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This presentation summarizes the achievemente of electronic prescription in Andalusia and its contribution to improve therapeutic adherence in patients with chronic conditions. The Public Healthcare Service of Andalusia has developed a long-term strategy about e-health called "Diraya". All the citizens of Andalusia have a single electronic health record, available at primary care centres, hospitals, pharmacy offices or emergency units. The system has a prescription module. Last year 121 million of electronic prescriptions were done in Andalusia. The system allows to saving costs in many ways: avoiding mistakes and duplications, facilitating the use of international non proprietary name (INN), reducing the number of consultations in primary care, and many other. Accumulated, every 100 euros invested, the system recovers 212 euros. This module and its decision support system may allow to identify patients with potential non-compliance behaviour by checking the treatment prescribed for a single drug and the withdrawal of boxes of this drug at the pharmacy offices. This approach should be complemented by other actions and tools, such as mems apps designed for smartphones and tablets; patient education, phone surveillance, and others.