Solez Medicine Writ Large Dalian China

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Dr. Kim Solez presents the "Chair's Introduction" and "Medicine Writ Large: The Ultimate in Translational Medicine" at BIT's 4th Annual World Congress of Molecular and Cell Biology, Big Challenges, Huge Opportunities, in Dalian, China on April 26, 2014.

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Solez Medicine Writ Large Dalian China

  1. 1. CMCB-2014, “Big Challenges, Huge Opportunities” Panel G1 Role of Molecular and Cell Biology in Translational Medicine Chair’s Introduction Kim Solez, M.D.
  2. 2. “A specialist is a barbarian whose ignorance is not well-rounded.” - Stanislaw Lem At age 26, just after graduation from medical school, I was a specialist interested in acute tubular injury: Solez, K., et al: Medullary plasma flow and intravascular leukocyte accumulation in acute renal failure. Kidney Int. 6:24-37, 1974.
  3. 3. This specialist interest shared by only to a few led eventually decades later to something very general and widely accessible, the concept of “Medicine Writ Large”, medicine as something much larger than you ever imagined!
  4. 4. Medicine Writ Large: The Ultimate in Translational Medicine Kim Solez, M.D.
  5. 5. Five years later I published the definitive description of the pathology of acute tubular injury. Solez et al. Morphology of "acute tubular necrosis" in man: Analysis of 57 renal biopsies and comparison with the glycerol model. Medicine 58:362-376, 1979.
  6. 6. The Banff Classification of Kidney Transplant Pathology Histologic criteria for the diagnosis of rejection and other conditions in the transplanted kidney, began in 1991, updated and expanded every two years in consensus meeting.
  7. 7. Banff Transplant Pathology Meetings Began in the Transcanada Pipelines Pavilion at the Banff Centre in 1991, Future Meetings Are Planned through 2021.
  8. 8. Slide 8 Banff Classification: Milestones • 1991 First Conference • 1993 First Kidney International publication • 1995 Integration with CADI • 1997 Integration with CCTT classification • 1999 Second KI paper. Clinical practice guidelines. Implantation biopsies, microwave. • 2001 Classification of antibody-mediated rejection – Regulatory agencies participating • 2003 Genomics focus, ptc cell accumulation scoring • 2005 Gene chip analysis. Elimination of CAN, identification of chronic antibody-mediated rejection. • 2007 First meeting far from a town called “Banff” – La Coruna, Spain. - 2013 Banff Foundation for Allograft Pathology created, Swiss non-profit foundation, provides infrastructure, succession planning.
  9. 9. Global consensus generation while maintaining intellectual freedom.
  10. 10. Like the mosh pit at a great rock concert. No partner, the ultimate in individuality, dangerous, but when the music is good everyone dances in sync and life is good.
  11. 11. Unique Multidisciplinary Course on Technology and the Future of Medicine LABMP 590 Created in 2011
  12. 12. The Technological Singularity The technological singularity occurs as artificial intelligences surpass human beings as the smartest and most capable life forms on the Earth. Technological development is taken over by the machines, who can think, act and communicate so quickly that normal humans cannot even comprehend what is going on. The machines enter into a "runaway reaction" of self- improvement cycles, with each new generation of A.I.s appearing faster and faster. From this point onwards, technological advancement is explosive, under the control of the machines, and thus cannot be accurately predicted (hence the term "Singularity"). – Ray Kurzweil
  13. 13. Moore’s Law Predicts Singularity
  14. 14. Evidence for the Coming Primacy of Machines • Evidence for the Coming Technological Singularity 1. Time Magazine cover Feb. 2011 “2045: The Year Man Becomes Immortal” 2. IBM’s Watson computer beats top human contenders on Jeopardy! 3. Foxconn announces plans to replace one milion workers with one million robots Nov. 2012 4. The Technological Singularity appears in Dilbert March 2013
  15. 15. • The technological Singularity. Existential risks, AI, genomics, and nanotech. • Ways to optimize a positive outcome for humanity in the co-evolution of humans and machines . The influence of these considerations on medicine of the future. • Balanced view provided by incorporating both tech skeptics and tech advocates. • Dean of Science speaking, prominent people internationally. Most lectures not very “medical”. Easily understood. • We could eliminate all diseases as we know them today and still have a terrible world. Need attention to the social responsibility of medicine, Medicine Writ Large. Course Content
  16. 16. Medicine Writ Large “Medicine is a social science, and politics is nothing else than medicine writ large. Medicine as a social science, as the science of human beings, has the obligations to point out problems and to attempt their theoretical solution: the politician, the practical anthropologist, must find the means for their practical solution.” – Rudolf Virchow
  17. 17. Medicine Writ Large “It is the curse of humanity that it learns to tolerate even the most horrible situations by habituation. Physicians are the natural attorneys of the poor, and the social problems should largely be solved by them.” – Rudolf Virchow
  18. 18. Medicine Writ Large Kim Solez, M.D.

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