Carefree Skincare CONFIDENTIAL BY
Our Company <ul><li>International skincare company based in the US </li></ul><ul><li>Focused on developing and commerciali...
Our Philosophy <ul><li>To provide our customers with cutting edge products that are sold through aesthetic professionals t...
Our Core Team CONFIDENTIAL Greg Chanitz Randy Kriech <ul><li>Managing Partner </li></ul><ul><li>Founder </li></ul><ul><li>...
The Skincare Revolution CONFIDENTIAL <ul><li>DNA repair is at the center of the coming revolution </li></ul><ul><li>Molecu...
Point of Distinction CONFIDENTIAL UV 10x more than oxidation DNA Damage is 10 times more prevalent than free radical damag...
The Next Wave in the Skincare Revolution CONFIDENTIAL <ul><li>Potent DNA repair enzymes </li></ul><ul><li>Powerful antioxi...
Photodamage is Complex <ul><li>Wrinkles </li></ul><ul><li>Increased UV spots </li></ul><ul><li>Loss of elasticity </li></u...
What is DNA Damage? <ul><li>The familiar double helix known as DNA is subject to thousands of daily assaults: from the out...
DNA Damage (cont.) <ul><li>Everyone Needs DNA Repair Enzymes </li></ul><ul><li>Some enzymes known as endonucleases assist ...
DNA Repair Enzymes CONFIDENTIAL Anacystis nidulans Micrococcus luteus Arabidopsis thaliana Enzyme Photolyase Endonuclease ...
DNA Repair Enzyme - Micrococcus luteus CONFIDENTIAL Untreated Treated with Micrococcus luteus <ul><li>Micrococcus luteus: ...
DNA Repair Enzyme - Anacystis nidulans CONFIDENTIAL <ul><ul><li>UV causes DNA damage </li></ul></ul><ul><ul><li>Liposomes ...
DNA Repair Enzyme - Anacystis nidulans CONFIDENTIAL <ul><ul><li>Anacystis nidulans  is a light sensitive enzyme, sourced b...
DNA Repair Enzyme – Anacystis nidulans CONFIDENTIAL <ul><ul><li>Anacystis nidulans  is a light sensitive enzyme, sourced b...
Micrococcus luteus and Anacystis nidulans CONFIDENTIAL Untreated Treated with M. luteus & A. nidulans <ul><li>Micrococcus ...
DNA Repair Enzyme – Arabidopsis thaliana CONFIDENTIAL <ul><ul><li>Arabidopsis thaliana,  also known as OGG1,  is a second ...
Liposome Delivery <ul><li>Most useful for being able to transfer and deliver active ingredients to the application site of...
Restore & Defend with DNA Focused Skincare CONFIDENTIAL
CELFIX Cosmeceuticals DNA Youth Recovery Facial Serum CONFIDENTIAL
DNA Youth Recovery <ul><li>CELFIX Cosmeceuticals:  DNA Youth Recovery Facial Serum 50 ml / 1.7 oz. </li></ul><ul><li>Benef...
DNA Youth Recovery cont. <ul><li>Makes use of targeted repair enzymes that are derived from natural sources such as marine...
DNA Youth Recovery (cont.) <ul><li>Speeds up the DNA repair process, therefore, assisting in the  recovery from non-invasi...
Key Ingredients <ul><li>Micrococcus luteus:  liposome delivery of this enzyme, sourced from marine microbes, recognizes ce...
To Be Clear <ul><li>CELFIX Cosmeceuticals:  DNA Youth Recovery </li></ul><ul><li>First and foremost, the product  does not...
How It Works <ul><li>Plant-derived enzymes mimic the body ’s natural response </li></ul><ul><li>Enzymes are encapsulated i...
Who Needs  CELFIX Cosmeceuticals:  DNA Youth Recovery <ul><li>Anyone concerned with overall skin health </li></ul><ul><li>...
Benefits <ul><li>CELFIX Cosmeceuticals:  DNA Youth Recovery </li></ul><ul><li>By assisting in DNA repair, it helps the ski...
CELFIX Cosmeceuticals   DNA Ceramide Renewal Nourishing Cream CONFIDENTIAL
Skin Barrier <ul><li>Barrier function in the skin depends on ceramide lipids. </li></ul><ul><li>Ceramides are fatty cells ...
DNA Ceramide Renewal <ul><li>CELFIX Cosmeceuticals:  DNA Ceramide Renewal </li></ul><ul><li>Nourishing Cream </li></ul><ul...
DNA Ceramide Renewal <ul><li>One pump for face, throat and decollete </li></ul><ul><li>Once or twice daily, morning & nigh...
Key Ingredients <ul><li>Rosemary extract  or ursolic acid is a natural component that provides a boost to the skin ’s natu...
Rosemary Extract Increases Ceramides CONFIDENTIAL Percent Ceramides Skin Lipids Increased Ceramides 30% Increase in 11 Days
Antioxidant ORAC Scores CONFIDENTIAL
CELFIX Testimonial <ul><li>Tina S. Alster, MD, FAAD </li></ul><ul><ul><li>Director, Washington Institute of  </li></ul></u...
CELFIX Testimonial <ul><li>Vivian Bucay, MD, FAAD </li></ul><ul><ul><li>Medical, Surgical & Cosmetic Dermatology </li></ul...
Clinical Analysis of CELFIX Products <ul><li>VISIA Complexion Analysis (Canfield Imaging Systems) </li></ul><ul><ul><li>Mu...
20% Reduction in UV Spots in 4 Weeks CONFIDENTIAL Before: 342 UV Spots  After: 4 Weeks: 271 UV Spots  Actual patient resul...
41% Reduction in UV Spots in 8 Weeks CONFIDENTIAL Before: 228 UV Spots  After: 8 Weeks: 135 UV Spots  Actual patient resul...
70% Reduction in UV Spots in 12 Weeks CONFIDENTIAL Before: 217 UV Spots  After: 12 Weeks: 64 UV Spots  Actual patient resu...
CELFIX Cosmeceuticals DNA iQuad Infusion Total Eye Complex CONFIDENTIAL
DNA iQuad Infusion <ul><li>CELFIX Cosmeceuticals:  DNA iQuad Infusion Total Eye Complex 15 ml / 0.5 oz. </li></ul><ul><li>...
DNA iQuad Infusion cont. <ul><li>Matrixyl 3000 , a combination of peptides that helps regulate cell activity and works tog...
Key Ingredients CONFIDENTIAL   Reduces Lines & Wrinkles Diminishes Dark Circles Lessens Puffiness Combats Photodamage Smoo...
45% Reduction of Wrinkles in 8 Weeks CONFIDENTIAL Baseline Week 8
Under-eye Circles Reduced in More Than 60% of Patients  CONFIDENTIAL Dark circles significantly reduced by 19% in 8 weeks.
The Next Wave In The Skincare Revolution CONFIDENTIAL
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Carefree overview ppt training[2]

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Overview on CELFIX DNA products.

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Carefree overview ppt training[2]

  1. 1. Carefree Skincare CONFIDENTIAL BY
  2. 2. Our Company <ul><li>International skincare company based in the US </li></ul><ul><li>Focused on developing and commercializing innovative and highly efficacious anti-aging products that enhance the health and appearance of aging skin </li></ul><ul><li>Markets and sells cosmeceutical products to aesthetic professionals in order to meet the rapidly growing patient demand for skin rejuvenation products </li></ul><ul><li>Boasts an accomplished management team with 35+ years industry experience </li></ul>CONFIDENTIAL
  3. 3. Our Philosophy <ul><li>To provide our customers with cutting edge products that are sold through aesthetic professionals to meet the needs of the rapidly growing skin rejuvenation market </li></ul><ul><li>To produce only high quality products, having partnered with an FDA-approved manufacturer, to ensure excellence in product development and formulations </li></ul><ul><li>To be an industry leader in customer service excellence </li></ul><ul><li>To be a leading player in the aesthetic skincare marketplace worldwide </li></ul>CONFIDENTIAL
  4. 4. Our Core Team CONFIDENTIAL Greg Chanitz Randy Kriech <ul><li>Managing Partner </li></ul><ul><li>Founder </li></ul><ul><li>Managing Partner </li></ul><ul><li>Founder </li></ul><ul><li>VP of Sales/Marketing, PRIORI Skincare </li></ul><ul><li>VP of Sales/Marketing, Percos India </li></ul><ul><li>Regional Sales Director, Triax Pharma </li></ul><ul><li>Sr. Sales/Marketing Mgr, SkinMedica </li></ul><ul><li>Regional Sales Director, Elan Dermatology </li></ul><ul><li>National Sales Director , AGI /Remergent </li></ul><ul><li>National Sales Director, Pierre Fabre / Avene </li></ul><ul><li>Regional Sales Director, Elan Dermatology </li></ul><ul><li>Director Business Development, Topiderm </li></ul>
  5. 5. The Skincare Revolution CONFIDENTIAL <ul><li>DNA repair is at the center of the coming revolution </li></ul><ul><li>Molecular biology applied to skin </li></ul><ul><li>Most important risk to skin DNA is the sun </li></ul><ul><li>Sunlight causes DNA damage </li></ul><ul><li>DNA repair enzymes excise DNA containing damage </li></ul><ul><li>Patched by the body’s natural repair process </li></ul>
  6. 6. Point of Distinction CONFIDENTIAL UV 10x more than oxidation DNA Damage is 10 times more prevalent than free radical damage DNA Youth Recovery DNA Damage Free Radicals DNA Oxidation Cell Oxidation ANTIOXIDANTS antioxidants
  7. 7. The Next Wave in the Skincare Revolution CONFIDENTIAL <ul><li>Potent DNA repair enzymes </li></ul><ul><li>Powerful antioxidants </li></ul><ul><li>Unique formulas </li></ul><ul><li>Next generation ingredients </li></ul><ul><li>Precise delivery technologies </li></ul><ul><li>Exceptional Results </li></ul>
  8. 8. Photodamage is Complex <ul><li>Wrinkles </li></ul><ul><li>Increased UV spots </li></ul><ul><li>Loss of elasticity </li></ul><ul><li>Hypo- and hyperpigmentation </li></ul><ul><li>Increased skin cancer risk </li></ul>CONFIDENTIAL
  9. 9. What is DNA Damage? <ul><li>The familiar double helix known as DNA is subject to thousands of daily assaults: from the outside by radiation, pollutants and thermal damage; from the inside by replication errors and the body ’s normal processes. </li></ul><ul><li>DNA is particularly susceptible to UV damage. While the skin’ s own melanin and added sunscreen reflect or absorb a certain amount of light, enough solar radiation invariably gets through to the cell’s nucleus to directly damage DNA. </li></ul><ul><li>The skin is not defenseless. There are many DNA repair enzymes that spring into action when the cell is alerted to damage. The damaged strand is recognized and snipped out, and polymerases takes over, using the opposite strand as a template to guide the correction. </li></ul>CONFIDENTIAL In a 24 hour period, your body can only repair 50% of photodamage
  10. 10. DNA Damage (cont.) <ul><li>Everyone Needs DNA Repair Enzymes </li></ul><ul><li>Some enzymes known as endonucleases assist in repairing the DNA by seeking out the damaged DNA and sending a rallying call for the body ’s own repair enzymes to remove lesions. </li></ul><ul><ul><li>Micrococcus luteus is one of the most UV-resistant microbes known to science. Liposome delivery of this marine microbe recognizes cellular UV damage and accelerates the skin ’s repair and recovery process. </li></ul></ul><ul><ul><li>Arabidopsis thaliana , also known as OGG1, is a second endonuclease repair enzyme found in the mustard plant. It targets both the nucleus and the energy-making mitochondria of the cell. OGG1 seeks out a common type of free radical damage to DNA and helps the body ’s natural process by initiating the cellular repair process. </li></ul></ul><ul><ul><li>Anacystis nidulans is a light sensitive enzyme, sourced by plankton and algae, that adheres directly to the damaged DNA and channels energy it absorbs from the sunlight to separate and then restore the fused rungs. About 20 minutes of sunshine or an hour of indoor light are sufficient to activate this photolyase enzyme and help clear the DNA of UV damage. </li></ul></ul><ul><li>The key to the effectiveness of these topically applied enzymes is their liposome delivery system, which transports them directly to the cells. </li></ul>CONFIDENTIAL
  11. 11. DNA Repair Enzymes CONFIDENTIAL Anacystis nidulans Micrococcus luteus Arabidopsis thaliana Enzyme Photolyase Endonuclease OGG1 Source Plankton Marine Micorbe Mustard Plant Human Repair Photoreactivation Base Excision Repair Base Excision Repair Light Dependent Independent Independent Speed Instant with Light 4-6 hours 4-6 hours Immune System Protection Protection Not Known Skin Protection Erythema Peeling Not Known
  12. 12. DNA Repair Enzyme - Micrococcus luteus CONFIDENTIAL Untreated Treated with Micrococcus luteus <ul><li>Micrococcus luteus: liposome delivery of this enzyme, sourced from marine microbes, recognizes cellular UV damage and accelerates the skin repair and recovery process </li></ul>DNA Damage
  13. 13. DNA Repair Enzyme - Anacystis nidulans CONFIDENTIAL <ul><ul><li>UV causes DNA damage </li></ul></ul><ul><ul><li>Liposomes deliver photolyase into skin </li></ul></ul><ul><ul><li>Photolyase activity recognizes DNA damage </li></ul></ul><ul><ul><li>Absorbs visible light and UVA </li></ul></ul><ul><ul><li>Reverses DNA damage </li></ul></ul>T T
  14. 14. DNA Repair Enzyme - Anacystis nidulans CONFIDENTIAL <ul><ul><li>Anacystis nidulans is a light sensitive enzyme, sourced by plankton and algae, that adheres directly to the damaged DNA and channels energy it absorbs from the sunlight to separate and then restore the fused rungs. </li></ul></ul><ul><ul><li>About 20 minutes of sunshine or an hour of indoor light are sufficient to activate this photolyase enzyme and help clear the DNA of UV damage. </li></ul></ul>UV UV+Photosomes Human skin UVB DNA damage (green) Anacystis nidulans light activation
  15. 15. DNA Repair Enzyme – Anacystis nidulans CONFIDENTIAL <ul><ul><li>Anacystis nidulans is a light sensitive enzyme, sourced by plankton and algae, that adheres directly to the damaged DNA and channels energy it absorbs from the sunlight to separate and then restore the fused rungs. </li></ul></ul><ul><ul><li>About 20 minutes of sunshine or an hour of indoor light are sufficient to activate this photolyase enzyme and help clear the DNA of UV damage. </li></ul></ul>It takes 45+ minutes to reach sunburn with Anacystis nidulans vs. 15 minutes without
  16. 16. Micrococcus luteus and Anacystis nidulans CONFIDENTIAL Untreated Treated with M. luteus & A. nidulans <ul><li>Micrococcus luteus + Anacystis nidulans + visible light </li></ul><ul><li>6 hour results </li></ul>DNA Damage
  17. 17. DNA Repair Enzyme – Arabidopsis thaliana CONFIDENTIAL <ul><ul><li>Arabidopsis thaliana, also known as OGG1, is a second endonuclease repair enzyme found in the mustard plant. </li></ul></ul><ul><ul><li>It targets both the nucleus and the energy-making mitochondria of the cell. </li></ul></ul><ul><ul><li>OGG1 seeks out a common type of free radical damage to DNA and helps the body ’s natural process by initiating the cellular repair process. </li></ul></ul>None 0h None 2h None 6h Vehicle 2h Vehicle 6h Arabidopsis 2h Arabidopsis 6h <ul><li>Repairs oxidative damage to DNA </li></ul><ul><li>90% elimination in 2 hrs </li></ul>
  18. 18. Liposome Delivery <ul><li>Most useful for being able to transfer and deliver active ingredients to the application site of topical products </li></ul><ul><li>The liposome wall is very similar, physiologically, to the material of cell membranes </li></ul><ul><li>When a product containing liposomes is applied to the skin, the liposomes are deposited on the skin and begin to merge with the cellular membranes </li></ul><ul><li>In the process, the liposomes release their payload of active materials into the cells </li></ul><ul><li>As a consequence, not only is delivery of the actives very specific--directly into the intended cells--but the delivery takes place over a longer period of time </li></ul><ul><li>Liposomes are manufactured from various fatty substances that are used to encapsulate, or to create a sphere around, active materials, acting as a delivery system </li></ul>CONFIDENTIAL
  19. 19. Restore & Defend with DNA Focused Skincare CONFIDENTIAL
  20. 20. CELFIX Cosmeceuticals DNA Youth Recovery Facial Serum CONFIDENTIAL
  21. 21. DNA Youth Recovery <ul><li>CELFIX Cosmeceuticals: DNA Youth Recovery Facial Serum 50 ml / 1.7 oz. </li></ul><ul><li>Benefits: </li></ul><ul><li>DNA technology for daily skincare </li></ul><ul><li>3 DNA Repair Enzymes </li></ul><ul><li>Repair of UV and free radical damage </li></ul><ul><li>Calms skin while speeding recovery </li></ul><ul><li>Indicated for photo-damaged skin, lines, wrinkles, </li></ul><ul><li>& uneven skin tones </li></ul>CONFIDENTIAL
  22. 22. DNA Youth Recovery cont. <ul><li>Makes use of targeted repair enzymes that are derived from natural sources such as marine plankton and other plants </li></ul><ul><li>Utilizes an encapsulated, liposomal delivery system to drive the enzymes into the nucleus of the skin cell </li></ul><ul><li>Employs a Chinese Evodia plant derivative which has been proven through clinical studies to help calm and soothe irritated skin </li></ul><ul><li>Uses hyaluronic acid, which has the ability to retain 1000 times its weight in water, to help the skin maintain its youthful appearance </li></ul><ul><li>Has a non-comedogenic, paraben-free formula </li></ul>CONFIDENTIAL
  23. 23. DNA Youth Recovery (cont.) <ul><li>Speeds up the DNA repair process, therefore, assisting in the recovery from non-invasive procedures </li></ul><ul><li>Provides faster DNA recovery, which offers added protection to the UV damage suffered from sun exposure </li></ul><ul><li>Holds off collagen degradation in the lower layers of the skin, therefore helping to reduce the appearance of fine lines and wrinkles </li></ul><ul><li>Is a must if you are concerned about overall skin health </li></ul>CONFIDENTIAL
  24. 24. Key Ingredients <ul><li>Micrococcus luteus: liposome delivery of this enzyme, sourced from marine microbes, recognizes cellular UV damage and accelerates the skin repair and recovery process </li></ul><ul><li>Arabidopsis thaliana: liposome delivery of the repair enzyme known as OGG1, sourced from mustard seed, recognizes DNA damage and helps the body ’s natural process by initiating the cellular repair process </li></ul><ul><li>Anacystis nidulans: liposome delivery of the repair enzyme photolyase, sourced from plankton, that can absorb and assist in reversing the effects of UV induced skin damage </li></ul><ul><li>Hyaluronic acid has the ability to retain 1000x ’s its weight in water which contributes significantly to the skin maintaining its youthful appearance </li></ul><ul><li>Evodia rutaecarpa fruit extract is derived from the Chinese Evodia plant and has been proven to calm and soothe irritated skin </li></ul><ul><li>L-ergothioneine is a powerful antioxidant that absorbs free radical chain initiators and inhibits ROS triggered by environmental exposure </li></ul>CONFIDENTIAL
  25. 25. To Be Clear <ul><li>CELFIX Cosmeceuticals: DNA Youth Recovery </li></ul><ul><li>First and foremost, the product does not repair damaged DNA </li></ul><ul><li>It assists in speeding up the body ’s natural process to repair damaged DNA </li></ul><ul><li>Liposome-delivered enzymes adhere to the damage, extract the damage, and allow the DNA to repair itself </li></ul><ul><li>This is what the body naturally does </li></ul><ul><li>However, the body can only repair 50% of the damage it receives in any given day </li></ul><ul><li>DNA Youth Recovery helps repair the other 50% </li></ul>CONFIDENTIAL
  26. 26. How It Works <ul><li>Plant-derived enzymes mimic the body ’s natural response </li></ul><ul><li>Enzymes are encapsulated in a liposomal delivery system which drives the enzymes into the nucleus of the skin cell </li></ul><ul><li>The cargo is released into the cell, searches and adheres to the damaged DNA strand only (search & destroy) </li></ul><ul><li>Damage is then extracted or cut out similar to the body ’s natural response </li></ul><ul><li>DNA mimics clean strand and replicates to a healthy cell </li></ul>CONFIDENTIAL
  27. 27. Who Needs CELFIX Cosmeceuticals: DNA Youth Recovery <ul><li>Anyone concerned with overall skin health </li></ul><ul><li>Anyone overexposed to the sun, past and present </li></ul><ul><li>Anyone exposed to environmental pollutants </li></ul><ul><li>Anyone concerned with fines lines, wrinkles and UV spots </li></ul><ul><li>Anyone recovering from a non-invasive procedure </li></ul><ul><li>Everyone needs help repairing damaged DNA </li></ul><ul><li>DNA Youth Recovery is engineered to fit with all skin types and current protocols, therefore, anyone can use it </li></ul>CONFIDENTIAL
  28. 28. Benefits <ul><li>CELFIX Cosmeceuticals: DNA Youth Recovery </li></ul><ul><li>By assisting in DNA repair, it helps the skin recover from non-invasive procedures </li></ul><ul><li>Because it helps the skin repair the “other” 50% of damaged DNA, it provides faster DNA recovery, which offers added protection/prevention to the UV damage suffered from sun exposure </li></ul><ul><li>Holds off collagen degradation in the lower layers of the skin, therefore, helping to reduce the appearance of fine lines and wrinkles </li></ul><ul><li>Has a non-comedogenic, paraben-free formulation </li></ul><ul><li>Fits perfectly with all skincare regimens </li></ul><ul><li>Attacks both past and present damage!! </li></ul>CONFIDENTIAL
  29. 29. CELFIX Cosmeceuticals DNA Ceramide Renewal Nourishing Cream CONFIDENTIAL
  30. 30. Skin Barrier <ul><li>Barrier function in the skin depends on ceramide lipids. </li></ul><ul><li>Ceramides are fatty cells essential to a strong barrier </li></ul><ul><ul><li>They are located in stratum corneum of skin and are an important part of the lipid barrier of the human skin which plays an essential role keeping the protective function of the skin against external insults and the hydration balance needed for its good conservation </li></ul></ul><ul><li>Barrier is outer layer of skin and should be strong not necessarily thick </li></ul><ul><li>Protects the skin from the UV rays and environmental insults </li></ul><ul><li>Building a better skin barrier: </li></ul><ul><ul><li>Apply topical ceramides </li></ul></ul><ul><ul><li>Accelerate keratinocyte maturation- late stage ceramide production </li></ul></ul><ul><ul><li>Stimulate keratinocyes to increase ceramides </li></ul></ul>CONFIDENTIAL
  31. 31. DNA Ceramide Renewal <ul><li>CELFIX Cosmeceuticals: DNA Ceramide Renewal </li></ul><ul><li>Nourishing Cream </li></ul><ul><li>50 ml / 1.7 oz. </li></ul><ul><li>Benefits </li></ul><ul><li>Contains 1 DNA Repair Enzyme </li></ul><ul><li>Builds upper skin barrier w/ ceramides </li></ul><ul><li>and antioxidants </li></ul><ul><li>Strengthens lower collagen layer </li></ul><ul><li>Reduce irritation and keeps skin moisturized </li></ul><ul><li>Stronger protection from the inside out! </li></ul>CONFIDENTIAL
  32. 32. DNA Ceramide Renewal <ul><li>One pump for face, throat and decollete </li></ul><ul><li>Once or twice daily, morning & night after cleansing and other treatments, before sunscreen </li></ul><ul><li>Patient Types: </li></ul><ul><li>Any patient post procedure </li></ul><ul><li>Men: post shave </li></ul><ul><li>Any patient w/ a compromised skin barrier </li></ul><ul><li>Any patient concerned with overall skin </li></ul><ul><li>health </li></ul>CONFIDENTIAL
  33. 33. Key Ingredients <ul><li>Rosemary extract or ursolic acid is a natural component that provides a boost to the skin ’s natural ability to increase ceramide production </li></ul><ul><li>Lactomide is an aqueous patented liposome dispersion containing a naturally derived ceramide (Ceramide-3) as well as milk lipids. Lactomide improves the constitution and structure of the barrier and therefore has a positive effect on skin hydration and reversing the signs of aging </li></ul><ul><li>Arabidopsis thaliana: liposome delivery of the repair enzyme known as OGG1, sourced from mustard seed, recognizes DNA damage and helps the body ’s natural process by initiating the cellular repair process </li></ul><ul><li>L-ergothioneine is a powerful antioxidant that absorbs free radical chain initiators and inhibits ROS triggered by environmental exposure </li></ul><ul><li>Evodia rutaecarpa fruit extract is derived from the Chinese Evodia plant and has been proven to calm and soothe irritated skin </li></ul><ul><li>Glycerin is a highly “hygroscopic” ingredient that helps to balance or maintain moisture levels in the skin </li></ul>CONFIDENTIAL
  34. 34. Rosemary Extract Increases Ceramides CONFIDENTIAL Percent Ceramides Skin Lipids Increased Ceramides 30% Increase in 11 Days
  35. 35. Antioxidant ORAC Scores CONFIDENTIAL
  36. 36. CELFIX Testimonial <ul><li>Tina S. Alster, MD, FAAD </li></ul><ul><ul><li>Director, Washington Institute of </li></ul></ul><ul><ul><li>Dermatologic Laser Surgery </li></ul></ul><ul><ul><li>Clinical Professor of Dermatology, </li></ul></ul><ul><ul><li>Georgetown University Medical Center </li></ul></ul><ul><ul><li>“ The impressive science-based technology of CELFIX DNA Youth Recovery makes it an important component of my patients ’ anti-aging skin care regimens. The formulation can easily be incorporated into a variety of existing skin care protocols to enhance the skin ’ s appearance. ” </li></ul></ul>CONFIDENTIAL
  37. 37. CELFIX Testimonial <ul><li>Vivian Bucay, MD, FAAD </li></ul><ul><ul><li>Medical, Surgical & Cosmetic Dermatology </li></ul></ul><ul><ul><li>San Antonio, TX </li></ul></ul><ul><ul><li>“ As a stage IV melanoma survivor, the topic of DNA repair intrigues me. In clinical practice, I have found a product known as CELFIX DNA Youth Recovery (Carefree Skincare) to be very similar to the original Remergent DNA repair. An unpublished study performed in my clinic involving approximately 100 patients demonstrated that after three months of twice daily application, a 40-50 percent reduction in UV spots was achieved as measured by the VISIA Complexion Analysis. ” </li></ul></ul>CONFIDENTIAL
  38. 38. Clinical Analysis of CELFIX Products <ul><li>VISIA Complexion Analysis (Canfield Imaging Systems) </li></ul><ul><ul><li>Multi-spectral imaging, using standard & UV photography </li></ul></ul><ul><ul><li>Quantitative assessment of sub-surface conditions </li></ul></ul><ul><ul><li>Fixed positioning & lightening to ensure accurateness of images between time points </li></ul></ul>CONFIDENTIAL
  39. 39. 20% Reduction in UV Spots in 4 Weeks CONFIDENTIAL Before: 342 UV Spots After: 4 Weeks: 271 UV Spots Actual patient results using CELFIX products. Images taken by Vivian Bucay, MD, FAAD (Medical, Surgical & Cosmetic Dermatology – San Antonio, TX) using the VISIA Complexion Analysis System.
  40. 40. 41% Reduction in UV Spots in 8 Weeks CONFIDENTIAL Before: 228 UV Spots After: 8 Weeks: 135 UV Spots Actual patient results using CELFIX products. Images taken by Vivian Bucay, MD, FAAD (Medical, Surgical & Cosmetic Dermatology – San Antonio, TX) using the VISIA Complexion Analysis System.
  41. 41. 70% Reduction in UV Spots in 12 Weeks CONFIDENTIAL Before: 217 UV Spots After: 12 Weeks: 64 UV Spots Actual patient results using CELFIX products. Images taken by Vivian Bucay, MD, FAAD (Medical, Surgical & Cosmetic Dermatology – San Antonio, TX) using the VISIA Complexion Analysis System.
  42. 42. CELFIX Cosmeceuticals DNA iQuad Infusion Total Eye Complex CONFIDENTIAL
  43. 43. DNA iQuad Infusion <ul><li>CELFIX Cosmeceuticals: DNA iQuad Infusion Total Eye Complex 15 ml / 0.5 oz. </li></ul><ul><li>Benefits: </li></ul><ul><li>1 DNA Repair Enzyme </li></ul><ul><li>Reduces appearance of lines & wrinkles </li></ul><ul><li>Diminishes dark circles </li></ul><ul><li>Treats photodamage </li></ul><ul><li>Lessens the appearance of puffiness </li></ul>CONFIDENTIAL
  44. 44. DNA iQuad Infusion cont. <ul><li>Matrixyl 3000 , a combination of peptides that helps regulate cell activity and works together to help restore and maintain the skin’s youthful appearance. Studies show a 45% reduction of wrinkles in 8 weeks. </li></ul><ul><li>Haloxyl is a combination of peptides that helps activate the elimination of blood originated pigments responsible for dark under-eye circles and puffiness while reinforcing firmness of the eye area. </li></ul><ul><li>Photolyase Liposomes , an organic DNA recovery enzyme derived from plankton which helps reverse photo damage and eliminate the appearance of UV spots on the skin. </li></ul>CONFIDENTIAL
  45. 45. Key Ingredients CONFIDENTIAL   Reduces Lines & Wrinkles Diminishes Dark Circles Lessens Puffiness Combats Photodamage Smoothes Skin Protects Moisturizes Matrixyl 3000 X       X     Haloxyl   X X         Photolyase X     X       Caffeine   X X   X X   Sunflower Seed Oil           X X Ivy Extract   X           Green Tea Extract           X   Sodium Hyaluronate X       X   X Licorice Extract     X     X   Ergothioneine           X   Tocopherol         X X X Ubiquinone X     X   X X
  46. 46. 45% Reduction of Wrinkles in 8 Weeks CONFIDENTIAL Baseline Week 8
  47. 47. Under-eye Circles Reduced in More Than 60% of Patients CONFIDENTIAL Dark circles significantly reduced by 19% in 8 weeks.
  48. 48. The Next Wave In The Skincare Revolution CONFIDENTIAL

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