Biology Futures

Biology Futures The revolution in personalized genomics and synthetic biology: technological status and ethical issues Melanie Swan MS Futures Group +1-650-681-9482 [email_address] www.melanieswan.com June 14, 2008 Slides: http//www.melanieswan.com/presentations/biology_futures.ppt

[object Object],[object Object],[object Object],[object Object],[object Object],Summary June 14, 2008

Agenda ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008

Key genomics tools June 14, 2008 ,[object Object],[object Object],[object Object],[object Object],[object Object],Sources: http://www.economist.com/background/displaystory.cfm?story_id=7854314, http://www.molsci.org/%7Ercarlson/Carlson_Pace_and_Prolif.pdf DNA Synthesizer Variation: SNP

Status of DNA sequencing June 14, 2008 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Ensembl gene browser

Genetic testing revolution ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008 1 http://www.forbes.com/free_forbes/2007/0618/052_2.html

Direct-to-consumer genomics service 23andme June 14, 2008 580,000 SNPs scanned and mapped to 78 conditions

23andme colorectal cancer marker June 14, 2008

Direct-to-consumer genomics controversy June 14, 2008 Drawbacks Advantages ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Implications of personalized genomics June 14, 2008 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Synthetic biology revolution ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008

BioBricks: Registry of Standard Biological Parts ,[object Object],June 14, 2008 Source: http://partsregistry.org (MIT)

BioBricks example: measurement device selection June 14, 2008

BioBricks example: obtain part sequence June 14, 2008

Synthetic biology status ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008

Biofuels ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008 Algal Oil

Biofood ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008 In vitro meat Corn images: http://www:science-interactive.co.uk Wild type corn Enhanced corn

Implications of synthetic biology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008 Spore Creature Creator

Bioethics and society ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008

Ethics of new technology: dual-use debate June 14, 2008 “ evil” Technophobic (Bill Joy) “ good” Technophilic (Ray Kurzweil) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Biological warfare and public health ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008

Ethics: practitioner standards ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008 1 http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0060073

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Ethics: intellectual property June 14, 2008

Pedagogy and scientific method ,[object Object],[object Object],[object Object],June 14, 2008 1 http://en.wikipedia.org/wiki/Synthetic_biology ,[object Object],[object Object],[object Object],“ From this combination of passion and inventiveness I sense that students are reinventing literacy. Literacy has been boiled down to reading and writing, but the means have changed since the Renaissance. In a very real sense post-digital literacy now includes 3D machining and microcontroller programming.” – Neil Gershenfeld, MIT 1

Advances in brain research ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008

Innovations underway ,[object Object],[object Object],[object Object],[object Object],June 14, 2008 Second Health Operating Theatre, Second Life Teraradiology Telemedicine da Vinci Robotic Surgery OR-Live.com

Long-term biology futures ,[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008 Image: Natasha Vita-More, Primo Posthuman

Resources ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],June 14, 2008

Thank you Melanie Swan MS Futures Group +1-650-681-9482 [email_address] www.melanieswan.com Slides: http//www.melanieswan.com/presentations/biology_futures.ppt Provided under an open source Creative Commons 3.0 license

Biology Futures

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Biology Futures