Bioengineering: making life from scratch

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An overview of bioengineering and synthetic biology; definition, history, key research findings, scientists, current initiatives and future outlook.

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Bioengineering: making life from scratch

  1. Bioengineering: making life from scratch Melanie Swan MS Futures Group +1-650-681-9482 [email_address] http://www.melanieswan.com Slides: http://slideshare.net/LaBlogga/slideshows NIH, Bethesda MD September 25, 2008 Must build it to understand it
  2. Synthetic biology Novel biological system
  3. The new biology: virtuous feedback loop Model and simulate Investigate and experiment Build
  4. Bio-SPICE Biological Simulation Program for Intra- and Inter-Cellular Evaluation http://biospice.org Model and simulate
  5. Registry of Standard Biological Parts Build http://partsregistry.org
  6. Parts Registry: select measurement device http://partsregistry.org
  7. Parts Registry: obtain part sequence DNA Synthesizer http://partsregistry.org
  8. The story of biocomputing <ul><li>Mapping genes to proteins -> life can be engineered </li></ul><ul><li>Genes can be turned on and off -> gene as binary switch </li></ul><ul><li>Systemic understanding of DNA -> genes as circuits </li></ul><ul><li>Cell noisiness -> need for stable and predictable circuits </li></ul>
  9. Repressilator schema “ Noisy” cells Michael Elowitz Stanislas Leibler Repressilator A synthetic oscillatory network of transcriptional regulators Michael B. Elowitz & Stanislas Leibler Nature. 2000 Jan 20;403(6767):335-38. http://www.nature.com/nature/journal/v403/n6767/full/403335a0.html
  10. Construction of a genetic toggle switch in Escherichia coli Gardner TS, Cantor CR, Collins JJ Nature. 2000 Jan 20;403(6767):339-42. http://www.ncbi.nlm.nih.gov/pubmed/10659857 Toggle switch induction threshold Toggle switch plasmid Gardner Cantor Collins Genetic toggle switch
  11. Open wetware Drew Endy <ul><li>Parts Registry </li></ul><ul><li>BioBricks Foundation </li></ul><ul><li>iGEM competition </li></ul>http://openwetware.org/ http://bbf.openwetware.org/ http://www.igem.org/ http://partsregistry.org
  12. Genome Craig Venter Synthetic life <ul><li>Synthetic life </li></ul><ul><li>Fourth-generation biofuels </li></ul>Mycoplasma genitalium Bacterial image Genetic map
  13. Further applications of bioengineering Coli-roid microbial camera Landmine sensing plant: Arabidopsis thaliana Amorphous computing Cellular colonies Natural genetic engineering Ciliate
  14. Summary Model and simulate Investigate and experiment Build
  15. Thank you Melanie Swan MS Futures Group +1-650-681-9482 [email_address] http://www.melanieswan.com Slides: http://slideshare.net/LaBlogga/slideshows NIH, Bethesda MD September 25, 2008

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