medicine ... if they had an alternative." -- CNN, November 2008 * Schernhammer ES, Coldit GZ. Am J Psychiatry. 2004 Dec; 161 (12):2295-302.
    19. 19. “Why I Left Medicine: A Burnt-Out Doctor’s Decision to Quit”* • “It may be dramatic and self-serving to frame my career change as a way to avoid suicide, but I can attest that medicine was not conducive to my health.” http://commonhealth.wbur.org/2013/10/why-i-left-medicine-a-burnt-out date 10/18/2013 – accessed 01/07/2014
    20. 20. REASON: “EHR” requirements. “Would cost too much in his small medical practice.”
    21. 21. “But I’m not a doctor; I’m not going to have those problems.” • Dentists, optometrists, DC’s – mixed fee for service model (at present) and insurance. • EVERYONE will be having higher deductibles (and be cash strapped). – Manifestations: deferred maintenance (Mercedes) • If hospitals, or clinics close, service providers connected with it will lose their jobs. • If you are a cosmetologist or server – declining business, declining tips
    22. 22. A TALE OF THREE WOMEN
    23. 23. Evansville Courier & Press: May 29, 2006
    24. 24. As of 03/20/2014
    25. 25. Could it happen to you?
    26. 26. What causes oxidative stress? • Environmental Toxins – Heavy metals – including Mercury (fillings!) – Pesticides/herbicides – Preservatives – PCB’s, Dioxins, Phthalates • Toxins produced in the body – Yeast and bacteria – Products of cellular metabolism • Emotional Stress – Anxiety/Tension – Fear – Anger
    27. 27. Oxidative stress in the BRAIN
    28. 28. Why is the brain so susceptible to oxidative stress? • Burns glucose – generates free radicals. • Uses 20% of total oxygen and energy consumed by the body. • ½ of this is for electrochemical nerve transmission. • Contains IRON • Contains essential fatty acids, which can be OXIDIZED (“rancid fat”) • Limited supply of own antioxidants • Limited ability to regenerate/repair damage
    29. 29. What are some consequences of oxidative stress? • Impaired cognitive function • Decreased memory • Depressed immune system • Increased inflammation • DNA damage • cancer • Behavioral deterioration
    30. 30. Antioxidant assessment Reference: www.cadywellness.com/cadyw Reference: www.cadywellness.com/cadyw
    31. 31. Center for Biomedical Optics – Dixon Laser Institute, University of Utah • Werner Gellermann, Ph.D. – Research Professor • Colleague – Igor Ermakov, Ph.D., et al. • Technologies – “Novel Raman Spectroscopy and Raman Imaging.” • Funding: – National Institutes of Health – State of Utah – Spectrotek, LLC
    32. 32. (c) 2013 Louis B. Cady, M.D. - all rights reserved
    33. 33. “A method and apparatus are provided for the determination of levels of carotenoids and similar chemical compounds in biological tissue such as living skin.”
    34. 34. “But is the scanner really valid and dependable?”
    35. 35. Scientific Validation: Peer-reviewed by the medical & research communities • Society of Investigative Dermatology, May 25, 2000. – Non-Invasive Raman Spectroscopic Detection of Carotenoids in Human Skin. • Arch Biochem Biophys. 2010 Dec 1;504(1):40-9. Epub 2010 Aug 1. – Validation model for Raman based skin carotenoid detection • J Eur Acad Dermatol Ven. 2011 Aug;25(8):945-9. – Skin carotenoid levels in adult patients with psoriasis.
    36. 36. • “The totality of the evidence supports the use of skin carotenoid status as an objective biomarker of fruits/vegetable intake…” • “..skin carotenoids may effectively serve as an integrated biomarker of health…” • “The totality of the evidence supports the use of skin carotenoid status as an objective biomarker of fruits/vegetable intake…” • “..skin carotenoids may effectively serve as an integrated biomarker of health…” • “Thus, this biomarker holds promise as both a health biomarker and an objective indicator of fruits & vegetables intake….” • “Thus, this biomarker holds promise as both a health biomarker and an objective indicator of fruits & vegetables intake….”
    37. 37. Where to read more…
    38. 38. “The Complete Idiot’s Guide to the “Cady White Paper” • Pp 1-3 Patent claim synthesis: assessing the overall antioxidant status in human tissue via Raman spectroscopy via measuring carotenoids – Carotenoids are antioxidants • Identified in 1992 • Potent antioxidants • Lycopenes and carotenoids appear to diminish risk of prostate CA. • P 4 Further discussion of prostate CA
    39. 39. Carotenoid correlation with other antioxidants (pp 4-6) • Cited: carotenoids as chemopreventive agents* • Carotenoids as first line of defense, associated with “antioxidant network” – with Vitamins C, E, Coenzyme Q10, ALA, and SE. ** • Yeum et al: need to measure water AND fat soluble vitamins identified.*** *Peng YM et al. Concentrations and plasma-tissue-diet relationships of carotenoids, retinoids, and tocopherols in humans. Nutr Cancer. 1995;23(3):233-46. ** Packet, Lester. The Antioxidant Miracle. John Wiley & Sons, Inc. © 1999 ***Yeum et al. Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma. Arch Biochem Biophys. 2004 Oct 1; 430(1):97-103.
    40. 40. Relationships of carotenoids to other more conventionally measured antioxidants (p 6 -7) • Svilaas et al (2004): – 2, 670 adults studied with serum carotenoids measured and correlated with vitamin consumption – serum carotenoids were stronger predictors of other antioxidants than were alpha, beta, delta, and gamma tocopherols, as well as glutathione.* * Svilaas A, et al. Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J Nutr. 2004 Mar;134(3):562-7.
    41. 41. Convenience of carotenoids as antioxidant measurement (pp 7-11) • Hata, et al (2000) – correlated skin carotenoids (Raman) with carotenoid levels from skin from abdominoplasty patients (HPLC). – “Our technique can be used…for assessing antioxidant status and the risk for diseases related to oxidative stress.” *Bernstein P et al. Raman detection of macular carotenoids pigments in intact human retina. Invest Opthalmol Vis Sc. 1998 Oct;39(11):2003-11. **Hata et al. Non-invasive Raman spectroscopic detection of carotenoids in human skin. J Invest Dermatol. 2000 Sep; 115(3):441-8.
    42. 42. The Svilaas/Hata Syllogism: • Hata (2000) – Raman measurements of carotenoid == HPLC skin measurements of carotenoids • Svilaas (2004) – serum carotenoids = better predictor of antioxidant status than mixed tocopherols and glutathione • THEREFORE [Cady]: Raman spectroscopy is a better measure of antioxidant status than mixed tocopherols and glutathione.
    43. 43. Dissolved carotenoids in stratum corneum 27 days
    44. 44. BTW – what does that “SCS” actually mean in REAL LAB MEASUREMENTS? • Y = 12703 * X + 5891.7 – Where Y is the SCS, and X is the carotenoid concentration in MICROgrams/ml, viz: • 25,000 = 12703X + 5891.7 • 25,000 – 5891.7 = 12703 * X • 19,108.3 = 12703 * X • 19,108.3 /12703 = X • X = 1.50 MICROgrams /ml • Rule of thumb: 1,000 on SCS = .06 ug carotenoid/ml blood serum • (e.g., SCS of 71,000 = 4.26 ug carotenoid/ml) Source: NuSkin/Pharmanex
    45. 45. “RSS spectroscopy is a reliable method for non-invasive measurement of B-carotene levels in skin, and may be used as an important biomarker of antioxidant status in nutritional and health studies in humans.” Ramirez-Velez, et al. Endocrinol Nutr. 2012 April
    46. 46. How are we doing? 2006 Data Histogram: N =2,591,667 Mean SCS = 26,673 Skin Carotenoid Score Frequency 5-9 Fruits & Vegetables Smokers Average (2-3 Fruits & Vegetables) Obesity LifePak LifePak + 5-9 Fruits & Vegetables Source: data reported by Pharmanex
    47. 47. 16,103 people – 1994 – 1996. ZERO got 100% of all required vitamins and nutrients - Highest – B12 =- 82.8% got enough - 66.8% - had adequate folate - Lowest – Zinc – only 26.6% got enough.
    48. 48. What’s New since the “cady report” (2006 & 2008)?
    49. 49. Lipid peroxidation, antioxidant status & survival in institutionalized elderly • Plasma MDA predicted mortality independently of all other variables. • B-carotene and alpha tocopherol were independently associated with survival. Huerta JM et al. Free Radical Research 2006, vol 40, no 6. pp 571-578.
    50. 50. Angela Mastaloudis Ph.D. Senior Scientist, Global Research & Development, Pharmanex
    51. 51. “RS accurately measures total carotenoids in human skin with less intra-individual variability than measurement of serum carotenoids by HPLC analysis. RS technology is a valid and reliable noninvasive method to rapidly assess carotenoid nutritional status in humans.” (J Am. Coll Nutr 2009)
    52. 52. Epidemiology of Vascular Aging (EVA)
    53. 53. • Study population: – N=1,389; age range {59-71 yoa} – 9 year study • Relative risks: – all cause mortality at 2.94X in men in lowest quintile (95% CI, P=0.03) – cancer 1.72X in men (95% CI, P=0.01 • “Total plasma carotenoids levels were independently associated with mortality risk in men.” Epidemiology of Vascular Aging (EVA)
    54. 54. Vitamin/mineral supplementation & cancer, cardiovascular, and all-cause mortality (EPIC-Heidelberg) Li K, Kaaks R., et al. Eur J Nutri July 2011 • Purpose: evaluate vitamin/mineral supplementation with CA, CV dz, and mortality • Methods: – 23,943 healthy participants, followed x 11 years – Baseline and “new-use” supplementation noted • Results: 513 CA deaths, 264 CV deaths – “No MVI supplement had any significant effect” – Baseline users of antioxidant supplements had significantly reduced risk of cancer [HR 0.52] and all cause mortality [0.58] • “sick user” phenomenon discussed.
    55. 55. Antioxidants and brain tumors? • “free radicals are another etiological factor of brain tumor and are removed by cellular antioxidants in the human body.” • Inverse correlation between: – antioxidant levels and oxidative DNA damage – Grades of malignancy • Decrease in antioxidants are associated with severity of malignancy
    56. 56. Conclusions • “It is concluded that administration of antioxidants could reduce the incidence of brain tumors and probably other types of cancer.” • - Shewelta SA , Sheikh, BY Curr Drug Metab. 2011 Jul;12(6):587-93. (Dept.of Biosciences & Technology, Alexandria University, Egypt.)
    57. 57. The GREAT news about a BAD study Conclusions: “In older women, several commonly used dietary vitamin and mineral supplements may be associated with increased total mortality risk; this association is strongest with supplemental iron.”
    58. 58. Not so fast! • 18 year duration; 38,000 “older” white women in Iowa • Supplements: MVI’s, A, D, E, Beta- carotene, B –vitamins, iron, calcium, copper, magnesium selenium, and zinc. • The real results: – Early results showed women who used C, D, E, and Calcium had significantly lower rates of death – Iron supplementation was highly correlated to death rates (but these results were mixed in)
    59. 59. A real hatchet job on MVI’s • Study measured “who dies over 18 years?” – Average age at start – 61 yoa – Average age at end of study 82 yoa – Average mortality for all women – 80 yoa in 2003 (during the study) • Conclusion: Over 50% of the women in the Iowa study lived longer than the average life expectancy. Mursu, Harnack et al – Dietary supplements and mortality rate in older women…. Arch Intern Med 2011 Oct 10;171(18):1625-33.
    60. 60. More hatcheting – poor controls • Hormones (Premarin/provera) – 13.5% of supplement users – 7.2% of non-supplement users • No explanation as to why so many women were taking iron. • Excess levels of vitamin A in some MVI brands • No evaluation of the quality or potency of the supplements Mursu, Harnack et al – Dietary supplements and mortality rate in older women…. Arch Intern Med 2011 Oct 10;171(18):1625-33. Nearly 2X as many!!
    61. 61. “Pending strong evidence …from randomized trials, it appears prudent for all adults to take vitamin supplements.” Fletcher & Fairfield, JAMA 2002
    62. 62. 44 million inpatients, 460 sites, 2000-2010 = 20% of all US inpatient episodes (1.6% were on ONS during the inpatient episode.) 44 million inpatients, 460 sites, 2000-2010 = 20% of all US inpatient episodes (1.6% were on ONS during the inpatient episode.) >/= 18 years. No terminal patients, tube feedings.>/= 18 years. No terminal patients, tube feedings. RESULTS for “ONS”: •2.3 day shorter length of stay •Decreased cost of $4,734 / episode •2.3% reduced probability of early readmission. RESULTS for “ONS”: •2.3 day shorter length of stay •Decreased cost of $4,734 / episode •2.3% reduced probability of early readmission. CONCLUSIONS: “Use of ONS decreases length of stay, episode cost, and 30 day readmission risk in the inpatient population.” CONCLUSIONS: “Use of ONS decreases length of stay, episode cost, and 30 day readmission risk in the inpatient population.” Tomas J, et al. Am J Manag Care. 2013;19(2):121-
    63. 63. So why do you need a SYSTEM in your vitamin supplement/mineral complex?? And what’s a ‘nano’?
    64. 64. What does “Nano” mean? • Cylcodextrin ring – benign, digestable • Feeds the gut microflora
    65. 65. How do nano-nutrients work? Nano-encapsulated nutrients do not clump; they DISPERSE. Fat-soluble nutrients like carotenoids and coenzyme Q10 CLUMP in watery milieu.
    66. 66. The Nanotechnology Differencepmol/mgprotein γ-cyclodextrin complex 5-fold increase in absorption! Adapted from Craft et al, FASEB Journal. 2005; 19(4): Abstract #281.6, A449.
    67. 67. The train has left the station…
    68. 68. what about other things besides carotenoids and “Antioxidants”?? B12, Magnesium, Selenium, Zinc, fish oil…
    69. 69. vitamins vitamins minerals minerals Omega-3 Omega-3 fatty acids fatty acids Phytonutrients Phytonutrients Antioxidants Antioxidants (bone health) (bone health)
    70. 70. LifePak Nano Contains • All 8 forms of natural vitamin E • Buffered vitamin C, Alpha lipoic acid • Nano Carotenoids: – as found in 5-10 fruits & vegetables per day • Over 20 Flavonoids: – green tea catechins, quercetin, citrus bioflavonoids, grape seed polyphenols, resveratrol • Selenium, Copper, Zinc, Mg++, Mb++ • B-vitamins complex, Biotin, D3 (150%) • 4 GRAMS fish oil (incl. 600mg EPA/400 mg DHA) 60+ Antioxidants, plus complete nutritional system
    71. 71. • Irritability • Apathy • Personality changes • Depression • Memory loss • Dementia • Hallucinations • Violent behavior • Anxiety Symptoms of B12 Deficiency • Diminished sense of touch and pain • Clumsiness • Weakness • Pernicious anemia • Chronic fatigue • Tremors • GI problems Mental Physical
    72. 72. LifePak Nano factoids - % RDA in 2 packets • B12 - 1,000% (as 60 MICROgrams cyanocobalamin) • Magnesium 76% (as 300 Mg amino acid chelate) • Zinc 100% (15 mg as zinc chelate) • Selenium 200% (L-selenomethionine & NaSeO3)
    73. 73. The Effects of high dose B vitamins on stress at work • “Occupational stress is increasing in Western societies.” • 3 month, double blind, placebo control, randomized study • Measured: Personality, work demands, mood, anxiety, and strain • After variances in personality and work demands were controlled, the vitamin B complex treated group reported significantly lower personal strain and a reduction in confusion and depressed/dejected mood after 12 weeks. Strough C et al. The effect of 90 day administration of a high dose vitamin B- coplex on work stress. Hum Psychopharmacol. 2011 Sept 8. doi 10.1002/hup.1229 (Swinburne University of Techbnology – Hawhorn, Victoria, Australia.)
    74. 74. Magnesium mementos • One of the first minerals to disappear with: – Processed food – Stress • Decreased by EtOH, caffeine, sodas, meds • Considered “anti-stress” mineral – Decreases cortisol (rel to sleep disruption) – Relaxes muscles, prevents cramps (sleep disruption) – Decreases anxiety; improves sleep
    75. 75. Symptoms of Magnesium Deficiency PSYCHIATRIC ISSUES: •Difficulty with memory and concentration •Depression, apathy •Emotional lability •Irritability, nervousness, anxiety •Insomnia Autism ADHD  Migraine headaches  PMS  Dysmenorrhea  Fibromyalgia  Fatigue  CONSTIPATION Health Conditions Associated with Magnesium Deficiency
    76. 76. SELENIUM DEFICIENCY in FASEB: • “Adaptive dysfunction of selenoproteins from the perspective of the ‘triage’ theory: why modest selenium deficiency may increase risk of diseases of aging.” Foundation of American Societies for Experimental Biology McCann, J, Ames BM. FASEB J. 2011 Jun;25(6):1793-814.
    77. 77. Negative downstream effects from selenium deficiency: “…cancer, heart disease, and immune dysfunction are prospectively associated with modest selenium deficiency…. suggesting that Se deficiency could be a CAUSATIVE factor” McCann, J, Ames BM. FASEB J. 2011 Jun;25(6):1793-814.
    78. 78. “the foot soldier” LifePak Nano has 200% of RDA of selenium. Se+  THYROID HORMONE
    79. 79. Fast food (low Zn) is bad for you. • Fast food = high energy density = low essential micronutrient density, ESPECIALLY ZINC • Antioxidant processes are dependent on Zinc • Fast food = severe decrease in antioxidant vitamins and zinc, correlating with inflammation in testicular tissue – with underdevelopment of testicular tissue and decreased testosterone levels
    80. 80. Special needs - Zinc • Low Zinc- associated with low testosterone – Per USDA, 60% of US men between 20 – 49 years of age do not get enough. – N.B.: Do not supplement with > 50 mg daily (can interfere with Cu+ metabolism) • Tsai, E.C., Boyko, E.J., Leonetti, D.L., & Fujimoto, W.Y. (2000). Low serum testosterone level as a predictor of increased visceral fat in Japanese- American men. International Journal of Obesity and Related Metabolic Dis 24, 485-491
    81. 81. Essential Fatty Acids – relevant for: “Psych” • Depression • Bipolar depression • Schizophrenia • Autism • AD(H)D • Learning disabilities “Medical” • Seizures • Rheumatoid arthritis (& anything with inflammation) • Coronary heart disease (or health maintenance)
    82. 82. Do YOU Need Fish Oil? 5X reduction
    83. 83. What happens with biotin deficiency? “Our results suggest that biotin deficiency promotes hyperglycemic mechanisms…and decreased insulin secretion and sensitivity to compensate for reduced blood glucose concentrations.” Two LifePak Nano packets have 100% of recommended daily requirements of Biotin.
    84. 84. A personal close How do you want to age?
    85. 85. Wrapping Up: The “Survival Curve” – Where Are You?
    86. 86. What can you do at 100? • Rita Levi Montalcini, MD • Nobel Prize – Medicine 1986 • Birthday – April 18, 1909 • “At 100, I have a mind that is superior – thanks to experience – than when I was 20.”
    87. 87. TR 90 – a look back October 28, 2013 January 28, 2014 Jan 29, 2014
    88. 88. Success and Failure (Jim Rohn) What about you? You’ve only got one body. • “Errors in judgement” - High glycemic eating, no exercise, poor nutrition, lousy or no supplementation, high stress lifestyle. - “Good disciplines” – appropriate diet, supplementation, exercise, hormones. Stress management. Decent lifestyle.
    89. 89. “For me, the practice of medicine has opened the door to the greatest adventure in life. Medicine is like a hallway lined with doors, each door opening into a different room, and each room opening into another hallway, again lined with doors. Medicine is always wonderful and never will be finished.” - Charles H. Mayo, M.D.
    90. 90. Contact information: Louis B. Cady, M.D. www.cadywellness.com www.tmsrelief.com Office: 812-429-0772 E-mail: lcady@cadywellness.com 4727 Rosebud Lane – Suite F Interstate Office Park Newburgh, IN 47630 (USA) Download from iTunes or Android App stores now!

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