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Microtubule severing with growth reinitiation - Marco Saltini

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QUANTITATIVE LAWS June 13 -June 24

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Microtubule severing with growth reinitiation - Marco Saltini

  1. 1. ..... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . ..... . .... . .... . Microtubule severing with growth reinitiation Marco Saltini Theory of Biomolecular Matter group AMOLF (Amsterdam) Marco Saltini FOM Institute AMOLF Microtubule severing with growth reinitiation
  2. 2. ..... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . ..... . .... . .... . Microtubules of plant cells reorient in response to the perception of blue light Marco Saltini FOM Institute AMOLF Microtubule severing with growth reinitiation
  3. 3. ..... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . ..... . .... . .... . Microtubules undergo severing at their crossovers katanin Marco Saltini FOM Institute AMOLF Microtubule severing with growth reinitiation
  4. 4. ..... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . ..... . .... . .... . Microtubules undergo severing at their crossovers katanin Marco Saltini FOM Institute AMOLF Microtubule severing with growth reinitiation
  5. 5. ..... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . ..... . .... . .... . Microtubules undergo severing at their crossovers katanin p+ 1-p+ Marco Saltini FOM Institute AMOLF Microtubule severing with growth reinitiation
  6. 6. ..... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . ..... . .... . .... . The mean number of MTs grows exponentially in time 0 100 200 300 400 500 0 5 10 15 20 25 30 numberofMTs time (sec) WT spr1 3xeb1 clasp 0 3 6 9 12 time (min) 0 0,1 0,2 0,3 0,4 0,5 fractionofextinctions WT spr1 3xeb1 clasp Marco Saltini FOM Institute AMOLF Microtubule severing with growth reinitiation
  7. 7. ..... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . ..... . .... . .... . The mean number of MTs grows exponentially in time 0 100 200 300 400 500 0 5 10 15 20 25 30 numberofMTs time (sec) WT spr1 3xeb1 clasp 0 3 6 9 12 time (min) 0 0,1 0,2 0,3 0,4 0,5 fractionofextinctions WT spr1 3xeb1 clasp numberofMTs time p+? Marco Saltini FOM Institute AMOLF Microtubule severing with growth reinitiation
  8. 8. ..... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . .... . .... . ..... . .... . ..... . .... . .... . Aknowledgments AMOLF (Amsterdam) Bela Mulder Theory of Biomolecular Matter group Technische Universiteit Delft Marileen Dogterom Lab Carnegie Institution for Science (Stanford) Jelmer Lindeboom Masayoshi Nakamura David Ehrhardt Marco Saltini FOM Institute AMOLF Microtubule severing with growth reinitiation

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