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Giulia Malaguti
Pieter Rein ten Wolde's group
AMOLF, Amsterdam
Quantitative Laws II, Como
June 13th, 2016
How can cell...
   
Cell sensing system is surprisingly accurate
ligand
molecules
receptors
cell surface
readout
molecules
ATP
   
ligand
molecules
receptors
cell surface
readout
molecules
Cell sensing system is surprisingly accurate
NOISE
NOISE
ATP
   
Cell sensing system is surprisingly accurate
ligand
molecules
receptors
cell surface
readout
moleculesNOISE
NOISE
What...
   
Cell sensing system is surprisingly accurate
ligand
molecules
receptors
cell surface
readout
moleculesNOISE
NOISE
Berg...
   
Cell sensing system is surprisingly accurate
ligand
molecules
receptors
cell surface
readout
moleculesNOISE
NOISE
What...
   
Cell resources fundamentally limit
the sensing precision
t
   
t
unbound
bound
N samples
Cell resources fundamentally limit
the sensing precision
unbound
bound
N samples
unbound
bou...
   
t
unbound
bound
N samples
# receptors
Cell resources fundamentally limit
the sensing precision
   
t
unbound
bound
N samples
ATP
# receptors
Cell resources fundamentally limit
the sensing precision
   
t
unbound
bound
N samples
ATP
# receptors
# readout molecules
Cell resources fundamentally limit
the sensing precision
   
t
unbound
bound
N samples
ATP
# receptors
# readout molecules
power
Cell resources fundamentally limit
the sensing pre...
   
t
unbound
bound
N samples
ATP
# receptors
# readout molecules
power
Cell resources fundamentally limit
the sensing pre...
   
Thank you for
your attention!
AMOLF
Biochemical Networks group
Yao Li Adithya
Vijaykumar
Pieter Rein
ten Wolde
Joris
P...
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How can cells precisely measure time-varying external signals? - Giulia Malaguti

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QUANTITATIVE LAWS
June 13 -June 24

Published in: Science
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How can cells precisely measure time-varying external signals? - Giulia Malaguti

  1. 1.     Giulia Malaguti Pieter Rein ten Wolde's group AMOLF, Amsterdam Quantitative Laws II, Como June 13th, 2016 How can cells precisely measure time-varying external signals?
  2. 2.     Cell sensing system is surprisingly accurate ligand molecules receptors cell surface readout molecules ATP
  3. 3.     ligand molecules receptors cell surface readout molecules Cell sensing system is surprisingly accurate NOISE NOISE ATP
  4. 4.     Cell sensing system is surprisingly accurate ligand molecules receptors cell surface readout moleculesNOISE NOISE What is the fundamental limit on the precision of concentration measurements? ATP
  5. 5.     Cell sensing system is surprisingly accurate ligand molecules receptors cell surface readout moleculesNOISE NOISE Berg and Purcell (1977). Bialek and Setayeshgar (2005). Ueda and Shibata (2007). Wang et al. (2007). Govern and ten Wolde (2012). Lang et al. (2014). Kaizu et al. (2014). Govern and ten Wolde (2014). Rappel et al. (2008). Endres and Wingreen (2009) Mora and Wingreen (2010). Skoge et al (2011­2013). What is the fundamental limit on the precision of concentration measurements? ATP
  6. 6.     Cell sensing system is surprisingly accurate ligand molecules receptors cell surface readout moleculesNOISE NOISE What is the fundamental limit on the precision of concentration measurements? When measuring time-varying ligand concentrations! Time­varying! ATP
  7. 7.     Cell resources fundamentally limit the sensing precision t
  8. 8.     t unbound bound N samples Cell resources fundamentally limit the sensing precision unbound bound N samples unbound bound N samples
  9. 9.     t unbound bound N samples # receptors Cell resources fundamentally limit the sensing precision
  10. 10.     t unbound bound N samples ATP # receptors Cell resources fundamentally limit the sensing precision
  11. 11.     t unbound bound N samples ATP # receptors # readout molecules Cell resources fundamentally limit the sensing precision
  12. 12.     t unbound bound N samples ATP # receptors # readout molecules power Cell resources fundamentally limit the sensing precision
  13. 13.     t unbound bound N samples ATP # receptors # readout molecules power Cell resources fundamentally limit the sensing precision Optimal resource allocation
  14. 14.     Thank you for your attention! AMOLF Biochemical Networks group Yao Li Adithya Vijaykumar Pieter Rein ten Wolde Joris Paijmans Michele Monti Harmen Wierenga Sosuke Ito

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