A Review of the Pharmanex Biophotonic Scanner, Supplementation and the “Cady White Paper”  An  Educational Presentation fo...
“ There are two objects of medical education: to heal the sick and to advance the science. ” - Dr. Charles H. Mayo, MD “ T...
CURRENT PRACTICE OF MEDICINE:  What a patient had to say about her “specialists”: <ul><li>“ They just monitor my degenerat...
 
Cady Wellness Institute – July 2005 The Reasons: <ul><li>Conventional medical practice had failed me twice. </li></ul><ul>...
 
 
Evansville Courier & Press : May 29, 2006
“ But my patients don’t know about this and aren’t asking for it….” <ul><li>“ It’s not the consumers’ job to know what the...
How not to get overwhelmed in this presentation:
What causes oxidative stress? <ul><li>Environmental Toxins </li></ul><ul><ul><li>Heavy metals </li></ul></ul><ul><ul><li>P...
Why is the brain so  susceptible to oxidative stress?
Why is the brain so  susceptible to oxidative stress? <ul><li>Burns glucose – generates free radicals. </li></ul><ul><ul><...
What are some consequences of oxidative stress? <ul><li>Impaired cognitive function </li></ul><ul><li>Decreased memory </l...
 
 
 
 
 
 
 
 
 
 
Where to read more…
 
The fastest, cheapest, most painless way to measure antioxidants…. <ul><li>US patent 6,205,354 – March 20, 2001 – Werner G...
Psst.  Hey buddy.  Wanna buy a portable Raman spectrometer?
“ The Complete Idiot’s Guide to the “Cady White Paper” <ul><li>Pp 1-3  Patent claim synthesis:  assessing the overall anti...
Carotenoid correlation with other antioxidants (pp 4-6) <ul><li>Correlation between carotenoids and other antioxidants, es...
Relationships of carotenoids to other more conventionally measured antioxidants (p 6 -7) <ul><li>Svilaas et al (2004):  </...
Missing point: Vitamin E as antioxidant predictor Jaques PF, et al.  Antioxidant status in persons with and without senile...
Higher Vitamin E lowers oxidative stress in Alzheimer’s disease <ul><li>“ Oxidative stress (OS) may be involved in the neu...
Vitamin E as antioxidant – a molecular biology assessment <ul><li>25 ESRD patients under chronic dialysis.  </li></ul><ul>...
Convenience of carotenoids as antioxidant measurement: from the eye to the skin (pp7-11) <ul><li>Bernstein P et al (1998) ...
Dissolved carotenoids in  stratum corneum 27 days
BTW – what does that “SCS” actually mean in REAL LAB MEASUREMENTS? <ul><li>Y  = 12703 * X + 5891.7 </li></ul><ul><ul><li>W...
The Svilaas/Hata Syllogism: <ul><li>Svilaas (2004) – skin carotenoids = better predictor of antioxidant status than mixed ...
Time warp – News Flash!
High oxidative stress = low skin carotenoids (p 11) <ul><li>Ermakov  IV et al (2005) – “carotenoids are a good indicator o...
Pharmanex research (pp 12-13), or, “Taking the Scanner Out to Play” <ul><li>Smidt C (2002) – study of 1,375 NUS employees ...
Biophotonic Scan scores as function of # of servings of fruits and vegetables (p 12) Smidt, C.  Clinical screening study: ...
Fun footnotes (p 13) <ul><li>MDA subjects (n=562) demonstrated LINEAR inverse correlation between urine MDA levels and Bio...
More fun with LifePak supplementation, prescanner (1999) p. 14 <ul><li>Changes measured in: </li></ul><ul><ul><li>Ascorbic...
More fun with LifePak supplementation, prescanner (1999) p. 14 RESULTS <ul><li>LP supplementation prolonged LDL oxidation ...
How are we doing? 2006 Data Histogram:  N =2,591,667  Mean SCS  =  26,673 Skin Carotenoid Score Frequency THE LIFE PAK’ERS...
Clinical opportunities – p. 16 <ul><li>1996 USDA survey of 5,188 – ZERO people got recommended daily allowances for all vi...
Final aspects of Cady White Paper  <ul><li>pp 16-20 – review of products and opportunity </li></ul><ul><li>P 21 – Article ...
What’s new since the 2006 “Cady Report”? <ul><li>Epidemiology of Vascular Ageing (EVA) study </li></ul><ul><ul><li>N=1,389...
Harvesting more data: Akbaraly and dysglycemia <ul><li>Akbaraly TN, et al.  Used same data set.  </li></ul><ul><li>127 cas...
More data: a mad dash through the literature <ul><li>September 24, 2011 </li></ul>One more time… no supplement, under the ...
 
 
 
 
 
 
 
 
But what about other  things besides carotenoids  and “Antioxidants”?? B12, Magnesium, Selenium, Zinc, fish oil…
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LifePak Nano factoids - % RDA in 2 packets <ul><li>B12 - 1,000% (as 60 MICROgrams cyanocobalamin) </li></ul><ul><li>Magnes...
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Dr. Cady on LifePak Nano & The Biophotonic Scanner

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This is the presentation given to the Health Care Professional Conference in Santa Barbara, CA on 12 3 2011

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  • FROM WIKIPEDIA - Epidermis Epidermis , &amp;quot;epi&amp;quot; coming from the Greek meaning &amp;quot;over&amp;quot; or &amp;quot;upon&amp;quot;, is the outermost layer of the skin. It forms the waterproof, protective wrap over the body&apos;s surface and is made up of stratified squamous epithelium with an underlying basal lamina. The epidermis contains no blood vessels, and cells in the deepest layers are nourished by diffusion from blood capillaries extending to the upper layers of the dermis. The main type of cells which make up the epidermis are Merkel cells, keratinocytes, with melanocytes and Langerhans cells also present. The epidermis can be further subdivided into the following strata (beginning with the outermost layer): corneum, lucidum (only in palms of hands and bottoms of feet), granulosum, spinosum, basale. Cells are formed through mitosis at the basale layer. The daughter cells (see cell division) move up the strata changing shape and composition as they die due to isolation from their blood source. The cytoplasm is released and the protein keratin is inserted. They eventually reach the corneum and slough off (desquamation). This process is called keratinization and takes place within about 27 days. This keratinized layer of skin is responsible for keeping water in the body and keeping other harmful chemicals and pathogens out, making skin a natural barrier to infection. From WIKIpedia
  • Based on clinical studies with the biophotonic scanner, we have identified a number of factors that may influence your score. The average skin carotenoid score for Europeans is 26,673, those who eat the recommended 5-9 fruits and vegetables or take lifepak regularly have even higher scores. What is really exciting is that people with the best lifestyles - eat the recommended 5-9 fruits and vegetables, take LifePak regularly, avoid cigarettes, and so on, have the very highest scores, in the 40,000 range. Therefore, the effects of a good lifestyle are cumulative when it comes to Antioxidant protection. The other point I would like to make is that people with known oxidative stress such as smokers, have lower scanner scores, just as we would predict, but people who are overweight or obese tend to have even lower scores than smokers! Thus it appears that obesity depletes antioxidant levels even more than smoking.
  • Dr. Greenblatt treats anyone at less than 600. “Serum levels don’t accurately reflect what’s in the CSF.”
  • When repleted - results pretty quickly. “If if spasms, think magnesium” – bowel, bronchial.
  • Dr. Cady on LifePak Nano & The Biophotonic Scanner

    1. 2. A Review of the Pharmanex Biophotonic Scanner, Supplementation and the “Cady White Paper” An Educational Presentation for Health Care Practitioners December 3, 2011 – Santa Barbara, CA Louis B. Cady, MD – CEO & Founder – Cady Wellness Institute Adjunct Professor – University of Southern Indiana Adjunct Clinical Lecturer – Indiana University School of Medicine Department of Psychiatry Child, Adolescent, Adult & Forensic Psychiatry – Evansville, Indiana Disclaimer: Pharmanex/NuSkin products are not FDA approved for the diagnosis or treatment of ANY disease or “medical condition.”
    2. 3. “ There are two objects of medical education: to heal the sick and to advance the science. ” - Dr. Charles H. Mayo, MD “ The glory of medicine is that it is always moving forward, that there is always more to learn.” - Dr. William J. Mayo
    3. 4. CURRENT PRACTICE OF MEDICINE: What a patient had to say about her “specialists”: <ul><li>“ They just monitor my degeneration.” </li></ul>
    4. 6. Cady Wellness Institute – July 2005 The Reasons: <ul><li>Conventional medical practice had failed me twice. </li></ul><ul><li>A lot of “psychiatric cases” WEREN’T “psychiatric.” </li></ul><ul><li>Nobody was integrated. </li></ul><ul><li>Nobody was looking at ALL of the peer-reviewed literature. </li></ul>
    5. 9. Evansville Courier & Press : May 29, 2006
    6. 10. “ But my patients don’t know about this and aren’t asking for it….” <ul><li>“ It’s not the consumers’ job to know what they want.” </li></ul><ul><li>- Steve Jobs </li></ul>
    7. 11. How not to get overwhelmed in this presentation:
    8. 12. What causes oxidative stress? <ul><li>Environmental Toxins </li></ul><ul><ul><li>Heavy metals </li></ul></ul><ul><ul><li>Pesticides/herbicides </li></ul></ul><ul><ul><li>Preservatives </li></ul></ul><ul><ul><li>PCB ’s, Dioxins, Phthalates </li></ul></ul><ul><li>Toxins produced in the body </li></ul><ul><ul><li>Yeast and bacteria </li></ul></ul><ul><ul><li>Products of cellular metabolism </li></ul></ul><ul><li>Emotional Stress </li></ul><ul><ul><li>Anxiety/Tension </li></ul></ul><ul><ul><li>Fear </li></ul></ul><ul><ul><li>Anger </li></ul></ul>
    9. 13. Why is the brain so susceptible to oxidative stress?
    10. 14. Why is the brain so susceptible to oxidative stress? <ul><li>Burns glucose – generates free radicals. </li></ul><ul><ul><li>Uses 20% of total oxygen and energy consumed by the body. </li></ul></ul><ul><ul><ul><li>½ of this is for electrochemical nerve transmission. </li></ul></ul></ul><ul><li>Contains IRON </li></ul><ul><li>Contains essential fatty acids, which can be OXIDIZED (“rancid fat”) </li></ul><ul><li>Limited supply of own antioxidants </li></ul><ul><li>Limited ability to regenerate/repair damage </li></ul>
    11. 15. What are some consequences of oxidative stress? <ul><li>Impaired cognitive function </li></ul><ul><li>Decreased memory </li></ul><ul><li>Depressed immune system </li></ul><ul><li>Increased inflammation </li></ul><ul><li>DNA damage </li></ul><ul><li>cancer </li></ul><ul><li>Behavioral deterioration </li></ul>
    12. 26. Where to read more…
    13. 28. The fastest, cheapest, most painless way to measure antioxidants…. <ul><li>US patent 6,205,354 – March 20, 2001 – Werner Gellerman, et al. Univ. of Utah </li></ul><ul><li>“ A method and apparatus are provided for the determination of levels of carotenoids and similar chemical compounds in biological tissue such as living skin.” </li></ul>
    14. 29. Psst. Hey buddy. Wanna buy a portable Raman spectrometer?
    15. 30. “ The Complete Idiot’s Guide to the “Cady White Paper” <ul><li>Pp 1-3 Patent claim synthesis: assessing the overall antioxidant status in human tissue via Raman spectroscopy via measuring carotenoids </li></ul><ul><ul><li>Carotenoids are antioxidants </li></ul></ul><ul><ul><ul><li>Identified in 1992 </li></ul></ul></ul><ul><ul><ul><li>Potent antioxidants </li></ul></ul></ul><ul><ul><ul><li>Lycopenes and carotenoids appear to diminish risk of prostate CA. </li></ul></ul></ul><ul><li>P 4 Further discussion of prostate CA </li></ul>
    16. 31. Carotenoid correlation with other antioxidants (pp 4-6) <ul><li>Correlation between carotenoids and other antioxidants, esp. tocopherols, previously noted. </li></ul><ul><ul><li>Cited: carotenoids as chemopreventive agents* </li></ul></ul><ul><ul><li>Carotenoids as first line of defense, associated with “antioxidant network” – with Vitamins C, E, Coenzyme Q10, ALA, and SE. ** </li></ul></ul><ul><ul><li>Yeum et al: need to measure water AND fat soluble vitamins identified.* ** </li></ul></ul>*Peng YM et al. Concentrations and plasma-tissue-diet relationships of carotenoids, retinoids, and tocopherols in humans. Nutr Cancer. 1995;23(3):233-46. ** Packet, Lester. The Antioxidant Miracle. John Wiley & Sons, Inc. © 1999 ***Yeum et al. Biomarkers of antioxidant capacity in the hydrophilic and lipophilic compartments of human plasma. Arch Biochem Biophys. 2004 Oct 1; 430(1):97-103.
    17. 32. Relationships of carotenoids to other more conventionally measured antioxidants (p 6 -7) <ul><li>Svilaas et al (2004): </li></ul><ul><ul><li>2, 670 adults studied with serum carotenoids measured and correlated with vitamin consumption </li></ul></ul><ul><ul><li>serum carotenoids were stronger predictors of other antioxidants than were alpha, beta, delta, and gamma tocopherols, as well as glutathione .* </li></ul></ul>* Svilaas A, et al. Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J Nutr. 2004 Mar;134(3):562-7.
    18. 33. Missing point: Vitamin E as antioxidant predictor Jaques PF, et al. Antioxidant status in persons with and without senile cataract. Arch Opthalmol. 1988;106(3):337-340. <ul><li>N=112, ages 40 – yo yoa. </li></ul><ul><li>77 subjects had at least one cataract. </li></ul><ul><li>Antioxidant status: superoxide dismutase, glutathione peroxidase, G6PD, Vit E, Vit C and carotenoids. </li></ul><ul><li>Grouped by low, moderate, or high enzymes and antioxidant status. </li></ul><ul><li>Subjects with at least 2/3 – vitamins E & C, and carotenoids – were at reduced risk. </li></ul>
    19. 34. Higher Vitamin E lowers oxidative stress in Alzheimer’s disease <ul><li>“ Oxidative stress (OS) may be involved in the neurodegenerative process in Alzheimer’s disease.” </li></ul><ul><li>MEASURED: </li></ul><ul><ul><li>8-iso-PGF2alpha (lipid-peroxidation product) </li></ul></ul><ul><ul><li>Methylated and non-methylated telomeres </li></ul></ul><ul><li>Oral administration of 400 mg (IU) Vitamin E partly reverses AD-associated alterations in OS markers. </li></ul>Guan, JZ et al. Effect of Vitamin E Adminsitration on the Elevated Oxygen Stress and the Telomeric and Subtelomeric status in Alzheimer’s Disease. Gerontology. 2011, Sept 7 (epub ahead of print)
    20. 35. Vitamin E as antioxidant – a molecular biology assessment <ul><li>25 ESRD patients under chronic dialysis. </li></ul><ul><li>Effects of vitamin E-coated dialyzer noted to have positive effect on antioxidant state. </li></ul><ul><li>“ Treatment with VitabranE significnatly decreases the expression of proteins and markers relevant to oxidative stress and inflammation tightly associated with cardiovascular disease….” </li></ul>Calo LA et al. Molecular biology-based assessment of vitamin E-coated dialyzer effects on oxidative stress, inflammation, and vascular remodeling. Artif Organs. 2011 Feb;35(2):E33-9. doi:10.1111/j. 1525-1594.2010.01125.x
    21. 36. Convenience of carotenoids as antioxidant measurement: from the eye to the skin (pp7-11) <ul><li>Bernstein P et al (1998) - Carotenoids useful as measure of antioxidant status in human retina* </li></ul><ul><li>Hata, et al (2000) – correlated skin carotenoids (Raman) with carotenoid levels from skin from abdominoplasty patients (HPLC). </li></ul><ul><ul><li>“ Our technique can be used…for assessing antioxidant status and the risk for diseases related to oxidative stress.” </li></ul></ul><ul><ul><li>Previous use in skin, retina, oral cavity and other tissues cited. Palm of skin = highest carotenoid location </li></ul></ul>*Bernstein P et al. Raman detection of macular carotenoids pigments in intact human retina. Invest Opthalmol Vis Sc. 1998 Oct;39(11):2003-11. **Hata et al. Non-invasive Raman spectroscopic detection of carotenoids in human skin. J Invest Dermatol. 2000 Sep; 115(3):441-8.
    22. 37. Dissolved carotenoids in stratum corneum 27 days
    23. 38. BTW – what does that “SCS” actually mean in REAL LAB MEASUREMENTS? <ul><li>Y = 12703 * X + 5891.7 </li></ul><ul><ul><li>Where Y is the SCS , and X is the carotenoid concentration in MICROgrams/ml , viz: </li></ul></ul><ul><ul><ul><li>25,000 = 12703X + 5891.7 </li></ul></ul></ul><ul><ul><ul><li>25,000 – 5891.7 = 12703 * X </li></ul></ul></ul><ul><ul><ul><li>19,108.3 = 12703 * X </li></ul></ul></ul><ul><ul><ul><li>19,108.3 /12703 = X </li></ul></ul></ul><ul><ul><ul><li>X = 1.50 MICROgrams /ml </li></ul></ul></ul><ul><li>Rule of thumb: 1,000 on SCS = .06 MICROgrams carotenoid/ml blood serum </li></ul>Source: NuSkin/Pharmanex
    24. 39. The Svilaas/Hata Syllogism: <ul><li>Svilaas (2004) – skin carotenoids = better predictor of antioxidant status than mixed tocopherols and glutathione </li></ul><ul><li>Hata (2000) – Raman measurements of carotenoid == HPLC skin measurements </li></ul><ul><li>THEREFORE [Cady]: Raman spectroscopy is a better measure of antioxidant status than mixed tocopherols and glutathione. </li></ul>
    25. 40. Time warp – News Flash!
    26. 41. High oxidative stress = low skin carotenoids (p 11) <ul><li>Ermakov IV et al (2005) – “carotenoids are a good indicator of antioxidant status.” </li></ul><ul><ul><li>Smokers and high sunlight exposure – have reduced skin carotenoid levels, independent of their dietary carotenoid consumption. </li></ul></ul><ul><ul><ul><li>[Cady – “bad stuff trumps reasonable diet”] </li></ul></ul></ul>Ermakov IV, et al. Resonance Raman detection of carotenoids antioxidants in living human tissue. J Biomed Opt. 2005 Nov-Dec;10(6):064028
    27. 42. Pharmanex research (pp 12-13), or, “Taking the Scanner Out to Play” <ul><li>Smidt C (2002) – study of 1,375 NUS employees </li></ul><ul><ul><li>Mean score of 19,072 </li></ul></ul><ul><ul><ul><li>Range from 1,556 – 73,416 </li></ul></ul></ul><ul><ul><ul><li>68% in range of {10,244 – 27,900} </li></ul></ul></ul><ul><ul><li>562 subjects – provided urine for MDA </li></ul></ul>Smidt, C. Clinical screening study: use of the Pharmanex ® BioPhotonic scanner to assess skin carotenoids as a marker of antioxidant status. Pharmanex, LCC, 75 West Center Street, Provo, UT. 2002
    28. 43. Biophotonic Scan scores as function of # of servings of fruits and vegetables (p 12) Smidt, C. Clinical screening study: use of the Pharmanex ® Biophotonic scanner to assess skin carotenoids as a marker of antioxidant status. 2002
    29. 44. Fun footnotes (p 13) <ul><li>MDA subjects (n=562) demonstrated LINEAR inverse correlation between urine MDA levels and Biophotonic scan scores </li></ul><ul><li>Inverse correlation between #of cigarettes smoked and scan score. </li></ul><ul><li>Strong and obvious correlation between use of LifePak & SCS </li></ul><ul><ul><li>One pack twice daily use showed 61% higher SCS than non users (p<0.001) </li></ul></ul>Smidt, C. , 2002, loc cit.
    30. 45. More fun with LifePak supplementation, prescanner (1999) p. 14 <ul><li>Changes measured in: </li></ul><ul><ul><li>Ascorbic acid, beta-carotene, alpha-carotene, and alpha tocopherol </li></ul></ul><ul><ul><li>FUNCTIONAL MEASUREMENT: decreased LDL oxidation </li></ul></ul><ul><li>Study of 50 healthy non smoker, crossover </li></ul><ul><ul><li>25 on either for six weeks, then crossed over for six weeks, then on alternate for six weeks </li></ul></ul>Smidt, CR et al. The effects of a nutritionally complete dietary supplement (LifePak®) on antioxidant status and LDL-oxidation in healthy non-smokers. Federation of American Society for Experimental Biology. 1999;13(4). Pharmanex Clinical Study Report published February 23, 2000.
    31. 46. More fun with LifePak supplementation, prescanner (1999) p. 14 RESULTS <ul><li>LP supplementation prolonged LDL oxidation 18% </li></ul><ul><li>Increase of: </li></ul><ul><ul><li>Ascorbic acid – 38% </li></ul></ul><ul><ul><li>Alpha-carotene – 678% </li></ul></ul><ul><ul><li>Beta-carotene – 114% </li></ul></ul><ul><ul><li>Alpha-tocopherol – 84% </li></ul></ul><ul><li>“ LP significantly increased antioxidant status, and decreased LDL oxidizability in healthy non-smokers.” </li></ul>Smidt, CR et al. (1999, 2000 loc cit)
    32. 47. How are we doing? 2006 Data Histogram: N =2,591,667 Mean SCS = 26,673 Skin Carotenoid Score Frequency THE LIFE PAK’ERS! Source: data reported by Pharmanex 5-9 Fruits & Vegetables Smokers Average (2-3 Fruits & Vegetables) Obesity LifePak LifePak + 5-9 Fruits & Vegetables
    33. 48. Clinical opportunities – p. 16 <ul><li>1996 USDA survey of 5,188 – ZERO people got recommended daily allowances for all vitamins and nutrients. * </li></ul><ul><li>1994-1996 – 16,103 people studied – ZERO got 100% of all nutrients required* </li></ul><ul><ul><li>82.8% of the population got enough B12 </li></ul></ul><ul><ul><li>66.8% got enough folate. </li></ul></ul><ul><ul><li>26.6% got enough Zinc. </li></ul></ul>* http://www.ars.usda.gov/Services/docs.htm?docid=7716
    34. 49. Final aspects of Cady White Paper <ul><li>pp 16-20 – review of products and opportunity </li></ul><ul><li>P 21 – Article on “The Raman Effect” </li></ul>
    35. 50. What’s new since the 2006 “Cady Report”? <ul><li>Epidemiology of Vascular Ageing (EVA) study </li></ul><ul><ul><li>N=1,389; age range {59-71 yoa} </li></ul></ul><ul><ul><li>9 year study </li></ul></ul><ul><li>Relative risks: </li></ul><ul><ul><li>all cause mortality at 2.94X in men in lowest quintile (95% CI, P=0.03) </li></ul></ul><ul><ul><li>cancer 1.72X in men (95% CI, P=0.01 </li></ul></ul><ul><li>“ Total plasma carotenoids levels were independently associated with mortality risk in men.” </li></ul>
    36. 51. Harvesting more data: Akbaraly and dysglycemia <ul><li>Akbaraly TN, et al. Used same data set. </li></ul><ul><li>127 cases of dysglycemia at 9 years. </li></ul><ul><li>“ After controlling for sociodemographic variables, lifestyle habits, cardiovascular disease, blood pressure, BMI , and lipid profile, risk of dysglycemia remained significantly lower in participants in the highest quartile of total plasma carotenoid compared with …. The lowest quartile.” </li></ul>Akbaraly TN et al. Plasma carotenoids and onset of dysglycemia in an elderly population: results of the Epidemiology of Vascular Ageing Study. Diabetes Care. 2008 Jul;31(7):1355-9.
    37. 52. More data: a mad dash through the literature <ul><li>September 24, 2011 </li></ul>One more time… no supplement, under the DSHEA act, may be represented to treat, cure, mitigate or prevent any disease. No such “health claims” are being advanced for any Pharmanex/NuSkin supplement or product. The following slides represents a LITERATURE REVIEW. Louis B. Cady, MD
    38. 61. But what about other things besides carotenoids and “Antioxidants”?? B12, Magnesium, Selenium, Zinc, fish oil…
    39. 62. <ul><li>Irritability </li></ul><ul><li>Apathy </li></ul><ul><li>Personality changes </li></ul><ul><li>Depression </li></ul><ul><li>Memory loss </li></ul><ul><li>Dementia </li></ul><ul><li>Hallucinations </li></ul><ul><li>Violent behavior </li></ul><ul><li>Anxiety </li></ul>Symptoms of B 12 Deficiency <ul><li>Diminished sense of touch and pain </li></ul><ul><li>Clumsiness </li></ul><ul><li>Weakness </li></ul><ul><li>Pernicious anemia </li></ul><ul><li>Chronic fatigue </li></ul><ul><li>Tremors </li></ul><ul><li>GI problems </li></ul>Mental Physical
    40. 63. <ul><li>“ Although reference range for vitamin B12 is 200-1100 pg/ml, it has been reported that between 5 and 10% of patients with values between 200 and 400 pg/ml may experience neuropsychiatric and hematologic abnormalities due to occult B12 deficiency : less than 1% of patients with values above 400 pg/ml will have symptoms.” </li></ul><ul><li>- Quest Diagnostic Laboratories </li></ul>B12
    41. 64. LifePak Nano factoids - % RDA in 2 packets <ul><li>B12 - 1,000% (as 60 MICROgrams cyanocobalamin) </li></ul><ul><li>Magnesium 76% (as 300 Mg amino acid chelate) </li></ul><ul><li>Zinc 100% (15 mg as zinc chelate) </li></ul><ul><li>Selenium 200% (L-selenomethionine & NaSeO3) </li></ul>
    42. 65. B 12 Deficiency <ul><li>Levitt and Joffe, Brit J Psychiatry, 1988 </li></ul><ul><ul><li>B 12 deficiency seen in those with psychotic depression </li></ul></ul><ul><li>Penninx, et al., Am J Psychiatry, 2000 </li></ul><ul><ul><li>B 12 deficiency doubled the risk of severe depression in physically disabled older women </li></ul></ul><ul><li>Catalano, et al., Ann Clin Psychiatry, 2001 </li></ul><ul><ul><li>Nearly 1/3 (of 115) patients with depression or mood disorders had low B 12 </li></ul></ul><ul><li>Silver, Israeli J Psychiatry and Related Sciences, 2000 </li></ul><ul><ul><li>20% of psychiatric patients were B 12 deficient </li></ul></ul>
    43. 66. Magnesium mementos <ul><li>One of the first minerals to disappear with: </li></ul><ul><ul><li>Processed food </li></ul></ul><ul><ul><li>Stress </li></ul></ul><ul><li>Decreased by EtOH , caffeine , sodas , meds </li></ul><ul><li>Considered “anti-stress” mineral </li></ul><ul><ul><li>Decreases cortisol (rel to sleep disruption) </li></ul></ul><ul><ul><li>Relaxes muscles, prevents cramps (sleep disruption) </li></ul></ul><ul><ul><li>Decreases anxiety ; improves sleep </li></ul></ul>
    44. 67. Symptoms of Magnesium Deficiency <ul><li>PSYCHIATRIC ISSUES: </li></ul><ul><li>Difficulty with memory and concentration </li></ul><ul><li>Depression, apathy </li></ul><ul><li>Emotional lability </li></ul><ul><li>Irritability, nervousness, anxiety </li></ul><ul><li>Insomnia </li></ul><ul><li>Autism </li></ul><ul><li>ADHD </li></ul><ul><li>Migraine headaches </li></ul><ul><li>PMS </li></ul><ul><li>Dysmenorrhea </li></ul><ul><li>Fibromyalgia </li></ul><ul><li>Fatigue </li></ul><ul><li>CONSTIPATION </li></ul>Health Conditions Associated with Magnesium Deficiency
    45. 68. SELENIUM DEFICIENCY in FASEB: <ul><li>“ Adaptive dysfunction of selenoproteins from the perspective of the ‘triage’ theory: why modest selenium deficiency may increase risk of diseases of aging.” </li></ul>Foundation of American Societies for Experimental Biology McCann, J, Ames BM. FASEB J. 2011 Jun;25(6):1793-814.
    46. 69. Negative downstream effects from selenium deficiency: <ul><li>“ The triage theory proposes that modest deficiency of any vitamin or mineral could increase age-related diseases.” </li></ul><ul><li>½ of known mammalian selenoproteins reviewed. </li></ul><ul><li>“ On modest selenium deficiency , nonessential selenoprotein activities and concentrations are preferentially lost … ” </li></ul><ul><li>“… cancer, heart disease, and immune dysfunction are prospectively associated with modest selenium deficiency…. Suggesting that Se deficiency could be a CAUSATIVE factor” </li></ul>McCann, J, Ames BM. FASEB J. 2011 Jun;25(6):1793-814.
    47. 70. “ the foot soldier” “ the evil twin ” LifePak Nano has 200% of RDA of selenium.
    48. 72. November 2009 “Alpha Male” issue <ul><li>Observational study of randomly selected men – Boston </li></ul><ul><li>3 cohorts of men: 1987-1989; 1995-1997; 2002 -2004. </li></ul><ul><li>1374, 906, and 489 men, respectively. </li></ul><ul><li>“ Age independent decline in T that does not appear to be attributable to observed changes in explanatory factors, including lifestyle characteristics such as smoking and obesity.” </li></ul><ul><li>“ Recent years have seen a SUBSTANTIAL , and as yet UNRECOGNIZED age-independent population-level decrease in T in American men.” Travison, Araujo, et al. Jrnl of Clin. Endocrinol & Metabol 92:1; 196-202. </li></ul>
    49. 73. Fast food (low Zn) is bad for you. <ul><li>Fast food = high energy density = low essential micronutrient density, ESPECIALLY ZINC </li></ul><ul><li>Antioxidant processes are dependent on Zinc </li></ul><ul><li>Fast food = severe decrease in antioxidant vitamins and zinc, correlating with inflammation in testicular tissue – with underdevelopment of testicular tissue and decreased testosterone levels </li></ul>
    50. 74. Special needs - Zinc <ul><li>Low Zinc- associated with low testosterone </li></ul><ul><ul><li>Per USDA, 60% of US men between 20 – 49 years of age do not get enough . </li></ul></ul><ul><ul><li>N.B.: Do not supplement with > 50 mg daily (can interfere with Cu+ metabolism) </li></ul></ul><ul><ul><ul><li>Tsai, E.C., Boyko, E.J., Leonetti, D.L., & Fujimoto, W.Y. (2000). Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men. International Journal of Obesity and Related Metabolic Disorders, 24, 485-491 </li></ul></ul></ul>
    51. 75. Essential Fatty Acids – relevant for: <ul><li>“ Psych” </li></ul><ul><li>Depression </li></ul><ul><li>Bipolar depression </li></ul><ul><li>Schizophrenia </li></ul><ul><li>Autism </li></ul><ul><li>AD(H)D </li></ul><ul><li>Learning disabilities </li></ul><ul><li>“ Medical” </li></ul><ul><li>Seizures </li></ul><ul><li>Rheumatoid arthritis (& anything with inflammation) </li></ul><ul><li>Coronary heart disease (or health maintenance) </li></ul>
    52. 76. Do YOU Need Fish Oil?
    53. 77. c. 15-20X Omega 6:3
    54. 78. Putting it all together…
    55. 79. The Effects of high dose B vitamins on stress at work Strough C et al. The effect of 90 day administration of a high dose vitamin B-coplex on work stress. Hum Psyhopharmacol. 2011 Sept 8. doi 10.1002/hup.1229 (Swinburne University of Techbnology – Hawhorn, Victoria, Australia.)
    56. 80. The Effects of high dose B vitamins on stress at work <ul><li>“ Occupational stress is increasing in Western societies.” </li></ul><ul><li>3 month, double blind, placebo control, randomized study </li></ul><ul><li>Measured: Personality, work demands, mood, anxiety, and strain </li></ul><ul><li>After variances in personality and work demands were controlled , the vitamin B complex treated group reported significantly lower personal strain and a reduction in confusion and depressed/dejected mood after 12 weeks . </li></ul>Strough C et al. The effect of 90 day administration of a high dose vitamin B-coplex on work stress. Hum Psychopharmacol. 2011 Sept 8. doi 10.1002/hup.1229 (Swinburne University of Techbnology – Hawhorn, Victoria, Australia.)
    57. 81. Erectile dysfunction & antioxidants with MVI’s??
    58. 82. Way to improve erectile quality (LP Nano concentrations in parentheses) <ul><li>Holistic: physical exercise, improved nutrition, weight control </li></ul><ul><li>Supplements: adequate intake </li></ul><ul><ul><li>Omega 3 fatty acids ( ~4 grams/ day in LP Nano) </li></ul></ul><ul><ul><li>Antioxidants {+++} </li></ul></ul><ul><ul><li>Calcium (600 mg = 60%) </li></ul></ul><ul><ul><li>Folic acid (folate – 600 ug = 150%) </li></ul></ul><ul><li>RX: Replacement of any T deficiency </li></ul>Meldrum DR et al. The link between erectile and cardiovascular health: the canary in the coal mine. Am J Cardiol. 2011 Aug 15;108(4):599-606
    59. 84. How to lie about vitamins and antioxidants…
    60. 85. How to Lie about Vitamins & Antioxidants
    61. 86. www.slideshare.net/lcadymd
    62. 87. “ If you’re going to be thinking anyway, you might as well thing big.” - Donald Trump
    63. 88. Perhaps the ability not only to acquire the confidence of the patient, but to deserve it, to see what the patient desires and needs, comes through the sixth sense we call intuition, which in turn comes from wide experience and deep sympathy for and devotion to the patient , giving to the possessor remarkable ability to achieve results. ...William J. Mayo, 1935

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