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Restless Legs Syndrome and       Niacin – Part 2         K. Thomas Pickard    Quantified Self Show&Tell #28         San Fr...
Our story begins with a musical…  • In 1981, I injured my back in high schoolSource: Beef and Boards Dinner Theater, India...
And continues with an L5-S1 injury• 1981 – Sciatic nerve damage• 1984 – Left leg starts  jumping                          ...
What is Restless Legs Syndrome (RLS)?• Uncomfortable/unpleasant sensation  in legs• Often with periodic limb movements  of...
Restless Legs Syndrome and me• Had it since my early 20’s• Diagnosed in 2001• Rx history  –2002 to 2012: Clonazepam 0.5   ...
How did I get started with QS?  • Genomera – Effects of Niacin on RLSSource: genomera.com/studies/effects-of-niacin-on-res...
Results: RLS Study #1 (Sept 2011)Source: bit.ly/pT1zok                 7
Results: RLS Study #1 (Sept 2011)• Niacin (0.5g/day) to control RLS• Niacin did not improve my RLS• I talked with my docto...
Then what happened?• Started daily iron supplement  – Ferrous gluconate (27 mg elemental Fe)• Ferritin level  14 ng/mL (Se...
So, why do this again?Source: http://blog.sethroberts.net/2012/06/22/genomera-study-about-effect-of-niacin-on-restless-leg...
Study #2: New RLS/niacin protocol• 0 to 2g/day niacin over six  weeks                          Niacin –                   ...
Differences from Study #1• Higher dose of niacin (2g vs 0.5g)• Used “flush free” niacin  –Niacin vs Inositol hexanicotinat...
Results: Better, but it did not work.                                    13
Niacin Pros and ConsPros                    Cons• Minor improvement     • RLS did not  in mental acuity        disappear• ...
What did I learn?• Protocols are important• Niacin is not recommended for  psoriatics• Normal ferritin and/or niacin may  ...
What else did I learn?• Talked with  doctor about  results                        L5-S1 disc                              ...
Questions?K. Thomas Pickard@kthomaspickardlinkd.in/kthomaspickardwww.genomedad.comDisclosure statement: Nothing to disclos...
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Restless Legs Syndrome and Niacin Part 2

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A second self-tracking study to measure the effects of niacin on restless legs syndrome (RLS).

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Restless Legs Syndrome and Niacin Part 2

  1. 1. Restless Legs Syndrome and Niacin – Part 2 K. Thomas Pickard Quantified Self Show&Tell #28 San Francisco, CA December 5, 2012
  2. 2. Our story begins with a musical… • In 1981, I injured my back in high schoolSource: Beef and Boards Dinner Theater, Indianapolis 2
  3. 3. And continues with an L5-S1 injury• 1981 – Sciatic nerve damage• 1984 – Left leg starts jumping L5 L5-S1 disc• 1999 – Bulge revealed by bulge MRI• 2003 – Cured back pain with pilates• But…RLS sensation remained 3
  4. 4. What is Restless Legs Syndrome (RLS)?• Uncomfortable/unpleasant sensation in legs• Often with periodic limb movements of sleep (PLMS)• Symptoms usually worse at night• Affects 7–10% of the population
  5. 5. Restless Legs Syndrome and me• Had it since my early 20’s• Diagnosed in 2001• Rx history –2002 to 2012: Clonazepam 0.5 mg/day –2005: Requip 1 mg/day –2012 to present: Mirapex 0.25 mg/day 5
  6. 6. How did I get started with QS? • Genomera – Effects of Niacin on RLSSource: genomera.com/studies/effects-of-niacin-on-restless-leg-syndrome 6
  7. 7. Results: RLS Study #1 (Sept 2011)Source: bit.ly/pT1zok 7
  8. 8. Results: RLS Study #1 (Sept 2011)• Niacin (0.5g/day) to control RLS• Niacin did not improve my RLS• I talked with my doctor “Let’s check your ferritin level” Range: 26–388 ng/mL for males My ferritin: 14 ng/mL 8
  9. 9. Then what happened?• Started daily iron supplement – Ferrous gluconate (27 mg elemental Fe)• Ferritin level 14 ng/mL (Sep 2011) 30 ng/mL (Nov 2011) 65 ng/mL (Sep 2012) Fingers no longer cold!• Energy level vastly improved 9
  10. 10. So, why do this again?Source: http://blog.sethroberts.net/2012/06/22/genomera-study-about-effect-of-niacin-on-restless-legs-syndrome 10
  11. 11. Study #2: New RLS/niacin protocol• 0 to 2g/day niacin over six weeks Niacin – Vitamin B3• Taper clonazepam at the end• Track “flush,” RLS and PLMS severity as before 11
  12. 12. Differences from Study #1• Higher dose of niacin (2g vs 0.5g)• Used “flush free” niacin –Niacin vs Inositol hexanicotinate• Reduce clonazepam after niacin ramp-up 12
  13. 13. Results: Better, but it did not work. 13
  14. 14. Niacin Pros and ConsPros Cons• Minor improvement • RLS did not in mental acuity disappear• Greater body • Easily awakened awareness • Psoriasis flared up• Potential natural alternative to meds 14
  15. 15. What did I learn?• Protocols are important• Niacin is not recommended for psoriatics• Normal ferritin and/or niacin may have lessened RLS severity• QS can be uncomfortable 15
  16. 16. What else did I learn?• Talked with doctor about results L5-S1 disc L5 bulge• Started Mirapex (Sept 2012)• After 30 years, Sciatic Nerve sciatic nerve S1 feeling returns The journey was worth it. 16
  17. 17. Questions?K. Thomas Pickard@kthomaspickardlinkd.in/kthomaspickardwww.genomedad.comDisclosure statement: Nothing to discloseSlides posted to: http://slideshare.net/kthomaspickard/restless-legs- syndrome-and-niacin-part-2 17

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