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- composed of the alimentary canal and the
  associated glands
- the alimentary canal is a long, tortuous
  tube, which begins with the lips and
  terminates with the anus
Common properties of the wall of the
digestive tract

The wall is composed of the following layers
   as follows from the lumen:
1. Tunica mucosa ( mucous membrane)
2. Tunica submucosa
3. Tunica muscularis
4. Tunica serosa ( serous membrane) or
   adventitia
the most inportant layer with various tissue
components
has diverse functions:
   - protection
   - secretion
   - absorption
- sublayers of the submucosa:

 1./ a. lamina epithelialis - epithelium
 1./ b. lamina propria connective tissue
                            proper
 1./ c. lamina muscularis mucosae smooth
                                       muscle
adluminal, covering epithelium
functions:
  physicochemical barrier between the lumen
  and the connective tissue
  selective absorption of the digested
  substances
  secretion of digestive enzymes and lubricating
  mucins
the types of the epithelium reflects the
special demands of the appropriate
segments of the alimentary canal
examples:
  oral cavity, esophagus stratified,
  nonkeratinized squamous epithelium
  stomach simple columnar epithelium
  small intestine simple columnar epithelium
  with cuticle
loose connective tissue, which contains blood -
and lymphatic vessels, nerve fibers and different
kinds of connective tissue cells
in the lamina propria of most segments of the
G.I.T., there are tubular glands, such as the
gastric - and intestinal glands
elements of the immune system is present
throughout the G.I.T. to defend the body
against possible bacterial attacks
thin layer of smooth muscle, which is
often composed of an inner circular and
outer longitudinal sublayers
contributes to the motility of the mucous
membrane; this movement is independent
of the peristaltic movement of the tract
connective tissue layer with various thickness;
here blood vessels run
contains plexus of lymphatics
contains vegetative ganglion cells and peripheral
nerves, which together make the submucous
plexus of Meisner
may contain glands in the submucosa of certain
segments ( esophagus and duodenum)
relatively thick layer with two sublayers of
smooth muscle in the vast majority of cases
inner circular sublayer ( str. circulare)
outer longitudinal sublayer ( str. longitudinale)
the sublayers are separated by thin connective
tissue containing the myenteric plexus of
Auerbach as well as blood and lymphatic vessels
there are striated muscles in the proximal
segments of the esophagus, and also in the
anal canal
there is a third muscular sublayer in the wall of
the stomach: inner oblique fibers
in the large intestine, the external sublayer
forms longitudinal bands of smooth muscle
taeniae coli
tunica serosa ( serous membrane) is the
outermost layer of those segments of the
alimentary canal that are enveloped by
peritoneum
   has simple squamous epithelium ( lamina
   epithelialis; mesothelium) and a thin connective
   tissue sublayer ( lamina propria serosae)
   the serous membrane is attached to the
   muscularis through a subserous connective
   tissue
Tunica advenitia

 certain segments of the G.I.T. are not
 enveloped by peritoneum
 in these segments, the outermost layer is
 loose connective tissue ( adventitia) , which
 connects the tract to the its surroundings
salivary glands in the lamina propria mucosae
submucous glands in the tela submucosa
extramural glands ( large digestive glands) are
located outside the wall of the tract ; they
discharge their products into G.I.T. lumen
through excretory ducts
characteristic anatomical items:
  lips
  teeth
  tounge
  salivary glands
border the mouth opening ( oral fissure)
there scaffoldings are striated muscle
fibers of the orbicularis oris m.
have cutaneous and mucous surfaces
( pars cutanea and pars mucosa)
Pars cutanea - outer surface, which is composed of skin ( epidermis,
dermis and hypodermis, which is also called subcutaneous tissue).
In this surface, there various derivatives of the skin: hair follicles,
sebaceous and sweat glands.
Pars mucosa inner surface, which lines the oral cavity. This
surface is covered by a mucous membrane, containing stratified,
nonkeratinized, squamous epithelium and connective tissue. In the
later layer there are small salivary glands: labial glands.
Rubor labii - vermilion zone between the ordinary skin and the
mucous membrane. The vermilion zone is covered by stratified,
keratinized, squamous epithelium. This zone is devoid of skin
appendages. However, the zone has capillary- rich connective tissue
papillae, the red color of which may be well visible through the
relatively thin skin.
The tongue is a muscular organ, covered by
mucous membrane. Its main mass is striated
muscle, fibers of which run in all directions of
space. This sort of organization is highly typical
of the tongue.
The mucous membrane on the superior and
inferior surfaces are very much different .
On the superior surface ( dorsum of tongue) ,
there are lingual papillae.
Behind the sulcus terminalis, there are
lymphatic follicles of the lingual tonsil.
The mucose membrane of the inferior
surface is smooth, lacks connective
tissue papillae.
serosus glands of Ebner, which open at the
base of vallate - and foliate papillae
mucinous glands in the root of tongue
posterior lingual glands
mixed glands in the apex of tongue
anterior lingual glands ( gland of Blandin and
Nuhn)
filiform papillae
fungiform papillae
foliata papillae
vallatae papillae
they are located in front of the sulcus terminalis
large, roundish lingual papillae with a diameter
of 2-3 mm; thus, they can be readily seen with
naked eyes
one man has 8-12 vallate papillae
have taste buds in their walls
each papilla is encircled by a moat - like trench
the Ebner s serous glands empty into the moats
of the papillae
are lightly stained oval bodies, located in the
stratified, nonkeratinized, squamous epithelium
of the mucous membrane
cell types:
  supporting cells
  secondary neuroepithelial cells
  undifferentiated stem cells
Parts
  crown of tooth
  neck of tooth
  root of tooth
inside the crown and neck, there is a tooth
pulp, inside the root , there is a root canal,
which opens in the apical foramen
Dentin ( substantia eburnea)

Enamel ( substantia adamantina,
enamelum)

Cementum ( substantia ossea, cementum)
inorganic substances: 80%
     hydroxy- apatite crystals
organic substances: 20%
     its 9/ 10: type I collagen
     its 1/ 10: proteoglycans
Enamel

inorganic substances: 98%
     hydroxy- apatite crystals
organic substances: 2%
     insoluble proteins
There are NO cells within the enamel!
Cementum


 covers the roots of teeth
 cementoblasts produce; the resting cells are
 cementocytes
 inorganic substances: 50%
 organic content is mainly made up of collagen fibers
 the cementum is tethered to the periodontium by
 Sharpey s fibers
PARODONTIUM


 Cementum
 Periodontium connecting tissue
 membrane, which is rich in fibers; contains
 blood vessels and nerves. Its cells are
 fibroblasts, which can be converted either
 cementoblasts or osteoblasts of alveolar
 bone.
 Alveolar bone
loose connecting tissue, which is rich in
capillaries and nerves
cells:
  fibroblasts, mast cells, macrophages,
  lymphocytes
  odontoblasts, which produce the dentin
Small salivary glands labial, buccal, palatine, linguales,
  etc. glands

Large salivary glands   parotid, submandibular, sublingual
  glands



All of them are exocrine glands.
secretory portion can be serous, mucous
or mixed / Gianuzzi s demilune/
excretory portion
  intralobular ducts   intercalated tubules, striated
  ducts
  interlobular ducts   excretory ducts
purely serous gland
there are many fat cells among the acini
well-developed intercalated tubules and salivary
ducts
in the interlobular septa, run the larger excretory
ducts, blood vessels and peripheral nerves
there may be many cross- sections of the
branches of the facial nerve, which pass the
parotid
mixed gland, but the mucous secretory
cells predominate over the serous ones.
the serous cells are located as small
clusters around the mucous acini: these
are Gianuzzi demilumes
both the intercalated tubules and the
striated ducts are usually absent
mixed gland, in which the serous secretory
cells predominate
the scattered mucous acini are partly
covered by serous cap / Gianuzzi s
demilune/
there are somewhat smaller number
intercalated tubules and striated ducts
than in the parotid
Histology of the digestive system part1

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Histology of the digestive system part1

  • 1.
  • 2. - composed of the alimentary canal and the associated glands - the alimentary canal is a long, tortuous tube, which begins with the lips and terminates with the anus
  • 3. Common properties of the wall of the digestive tract The wall is composed of the following layers as follows from the lumen: 1. Tunica mucosa ( mucous membrane) 2. Tunica submucosa 3. Tunica muscularis 4. Tunica serosa ( serous membrane) or adventitia
  • 4. the most inportant layer with various tissue components has diverse functions: - protection - secretion - absorption
  • 5. - sublayers of the submucosa: 1./ a. lamina epithelialis - epithelium 1./ b. lamina propria connective tissue proper 1./ c. lamina muscularis mucosae smooth muscle
  • 6. adluminal, covering epithelium functions: physicochemical barrier between the lumen and the connective tissue selective absorption of the digested substances secretion of digestive enzymes and lubricating mucins
  • 7. the types of the epithelium reflects the special demands of the appropriate segments of the alimentary canal examples: oral cavity, esophagus stratified, nonkeratinized squamous epithelium stomach simple columnar epithelium small intestine simple columnar epithelium with cuticle
  • 8. loose connective tissue, which contains blood - and lymphatic vessels, nerve fibers and different kinds of connective tissue cells in the lamina propria of most segments of the G.I.T., there are tubular glands, such as the gastric - and intestinal glands elements of the immune system is present throughout the G.I.T. to defend the body against possible bacterial attacks
  • 9. thin layer of smooth muscle, which is often composed of an inner circular and outer longitudinal sublayers contributes to the motility of the mucous membrane; this movement is independent of the peristaltic movement of the tract
  • 10. connective tissue layer with various thickness; here blood vessels run contains plexus of lymphatics contains vegetative ganglion cells and peripheral nerves, which together make the submucous plexus of Meisner may contain glands in the submucosa of certain segments ( esophagus and duodenum)
  • 11. relatively thick layer with two sublayers of smooth muscle in the vast majority of cases inner circular sublayer ( str. circulare) outer longitudinal sublayer ( str. longitudinale) the sublayers are separated by thin connective tissue containing the myenteric plexus of Auerbach as well as blood and lymphatic vessels
  • 12. there are striated muscles in the proximal segments of the esophagus, and also in the anal canal there is a third muscular sublayer in the wall of the stomach: inner oblique fibers in the large intestine, the external sublayer forms longitudinal bands of smooth muscle taeniae coli
  • 13. tunica serosa ( serous membrane) is the outermost layer of those segments of the alimentary canal that are enveloped by peritoneum has simple squamous epithelium ( lamina epithelialis; mesothelium) and a thin connective tissue sublayer ( lamina propria serosae) the serous membrane is attached to the muscularis through a subserous connective tissue
  • 14. Tunica advenitia certain segments of the G.I.T. are not enveloped by peritoneum in these segments, the outermost layer is loose connective tissue ( adventitia) , which connects the tract to the its surroundings
  • 15. salivary glands in the lamina propria mucosae submucous glands in the tela submucosa extramural glands ( large digestive glands) are located outside the wall of the tract ; they discharge their products into G.I.T. lumen through excretory ducts
  • 16. characteristic anatomical items: lips teeth tounge salivary glands
  • 17. border the mouth opening ( oral fissure) there scaffoldings are striated muscle fibers of the orbicularis oris m. have cutaneous and mucous surfaces ( pars cutanea and pars mucosa)
  • 18. Pars cutanea - outer surface, which is composed of skin ( epidermis, dermis and hypodermis, which is also called subcutaneous tissue). In this surface, there various derivatives of the skin: hair follicles, sebaceous and sweat glands. Pars mucosa inner surface, which lines the oral cavity. This surface is covered by a mucous membrane, containing stratified, nonkeratinized, squamous epithelium and connective tissue. In the later layer there are small salivary glands: labial glands. Rubor labii - vermilion zone between the ordinary skin and the mucous membrane. The vermilion zone is covered by stratified, keratinized, squamous epithelium. This zone is devoid of skin appendages. However, the zone has capillary- rich connective tissue papillae, the red color of which may be well visible through the relatively thin skin.
  • 19.
  • 20.
  • 21.
  • 22. The tongue is a muscular organ, covered by mucous membrane. Its main mass is striated muscle, fibers of which run in all directions of space. This sort of organization is highly typical of the tongue. The mucous membrane on the superior and inferior surfaces are very much different . On the superior surface ( dorsum of tongue) , there are lingual papillae.
  • 23. Behind the sulcus terminalis, there are lymphatic follicles of the lingual tonsil. The mucose membrane of the inferior surface is smooth, lacks connective tissue papillae.
  • 24. serosus glands of Ebner, which open at the base of vallate - and foliate papillae mucinous glands in the root of tongue posterior lingual glands mixed glands in the apex of tongue anterior lingual glands ( gland of Blandin and Nuhn)
  • 25. filiform papillae fungiform papillae foliata papillae vallatae papillae
  • 26.
  • 27.
  • 28. they are located in front of the sulcus terminalis large, roundish lingual papillae with a diameter of 2-3 mm; thus, they can be readily seen with naked eyes one man has 8-12 vallate papillae have taste buds in their walls each papilla is encircled by a moat - like trench the Ebner s serous glands empty into the moats of the papillae
  • 29.
  • 30. are lightly stained oval bodies, located in the stratified, nonkeratinized, squamous epithelium of the mucous membrane cell types: supporting cells secondary neuroepithelial cells undifferentiated stem cells
  • 31.
  • 32. Parts crown of tooth neck of tooth root of tooth inside the crown and neck, there is a tooth pulp, inside the root , there is a root canal, which opens in the apical foramen
  • 33. Dentin ( substantia eburnea) Enamel ( substantia adamantina, enamelum) Cementum ( substantia ossea, cementum)
  • 34. inorganic substances: 80% hydroxy- apatite crystals organic substances: 20% its 9/ 10: type I collagen its 1/ 10: proteoglycans
  • 35. Enamel inorganic substances: 98% hydroxy- apatite crystals organic substances: 2% insoluble proteins There are NO cells within the enamel!
  • 36. Cementum covers the roots of teeth cementoblasts produce; the resting cells are cementocytes inorganic substances: 50% organic content is mainly made up of collagen fibers the cementum is tethered to the periodontium by Sharpey s fibers
  • 37. PARODONTIUM Cementum Periodontium connecting tissue membrane, which is rich in fibers; contains blood vessels and nerves. Its cells are fibroblasts, which can be converted either cementoblasts or osteoblasts of alveolar bone. Alveolar bone
  • 38. loose connecting tissue, which is rich in capillaries and nerves cells: fibroblasts, mast cells, macrophages, lymphocytes odontoblasts, which produce the dentin
  • 39.
  • 40.
  • 41. Small salivary glands labial, buccal, palatine, linguales, etc. glands Large salivary glands parotid, submandibular, sublingual glands All of them are exocrine glands.
  • 42. secretory portion can be serous, mucous or mixed / Gianuzzi s demilune/ excretory portion intralobular ducts intercalated tubules, striated ducts interlobular ducts excretory ducts
  • 43. purely serous gland there are many fat cells among the acini well-developed intercalated tubules and salivary ducts in the interlobular septa, run the larger excretory ducts, blood vessels and peripheral nerves there may be many cross- sections of the branches of the facial nerve, which pass the parotid
  • 44.
  • 45.
  • 46. mixed gland, but the mucous secretory cells predominate over the serous ones. the serous cells are located as small clusters around the mucous acini: these are Gianuzzi demilumes both the intercalated tubules and the striated ducts are usually absent
  • 47.
  • 48.
  • 49. mixed gland, in which the serous secretory cells predominate the scattered mucous acini are partly covered by serous cap / Gianuzzi s demilune/ there are somewhat smaller number intercalated tubules and striated ducts than in the parotid