Disease Systems Biology       Lars Juhl Jensen
protein networks
cellular signaling
Horn, Schoof et al., in preparation, 2012
sequence motif atlas
functional associations
Szklarczyk, Franceschini et al., Nucleic Acids Research, 2011
computational predictions
experimental data
curated knowledge
confidence scores
orthology-based transfer
Franceschini, Szklarczyk, Frankild et al., Nucleic Acids Research, 2013
functional modules
Palleja et al., in preparation, 2012
literature mining
~22 million abstracts
~4 million full-text articles
comprehensive lexicon
co-mentioning
proteins
compartments
compartments.jensenlab.org
tissues
tissues.jensenlab.org
diseases
diseases.jensenlab.org
diseases.jensenlab.org
behavioral phenotypes
diseases.jensenlab.org
medical data mining
electronic health records
Jensen et al., Nature Reviews Genetics, 2012
structured data
Jensen et al., Nature Reviews Genetics, 2012
unstructured data
patient stratification
Roque et al., PLoS Computational Biology, 2011
comorbidity
Roque et al., PLoS Computational Biology, 2011
disease trajectories
Jensen et al., in preparation, 2012
pharmacovigilance
Eriksson et al., in preparation, 2012
conferences
questions?
Disease systems biology
Disease systems biology
Disease systems biology
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Disease systems biology

  1. 1. Disease Systems Biology Lars Juhl Jensen
  2. 2. protein networks
  3. 3. cellular signaling
  4. 4. Horn, Schoof et al., in preparation, 2012
  5. 5. sequence motif atlas
  6. 6. functional associations
  7. 7. Szklarczyk, Franceschini et al., Nucleic Acids Research, 2011
  8. 8. computational predictions
  9. 9. experimental data
  10. 10. curated knowledge
  11. 11. confidence scores
  12. 12. orthology-based transfer
  13. 13. Franceschini, Szklarczyk, Frankild et al., Nucleic Acids Research, 2013
  14. 14. functional modules
  15. 15. Palleja et al., in preparation, 2012
  16. 16. literature mining
  17. 17. ~22 million abstracts
  18. 18. ~4 million full-text articles
  19. 19. comprehensive lexicon
  20. 20. co-mentioning
  21. 21. proteins
  22. 22. compartments
  23. 23. compartments.jensenlab.org
  24. 24. tissues
  25. 25. tissues.jensenlab.org
  26. 26. diseases
  27. 27. diseases.jensenlab.org
  28. 28. diseases.jensenlab.org
  29. 29. behavioral phenotypes
  30. 30. diseases.jensenlab.org
  31. 31. medical data mining
  32. 32. electronic health records
  33. 33. Jensen et al., Nature Reviews Genetics, 2012
  34. 34. structured data
  35. 35. Jensen et al., Nature Reviews Genetics, 2012
  36. 36. unstructured data
  37. 37. patient stratification
  38. 38. Roque et al., PLoS Computational Biology, 2011
  39. 39. comorbidity
  40. 40. Roque et al., PLoS Computational Biology, 2011
  41. 41. disease trajectories
  42. 42. Jensen et al., in preparation, 2012
  43. 43. pharmacovigilance
  44. 44. Eriksson et al., in preparation, 2012
  45. 45. conferences
  46. 46. questions?

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