A Review of the Pharmanex Biophotonic Scanner,
Supplements, the “Cady White Paper,” & Relevant
Genomic Science in New AgeL...
Background for this presentation:
• There are no “drug claims” made for any
products from NuSkin/Pharmanex
• No NuSkin/Pha...
CURRENT PRACTICE OF MEDICINE:
What a patient had to say about her “specialists”:

“They just monitor my
degeneration.”
Cady Wellness Institute – July 2005
The Reasons:
•
•
•
•

Conventional medical practice had failed me twice.
A lot of “psy...
Today:
A Tale of FOUR
Guys…
Learning objectives
• Importance of antioxidants (with refs)
• Origins and validity of the Biophotonic
Scanner
• The criti...
“Streaking”, or…..

Better Buckle Up!!!
• Definition: Streaking is the act of taking off

one's clothes and running naked ...
www.slideshare.net/lcadymd
Here it is again… :)
www.slideshare.net/lcadymd
Evansville Courier & Press: May 29,
2006
As of 11/8/2013
As of 11/8/2013
As of 11/8/2013
Could it happen to you?
What causes oxidative stress?
• Environmental Toxins
–
–
–
–

Heavy metals – including Mercury (fillings!)
Pesticides/herb...
Oxidative stress in the BRAIN – why
you should “know your numbers”
Why is the brain so
susceptible to oxidative stress?
• Burns glucose – generates free radicals.
• Uses 20% of total oxygen...
•
•
•
•

What are some consequences of
oxidative stress?
Behavioral deterioration
Impaired cognitive function
Decreased me...
Antioxidant assessment

Reference:
www.cadywellness.com/cadyw
Center for Biomedical Optics – Dixon
Laser Institute, University of Utah
• Werner Gellermann, Ph.D. – Research
Professor
•...
“A method and apparatus are provided
for the determination of levels of
carotenoids and similar chemical
compounds in biol...
Dissolved carotenoids in stratum corneum

27 days
Scientific Validation: Peer-reviewed by the
medical & research communities
• Society of Investigative Dermatology, May 25,...
“RSS spectroscopy is a reliable
method for non-invasive
measurement of B-carotene
levels in skin, and may be used
as an im...
“But is the scanner really valid and
dependable?”
• “The totality of the evidence supports the use of skin carotenoid
status as an objective biomarker of fruits/vegetable i...
Scamo S et al. Br J Nutr. 2013
Sep 14;110(5):911-7.

• Good agreement between single and multiple measures (95% CI)
• + as...
So where do I find this
“white paper”?
• www.google.com
• www.cadywellness.com/
cadywhitepaper2008.pdf
Relationships of carotenoids to other more
conventionally measured antioxidants (p 6 -7)

• Svilaas et al (2004):
– 2, 670...
Convenience of carotenoids as antioxidant
measurement (pp7-11)
• Hata, et al* (2000) – correlated skin

carotenoids (Raman...
The Svilaas/Hata Syllogism:
• Hata (2000) – Raman measurements of
carotenoid == HPLC skin measurements
• Svilaas (2004) – ...
BTW – what does that “SCS” actually
mean in REAL LAB MEASUREMENTS?
• Y = 12703 * X + 5891.7

– Where Y is the SCS, and X i...
“You don’t need vitamins: (a) you can get’em in
your food; (b)they just make expensive urine.”
“I don’t believe in antioxi...
“Inadequate intakes may result in chronic
metabolic disruption, including mitochondrial
decay.”
“[They] cause DNA damage, ...
16,103 people – 1994 – 1996.
ZERO got 100% of all required vitamins and
nutrients
- Highest – B12 =- 82.8% got enough
- 66...
Seismic shift in the
medical literature - 2002

“Pending strong evidence …from randomized trials, it
appears prudent for a...
What’s New since the “cady
report” (2006 & 2008)?
Angela Mastaloudis Ph.D.
Senior Scientist, Global Research &
Development, Pharmanex
“RS accurately measures total carotenoids in human skin
with less intra-individual variability than measurement of
serum c...
Epidemiology of Vascular Aging (EVA)
Epidemiology of Vascular Aging (EVA)
• Study population:
– N=1,389; age range {59-71 yoa}
– 9 year study

• Relative risks...
Vitamin/mineral supplementation & cancer,
cardiovascular, and all-cause mortality
(EPIC-Heidelberg) Li K, Kaaks R., et al....
Antioxidants and brain tumors?

• “free radicals are another etiological factor
of brain tumor and are removed by cellular...
Conclusions

• “It is concluded that
administration of antioxidants
could reduce the incidence of
brain tumors and probabl...
So why do you need a
SYSTEM in your vitamin
supplement/mineral
complex?? And what’s a
‘nano’?
A SYSTEMS approach to nutritional
optimization
3
ega- s
Om cid
tty a
fa

nts
trie
ns
mi
onu
vita
hyt
P
nts
s
a
ral
xid
ine...
What does “Nano” mean?

• Cylcodextrin ring – benign, digestable
• Feeds the gut microflora
How do nano-nutrients work?
Fat-soluble nutrients like
Nano-encapsulated nutrients do
carotenoids and coenzyme Q10 not clu...
The Nanotechnology Difference

pmol/mg protein

5-fold increase in absorption!

Adapted from Craft et al, FASEB Journal. 2...
The train has left the station…
Can you relax with an
81,000 scan score??
Total organic fruits/vegetables intake, 9
– 12 servings per day. No supplements.
74,000
what about other
things besides carotenoids
and “Antioxidants”??
Or… why can’t you just “juice” your way
to complete and o...
Essential Fatty Acids – relevant for:
“Psych”

“Medical”

•
•
•
•
•
•

• Seizures
• Rheumatoid arthritis
(& anything with
...
Do YOU Need Fish Oil?

5X reduction
Symptoms of B12 Deficiency
Mental
•
•
•
•
•
•
•
•
•

Irritability
Apathy
Personality changes
Depression
Memory loss
Dement...
LifePak Nano - % RDA in 2 packets
• B12
1,000% (as 60 MICROgrams
cyanocobalamin)
• B6
500%
• Folic acid/folate - 150%
• Ma...
Why there is an epidemic of B12
deficiency??

• Gastric intrinsic factor produced by parietal
cells of stomach;. H1 blocke...
Your brain and B12
• If you are in the bottom 1/3rd for B-12
levels….

• SIX TIMES increase risk of
brain volume loss (Odd...
BRAIN SHRINKAGE…

CONCLUSIONS: “The
accelerated rate of brain
atrophy in elderly with MCI can
be slowed by treatment with
...
LifePak Nano - % RDA in 2 packets
• B12
1,000% (as 60 MICROgrams
cyanocobalamin)
HOMOCYSTEINE
• B6
500%
lowering
• Folic a...
OK. It slows shrinkage. But are they sharper?
[deJager CA et al. Int J Geriatr Psychiatry. 2012 June;27(6):592-600]

“B-vi...
The Effects of high dose B vitamins
on stress at work

• 3 month, double blind, placebo control, randomized study
– Measur...
“Micronutrient supplementation has a beneficial
effect on perceived stress, mild psychiatric
symptoms, and aspects of mood...
What happens with biotin
deficiency?
Two LifePak Nano packets have
100% of recommended daily
requirements of Biotin.

“Our...
One more time… no supplement, under the DSHEA act, may
be represented to treat, cure, mitigate or prevent any disease.
No ...
“Chile has an increased cancer prevalence which is associated
with poor quality diets, rising mean body mass index and a
s...
100 more citations in the last year!
OK.
So I’ll just drink
carrot juice and
pop some high
potency B’s. What
me worry?
20 years ago - a hint of bad things to come…

• North Americans, unfortunately,
obtain about one-third of their total
calo...
Magnesium mementos
• One of the first minerals to disappear with:
– Processed food
– Stress

• Decreased by EtOH, caffeine...
Symptoms of Magnesium Deficiency
PSYCHIATRIC ISSUES:
•Difficulty with memory and
concentration
•Depression, apathy
•Emotio...
SELENIUM DEFICIENCY in FASEB:
• “Adaptive dysfunction of
selenoproteins from the
perspective of the ‘triage’
theory: why

...
I+

Se+



“the foot soldier”

LifePak Nano has 200% of RDA
of selenium.
And 76%of RDA of iodine.
 “Recent

years have seen a
SUBSTANTIAL, and as yet
UNRECOGNIZED ageindependent population-level
decrease in T in America...
Fast food (low

Zinc) is bad for you.

• Fast food = high energy density = low essential
micronutrient density, ESPECIALLY...
Low Zinc associated with low
testosterone
• Per USDA, 60% of US men between 20
– 49 years of age do not get enough.
– [N.B...
Erectile dysfunction & antioxidants
with MVI’s??
Ways to improve erectile quality
(LP Nano concentrations in parentheses)

• Holistic: physical exercise, improved nutritio...
New Partners, New Products
LifeGen acquisition: Why?
• Owns all current and future genetic data
on aging
– monopolizes the genetic knowledge on aging...
Is it safe to Influence Genes?
ageLOC is NOT:
gene therapy
genetic engineering
gene splicing

ageLOC is:
• NuSkin/Pharmane...
An Entirely New Class of Anti-aging Products
BEFORE

AFTER 6 MONTHS
*Twice daily usage of ageLOC
Transformation, and twice weekly
usage of ageLOC Galvanic Spa and
Faci...
Mitochondrial Damage:
Loss of Energy

Mitochondria
Free radical
damage alters
their energy
production
capability. Plus,
th...
MITOCHONDRIAL ACTIVITY DECLINES WITH AGE
8

6

- 40%

4

2

18~39

61~84

”Mitochondrial Dysfunction in the Elderly: Possi...
“Transcriptional Biomarkers of Mitochondrial Aging and
Modulation by Cordyceps sinensis CS-4.”

Muscle

Brain

R Weindruch...
TARGET & RESET YOUTH GENE
CLUSTERS
Young Gene
Expression
TARGET

Old Gene
Expression

Old Gene
Expression
RESET

Transcrip...
“Youth Gene Clusters” – bogus
or bonanza?
Yeast species
SPECIFIC genes
Comparative genomics of fungal allergens
and epitop...
Prostate Cancer – more
relevant?
Pre-invention gene
expression

Post-intervention
gene expression

Changes in prostate gen...
Active mitochondrial research on
energy
http://www.nature.com/scitable/topicpage/mtdna-andmitochondrial-diseases-903
Three active botanicals:
•Cordyceps
•Pomegranate extract
•Panax ginseng
Promotes Three Dimensions
of Vitality:*
•Physical ...
Week 12 = +20%
P=0.021
Vitality vs. Placebo
“Targeting Age-related gene expression improves
mental and physical vitality” ...
“Excess body weight is correlated with excess morbidity
and mortality. In particular, Grade 2 or higher obesity
(BMI>35) s...
Obesity – a national crisis

A $586 Billion Market in
2014

Fortune Magazine Feb 3, 2003
How do you lose it?
• TBL: It’s the
INSULIN
RESPONSE
• RX: EAT LESS
CARBS AND
SUGAR!!

NEW APPROACH:
-Turn on your genes in your fat cells to ...
ageLOC TR90 Summary
• Healthy weight management and Body
Shaping program.
• Based on gene expression science.
– Promotes L...
Comparison of Genetic Profiles of Adipose Tissue
in Identical Twins
Pietiläinen et al. PLoS Med. 2008 Mar 11;5(3):e51.

Ov...
Identified Gene Expression Pathways Linked to
Fat Storage and Fat Metabolism

LifeGen pre-clinical study of Adipose,
Gastr...
Plants altering gene expression
Ingredient

Effect

From PubMed

Prickly pear fruit

“body silhouette”

Potent antioxidant...
Green tea, black tea, epigallocatechin:
•Modifies body composition
•Improves glucose tolerance
•DIFFERENTIALLY ALTERS GENE...
Gene Expression relates to the Appetite Control
Center of the Brain
•
•
•

Appetite Control
Eating Behavior
Regulation of ...
Eating Plan Based on:
Protein Science & Nutrition Science
• “3-2-1 eating” plan designed to
complement the supplements.
• ...
Eating Most of Your Protein with Only One Meal of the
Day Limits Duration of Metabolic Burn

FAT STORING

ZONES

FAT BURNI...
Eating Protein with Each Meal
Accelerates Metabolic Burn

FAT STORING

ZONES

FAT BURNING

Time in Metabolic Burn Zone = 9...
So what the
heck am I
supposed to
do with this
stuff?
A personal close:
How do YOU want to age?

Me – Jan 2013
The “First Guy” on TR90
• Measurements from 10/25/13 (start date) –
11/6/13
• Lost:
– ¾” on waist (one belt loop)
– 1.25” ...
Wrapping Up: The “Survival Curve” –
Where Are You?
“For me, the practice of medicine has
opened the door to the greatest adventure in
life. Medicine is like a hallway lined ...
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science
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A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science

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In his return to the Orange County, CA area, Dr. Cady quickly reviews the key points of his previous presentation and integrates new science and citations about wellness and the key concepts of nutritional supplementation with balanced products. He then turns his attention to new developments in genomic science, reviews key scientific milestones, and describes how the NuSkin/Pharmanex line of AgeLOC products have profound implications for the improvement of energy, sexual functioning, mental focus, and weight loss through the optimization of the function of the human body.

Published in: Health & Medicine, Technology
  • Dr. Cady did an outstanding presentation at the Pharmanex Biophotonic Scanner Meeting yesterday in Orange County. Thank You Dr. Cady for sharing all your knowledge and white pages. Such a wealth of information.
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A Review of the Cady White Paper, the Biophotonic Scanner, Supplementation and New Developments in Genomic Science

  1. 1. A Review of the Pharmanex Biophotonic Scanner, Supplements, the “Cady White Paper,” & Relevant Genomic Science in New AgeLOC Products Santa Ana, California – November 9, 2013 Louis B. Cady, MD – CEO & Founder – Cady Wellness Institute Adjunct Professor – University of Southern Indiana Adjunct Clinical Lecturer – Indiana University School of Medicine Department of Psychiatry Child, Adolescent, Adult & Forensic Psychiatry – Evansville, Indiana
  2. 2. Background for this presentation: • There are no “drug claims” made for any products from NuSkin/Pharmanex • No NuSkin/Pharmanex product– nor any other “OTC” vitamin or supplement – is designed to treat, prevent, mitigate, diagnose or do anything else to or for any disease. • Pharmanex nutritional supplements & weight control products are designed to support the structure and function of the human body. (c) 2013 Louis B. Cady, M.D. - all rights reserved
  3. 3. CURRENT PRACTICE OF MEDICINE: What a patient had to say about her “specialists”: “They just monitor my degeneration.”
  4. 4. Cady Wellness Institute – July 2005 The Reasons: • • • • Conventional medical practice had failed me twice. A lot of “psychiatric cases” WEREN’T “psychiatric.” Nobody was integrated. Nobody was looking at ALL of the peer-reviewed literature.
  5. 5. Today: A Tale of FOUR Guys…
  6. 6. Learning objectives • Importance of antioxidants (with refs) • Origins and validity of the Biophotonic Scanner • The critical “three points” of the “Cady White Paper” • AgeLOC technology and “YGC’s” (??) • Vitality and TR90
  7. 7. “Streaking”, or….. Better Buckle Up!!! • Definition: Streaking is the act of taking off one's clothes and running naked through a public place. [ref: http://en.wikipedia.org/wiki/Streaking - accessed 09 02 2013] • “In 1973, what the press called a ‘streaking epidemic’ hit Stephen F. Austin State University in Nacogdoches, TX, with streakers being seen in residence halls, at football games and at various other on-campus locations and events, including Spring graduation.” (Harvard-Yale game, 2006)
  8. 8. www.slideshare.net/lcadymd
  9. 9. Here it is again… :) www.slideshare.net/lcadymd
  10. 10. Evansville Courier & Press: May 29, 2006
  11. 11. As of 11/8/2013
  12. 12. As of 11/8/2013
  13. 13. As of 11/8/2013
  14. 14. Could it happen to you?
  15. 15. What causes oxidative stress? • Environmental Toxins – – – – Heavy metals – including Mercury (fillings!) Pesticides/herbicides Preservatives PCB’s, Dioxins, Phthalates • Toxins produced in the body – Yeast and bacteria – Products of cellular metabolism • Emotional Stress – Anxiety/Tension – Fear – Anger
  16. 16. Oxidative stress in the BRAIN – why you should “know your numbers”
  17. 17. Why is the brain so susceptible to oxidative stress? • Burns glucose – generates free radicals. • Uses 20% of total oxygen and energy consumed by the body. • ½ of this is for electrochemical nerve transmission. • Contains IRON • Contains essential fatty acids, which can be OXIDIZED (“rancid fat”) • Limited supply of own antioxidants • Limited ability to regenerate/repair damage
  18. 18. • • • • What are some consequences of oxidative stress? Behavioral deterioration Impaired cognitive function Decreased memory Psychiatric symptoms • Increased inflammation • Depressed immune system • DNA damage • cancer
  19. 19. Antioxidant assessment Reference: www.cadywellness.com/cadyw
  20. 20. Center for Biomedical Optics – Dixon Laser Institute, University of Utah • Werner Gellermann, Ph.D. – Research Professor • Colleague – Igor Ermakov, Ph.D., et al. • Technologies – “Novel Raman Spectroscopy and Raman Imaging.” • Funding: – National Institutes of Health – State of Utah – Spectrotek, LLC
  21. 21. “A method and apparatus are provided for the determination of levels of carotenoids and similar chemical compounds in biological tissue such as living skin.”
  22. 22. Dissolved carotenoids in stratum corneum 27 days
  23. 23. Scientific Validation: Peer-reviewed by the medical & research communities • Society of Investigative Dermatology, May 25, 2000. – Non-Invasive Raman Spectroscopic Detection of Carotenoids in Human Skin. • Arch Biochem Biophys. 2010 Dec 1;504(1):40-9. Epub 2010 Aug 1. – Validation model for Raman based skin carotenoid detection • J Eur Acad Dermatol Ven. 2011 Aug;25(8):945-9. – Skin carotenoid levels in adult patients with psoriasis.
  24. 24. “RSS spectroscopy is a reliable method for non-invasive measurement of B-carotene levels in skin, and may be used as an important biomarker of antioxidant status in nutritional and health studies in humans.” Ramirez-Velez, et al. Endocrinol Nutr. 2012 April
  25. 25. “But is the scanner really valid and dependable?”
  26. 26. • “The totality of the evidence supports the use of skin carotenoid status as an objective biomarker of fruits/vegetable intake…” • “..skin carotenoids may effectively serve as an integrated biomarker of health…” • “Thus, this biomarker holds promise as both a health biomarker and an objective indicator of fruits & vegetables intake….”
  27. 27. Scamo S et al. Br J Nutr. 2013 Sep 14;110(5):911-7. • Good agreement between single and multiple measures (95% CI) • + association with intake of total carotenoids • “A single RRS measure was reasonably accurate at classifying usual skin carotenoid state.”
  28. 28. So where do I find this “white paper”? • www.google.com • www.cadywellness.com/ cadywhitepaper2008.pdf
  29. 29. Relationships of carotenoids to other more conventionally measured antioxidants (p 6 -7) • Svilaas et al (2004): – 2, 670 adults studied with serum carotenoids measured and correlated with vitamin consumption – serum carotenoids were stronger predictors of other antioxidants than were alpha, beta, delta, and gamma tocopherols, as well as glutathione.* * Svilaas A, et al. Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J Nutr. 2004 Mar;134(3):562-7.
  30. 30. Convenience of carotenoids as antioxidant measurement (pp7-11) • Hata, et al* (2000) – correlated skin carotenoids (Raman) with carotenoid levels from skin from abdominoplasty patients (HPLC). • “Our technique can be used…for assessing antioxidant status and the risk for diseases related to oxidative stress.” [Palm of skin = highest carotenoid location] *Hata et al. Non-invasive Raman spectroscopic detection of carotenoids in human skin. J Invest Dermatol. 2000 Sep; 115(3):441-8.
  31. 31. The Svilaas/Hata Syllogism: • Hata (2000) – Raman measurements of carotenoid == HPLC skin measurements • Svilaas (2004) – skin carotenoids = better predictor of antioxidant status than mixed tocopherols and glutathione • THEREFORE [Cady]: Raman spectroscopy is a better measure of antioxidant status than mixed tocopherols and glutathione.
  32. 32. BTW – what does that “SCS” actually mean in REAL LAB MEASUREMENTS? • Y = 12703 * X + 5891.7 – Where Y is the SCS, and X is the carotenoid concentration in MICROgrams/ml, viz: • • • • • 25,000 = 12703X + 5891.7 25,000 – 5891.7 = 12703 * X 19,108.3 = 12703 * X 19,108.3 /12703 = X X = 1.50 MICROgrams /ml • Rule of thumb: 1,000 on SCS = .06 ug carotenoid/ml blood serum • (e.g., SCS of 40,000 = 2.4 ug carotenoid/ml) Source: NuSkin/Pharmanex
  33. 33. “You don’t need vitamins: (a) you can get’em in your food; (b)they just make expensive urine.” “I don’t believe in antioxidants.” – from an MD!!
  34. 34. “Inadequate intakes may result in chronic metabolic disruption, including mitochondrial decay.” “[They] cause DNA damage, such as chromosome breaks, in cultured human cells or in vivo.” “triage theory
  35. 35. 16,103 people – 1994 – 1996. ZERO got 100% of all required vitamins and nutrients - Highest – B12 =- 82.8% got enough - 66.8% - had adequate folate - Lowest – Zinc – only 26.6% got enough.
  36. 36. Seismic shift in the medical literature - 2002 “Pending strong evidence …from randomized trials, it appears prudent for all adults to take vitamin supplements.” Fletcher & Fairfield, JAMA 2002
  37. 37. What’s New since the “cady report” (2006 & 2008)?
  38. 38. Angela Mastaloudis Ph.D. Senior Scientist, Global Research & Development, Pharmanex
  39. 39. “RS accurately measures total carotenoids in human skin with less intra-individual variability than measurement of serum carotenoids by HPLC analysis. RS technology is a valid and reliable noninvasive method to rapidly assess carotenoid nutritional status in humans.” (J Am. Coll Nutr 2009)
  40. 40. Epidemiology of Vascular Aging (EVA)
  41. 41. Epidemiology of Vascular Aging (EVA) • Study population: – N=1,389; age range {59-71 yoa} – 9 year study • Relative risks: – all cause mortality at 2.94X in men in lowest quintile (95% CI, P=0.03) – cancer 1.72X in men (95% CI, P=0.01 • “Total plasma carotenoids levels were independently associated with mortality risk in men.”
  42. 42. Vitamin/mineral supplementation & cancer, cardiovascular, and all-cause mortality (EPIC-Heidelberg) Li K, Kaaks R., et al. Eur J Nutri July 2011 • Purpose: evaluate vitamin/mineral supplementation with CA, CV dz, and mortality • Methods: – 23,943 healthy participants, followed 11 years – Baseline and “new-use” supplementation noted • Results: 513 CA deaths, 264 CV deaths – “No MVI supplement had any significant effect” • “sick user” phenomenon discussed. • Baseline users of antioxidant supplements had significantly reduced risk of cancer [HR 0.52] and all cause mortality [0.58]
  43. 43. Antioxidants and brain tumors? • “free radicals are another etiological factor of brain tumor and are removed by cellular antioxidants in the human body.” • Inverse correlation between: – antioxidant levels and oxidative DNA damage – Grades of malignancy • Decrease in antioxidants are associated with severity of malignancy
  44. 44. Conclusions • “It is concluded that administration of antioxidants could reduce the incidence of brain tumors and probably other types of cancer.” • - Shewelta SA , Sheikh, BY Curr Drug Metab. 2011 Jul;12(6):587-93. (Dept.of Biosciences & Technology, Alexandria University, Egypt.)
  45. 45. So why do you need a SYSTEM in your vitamin supplement/mineral complex?? And what’s a ‘nano’?
  46. 46. A SYSTEMS approach to nutritional optimization 3 ega- s Om cid tty a fa nts trie ns mi onu vita hyt P nts s a ral xid ine ntio m lth) A hea one (b
  47. 47. What does “Nano” mean? • Cylcodextrin ring – benign, digestable • Feeds the gut microflora
  48. 48. How do nano-nutrients work? Fat-soluble nutrients like Nano-encapsulated nutrients do carotenoids and coenzyme Q10 not clump; they DISPERSE. CLUMP in watery milieu.
  49. 49. The Nanotechnology Difference pmol/mg protein 5-fold increase in absorption! Adapted from Craft et al, FASEB Journal. 2005; 19(4): Abstract #281.6, A449. γ-cyclodextrin complex
  50. 50. The train has left the station…
  51. 51. Can you relax with an 81,000 scan score??
  52. 52. Total organic fruits/vegetables intake, 9 – 12 servings per day. No supplements.
  53. 53. 74,000
  54. 54. what about other things besides carotenoids and “Antioxidants”?? Or… why can’t you just “juice” your way to complete and optimal health???
  55. 55. Essential Fatty Acids – relevant for: “Psych” “Medical” • • • • • • • Seizures • Rheumatoid arthritis (& anything with inflammation) • Coronary heart disease (or health maintenance) Depression Bipolar depression Schizophrenia Autism AD(H)D Learning disabilities
  56. 56. Do YOU Need Fish Oil? 5X reduction
  57. 57. Symptoms of B12 Deficiency Mental • • • • • • • • • Irritability Apathy Personality changes Depression Memory loss Dementia Hallucinations Violent behavior Anxiety Physical • Diminished sense of touch and pain • Clumsiness • Weakness • Pernicious anemia • Chronic fatigue • Tremors • GI problems
  58. 58. LifePak Nano - % RDA in 2 packets • B12 1,000% (as 60 MICROgrams cyanocobalamin) • B6 500% • Folic acid/folate - 150% • Magnesium 76% (as 300 Mg amino acid chelate) • Zinc 100% (15 mg as zinc chelate) • Selenium 200% (L-selenomethionine & NaSeO3) • Iodine 76% • Chromium 166% • Vitamin C 834% • Vitamin A 300% (83% as Beta carotene and plant extracts)
  59. 59. Why there is an epidemic of B12 deficiency?? • Gastric intrinsic factor produced by parietal cells of stomach;. H1 blockers shut them down • Can’t absorb B-12 without it. • Complex goes to last portion of small intestine, where complex is absorbed and B12 liberated.
  60. 60. Your brain and B12 • If you are in the bottom 1/3rd for B-12 levels…. • SIX TIMES increase risk of brain volume loss (Odds ratio = 6.17, 95% CI) – Vogiatzoglou A et al. Vitamin B12 status and rate of brain volume loss in community-dwellers. Neurology. 2008 Sep 9;71(11):826-32. – (107 volunteers aged 61-87 years of age)
  61. 61. BRAIN SHRINKAGE… CONCLUSIONS: “The accelerated rate of brain atrophy in elderly with MCI can be slowed by treatment with homocysteine-lowering Bvitamins.” Smith AD, Smith SM, de Jager CA, Whitbread P, et al. (2010) Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial. PLoS ONE 5(9): e12244. doi:10.1371/journal.pone.0012244 http://www.plosone.org/article/info:doi/10.1371/journal.pone.0012244
  62. 62. LifePak Nano - % RDA in 2 packets • B12 1,000% (as 60 MICROgrams cyanocobalamin) HOMOCYSTEINE • B6 500% lowering • Folic acid/folate - 150% • Magnesium 76% (as 300 Mg amino acid chelate) • Zinc 100% (15 mg as zinc chelate) • Selenium 200% (L-selenomethionine & NaSeO3) • Iodine 76% • Chromium 166% • Vitamin C 834% • Vitamin A 300% (83% as Beta carotene and plant extracts)
  63. 63. OK. It slows shrinkage. But are they sharper? [deJager CA et al. Int J Geriatr Psychiatry. 2012 June;27(6):592-600] “B-vitamins appear to slow cognitive and clinical decline in people with MCI.”
  64. 64. The Effects of high dose B vitamins on stress at work • 3 month, double blind, placebo control, randomized study – Measured: Personality, work demands, mood, anxiety, and strain • The vitamin B complex treated group reported significantly lower personal strain and a reduction in confusion and depressed/dejected mood after 12 weeks. Strough C et al. The effect of 90 day administration of a high dose vitamin Bcomplex on work stress. Hum Psychopharmacol. 2011 Sept 8. doi 10.1002/hup.1229 (Swinburne University of Technology – Hawthorn, Victoria, Australia.)
  65. 65. “Micronutrient supplementation has a beneficial effect on perceived stress, mild psychiatric symptoms, and aspects of mood in apparently healthy individuals. Supplements containing high doses of B vitamins may be more effective in improving mood states.”
  66. 66. What happens with biotin deficiency? Two LifePak Nano packets have 100% of recommended daily requirements of Biotin. “Our results suggest that biotin deficiency promotes hyperglycemic mechanisms…and decreased insulin secretion and sensitivity to compensate for reduced blood glucose concentrations.”
  67. 67. One more time… no supplement, under the DSHEA act, may be represented to treat, cure, mitigate or prevent any disease. No such “health claims” are being advanced for any Pharmanex/NuSkin supplement or product. The following slides represents a LITERATURE REVIEW It correlates antioxidants, carotenoids and various conditions described in the peer reviewed medical literature. - Louis B. Cady, MD On November 8th, 2013 More data: a mad dash through the literature
  68. 68. “Chile has an increased cancer prevalence which is associated with poor quality diets, rising mean body mass index and a sedentary behavior.”
  69. 69. 100 more citations in the last year!
  70. 70. OK. So I’ll just drink carrot juice and pop some high potency B’s. What me worry?
  71. 71. 20 years ago - a hint of bad things to come… • North Americans, unfortunately, obtain about one-third of their total calories from nutrient-poor junk food. Even well-educated… adults…. fall short in their consumption of important minerals, like magnesium, iron, zinc, and calcium. Hallfrishch, J., Muller, D. 1993. Experimental Gerontology, v28 : 473-83.
  72. 72. Magnesium mementos • One of the first minerals to disappear with: – Processed food – Stress • Decreased by EtOH, caffeine, sodas, meds • Considered “anti-stress” mineral – Decreases cortisol (rel to sleep disruption) – Relaxes muscles, prevents cramps – Decreases anxiety; improves sleep
  73. 73. Symptoms of Magnesium Deficiency PSYCHIATRIC ISSUES: •Difficulty with memory and concentration •Depression, apathy •Emotional lability •Irritability, nervousness, anxiety •Insomnia Autism ADHD Health Conditions Associated with Magnesium Deficiency  Migraine headaches  PMS  Dysmenorrhea  Fibromyalgia  Fatigue  CONSTIPATION
  74. 74. SELENIUM DEFICIENCY in FASEB: • “Adaptive dysfunction of selenoproteins from the perspective of the ‘triage’ theory: why modest selenium deficiency may increase risk of diseases of aging.” Foundation of American Societies for Experimental Biology McCann, J, Ames BM. FASEB J. 2011 Jun;25(6):1793-814.
  75. 75. I+ Se+  “the foot soldier” LifePak Nano has 200% of RDA of selenium. And 76%of RDA of iodine.
  76. 76.  “Recent years have seen a SUBSTANTIAL, and as yet UNRECOGNIZED ageindependent population-level decrease in T in American men.” November 2009 Travison, Araujo, et al. Jrnl of Clin. Endocrinol & Metabol 92:1; 196-202. 3 cohorts of men: 1987-1989; 1995-1997; 2002 -2004. “Alpha Male” issue
  77. 77. Fast food (low Zinc) is bad for you. • Fast food = high energy density = low essential micronutrient density, ESPECIALLY ZINC • Antioxidant processes are dependent on Zinc • Fast food = severe decrease in antioxidant vitamins and zinc, correlating with inflammation in testicular tissue – with underdevelopment of testicular tissue and decreased testosterone levels
  78. 78. Low Zinc associated with low testosterone • Per USDA, 60% of US men between 20 – 49 years of age do not get enough. – [N.B.: Do not supplement with > 50 mg daily (can interfere with Cu+ metabolism); rationale for SYSTEMS approach] • Tsai, E.C., Boyko, E.J., Leonetti, D.L., & Fujimoto, W.Y. (2000). Low serum testosterone level as a predictor of increased visceral fat in JapaneseAmerican men. International Journal of Obesity and Related Metabolic Disorders, 24, 485-491 LifePak Nano has 100% of daily RDA for Zinc.
  79. 79. Erectile dysfunction & antioxidants with MVI’s??
  80. 80. Ways to improve erectile quality (LP Nano concentrations in parentheses) • Holistic: physical exercise, improved nutrition, weight control (R90 & TR90) • Supplements: adequate intake – Omega 3 fatty acids ( ~4 grams/ day in LP Nano) – Antioxidants {+++} – Calcium (600 mg = 60%) – Folic acid (folate – 600 ug = 150%) • RX: Replacement of any T deficiency Meldrum DR et al. The link between erectile and cardiovascular health: the canary in the coal mine. Am J Cardiol. 2011 Aug 15;108(4):599-606
  81. 81. New Partners, New Products
  82. 82. LifeGen acquisition: Why? • Owns all current and future genetic data on aging – monopolizes the genetic knowledge on aging • Applies LifeGen science to all products – Unrestricted access • Builds barrier to entry • Enhances Nu Skin product innovation in antiaging (“Apple” of the industry) 99
  83. 83. Is it safe to Influence Genes? ageLOC is NOT: gene therapy genetic engineering gene splicing ageLOC is: • NuSkin/Pharmanex - novel approach to developing products designed to support youthful gene expression.
  84. 84. An Entirely New Class of Anti-aging Products
  85. 85. BEFORE AFTER 6 MONTHS *Twice daily usage of ageLOC Transformation, and twice weekly usage of ageLOC Galvanic Spa and Facial Gels.
  86. 86. Mitochondrial Damage: Loss of Energy Mitochondria Free radical damage alters their energy production capability. Plus, they “breathe their own exhaust.”
  87. 87. MITOCHONDRIAL ACTIVITY DECLINES WITH AGE 8 6 - 40% 4 2 18~39 61~84 ”Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance” Science 16 May 2003:Vol. 300. no. 5622, pp. 1140 – 1142
  88. 88. “Transcriptional Biomarkers of Mitochondrial Aging and Modulation by Cordyceps sinensis CS-4.” Muscle Brain R Weindruch, A Mastaloudis, SB Ferguson et al. Presented at Biology of Aging, Determinants of Health-Span. Switzerland August 22-27,2010
  89. 89. TARGET & RESET YOUTH GENE CLUSTERS Young Gene Expression TARGET Old Gene Expression Old Gene Expression RESET Transcriptional Biomarkers of Mitochondrial Aging and Modulation by Cordyceps Sinensis Cs-4. Gordon Research Conference, Biology of Aging, Determinants of Health-Span: From Cells to Humans, August 22-27, 2010. Les Diablerets Conference Center, Les Diablerets, Switzerland. 1
  90. 90. “Youth Gene Clusters” – bogus or bonanza? Yeast species SPECIFIC genes Comparative genomics of fungal allergens and epitopes show widespread distribution of closely related allergen and epitope orthologues. Bower P, et al, BMC Genomics. 2006; 7:251.
  91. 91. Prostate Cancer – more relevant? Pre-invention gene expression Post-intervention gene expression Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention. Ornish, Dean Proc Natl Acad Sci USA 2008 June 17; 105(24):8369-8374 et al.
  92. 92. Active mitochondrial research on energy
  93. 93. http://www.nature.com/scitable/topicpage/mtdna-andmitochondrial-diseases-903
  94. 94. Three active botanicals: •Cordyceps •Pomegranate extract •Panax ginseng Promotes Three Dimensions of Vitality:* •Physical Vigor •Mental Acuity •Sexual Health * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
  95. 95. Week 12 = +20% P=0.021 Vitality vs. Placebo “Targeting Age-related gene expression improves mental and physical vitality” Ferguson SB SM et al. Paper presented at 1st World Congress on Targeting Mitochondria, Strategies, Innovations & Clinical Applications. Berlin, German. November 18-19, 2010.
  96. 96. “Excess body weight is correlated with excess morbidity and mortality. In particular, Grade 2 or higher obesity (BMI>35) significantly increases the risk of death.” (c) 2013 Louis B. Cady, M.D. - all (www.cdc.gov/nchs/data/hus/hus11_InBrief.pdf) rights reserved
  97. 97. Obesity – a national crisis A $586 Billion Market in 2014 Fortune Magazine Feb 3, 2003
  98. 98. How do you lose it?
  99. 99. • TBL: It’s the INSULIN RESPONSE • RX: EAT LESS CARBS AND SUGAR!! NEW APPROACH: -Turn on your genes in your fat cells to burn more fat and store less fat!! - Change hunger signaling to brain by changing gene expression
  100. 100. ageLOC TR90 Summary • Healthy weight management and Body Shaping program. • Based on gene expression science. – Promotes Lean Muscle Maintenance - Appetite Control • Studies on TR90 weight management program resulted in significant weight loss, fat loss and changes in gene expression.
  101. 101. Comparison of Genetic Profiles of Adipose Tissue in Identical Twins Pietiläinen et al. PLoS Med. 2008 Mar 11;5(3):e51. Overweight Twin Normal Weight Twin Same DNA Different Expression of Genes Compared to their normal weight twin, overweight twins exhibited down regulation of gene expression pathways related to: • • Fat Regulation (storage versus utilization) Muscle Protein Synthesis
  102. 102. Identified Gene Expression Pathways Linked to Fat Storage and Fat Metabolism LifeGen pre-clinical study of Adipose, Gastrocnemius muscle, Hypothalamus
  103. 103. Plants altering gene expression Ingredient Effect From PubMed Prickly pear fruit “body silhouette” Potent antioxidant Green tea catechins Thermogenesis (Established) pomegranate Fat reduction related to the presence of anthocyanins, tannins, and very high levels of antioxidants, including polyphenols and flavonoids. Tart cherry Prevents muscle damage increasing total antioxidative capacity, reducing inflammation, lipid peroxidation
  104. 104. Green tea, black tea, epigallocatechin: •Modifies body composition •Improves glucose tolerance •DIFFERENTIALLY ALTERS GENE EXPRESSION
  105. 105. Gene Expression relates to the Appetite Control Center of the Brain • • • Appetite Control Eating Behavior Regulation of energy intake Ghrelin Leptin Insulin References: 1. 2. 3. 4. 5. 6. 7. 8. 9. Smeets et al. Proceeding of the Nutrition Society. 2012;71:511-520. Guthoff M, et al. J Clin Endocrinol Metab. 2010;95:748-755. De Silva, et al. Cell Metab. 2011;14:700-706. Malik S, et al. Cell Metab. 2008;7:400-409. Farooqi IS, et al. Science. 2007;317:1355 Suzuki K, et al. Experimental Diabetes Research. 2012:1-19. Viquerie N, et al. Diabetologia. 2005;48(1):123-131. Mager et al. European Journal of Endocrinology. 2008;158: Mutch DM, et al. Am J Clin Nutr. 2011;94(6):1399-1409.
  106. 106. Eating Plan Based on: Protein Science & Nutrition Science • “3-2-1 eating” plan designed to complement the supplements. • Supports metabolically-active lean muscle and inhibits fat storage. Reference: Wycherley TP, et al. AJCN. 2012;96(6):1281-98.
  107. 107. Eating Most of Your Protein with Only One Meal of the Day Limits Duration of Metabolic Burn FAT STORING ZONES FAT BURNING Time in Metabolic Burn Zone = Only 3 hours/day Breakfast Lunch Adapted from: 1.Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86. 2.Layman DL. Nutrition and Metabolism, 2009; 6:12. Dinner
  108. 108. Eating Protein with Each Meal Accelerates Metabolic Burn FAT STORING ZONES FAT BURNING Time in Metabolic Burn Zone = 9 hours/day Breakfast Lunch Adapted from: 1.Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86. 2.Layman DL. Nutrition and Metabolism, 2009; 6:12. Dinner
  109. 109. So what the heck am I supposed to do with this stuff?
  110. 110. A personal close: How do YOU want to age? Me – Jan 2013
  111. 111. The “First Guy” on TR90 • Measurements from 10/25/13 (start date) – 11/6/13 • Lost: – ¾” on waist (one belt loop) – 1.25” total – 4.4 lbs • In 10 days
  112. 112. Wrapping Up: The “Survival Curve” – Where Are You?
  113. 113. “For me, the practice of medicine has opened the door to the greatest adventure in life. Medicine is like a hallway lined with doors, each door opening into a different room, and each room opening into another hallway, again lined with doors. Medicine is always wonderful and never will be finished.” - Charles H. Mayo, M.D.

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