News report folding laura_ccv_21 de julio

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News report folding laura_ccv_21 de julio

  1. 1. RESEARCH NEWS EXPERIMENTAL MODELS Drug's effect on Alzheimer's may depend on severity of disease and Mutation stops worms from getting drunk Laura Cristina Castrillón Valencia Medicine student
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  4. 4. Cells as Experimental Models In the investigation, specially medical research is used the scientific method, which is based in the evidence; work with humans in a laboratory or in an experimental treatment is very expensive and unethical, for the possible risks that have an experimental process, for that reason several different kind of cells and organisms are used for experimental trials, it is possible because although phenotypically organisms are different, the unit of the live, the cell, has characteristics and the fundamental properties, which have been conserved during evolution, it allows perform changes with one type of cell and apply the similar process to other cells. In this presentation you could know two different examples of organisms as experimental models used in investigation: A transgenic mouse studied in an Alzheimer ´s disease and a mutant worms that don’t get intoxicated by alcohol, which could be lead to new drugs to treat the symptoms of people going through alcohol withdrawal.
  5. 5. Drug's effect on Alzheimer's may depend on severity of disease ¿What is about this new? Researchers at the University of Illinois at Chicago College of Medicine work in a transgenic mouse, which currently is the best animal model of the Alzheimer´s disease (AD), because it has a human gene that confers on people a 15-fold elevated risk of developing AD. They are doing tests with a cancer drug, bexarotene, which in late-stage Alzheimer´s reduces 40 percent levels of neurotoxic protein amiloyd-beta, which is increased in AD.
  6. 6. Alzheimer's disease It is the most common form of dementia in older people. It affects parts of the brain that control thought, memory and language Dementia Symptoms caused by disorders that affect the brain It is the progressive loss of cognitive functions, but not a specific disease Drug's effect on Alzheimer's may depend on severity of disease
  7. 7. One of the principal characteristics of the Alzheimer’s diseases is the accumulation dense plaques in the brain composed of clumps of amyloid- beta. Everybody produce this protein in the brain, but there are a mechanism responsible to clean this clumps, it is for ApoE , which is a protein mutated in patients with AD. Drug's effect on Alzheimer's may depend on severity of disease
  8. 8. “ApoE4 is the greatest genetic risk factor for Alzheimer´s disease”, said LaDu, who is one of the researcher. Alzheimer treatment pretends eliminate clumps of amyloid-beta, for that reason the investigations are focus in this challenge. Bexarotene is a cancer drug used for skin cancer, but also it reduces the clumps of amyloid-beta. Drug's effect on Alzheimer's may depend on severity of disease
  9. 9. I think is very important have different points of view about the same problem investigation, because diseases like Alzheimer, which is unknown the real cause and just know some characteristics of the diseases need advance in the evidence about the hypothesis raised, and in this case the use of cells as experimental models is crucial to reduce the experimenter bias and propose solutions for diseases that are increase exponentially. Drug's effect on Alzheimer's may depend on severity of disease PERSONAL OPINION
  10. 10. Mutation stops worms from getting drunk Mutant worms have been generated by researchers at The University of Texas at Austin, who pretend create a new drug to treat the symptoms of people going through alcohol withdrawal. Scientists insert a modified human alcohol target into the worms, which give them the first example of altering a human alcohol target to prevent intoxication in an animal. Caenorhabditis elegans, was the model intoxication used in the study.
  11. 11. Mutation stops worms from getting drunk - Alcohol causes the worms to slow their crawling with less wriggling from side to side. - The intoxicated worms also stop laying eggs, which build up in their bodies and can be easily counted. But these worms are not as ideal for studying the other areas of alcohol addiction, for that reason mice cold be an excellent model. What happen with worms´s modification?
  12. 12. Mutation stops worms from getting drunk It is any neuronal molecule that binds alcohol The effects of alcohol on the body are complex and have many targets across the brain One important aspect of this modified alcohol target: a neuronal channel called the BK channel, which has several functions The mutation only affects its response to alcohol Alcohol target
  13. 13. Mutation stops worms from getting drunk Typically regulates many important functions including activity of neurons, blood vessels, the respiratory tract and bladder. The voltage- and Ca(2+)-activated K(+) (BK) channels. It is very important in the neurotransmitter´s regulation and neural excitability Structurally are homologous to voltage and ligand-gated K(+) channels, having a voltage sensor and pore as the membrane-spanning domain and a cytosolic domain containing metal binding sites BK channels also contribute to the behavioral effects of ethanol in the worm C. elegans BK channel
  14. 14. Mutation stops worms from getting drunk PERSONAL OPINION For the human, the self-will is the most complicated psychological aspects of dealing, and currently molecular biology and genetic are the future of medicine, according to these ideas, I think this investigation is a perfect example of the molecular and genetic application: prevent problems in alcohol abuse disorders using modified human alcohol target.
  15. 15. MEDICAL UTILITY Currently in the word 26 million people suffer from some form of dementia. Predictions says that the number could be double every 20 years until 81 million in 2040.
  16. 16. Clinical trials are used in medicine to study and analyze the behavior of some treatment with the objective to improve alternatives for some diseases. Alzheimer is the most common form of dementia and there are several investigation focus in this disease. MEDICAL UTILITY
  17. 17. MEDICAL UTILITY The results of this investigation could potentially be used to treat alcoholics, since it would counteract the intoxicating and potentially addicting effects of the alcohol.
  18. 18. MEDICAL UTILITY These modified mice would allow scientists to investigate whether this particular alcohol target also affects tolerance, craving and other symptoms relevant to humans.
  19. 19. BIBLIOGRAPHY 1. Case Western Reserve University. Hallan forma de revertir los efectos del Alzheimer en el cerebro. [ online ]. BBC mundo, 2012. <Avaible from: http://www.bbc.co.uk/mundo/noticias/2012/02/120210_alzheimer_farmaco_placas_men.shtml> [ Retrieved July 18, 2014] 2. COOPER, GM. The Cell: A Molecular Approach. 2nd edition. Sunderland (MA): Sinauer Associates; 2000. Cells As Experimental Models. Available from: http://www.ncbi.nlm.nih.gov/books/NBK9917/ 3. MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB. Fac. de Medicina, 2012. 10-12p. 4. University of Illinois at Chicago. Drug's effect on Alzheimer's may depend on severity of disease. [ online ]. ScienceDaily, 2014. . <Avaible on: www.sciencedaily.com/releases/2014/07/140716123450.htm> [ Retrieved July 16, 2014] 5. University of Illinois at Chicago. Mutation stops worms from getting drunk. [ online ]. ScienceDaily, 2014. . <Avaible from: www.sciencedaily.com/releases/2014/07/140715214303.htm> [ Retrieved July 16, 2014]
  20. 20. THANKS

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