Max cady-4152010


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The powerpoint presentation delivered LIVE at CWI 4/15/2010 by Louis B. Cady, MD, Founder and CEO of Cady Wellness Institute, on the topic of Max GXL, glutathione augmentation, and vitamin supplementation.

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  • Now, let’s summarize how we age: [next] Here is a typical body cell… [next] …which has a nucleus and mitochondria, both containing DNA. [next] As we age, our antioxidant defense system becomes weaker, leading to more free radical damage to DNA, which causes... [next] …impaired cellular function and regeneration. At the same time, [next] the large amounts of free radicals produced in the mitochondria damage mitochondrial DNA… [next] …which leads to impaired energy production, which also impairs cellular function and regeneration. [next] These are the two major ways which lead to the appearance of aging symptoms. [next]
  • Now, let’s look at how DNA gets damaged. Most often, DNA is damaged by free radicals. Free radicals are highly reactive compounds that are ubiquitous in the body and in our environment. [next] This is a DNA molecule that’s being attacked by two free radicals… [next] …literally breaking the DNA into pieces. How does the body prevent this free radical damage? [next] It prevents DNA damage with antioxidants, which are compounds that can catch or neutralize free radicals before they can hurt us. [next]
  • Now, here is a scary fact: [next] Every day, the DNA in a single body cell gets damaged 73,000 times! [next] Fortunately, our cells have DNA repair enzymes that fix most of this damage. So aging depends on a delicate balance of DNA damage and repair. Unfortunately, as we age this balance seems to shift in favor of DNA damage because our antioxidant defense system becomes less efficient. [next]
  • Cordyceps – note that it reduces nuclear factor kappa beta activity in macrphages.
  • Cordyceps – note that it reduces nuclear factor kappa beta activity in macrphages.
  • Max cady-4152010

    1. 1. Louis B. Cady, MD – CEO & Founder – Cady Wellness Institute Adjunct Professor – University of Southern Indiana Adjunct Clinical Lecturer – Indiana University School of Medicine Department of Psychiatry Child, Adolescent, Adult & Forensic Psychiatry – Evansville, Indiana A Scientific (& FUN!) Review of MAX GXL & N-Fuze [full page photos except magazine clippings © Louis B. Cady, MD]
    2. 2. “ There are two objects of medical education: to heal the sick and to advance the science.” - Dr. Charles H. Mayo, MD “ The glory of medicine is that it is always moving forward, that there is always more to learn.” - Dr. William J. Mayo
    3. 3. Background for tonight’s talk <ul><li>There are no drug claims made for MAX GXL. </li></ul><ul><li>MAX GXL is not designed to treat, prevent, mitigate, diagnose or do anything else to or for any disease. </li></ul><ul><li>It is a nutritional supplement designed to support the structure and function of the human body. </li></ul>
    4. 4. Death Optimal Health Traditional Medicine Hormone Modulation No Disease = Health Diet, Exercise Nutritional Supplementation Age Management Medicine Diagnose and Treat Disease New Drugs New Surgical Techniques Forestall and PREVENT Disease – Optimize Function
    5. 5. American Journal of Health Promotion; November/December, 2002 19% of those surveyed were completely healthy with high levels of both physical and mental health and a low level of illness . 18.8% completely unhealthy, defined as having low levels of health with high levels of illness. Two-thirds of the adults reported some degree of mental or physical illness that kept them from being completely healthy. “ Incompletely healthy.” HEALTH continuum DEAD OPTIMAL 66% “ Incompletely healthy”
    6. 6. Health is a state of complete physical, mental and social well-being, and not merely the absence of disease or infirmity.  -  World Health Organization
    7. 7. How would you take care of a classic? “ Chronic diseases affect at least 125 million Americans & cost more than $500 billion last year.” Centers for DiseaseControl – Dec 2003
    8. 8. “ Age management” “Conventional practice” There are fuel additives we can use to keep our cars burning cleaner and preserve engines. No fuel additives should be used. They are unnatural. Gas is all that is required. We should use optimal quality of gas. Cheap gas causes “pinging” which is hard on the engine. The quality of the gas is irrelevant. Anything that the motor will burn is adequate. We should take our car in for preventive maintenance before anything breaks. Preventive maintenance? This is silly! Wait until something breaks, then have the car towed in so the mechanic can really tell what is wrong.
    10. 10. “ All truth passes through three phases: <ul><li>First, it is ridiculed. </li></ul><ul><li>Second, it is violently opposed, and… </li></ul><ul><li>Third, it is accepted as self-evident.” </li></ul><ul><ul><ul><li>Arthur Shopenhauer, 1788-1860 </li></ul></ul></ul>
    11. 12. Today’s Medical Practice Challenges <ul><li>Obesity, diabetes, auto-immune, inflammatory and chronic diseases increasing </li></ul><ul><li>Inflammatory triggers increasing </li></ul><ul><li>Novel viruses and infective organisms </li></ul><ul><ul><li>Animal infections non-responsive to any therapy </li></ul></ul><ul><li>Unresponsive/resistant infections </li></ul><ul><li>Weakened immune systems </li></ul><ul><li>GI decline/inflammation </li></ul><ul><li>Poor quality medicinals/foods/nutritionals </li></ul>
    12. 13. ENERGY!
    13. 14. “ The Complete Idiot’s Guide to Free Radicals and What They Do” <ul><li>Rob you of energy. </li></ul><ul><li>Kill you with heart attacks and strokes. </li></ul><ul><li>Give you cancer because of altered DNA. </li></ul><ul><li>Age your skin before your time. </li></ul>
    14. 15. Oxidative damage – lack of “antioxidant” status [wax]
    15. 16. Summary: How Do We Age? Body Cell Weak Antioxidant Defense DNA Damage Free Radical Production DNA Damage Impaired Cellular Function and Cell Regeneration Impaired Energy Production Aging Symptoms Mitochondria Cell Nucleus
    16. 17. Mitochondrial Damage: Loss of Energy <ul><li>Mitochondria </li></ul><ul><li>Free radical damage alters their energy production capability. Plus, they “breathe their own exhaust.” </li></ul>
    17. 18. Oxidation (“Rusting”) of LDL: Loss of LIFE <ul><li>Blood and tissue Lipids </li></ul><ul><li>Free radicals cause lipid peroxidation (“spoilage of fats”). </li></ul><ul><li>“ Spoiled” LDL cholesterol = Lip(a). It becomes sticky and can clog arteries and cause macrophages to become foam cells. This causes arteriosclerosis . Too much = stroke or MI. </li></ul>
    18. 19. <ul><li>DNA is damaged by free radicals: </li></ul>Antioxidants “catch” free radicals before they can hurt us A
    19. 20. Extent of DNA Damage: 73,000 events/day DNA repair enzymes fix most of the damage
    20. 21. Oxidative stress [DAMAGE] on DNA: Cancer & Loss of Life <ul><li>Free radicals in the nucleus of the cell can attack a gene and damage the chemical bonds and alter the information transcribed , or they can cause cross-linking (shutting down replication). </li></ul>
    21. 22. Skin changes…. 2000
    22. 24. <ul><li>Today’s salad: </li></ul><ul><li>-mixed greens, peppers, onions, tomato, olive oil </li></ul><ul><li>it has nearly 63% less nutrient compared to 1940 </li></ul><ul><li>plus residues of pesticides and nitrates </li></ul><ul><li>Nutrition on the farm (not found in 1940) </li></ul>Courtesy of Arden Andersen, DO, FS.
    23. 25. % Mineral depletion from the soil during the past 100 years, by continent Source: UN Earth Summit Report 1992 North America 85% South America 76% Asia 76% Africa 74% Europe 72% Australia 55%
    24. 26. Cf:
    25. 27. % U.S. Women with inadequate quantities of nutrients Arab L, Carriquiry A, Steck-Scott S, Gaudet MM. Ethnic differences in the nutrient intake adequacy of premenopausal US women: results from the Third National Health Examination Survey. J Am Diet Assoc 2003; 103:1008-14.
    26. 28. Glutathione <ul><li>“ one of the most important free radical traps in the human body.” Keller, R. citations: </li></ul><ul><ul><li>(7) Chen – Clin Chemistry (2005) </li></ul></ul><ul><ul><li>(11) Evelson (2001). Arch. Biochem Biophysc. </li></ul></ul><ul><ul><li>(32) Yarbro (1983) Semin Oncol. </li></ul></ul>
    27. 29. Glutathione in the National Library of Medicine– citation count, 12/9/09, (3/16/2010), 4/14/10
    28. 34. IN MEMORIAM <ul><li>Richard Brannan Cass </li></ul><ul><li>May 3, 1931 – Nov. 28, 2009 </li></ul>
    30. 36. <ul><li>Glutathione: drops 8 – 12 % per decade after 20 </li></ul><ul><li>Oxidative stress: toxins, (tobacco), inadequate nutrition, stress </li></ul>
    31. 38. Robert H. Keller, MD, MS, FACP <ul><li>Faculty: Mayo, Univ. Of WI </li></ul><ul><li>Triple boarded: Internal Medicine, Hematology, Immunology </li></ul><ul><li>Author: 100 original articles </li></ul><ul><li>Humanitarian of the Year – 1999, National Hemophilia Assn. </li></ul><ul><li>1 of 2000 Outstanding Global Scientists for 21 st Century (Cambridge) </li></ul><ul><li>Board of Governors – American Acad. of HIV Medicine </li></ul><ul><li>Sat on scientific review panels – National Institutes of Health and the VA </li></ul><ul><li>Ranked one of the top physicians in the US 2003 - 2007 </li></ul>
    32. 40. MAX GXL – how does it work? <ul><li>Increases glutathione synthesis (with + downstream effects) </li></ul><ul><li>Maximizes GI health to facilitate nutrient absorption </li></ul><ul><li>Protects liver </li></ul><ul><li>Recycles existing glutathione and promotes glutathione synthesis </li></ul>
    33. 41. NOTE: This is a double-blind , placebo controlled , crossover study.
    34. 42. % Change in intracellular glutathione levels from baseline at 1 and 2 months, GXL vs. Placebo 1 month, 121% , p< 0.01; 2 months = 276% change, p< 0.001 (placebo change not statistically significant)
    35. 43. <ul><li>Mitochondrial diseases are due to impairment of chemical reactions. </li></ul><ul><li>A reasonable theory is oxidative stress. </li></ul><ul><li>Few studies have actually been done on this. </li></ul><ul><li>Glutathione deficiency is known in mitochondrial disease. </li></ul><ul><li>Biosynthesis of glutathione depends on cysteine availability. </li></ul><ul><li>“ Our findings reinforce the notions that in mitochondrial disease, oxidative stress is important and can be reduced by administration of a cysteine donor.” </li></ul>
    36. 44. % Change in plasma DHEA levels from baseline at 1 and 2 months, GXL vs. Placebo 1 month, 18% , p< 0.05; 2 months = 46% change, p< 0.001 (placebo change not statistically significant)
    37. 45. % Change in plasma IGF-1 (growth hormone proxy) levels from baseline at 1 and 2 months, GXL vs. Placebo 1 month, 16% , p< 0.05; 2 months = 41% change, p< 0.001 (placebo change not statistically significant)
    38. 46. % Change in TNF-alpha levels from baseline at 1 and 2 months, GXL vs. Placebo 1 month, -41% , p< 0.001; 2 months = - 61% change, p< 0.0001 (placebo change not statistically significant)
    39. 47. MAX GXL – a chemical exegesis <ul><li>Increase synthesis: </li></ul><ul><ul><li>NAC (main ingredient) + Vit C (improved transport) </li></ul></ul><ul><ul><li>ALA </li></ul></ul><ul><li>Maximize GI health to facilitate nutrient absorption: </li></ul><ul><ul><li>L-glutamine – nourishes enterocytes (‘fuel”) </li></ul></ul><ul><ul><li>N-acetyl d-glucosamine (NAG) – glycocalyx production </li></ul></ul><ul><li>Protect liver: </li></ul><ul><ul><li>Sylimarin – quenches free radicals, stimulates protein synthesis </li></ul></ul><ul><ul><li>Quercetin – eliminates toxic compounds in liver. </li></ul></ul><ul><ul><li>L-glutamine </li></ul></ul><ul><li>Recycle existing glutathione and promote glutathione synthesis: </li></ul><ul><ul><li>Vit. C conserves GSH in cytosol </li></ul></ul>Sources: original patent. Cf: also
    40. 48. The Four Main Benefits of MAX GXL (presumptively as a result of improvement in body’s fxn ) <ul><ul><li>Improved energy (mitochondrial function) </li></ul></ul><ul><ul><ul><li>Increase in DHEA (?increase testosterone?) </li></ul></ul></ul><ul><ul><ul><li>Increase in IGF-1 </li></ul></ul></ul><ul><li>Improved concentration </li></ul><ul><ul><li>Improvement in neuronal mitochondria </li></ul></ul><ul><ul><li>Increase in IGF1 </li></ul></ul><ul><li>Decreased pain </li></ul><ul><ul><li>Increase in IGF1; decreased TNF-alpha </li></ul></ul><ul><li>Improved sleep (Oxidized GS-SG) </li></ul>
    41. 49. Lymphocytes are used for FIA
    42. 50. “ Harold was impressed with the cells’ performance.”
    43. 54. Adrenal Burnout
    44. 56. “ We found significantly lower serum DHEAS concentrations in CFS , but no significant differences either in IGF1 or the IGFBP3/IGF1 ratio between CFS patients and normal controls. The decrease in serum DHEA-S WAS HIGHLY SENSITIVE AND SPECIFIC FOR CFS.” [emphasis by Cady] Neuro Endocrinol Lett. 2005 Oct;26(5):487-92.
    45. 57. Patient clinical report <ul><li>“ Sleep is freakishly good.” </li></ul><ul><li>“ Everyone else has a bah, humbug attitude, and I’m the one that’s setting up the Christmas tree and singing Christmas songs.” </li></ul><ul><li>Improved energy. </li></ul><ul><li>Decreased pain. </li></ul><ul><li>Improved concentration (but also on Rx for ADD) </li></ul>
    46. 58. Patient report – February 2, 2010 “ Mainly it’s my body – I’m losing fluid – the sacs of fluid under my eyes – those have gone completely away. Cognitively, I can notice a difference. There’s a clarity…. Not the kind I receive on Ritalin or Concerta – it’s a different type. It was like my engine was clogged… I don’t know if it’s detoxing my whole body, but that’s what it feels like… like I was stopped up with chemicals and past stuff for a long time… and I’ve taken vitamins and everything else, but nothing has really wiped the slate clean….. it’s like, wow, this is changing everything.”
    47. 59. Wrap up: review & personal observations…. <ul><li>Vitamins </li></ul><ul><li>Your finances </li></ul><ul><li>Your general health, wellness, and life </li></ul>
    48. 60. Source: Jerry Brunetti –
    49. 67. November 2009 “Alpha Male” issue <ul><li>Observational study of randomly selected men – Boston </li></ul><ul><li>3 cohorts of men: 1987-1989; 1995-1997; 2002 -2004. </li></ul><ul><li>1374, 906, and 489 men, respectively. </li></ul><ul><li>“ Age independent decline in T that does not appear to be attributable to observed changes in explanatory factors, including lifestyle characteristics such as smoking and obesity.” </li></ul><ul><li>“ Recent years have seen a SUBSTANTIAL , and as yet UNRECOGNIZED age-independent population-level decrease in T in American men.” Travison, Araujo, et al. Jrnl of Clin. Endocrinol & Metabol 92:1; 196-202. </li></ul>
    50. 68. Fast food (low Zn) is bad for you. <ul><li>Fast food = high energy density = low essential micronutrient density, ESPECIALLY ZINC </li></ul><ul><li>Antioxidant processes are dependent on Zinc </li></ul><ul><li>Fast food = severe decrease in antioxidant vitamins and zinc, correlating with inflammation in testicular tissue – with underdevelopment of testicular tissue and decreased testosterone levels </li></ul>
    51. 69. Special needs - Zinc <ul><li>Low Zinc- associated with low testosterone </li></ul><ul><ul><li>Per USDA, 60% of US men between 20 – 49 years of age do not get enough . </li></ul></ul><ul><ul><li>N.B.: Do not supplement with > 50 mg daily (can interfere with Cu+ metabolism) </li></ul></ul><ul><ul><ul><li>Tsai, E.C., Boyko, E.J., Leonetti, D.L., & Fujimoto, W.Y. (2000). Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men. International Journal of Obesity and Related Metabolic Disorders, 24, 485-491 </li></ul></ul></ul>
    52. 76. Progression of the current recession: an epidemic of pain and broken dreams Jan 2007 – Dec. 2009 source:
    53. 77. Getting your house repo’ed – April 15, 2010
    54. 78. Jim Rohn <ul><li>Success – “A few good disciplines, practiced each day.” </li></ul><ul><li>Failure – “A few errors in judgement, repeated each day.” </li></ul>
    55. 80. Aging in America - 80 – The 3 rd Half of Life!
    56. 81. What can you do at 100? <ul><li>Rita Levi Montalcini, MD </li></ul><ul><li>Nobel Prize – Medicine 1986 </li></ul><ul><li>Birthday – April 18, 1909 </li></ul><ul><li>“ At 100, I have a mind that is superior – thanks to experience – than when I was 20.” </li></ul><ul><li>“ Above all, don’t fear difficult moments. The best comes from them.” </li></ul>
    57. 83. SURVIVAL CURVE: Where are You? Where would you like to be?
    58. 84. American Journal of Health Promotion; November/December, 2002 19% of those surveyed were completely healthy with high levels of both physical and mental health and a low level of illness . 18.8% completely unhealthy, defined as having low levels of health with high levels of illness. Two-thirds of the adults reported some degree of mental or physical illness that kept them from being completely healthy. “ Incompletely healthy.” HEALTH continuum DEAD OPTIMAL 66% “ Incompletely healthy”
    59. 85. <ul><li>“ Errors in judgment” - High glycemic eating, no exercise, poor nutrition, lousy/no supplementation, poor anti-ox and glutathione status. </li></ul><ul><li>“ Good disciplines” – healthy diet. Rational supplementation. </li></ul>You’ve only got one body.
    60. 86. &quot;If I hadn't believed it, I wouldn't have seen it.&quot; - Yogi Berra Personal collection Louis B. Cady, M.D.
    61. 87. Thanks for coming! And now – Mr. Eric Rondeau – the “Voice of Max,” MVP of the company for 2009, and My Pal!!  Sunset at CWI –by Louis B. Cady, M.D.