![Democratizing the Genome Melanie Swan Founder DIYgenomics +1-650-681-9482 @DIYgenomics www.DIYgenomics.org [email_address] June 12, 2010 H+ Summit, Harvard University Slides: http://slideshare.net/LaBlogga/slideshows](https://image.slidesharecdn.com/democratizingthegenome-100605200014-phpapp02/75/democratizing-the-genome-1-2048.jpg?cb=1668990251)
![Summary ,[object Object],[object Object],[object Object],[object Object],June 12, 2010 DIYgenomics.org Image credit: http://www-nmr.cabm.rutgers.edu/photogallery/proteins/gif/dna.gif](https://image.slidesharecdn.com/democratizingthegenome-100605200014-phpapp02/75/democratizing-the-genome-2-2048.jpg?cb=1668990251)
![Confluence of factors shaping DIYgenomics June 12, 2010 DIYgenomics.org 1. Rapid declines in the cost of DNA sequencing ,[object Object],[object Object],[object Object],[object Object],3. Web 2.0 and Social Networking 2. Big data era: 1 zettabyte](https://image.slidesharecdn.com/democratizingthegenome-100605200014-phpapp02/75/democratizing-the-genome-5-2048.jpg?cb=1668990251)
![Unbounded opportunity: read and write DNA ,[object Object],[object Object],June 12, 2010 DIYgenomics.org Image credit: http://www.guardian.co.uk/science/2010/may/20/craig-venter-synthetic-life-form May 22, 2010 Source: Gibson DG et al. Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome. Science. 2010 May 20.](https://image.slidesharecdn.com/democratizingthegenome-100605200014-phpapp02/75/democratizing-the-genome-7-2048.jpg?cb=1668990251)
![DIYgenomics citizen science study structure June 12, 2010 DIYgenomics.org ,[object Object],Genotype MTHFR SNPs: rs1801133 (A/G) rs1801131 (A/G) Phenotype Blood tests: B-12 and Homocysteine Intervention ,[object Object],[object Object],[object Object],Findings Analyze, explore, implement, share, and publish](https://image.slidesharecdn.com/democratizingthegenome-100605200014-phpapp02/75/democratizing-the-genome-8-2048.jpg?cb=1668990251)
![25+ DIYgenomics studies outlined ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 12, 2010 DIYgenomics.org Source: http://diygenomics.pbworks.com Image credit: http://www.tigerteamconsulting.com/TTC_Site/sectors_binf.jsp](https://image.slidesharecdn.com/democratizingthegenome-100605200014-phpapp02/75/democratizing-the-genome-9-2048.jpg?cb=1668990251)
![Personal genome analysis tools June 12, 2010 DIYgenomics.org ,[object Object],Risk for top 20 Health Conditions Response to 250 Drugs Sample data CC TT A G CC TT](https://image.slidesharecdn.com/democratizingthegenome-100605200014-phpapp02/75/democratizing-the-genome-10-2048.jpg?cb=1668990251)
![DIYgenomics Citizen Science – Join Us! ,[object Object],[object Object],[object Object],[object Object],[object Object],June 12, 2010 DIYgenomics.org Image credit: http://www.uchsc.edu/vivat/2006/September2006/images/DNA_strand.jpg](https://image.slidesharecdn.com/democratizingthegenome-100605200014-phpapp02/75/democratizing-the-genome-11-2048.jpg?cb=1668990251)
![Thank you! Melanie Swan Founder DIYgenomics +1-650-681-9482 @DIYgenomics www.DIYgenomics.org [email_address] Slides: http://slideshare.net/LaBlogga/slideshows Creative Commons 3.0 license Collaborators: Raymond McCauley Lucymarie Mantese Marat Nepomnyashy Roland Parnaso Aaron Vollrath Lawrence S. Wong Crowd-sourced clinical trials Personal genome apps](https://image.slidesharecdn.com/democratizingthegenome-100605200014-phpapp02/75/democratizing-the-genome-12-2048.jpg?cb=1668990251)
Democratizing the genome
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DIYgenomics (www.DIYgenomics.org) is a new platform bringing citizen scientists together to run peer cohort research studies and conduct novel research linking genetic data and physical biomarkers. Some norms are developing in response to the variety of community-based research issues that arise such as adaptive studies, informed consent, security, anonymity, and study design.
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Democratizing the genome
- 1. Democratizing the Genome Melanie Swan Founder DIYgenomics +1-650-681-9482 @DIYgenomics www.DIYgenomics.org [email_address] June 12, 2010 H+ Summit, Harvard University Slides: http://slideshare.net/LaBlogga/slideshows
- 3. We are standing in a new era June 12, 2010 DIYgenomics.org 1999-2009: cost of DNA sequencing decreased 14,000x. April 1, 2010. Image credit: http://pubs.acs.org/cen/_img/87/i50/8750cover2_law.gif Dec. 14, 2009
- 4. A new construct of biocitizen identity June 12, 2010 DIYgenomics.org Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumer personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009 , 2, 492-525, Figure 1.
- 6. 3 rd and 4 th generation sequencing arrives June 12, 2010 DIYgenomics.org 3 rd Gen: Sequencing by Synthesis 2 nd Gen: Parallelized sequencing 1 st Gen: Sanger Sequencing 4 th Gen: Electronic Synthesis Sources: http://www.genomicseducation.ca/files/images/information_articles/sequencing.gif, http://www.wellcome.ac.uk/News/2009/Features/WTX056032.htm, http://www.pacificbiosciences.com/video_lg.html, http://www.nanoporetech.com/sequences
- 12. Thank you! Melanie Swan Founder DIYgenomics +1-650-681-9482 @DIYgenomics www.DIYgenomics.org [email_address] Slides: http://slideshare.net/LaBlogga/slideshows Creative Commons 3.0 license Collaborators: Raymond McCauley Lucymarie Mantese Marat Nepomnyashy Roland Parnaso Aaron Vollrath Lawrence S. Wong Crowd-sourced clinical trials Personal genome apps