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There are many exciting innovations in translational anti-aging skin research. Personalized genomics is an important emerging field of science being applied to human biology with applications in skin disease risk assessment, wellness profiling, and product response customization. Simultaneously, there are promising anti-wrinkle remedies being commercialized such as cellular therapies, topical treatments, retinoid and botox substitutes, and advances in skin manufacturing initially developed by the military for battlefield healing are starting to be applied to the aesthetic dermatology market, for example, dermal substitutes, next-generation skin grafting, and spray-on skin.