Where does metformin fit
• Glucose intolerance.
• Role in obese > 35 .
• CC resistance.
In 2006 2 large RCT did not show any benifit
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Avoid multiple follicle and hyperstimulation
1. THE RECOMMENDED STARTING DOSE OF GONADOTROPIN
IS 37.5–50.0 IU/DAY.
2 SMALL FSH DOSE INCREMENTS OF 50% OF THE INITIAL OR
3 PREVENTING ALL MULTIPLE PREGNANCIES AND OHSS IS
POSSIBLE AT THIS TIME.
Boomsma, C.M. et al. Hum Reprod Update 2006 12:673-683; doi:10.1093/humupd/dml036
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Prevalence of metabolic syndrome at
the age of 65 yrs in relation to birth
Diagnostic Algorithm for the Polycystic Ovary Syndrome
Ehrmann D. N Engl J Med 2005;352:1223-1236
Dr G A RAMA RAJU
• Krishna ivf clinic Visakhapatnam.
• Visiting professor Giessen university
• Published 8 article in peer review journal
with 70 citations
• PhD guide in human genetics ,andhra