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3. perinatal infections; pediatric pathology

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3. perinatal infections; pediatric pathology

  1. 1. Pediatric Pathology Pediatric Pathology 1 Dr. Krishna Tadepalli, MD, www.mletips.com
  2. 2. 3. Perinatal Infections 3. Perinatal Infections 2 Dr. Krishna Tadepalli, MD, www.mletips.com
  3. 3. Perinatal Infections • • • • • • • • • • • • • • • • Infections of fetus (after 20wks.) and neonate Trans- cervical = Ascending Mostly bacterial and few viral Route of microbial entry – cervico -vaginal Mode of infection ;- fetal inhalation of infected amniotic fluid or during passage through birth canal Risk factors ;- preterm baby, PPROM, Pathologically ;- inflammation of membranes and cord Clinically ;- MC are Pneumonia, sepsis, meningitis Transplacental (hematologic) Mostly parasitic and viral and few bacterial Route of microbial entry; – Transplacental via villi When?;- anytime during gestation or during labor (HBV, HIV) Risk factors ;- preterm baby, PPROM, pathologically -;- inflammation of membranes and cord Clinically ;- Erythema infectiosum or 5th disease (Parvo B19) without any damage, TORCH group – fever, encephalitis, chorioretinits, pneumonitis, Myocarditis, hemolytic anemia 3 Complications;- MR, Blindness (cataracts), Congenital Heart anomalies, bone Dr. Krishna Tadepalli, MD, www.mletips.com
  4. 4. Parvovirus B 19 Parvovirus B 19 4 Dr. Krishna Tadepalli, MD, www.mletips.com
  5. 5. Perinatal Infections • Sepsis • • • Can be Early onset = within 7 days of postnatal life; present with pneumonia and sepsis; MCC – Group B strep. (MCC of bacterial meningitis); Late onset = > 7days; Listeria and Candida 5 Dr. Krishna Tadepalli, MD, www.mletips.com
  6. 6. 6 Dr. Krishna Tadepalli, MD, www.mletips.com
  7. 7. 6 Dr. Krishna Tadepalli, MD, www.mletips.com

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