Protein 'Passport' Helps Nanoparticles Get Past Immune System & Protein “Filmed” While Unfolding at Atomic Resolution
PROTEIN PASSPORT HELPSNANOPARTICLES GET PAST IMMUNE SYSTEM & PROTEIN “FILMED” WHILE UNFOLDING AT ATOMIC RESOLUTION JUAN ESTEBAN QUIROZ ÁLVAREZ III SEMESTER OF MEDICINE TEACHER: LINA MARIA MARTÍNEZ SÁNCHEZ MOLECULAR BIOLOGY MARCH 04, 2013
STRUCTURAL LEVELS: -Primary structure: Amino line. -Secondary structure: Alpha and B pleated sheet. -Tertiary structure: Alpha and B Togheter. -Quaternary structure: Multiple domains.CHARACTERISTIC:-Affect the properties thatcharacterize living organisms.-Participation in the immunesystem.-Control gene expression.
PROTEIN “PASSPORT” HELPSNANOPARTICLES GET PASTINMUNE SYSTEM. Researchers at the University of Pennsylvania with these proteins discovered how to prevent the body from rejecting medical and therapeutic devices.
PROTEIN “PASSPORT”HELPSNANOPARTICLES GET PAST INMUNE SYSTEM Protein “Passport”: The adaptive immune system does not work -Avoid inflammatory in the same way, in response innate this B and T immune system, lymphocytes because this system produces antibodies, attacks foreign which generates an bodies in general. improved resistance to reinfection and -In this type of does not attack the response body in a general macrophages are way. involved.
PROTEIN “PASSPORT”HELPSNANOPARTICLES GET PAST INMUNE SYSTEM. Macrophages: -Cellular component in innate immune response. -Recognize and destroy the invaders. -The proteins bind to the macrophages… then these proteins bind to the object in the blood called macrophages, if they consider that these proteins have a foreign invader attack him, for this is that these “passport” taunt this recognition to prevent the therapeutic agent is degraded.
PROTEIN “PASSPORT”HELPSNANOPARTICLES GET PAST INMUNE SYSTEM.
PROTEIN “FILMED” WHILE UNFOLDING AT ATOMIC. Scientists in Warsaw and elsewhere have shown in atomic resolutionprotein that is losing its shape all with the goal of showing how and why a protein loses its three-dimensional structure.
PROTEIN “FILMED” WHILE UNFOLDING AT ATOMIC. “The scientists findings may help to gain deeper insights into how proteins assume their spatial structure and why intermediate forms of certain proteins misfold in the event of illness”.
OBSERVATION Most importantly, looking ahead in myopinion is that to know the description of the structure of the protein on various factors such as temperature, pH and others can start making treatments of neurodegenerative diseases likeAlzheimers that is today little that can be done about this. I also believe that with the development of know proteins can look at the molecular processes which can prevent the folding of proteins in disease.
MEDICAL UTILITYPROTEIN “PASSPORT” HELPS NANOPARTICLES GET PAST INMUNE SYSTEM.
MEDICAL UTILITYPROTEIN “PASSPORT” HELPS NANOPARTICLES GET PAST INMUNE SYSTEM. Creation of nanoparticles whichmay be joined to a wide range of vehicles for drug delivery, utilization of these in multiple experimentssuch as the inhibitionof macrophages. Turn on the selection of cancerous cells or diseased tissues.
MEDICAL UTILITY PROTEIN “FILMED” WHILE UNFOLDING AT ATOMIC. With the discovery of the structures of proteins can perform a treatment early to prevent these to fold and form clusters that cause central nervous system diseases, then this knowledge can develop and administer medication to avoid these folds, this help to reduce global mortality, as well as this study was done in bacteria can implement measures to counter bacterial infections especially in places that need greater security against these pathogens such as hospitals.
MEDICAL UTILITYPROTEIN “FILMED” WHILE UNFOLDING AT ATOMIC.
BIBLIOGRAPHYMartínez Sánchez, Lina Maria; “Biología Molecular”; 7 edition; Upb medical faculty. Protein Passport Helps Nanoparticles Get Past Immune System. Science Daily. Feb.21,2013.Protein Filmed While Unfolding at Atomic Resolution. Science Daily. Feb.11,2013.