Image Processing (I)

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CURSO:
Genómica aplicada a la Medicina Clínica
BIOINFORMÁTICA Y NANOMEDICINA

Barcelona
24/11/2010

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Image Processing (I)

  1. 1. Image Processing (I) José Ramón Macías
  2. 2. Genome Replication
  3. 3. Transcription
  4. 4. Translation
  5. 5. Signal Transduction
  6. 6. Protein Folding
  7. 7. Viral Infection
  8. 8. Motility
  9. 9. Cellular Components
  10. 10. researchers use models from structural studies to explain the functions and mechanisms of biological processes at the molecular level
  11. 11. many key biological processes are carried out by large macromolecular complexes acting as nanomachines
  12. 12. 15m 15x10-9m
  13. 13. Image Processing
  14. 14. 3D Electron Microscopy
  15. 15. Top Side Bottom
  16. 16.          N i K k i dkPkXPL 1 1 )|,(,,|log|  X                K k nn i nn in i dkPkXP kPkXP XkP 1' ' )()( )()( )( '|',',','| |,,,| ,|,             0 ,|, ,|, ,|, 1 2 1 )( 1 )( )1( 1 )(               K k N i n i N i i n i n k N i n i dXkP dXXkP VRdXkP                     N i n i N i i n i n k dXkP dXXkP A 1 )( 1 )( )1( ,|, ,|,                         2 2 2 exp 2 1 ,,|     ik M i XA kXP
  17. 17. 91,114 particles (resolution: 9.9 Å)
  18. 18. 22,176 27,416 25,651 15,871 91,114 particles
  19. 19. 64 CPU’s : 3 days1 CPU: 6 months
  20. 20. Storage
  21. 21. E M D B lectron icroscopy ata ank
  22. 22. 10 40 67 117 193 266 363 720 931 2002 2003 2004 2005 2006 2007 2008 2009 2010 since June 2002, the number of structures has increased steadily. “ ”
  23. 23. Single Particle Icosahedral Helical Individual Structure 2D Crystal Today: 931 map volume entries
  24. 24. Competitors
  25. 25. X-Ray Crystallography Requires Crystals High Resolution  3D Electron Microscopy Medium Resolution  Crystals Not required Hybrid Models Fitting
  26. 26. 3D-EM model Atomic model
  27. 27. Hybrid model
  28. 28. Hybrid model 3D-EM model Atomic model
  29. 29. Data Integration
  30. 30. http://biocomp.cnb.csic.es/das/PeppeR DASx3DEM & PeppeR VisualOmics

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