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Banned madicines, sell in india


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Banned madicines, sell in india

  1. 1. Banned Medicines Still Selling In India Here are some of the Drugs that have been globally discarded but are available in Indian markets: Analgin It is a painkiller Reason for ban: Bone marrow depression. Brand name: Novalgin Cisapride For acidity, constipation Reason for ban: Irregular heartbeat Brand name: Ciza, Syspride Droperidol Anti-depressant. Reason for ban : Irregular heartbeat. Brand name: Droperol Furazolidone Anti-diarrhoeal Reason for ban: Cancer Brand name: Furoxone, Lomofen Nimesulide Painkiller, fever Reason for ban: Liver failure Brand name: Nise, Nimulid Nitrofurazone Anti-bacterial cream Reason for ban: Cancer Brand name: Furacin Phenolphthalein Laxative Reason for ban: Cancer Brand name: Agarol Phenylpropanolamine Cold and cough Reason for ban: stroke Brand name: D’cold, Vicks Action – 500
  2. 2. Oxyphenbutazone Non-steroidal anti-inflammatory drug Reason for ban: Bone marrow depression Brand name : Sioril Piperazine Anti-worms Reason for ban: Nerve damage Brand name: Piperazine Quiniodochlor Anti-diarrhoeal Reason for ban: Damage to sight Brand name: Enteroquinol Tegaserod Tegaserod is a drug that is used to treat patients with irritable bowel syndrome with predominantly constipation. It was withdrawn from the market since patients taking this drug showed increased incidence of heart attack and stroke. Human Placental extract Human placental extract is used in the cosmetic industry in the form of lotion, gel and injection. It is not permitted in some countries since it can transmit diseases to the user. It is under the scanner and may be banned in the future. Thioridazine Thioridazine is an antipsychotic drug. It causes adverse effects like arrhythmia (abnormal heart rhythm), eye damage, and a condition called neuroleptic malignant syndrome. Read more: Vicks Action 500 is the brand name of a combination medicine that contains: paracetamol 500 mg + phenylpropanolamine (PPA) 25 mg + caffeine 32 mg per tablet. Paracetamol is a pain-killer while PPA is a decongestant. Caffeine is added to counteract the sedative side effect of PPA. Vicks Action 500 is not a very safe medicine because one of its ingredients (PPA) is banned in nearly all European and North American countries. PPA has been implicated in causation of stroke - a potentially dangerous and life-threatening side effect. Unfortunately the Indian drug control systemdue to a variety of non-scientific reasons has not banned the use of PPA in India. (Source:
  3. 3. Read more: Drugs Prohibited from the date of Notification 1. Amidopyrine. 2. Fixed dose combinations of vitamins with anti–inflammatory agents and tranquilizers. 3. Fixed dose combinations of Atropine in Analgesics and Antipyretics. 4. Fixed dose combinations of Strychnine and Caffeine in tonics. 5. Fixed dose combinations of Yohimbine and Strychnine with Testosterone and Vitamins. 6. Fixed dose combinations of Iron with Strychnine, Arsenic and Yohimbine. 7. Fixed dose combinations of Sodium Bromide/chloral hydrate with other drugs. 8. Phenacetin. 9. Fixed dose combinations of antihistaminic with anti-diarrhoeals. 10. Fixed dose combinations of Penicillin with Sulphonamides. 11. Fixed dose combinations of Vitamins with Analgesics. 12. Fixed dose combinations of any other Tetracycline with Vitamin C. 13. Fixed dose combinations of Hydroxyquinoline group of drugs with any other drug except for preparations meant for external use. 14. Fixed dose combinations of Corticosteroids with any other drug for internal use. 15. Fixed dose combinations of Chloramphenicol with any other drug for internal use. 16. Fixed dose combinations of crude Ergot preparations except those containing Ergotamine, Caffeine, analgesics, antihistamines for the treatment of migraine, headaches. 17. Fixed dose combinations of Vitamins with Anti TB drugs except combination of Isoniazid with Pyridoxine Hydrochloride (Vitamin B6). 18. Penicillin skin/eye Ointment. 19. Tetracycline Liquid Oral preparations. 20. Nialamide. 21. Practolol. 22. Methapyrilene, its salts. 23. Methaqualone. 24. Oxytetracycline Liquid Oral preparations. 25. Demeclocycline Liquid Oral preparations. 26. Combination of anabolic Steroids with other drugs. 27. Fixed dose combination of Oestrogen and Progestin (other than oral contraceptive) containing per tablet estrogen content of more than 50 mcg (equivalent to Ethinyl Estradiol) and progestin content of more than 3 mg (equivalent to Norethisterone Acetate) and all fixed dose combination injectable preparations containing synthetic Oestrogen and Progesterone. (Subs. By Noti. No. 743 (E) dt 10-08-1989) 28. Fixed dose combination of Sedatives/ hypnotics/anxiolytics with analgesics-antipyretics.
  4. 4. 29. Fixed dose combination of Rifanpicin, isoniazid and Pyrazinamide, except those which provide daily adult dose given below: Drugs Minimum Maximum Rifampicin 450 mg 600 mg Isoniazid 300 mg 400 mg Pyrazinamide 1000mg 1500 mg 30. Fixed dose combination of Histamine H-2 receptor antagonists with antacids except for those combinations approved by Drugs Controller, India. 31. The patent and proprietary medicines of fixed dose combinations of essential oils with alcohol having percentage higher than 20% proof except preparations given in the Indian Pharmacopoeia. 32. All Pharmaceutical preparations containing Chloroform exceeding 0.5% w/w or v/v whichever is appropriate. 33. Fixed dose combination of Ethambutol with INH other than the following: INH Ethambutol 200 mg. 600 mg. 300 mg. 800 mg. 34. Fixed dose combination containing more than one antihistamine. 35. Fixed dose combination of any anthelmintic with cathartic/purgative except for piperazine/Santonim. 36. Fixed dose combination of Salbutamol or any other bronchodilator with centrally acting anti-tussive and/or antihistamine. 37. Fixed dose combination of laxatives and/or anti-spasmodic drugs in enzyme preparations. 38. Fixed dose combination of Metoclopramide with systemically absorbed drugs except fixed dose combination of metoclopramide with aspirin/paracetamol 39. Fixed dose combination of centrally acting, antitussive with antihistamine, having high atropine like activity in expectorants. 40. Preparations claiming to combat cough associated with asthma containing centrally acting antitussive and/ or an antihistamine. 41. Liquid oral tonic preparations containing glycerophosphates and/or other phosphates and / or central nervous system stimulant and such preparations containing alcohol more than 20% proof. 42. Fixed dose combination containing Pectin and/or Kaolin with any drug which is systemically absorbed from GI tract except for combinations of Pectin and/or Kaolin with drugs not systemically absorbed. 43. Chloral Hydrate as a drug. 44. Dovers Powder I.P. 45. Dover’s Powder Tablets I.P. 46. Antidiarrhoeal formulations containing Kaolin or Pectin or Attapulgite or Activated Charcoal.
  5. 5. 47. Antidiarrhoeal formulations containing Phthalyl Sulphathiazole or Sulphaguanidine or Succinyl Sulphathiazole. 48. Antidiarrhoeal formulations containing Neomycin or Streptomycin or Dihydrostreptomycin including their respective salts or esters. 49. Liquid Oral antidiarrhoeals or any other dosage form for pediatric use containing Diphenoxylate Lorloperamide or Atropine or Belladona including their salts or esters or metabolites Hyoscyamine or their extracts or their alkaloids. 50. Liquid Oral antidiarrhoeals or any other dosage form for pediatric use containing halogenated hydroxyquinolines. 51. Fixed dose combination of antidiarrhoeals with electrolytes. 52. Patent and Proprietary Oral Rehydration Salts other than those conforming to the 53. Fixed dose combination of Oxyphenbutazone or Phenylbutazone with any other drug. 54. Fixed dose combination of Analgin with any other drug. 55. Fixed dose combination of dextropropoxyphene with any other drug other than anti- spasmodics and/or non-steriodal anti-inflammatory drugs (NSAIDS). 56. Fixed dose combination of a drug, standards of which are prescribed in the Second Schedule to the said Act with an Ayurvedic, Siddha or Unani drug. 57. Mepacrine Hydrochloride (Quinacrine and its salts) in any dosage form for use for female sterilization or contraception. 58. Fenfluramine and Dexfenfluramine. 59. Fixed dose combination of Diazepam and Diphenhydramine Hydrochloride. 60. Rimonabant. 61. Rosiglitazone 62. Nimesulide formulations for human use in children below 12 years of age. 63. Cisapride and its formulations for human use. 64. Phenylpropanolamine and its formulation for human use. 65. Human Placental Extract and its formulations for human use. 66. Sibutramine and its formulations for human use, and 67. R-Sibutramine and its formulations for human use. 68. Gatifloxacin formulation for systemic use in human by any route including oral and injectable 69. Tegaserod and its formulation for human use. Why they are banned? Drug No. 61 Rosiglitazone is an antidiabetic drug in the thiazolidinedione class of drugs. It works as an insulinsensitizer, by binding to the PPAR receptors in fat cells and making the cells more responsivetoinsulin.
  6. 6. The main reason behind banning this drug was associated with a significantly increased risk ofheartattack. A meta-analysis of observational studies released in March, 2011 provides more evidence that rosiglitazone is associated with a higher risk of heart failure, myocardial infarction (MI) and death. Datta Nirmal Pune Top  Fri, 2011-10-07 15:12 #2 Anonymous Nimesulide formulations for human use in children below 12 years Some common side effects linked with Nimesulide use are nausea, vomiting, diarrhea, pruritis, skin rashes, headaches and dizziness. Some serious side effects when used in newborns are renal failure and hepatic failure. According to International Society of Drug Bulletins (ISDB), this non-steroidal anti- inflammatory drug (NSAID) offers no therapeutic advantage or better gastrointestinal safety compared with other NSAIDs, whereas it exposes patients to a higher risk of fatal hepatic disorders. Nimesulide has been drawn aside from the pharmaceitical market because of its hepatic effects (risk of hepatatoxicity) on patients. Mahendra singh from Panjab University, Chandigarh Top  Thu, 2011-10-06 23:46 #3 Anonymous no. 32/ In high amount chloroform can be carcinogenic and also have severe harmful effect on CNS Top  Thu, 2011-10-06 23:27 #4
  7. 7. Anonymous Drug Number 60 / Rimonabant Rimonabant is anorectic antiobesity drug. It is -1 agonist for the cannabinoid receptor CB1. Shortly after market introduction, press reports and independent studies suggested side effects occurred more intensely and more commonly than shown by the manufacturer in their clinical studies. Resulting from drug actions at CB1 receptors in the brain, reports of severe depression and suicidal thoughts are frequent. AND IT IS WITHDRWN FROM THE MARKET. Top  Thu, 2011-10-06 23:19 #5 Anonymous No. 66 / Sibutramine and its formulations for human Hello, Good evening Sibutramine is a centrally-acting serotonin-norepinephrine reuptake inhibitor structurally related to amphetamines. Sibutramine can substantially increase blood pressure and pulse in some patients. In 2010 the FDA noted the concerns that sibutramine increases the risk of heart attacks and strokes in patients with a history of cardiovascular disease. Sibutramine has been associated with increased cardiovascular events and strokes and has been withdrawn from the market in countries and regions including Australia, Canada, China, the European Union, Hong Kong, India, Mexico, Thailand, the UK and the United States. --- Kamal Patel Manipal Top  Thu, 2011-10-06 23:10 #6 Anonymous No. 68 / GATIFLOXACIN Hi, I am Karan Mistry
  8. 8. A Canadian study published in the New England Journal of Medicine in March 2006 claims Tequin {brand name of gatifloxacin} can have "life threatening" side effects including serious diabetes. Other serious side effects reported with gatifloxacin include hallucinations, liver damage and purpura. Union Health and Family Welfare Ministry of India on 18 march 2011 banned the manufacture, sale and distribution of Gatifloxacin as it caused certain adverse side effects Top  Mon, 2011-10-10 00:18 #7 Anonymous its at serial no. 68 68 Top  Thu, 2011-10-06 16:31 #8 Anonymous no. 20 / Nialamide Nialamide is an irreversible and non-selective monoamine oxidase inhibitor Banned May be due to extreme side effects: euphoria, psychomotor agitation, insomnia, anxiety, headache, vertigo, tremor, hyperreflexia, manic state, or turnig a depression into mania in bipolar disorder. Other side effects are arterial hypotension, orthostatic hypotension, arterial hypertension, palpitations, hyperhidrosis, dry mouth, nausea, vomiting, epigastric pain, constipation, vision problems, retrobulbar optic neuritis, polyneuritis, weight gain, acute cardiac insufficiency, tachycardia, peripheral neuropathy, jaundice, hepatomegaly, hyperbilirubinemia, urinary retention, elevated transaminases, cutaneous eruptions, impotence, and delayed ejaculation. Dangerous side effects are drug-induced hepatitis and hepatocellular insufficiency. Top  Thu, 2011-10-06 16:24 #9 Anonymous no.3 / Fixed dose combinations of Atropine in Analgesics..
  9. 9. Anticholinergic agents may delay and/or decrease the gastrointestinal absorption of acetaminophen by reducing gastric motility and delaying gastric emptying. However, the clinical relevance is probably minimal. Top  Thu, 2011-10-06 15:52 #10 Anonymous No . 54 / Analgin Analgin known to cause agranulocytosis , widely used in Indian mmarket.... Top  Thu, 2011-10-06 15:32 #11 Anonymous no-10 / Fixed dose combinations of Penicillin with Sulphonamide Bacterial resistance is the main reason behind banning penicillin and sulphonamide combination. Top  Thu, 2011-10-06 15:25 #12 Anonymous DRUG No. 21 / PRACTOLOL Practolol is selective beta blocker and structurally similar as propanolol but it is banned because of toxic effect. * practolol disaster is considered the worst medical blunders since thalidomide. It may cause oculomucocutaneous syndrome which is a severe syndrome whose signs include conjunctivitis sicca and psoriasiform rashes, otitis and sclerosing serositis. - Rohit Pagare GLOBALLY BANNED MEDICINES STILL USING IN INDIA WHY ? Banned drugs are flourishing through Indian markets lets look some of the banned drugs which is highly used by most of Indians. Some medicines are even prescribed by doctors. Self medication is the other threat among peoples
  10. 10. as just a simple cold or some pain comes most of the affected ones goes to medical stores or nearby pharmacy and purchase some drugs not knowing these simple symptoms are the part of big picture. Lets stop self medication and put a habit of visiting hospital so to make a better healthy habits .let look some of the mostly used drugs in Indian markets and their side effects which after reading should shock most of us. These drugs are banne d globally then why it is selling in India it’s a big irony as authorities should do very stern action against as these medicines usually cause death of the users. Analgin Mostly commonly used as a Pain killer Reason of ban is bone marrow depression Famous brand name novalgin. Cisapride Mostly used for acidity, constipation. Reason for ban is irregular heart beat Some brands like ciza, syspride is commonly used. Phenolphthalein Mainly used as laxative reason for ban is this medicine cause’s cancer Some famous brand name agarol DROPERIDOL: Used mainly as Anti-depressant. Reason for ban: Irregular heartbeat. Brand name: Droperol FURAZOLIDONE: Used as antidiarrhoeal. Reason for ban: Cancer. Brand name: Furoxone, Lomofen NIMESULIDE: Used as Painkiller, fever. Reason for ban: Liver failure. Brand name: Nise, Nimulid NITROFURAZONE: Used mainly as Antibacterial cream. Reason for ban: Cancer. Brand name: Furacin PHENYLPROPANOLAMINE:
  11. 11. Used as Cold and cough. Reason for ban: stroke. Brand name: D'cold, Vicks Action-500 OXYPHENBUTAZONE: Used as Non-steroidal anti-inflammatory drug. Reason for ban: Bone marrow depression. Brand name: Sioril PIPERAZINE: Used as Anti-worms. Reason for ban: Nerve damage. Brand name: Piperazine QUINIODOCHLOR: Used as Anti-diarrhoeal. Reason for ban: Damage to sight. Brand name: Enteroquinol DANGEROUS DRUGS: THESE DRUGS HAVE BEEN GLOBALLY DISCARDED BUT ARE AVAILABLE IN INDIA. The most common ones are D cold, action 500 & Nimulid so if you have any symptoms do not take these medicines and also to do not give your dear and near ones as it may cause serious issues like stroke and even death visit your nearest GP.