Translational Research Informatics Software System
Track all clinical & research data in a hierarchical and relational manner that facilitates secure collaborative data entr...
<ul><li>Patient Data Capture: </li></ul><ul><li>Clinical & demographics info </li></ul><ul><li>Patient’s specimens & deriv...
<ul><li>Specimen Data Capture: </li></ul><ul><li>Physical measurements & desc. </li></ul><ul><li>Current status & conditio...
<ul><li>Calculate aliquots: </li></ul><ul><li>by volume </li></ul><ul><li>by mass </li></ul><ul><li>by concentration </li>...
- Design flexible specimen storage containers - Batch assign & update samples to storage locations - Generate or print fre...
Track specimens and their derivatives’ lineage relationship Associate image files and all other types of flexible, custom-...
Multiple data record updates You can update multiple sample records:  … via Labmatrix’s graphic user interface… …  or thro...
Proprietary & Confidential Define shortcuts to quickly create all expected sample records (and their derivatives) based on...
<ul><li>Create specimen requests </li></ul><ul><li>Change & monitor approval status </li></ul><ul><li>Check & resolve “pul...
Create any data form - tailored to your research
This is a scalable solution that communicates with  all  data sources SOAP tab-delimited text DB SOAP RMI HTTP DB Large Fl...
<ul><li>Now that you have: </li></ul><ul><ul><li>Collected…  (  ) </li></ul></ul><ul><ul><li>Standardized…   (Not yet? Us...
Typical Scientific Data Workflow <ul><li>1. Data Acquisition </li></ul><ul><li>Excel, Access, homebrews </li></ul><ul><li>...
Cryptic DB you’ll never  have easy access to Case Study: Common Problem in Translational Research
The Solution Qiagram : our award-winning “draw-your-question” interface - SQL or programming training NOT required! Just d...
Qiagram: a visual data query tool Example 1: “reporting & operational statistics” data query
Qiagram: a visual data query tool Example 2: hypothesis-driven data exploration
Centralize Data:  web-accessible  system enables multi-site collaboration and data collection, data/site management, data ...
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Labmatrix

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Labmatrix is a software application that manages the operational aspects of collaborative clinical and translational research programs, including patient recruiting, consenting, sample management (biobanking), experimental characterization of the samples and tracking of patient clinical profiles.

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  • Data is the lifeblood of the scientific process. Data is used to prove or disprove hypotheses and to guide decision-making. Its lifespan starts with data generation and ends with achieving concrete insights. There is a step in the middle, however, that is often overlooked: data exploration - the stage of hypothesis generation and decision-making during which the researcher takes a high-level, exploratory view of the available data. Data acquisition --&gt; Data exploration --&gt; Data analysis This data exploration stage is often used to determine the availability of &amp;quot;interesting data&amp;quot; that can be used in further analysis.
  • By removing the barrier of specialized database languages, we enable researchers to directly investigate their data by simply drawing a diagram. This frees up IT to better focus on infrastructure and support operations.
  • Labmatrix

    1. 1. Translational Research Informatics Software System
    2. 2. Track all clinical & research data in a hierarchical and relational manner that facilitates secure collaborative data entry, and easy ad hoc data retrieval. Patient Data Biospecimen Data The Patient and Biospecimen data hubs in Labmatrix Medications Family History Questionnaires Demographics Visits History Pathology Storage Location Gene Expression Proteomics Custody History Etc… Etc…
    3. 3. <ul><li>Patient Data Capture: </li></ul><ul><li>Clinical & demographics info </li></ul><ul><li>Patient’s specimens & derivatives </li></ul><ul><li>Phenotypes & genotypes tracking </li></ul><ul><li>All other customizable study data </li></ul>
    4. 4. <ul><li>Specimen Data Capture: </li></ul><ul><li>Physical measurements & desc. </li></ul><ul><li>Current status & condition </li></ul><ul><li>Storage location & barcodes </li></ul><ul><li>Workflow processing status </li></ul><ul><li>Usage & custody history </li></ul>
    5. 5. <ul><li>Calculate aliquots: </li></ul><ul><li>by volume </li></ul><ul><li>by mass </li></ul><ul><li>by concentration </li></ul><ul><li>by # of slides </li></ul><ul><li>Print barcodes: </li></ul><ul><li>existing labels </li></ul><ul><li>new GUID labels </li></ul>Research BioBank 1B Pathology Sample A597 (text-only label) Specimen Barcoding & Aliquoting
    6. 6. - Design flexible specimen storage containers - Batch assign & update samples to storage locations - Generate or print freezer maps & barcode labels Specimen Storage Management (electronic sample inventories) Freezer Map
    7. 7. Track specimens and their derivatives’ lineage relationship Associate image files and all other types of flexible, custom-defined data for specimens Track Lineage, Images, and Custom-Defined Data
    8. 8. Multiple data record updates You can update multiple sample records: … via Labmatrix’s graphic user interface… … or through Excel and/or other text editors. (Also through our programmatic API)
    9. 9. Proprietary & Confidential Define shortcuts to quickly create all expected sample records (and their derivatives) based on your study’s specific SOPs or workflows “ Specimen Factory”: one-click to generate all samples in your workflow
    10. 10. <ul><li>Create specimen requests </li></ul><ul><li>Change & monitor approval status </li></ul><ul><li>Check & resolve “pull-list” items </li></ul><ul><li>Update & track shipment status </li></ul>Manage sample requests, inventory resolution, and shipments
    11. 11. Create any data form - tailored to your research
    12. 12. This is a scalable solution that communicates with all data sources SOAP tab-delimited text DB SOAP RMI HTTP DB Large Flat Files DB Web Forms, Data Files XML Java Objects .TXT Federation Engine DB DB Many ways to get data into the system: Labmatrix Framework Database ETL Framework Data Transformer Labmatrix Core API Custom Web Services Enterprise System RMI API Enterprise System WEB UI SQL Scripts
    13. 13. <ul><li>Now that you have: </li></ul><ul><ul><li>Collected… (  ) </li></ul></ul><ul><ul><li>Standardized… (Not yet? Use built-in data cleaning tools) </li></ul></ul><ul><ul><li>Normalized… (Not yet? Use built-in formula calculation tools) </li></ul></ul><ul><li>… some, or all of your project data , how do you best make use of them? </li></ul>
    14. 14. Typical Scientific Data Workflow <ul><li>1. Data Acquisition </li></ul><ul><li>Excel, Access, homebrews </li></ul><ul><li>(Electronic?!) forms, notes </li></ul><ul><li>LIMS & instruments output </li></ul><ul><li>Labmatrix forms & records </li></ul><ul><li>Other enterprise resources </li></ul><ul><li>Etc… </li></ul>2. Data Exploration <ul><li>3.Data Analysis </li></ul><ul><li>SAS, R </li></ul><ul><li>Spotfire </li></ul><ul><li>Tableau </li></ul><ul><li>Statisticians </li></ul><ul><li>Etc… </li></ul><ul><li>Easy, graphical queries </li></ul><ul><li>ETL & data cleaning tools </li></ul><ul><li>Formulas & calculations </li></ul><ul><li>Visualize charts & graphs </li></ul>Exploration Ad-hoc Query Relationships Intelligence Decisions Acquisition Analysis Analysis
    15. 15. Cryptic DB you’ll never have easy access to Case Study: Common Problem in Translational Research
    16. 16. The Solution Qiagram : our award-winning “draw-your-question” interface - SQL or programming training NOT required! Just drag & drop, and run your query!
    17. 17. Qiagram: a visual data query tool Example 1: “reporting & operational statistics” data query
    18. 18. Qiagram: a visual data query tool Example 2: hypothesis-driven data exploration
    19. 19. Centralize Data: web-accessible system enables multi-site collaboration and data collection, data/site management, data QA/review/reports, and immediate data querying results; scalable, web browser client-server architecture Encourage Standardization: increase & mandate data quality via standardized (and customizable) data-entry interfaces, standardized vocabularies, and standardized data models Enforce User Roles & Permissions: flexible configurations of how different users/groups/TAs can access specific data sets in collaborative settings Maintain Security & Compliance: transmit data securely, facilitate regulatory compliance, and track all data changes via detailed audit logs in this HIPAA/PHI-compliant system; customizable data backup & recovery plans Integration & Interoperability: multiple interfaces to communicate with other data systems in your IT infrastructure; vocabulary & ontology definitions KEY FRAMEWORK FEATURES

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