Doxycycline-tetracycline

1,462 views

Published on

pharmacodynamics of tetracycline

Published in: Education, Health & Medicine
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
1,462
On SlideShare
0
From Embeds
0
Number of Embeds
10
Actions
Shares
0
Downloads
125
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Doxycycline-tetracycline

  1. 1. Amin ullah Daavi Roll no 215
  2. 2. Introduction. Chemical structure of doxycycline. Mechanism of action. Resistance. Antimicrobial activity. Clinical uses. Adverse effect. Contraindication.
  3. 3.  Doxycycline is a synthetic broad spectrum antibiotic drug derived from tetracycline which inhibit protein synthesis.
  4. 4. A. Short acting(6-8 hours)  Chlortetracycline  Oxytetracycline B. Intermediate acting (12 hrs)  Demeclocycline  Methacycline C. Long acting(16-18 hours)  Doxycycline  Minocycline
  5. 5. Doxycycline reversiably bind to 30s subunit at A site Block the binding of aminoacyl t-RNA to m-RNA inhibit the addition of new aminoacid to growing peptide chain Stop the translation process
  6. 6. Mechanism of resistance. Impaired influx or increase efflux Ribosomal protein production that interfere the binding of doxycycline Enzymatic inactivation
  7. 7. Tet (AE)efflux pump Resistance. Tet(M) efflux pump Resistance. Tet(K) efflux pump susceptible.
  8. 8. Doxycycline are sensitive against  Many gram-positive and gram-negative bacteria.  Bacillus anthracis.  Staphylococcus aureus.  Listeria monocytogenes.  Mycoplasma pneumoniae.  Chlamydiae and spirochetes.  Rickettsiae .  Vibrio cholera.  Neisseria gonorrhoea.  Haemophilus influenzae.
  9. 9.  Doxycyline is the drug of choice in infaction caused by  Mycoplasma Pneumonia.  Rickettsiae Rocky mountain spotted fever and rickettsial pox.  Chlamydia Trachoma and peittacosis.  Vibrio Cholera.  Bacillus anthracis Anthrax.  Spirochetes Lyme’s disease.
  10. 10. Doxycycline use in a regimen for treatment of gastic ulcer caused by helicobacter pylori Also with amino glycoside for plague, tularemia and brocellosis
  11. 11. A. Gastrointestinal adverse effects Nausea vomiting and diarrhea. B. Bony structures and teeth During pregnancy it can deposited in fetal teeth leading to fluorescence ,discoloration and enamel dysplasia. C. Liver toxicity Hepatic toxicity leading to hepatic necrosis.
  12. 12. D. Kidney toxicity. E. Local tissue toxicity. F. Vestibular toxicity. G. Photosensitizat ion.
  13. 13. Hypersensitivity Pregnancy Infants and children
  14. 14. Basic and clinical pharmacology (11th edition) Chapter 44(796-799) Lippincoatt’s illustrated reviews Pharmacology (4th edition) chapter 32(373-376)  httpwww.drugs.comdoxycycline.html

×