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Novel Method for
Determining Aortic
Compliance and Peripheral
Resistance
October 30, 2018
What is the problem?
• High blood pressure can
be caused by
– Blockages in the arteries
– Hardening of the arteries
(arteriosclerosis)
• Each cause requires a
different treatment, but
patients having high blood
pressure are routinely
treated for blockages or
plaque buildup
How does product/service solve problem?
• Giovanna Guidoboni developed a closed loop
mathematical model that simulates the mechanisms
generating the BCG signal
1
ln( / )
1 1 ( / )
ln( / )
1 ( / )
1
For ...
3
2
.
ln( / )
e
e
e
e
M S D
T
T T
e S D
T
D e S D T T
S D
e
S DS D S D
V T T
C
P T P P
V T T P P
P T P P
P P
T
T
V
C
P PP P P P


 

  





 
1 ( / )
1 ( / )
1
For ...
3
.
3
e
e
e
T
T T
M D e S D
T
T T
S D
e
S D S D
P T P T P P
R
V V
P P
T
T
P P P P T
R
V



 
 


 


How does product/service solve problem?
• By inputting blood pressure,
heart rate, ejection period and
stroke volume, we get
– Aortic Capacitance (stiffness)
– Peripheral resistance (blockage)
What is the market use?
• Routine test for all patients suffering from high
blood pressure
What competition exists?
• Hypertension Diagnostics has a competing
product
What is the status of the intellectual property?
• Patent pending
What is the stage of development?
• Must be tested with more data
What is needed for further development?
• More validation with more patients
• Determine if direct measurement of ejection
period and stroke volume is necessary using an
echocardiogram
• Find an entrepreneur/licensee with
cardiovascular expertise to assist in validation
and/or a commercial deployment
Contact
For more information please contact Jim Baxendale, Director of
Whiteboard2Boardroom:baxendalej@umkc.edu.

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University of Missouri-Columbia, Cardiovascular Diagnosis from Ballistocardiogram

  • 1. Novel Method for Determining Aortic Compliance and Peripheral Resistance October 30, 2018
  • 2. What is the problem? • High blood pressure can be caused by – Blockages in the arteries – Hardening of the arteries (arteriosclerosis) • Each cause requires a different treatment, but patients having high blood pressure are routinely treated for blockages or plaque buildup
  • 3. How does product/service solve problem? • Giovanna Guidoboni developed a closed loop mathematical model that simulates the mechanisms generating the BCG signal 1 ln( / ) 1 1 ( / ) ln( / ) 1 ( / ) 1 For ... 3 2 . ln( / ) e e e e M S D T T T e S D T D e S D T T S D e S DS D S D V T T C P T P P V T T P P P T P P P P T T V C P PP P P P                1 ( / ) 1 ( / ) 1 For ... 3 . 3 e e e T T T M D e S D T T T S D e S D S D P T P T P P R V V P P T T P P P P T R V             
  • 4. How does product/service solve problem? • By inputting blood pressure, heart rate, ejection period and stroke volume, we get – Aortic Capacitance (stiffness) – Peripheral resistance (blockage)
  • 5. What is the market use? • Routine test for all patients suffering from high blood pressure
  • 6. What competition exists? • Hypertension Diagnostics has a competing product
  • 7. What is the status of the intellectual property? • Patent pending
  • 8. What is the stage of development? • Must be tested with more data
  • 9. What is needed for further development? • More validation with more patients • Determine if direct measurement of ejection period and stroke volume is necessary using an echocardiogram • Find an entrepreneur/licensee with cardiovascular expertise to assist in validation and/or a commercial deployment
  • 10. Contact For more information please contact Jim Baxendale, Director of Whiteboard2Boardroom:baxendalej@umkc.edu.