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The Dictionary
of Substances
and their Effects
Second Edition
The Dictionary
of Substances
and their Effects
Second Edition

EDITOR

S Gangolli, Consultant, MRC Toxicology Unit, UK
EDI...
PRODUCTION TEAM
Ken Wilkinson (Staff Editor)
Richard Ellis
Sally Faint
Julie Hetherington
Alan Skull
The publishers make n...
Contents
Volume 1
Foreword
htroduction
Guide to Content
A-B Compounds
Abbreviations
Glossary of Medical and Biological Ter...
Guide to Content
The data for each chemical in DOSE are organised as follows:

DOSE No.
Chemical name
Structure/line formu...
Dose No.
Each of the 4123 compounds in DOSE is identified by a unique, sequential alphanumeric
DOSE No. For example, the f...
Uses
Principal uses of the substances are given, with information on other significant uses in
industrial processes.
Occur...
The airborne limits of permitted concentrations of hazardous chemicals represent conditions
under which it is believed tha...
The threshold limit values for the USA have been taken from the Threshold Limit Values and
Biological Exposure Indices, 29...
approved for the classification and labelling of substances and preparations dangerous for
supply [Chemicals (Hazard Infor...
Toxicity to other species
Toxicity to species other than mammals, birds, invertebrates and fish (e.g. reptiles,
amphibians...
Carbonaceous inhibition
Another major biogeochemical process is the recycling of carbon via the decomposition of
complex o...
Mammalian and avian toxicity
Studies on mammalian species are carried out to determine the potential toxicity of
substance...
lrritancy
Chemical substances which cause irritation (itching, inflammation) to skin, eye and mucous
membranes on immediat...
Legislation
Any form of legislation, medical (food and drugs) or environmental from European,
American and worldwide sourc...
Note
The Royal Society of Chemistry (RSC) has only assessed published information in compiling
The Dictionary of Substance...
kadethrin

C23H2404S

Mol. Wt. 396.51

CAS Registry No. 58769-20-3

Synonyms cyclopropanecarboxylic acid, 3-[(dihydro-2-ox...
K2

kaolin
AlzH409SiZ

Mol. Wt. 258.16

CAS Registry No. 1332-58-7

Synonyms Argiflex; Hydrogloss; Lustra; Porcelain clay;...
Genotoxicity
Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538 with and without metabolic activation negative (2)...
Other comments
Stable in acid media.

References
1.
2.
3.
4.

5.

K5

The Pesticide Manual9th ed., 1993, British Crop Prot...
Environmental fate
Abiotic removal
At 50°C, tl/2 47 day at pH 5 and tl/2 14 day at pH 9 (3).

Mammalian & avian toxicity
A...
K6

kelevan
CI

/




C17H12C11004

OH
CHZCOCH~CH~CO~CH~CH~

CI

Mol. Wt. 634.81

CAS Registry No. 4234-79-1

Synonyms 1,3...
K7

kerosene
CAS Registry No. 8008-20-6
Synonyms kerosine; jet fuel
RTECS No. OA 5500000

EINECS NO.232-366-4

Uses Fuel i...
Irritancy
Dermal rabbit (duration not specified) 500 mg caused severe irritation (2).
Dermal (90 wk) 9 B6C3F1 mice 500 mg ...
K8

ketene

C2H20

Mol. Wt. 42.04

CAS Registry No. 463-51-4

Synonyms ethenone; carbomethene
RTECS No. OA 7700000

EINECS...
ketoconazole

C26H28C12N404

Mol. Wt. 531.44

CAS Registry No. 65277-42-1

Synonyms cis-l-acetyl-4-[4-[[2-(2,4-dichlorophe...
Irritancy
Healthy adult subjects 2% cream single application (5 g) did not cause skin irritation (9).

Other effects
Other...
KIO

ketoprofen
CHC02H
/

C610
1H43

Mol. Wt. 254.29

CAS Registry No. 22071-15-4

Synonyms 3-benzoyl-a-methylbenzeneaceti...
Cardiac and respiratory arrest occurred in an asthmatic patient (8).
Reported to cause photosensitivity reactions (9).
Any...
Environmental fate
Adsorption and retention
Activated carbon was effective in adsorbing plant growth regulators including ...
changes in either extracellular pH or extracellular sodium ion concentration. Rates of lactate conversion into
glucose and...
Genotoxicity
Sacchararnyces cerevisiae and Salmonella typhimuriurn with and without metabolic activation, negative (16).
S...
23.
24.
25.
26.
27.

L2

S. I. 1991 No. 472 The Environmental Protection (Prescribed Processes and Substances) Regulations...
teratogenicity and biochemical mechanism studies of a series of structurally similar aliphatic nitriles, including
lactoni...
References
1.
2.
3.

L4

Kornbluth, J. et a1 Cell. Immunol. 1984,88(1), 162-173.
S. I. 1997 No. 472 The Environmental Prot...
Legislat ion
Included in Schedule 4 (Release into Air: Prescribed Substances) Statutory Instrument No. 472,1991 (8).

Othe...
LD50 subcutaneous mouse 2420 mg
LD50 intravenous rabbit 148 mg

kl1.
g()

kg-1 (1).

Other effects
Any other adverse effec...
Physical properties
M. Pt. 94-95.5"C
Solubility Organic solvents: benzene, diethyl ether, ethanol

Mammalian & avian toxic...
Other comments
Reviews on environmental toxicology and human health effects listed (19).
It is a pyrrolizidine alkaloid.

...
Genotoxicity
Chinese hamster ovary cells with and without metabolic activation sister chromatid exchanges positive and
chr...
Degradation studies
Activated sludge (6 hr) 4.1% ThOD; (12 hr) 4.3% ThOD; (24 hr) 6.1% ThOD (5).

Mammalian & avian toxici...
Occupational exposure
Supply classification oxidising
Risk phrases May cause fire (R7)
Safety phrases Keep out of reach of...
References
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.

LIO

ZARC Monograph 1987, Suppl. 7,65.
Van Duuren, B. L. et a1 I. Natl. Cnncer ...
Other effects
Other adverse effects (human)
Human mixed lymphocyte reaction 94% inhibition and toxic to cells (5).

Legisl...
SE-LEVL 0.1 mg m-3 (total dust); 0.05 mg m-3 (respirable dust)
UK-LTEL 0.15 mg m-3
US-TWA 0.05 mg m-3

Ecotoxicity
Fish to...
Atotobacter exposed to high concentrations showed inhibited urease activity. Inhibition threshold concentration
range 30-5...
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The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
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The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
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The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
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The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
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The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
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The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
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The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
The Dictionary of Substances and Their Effects (DOSE): Volume 05 K–N
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