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Drug Innovation 2.0 (Slides)


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Drug Innovation 2.0 – Why we Need Knowledge Metrics for Democratic Action

In this presentation we share three current challenges for innovation in drug design. 1) Group dynamics – Scientific collaboration typically occurs through networks. Inefficient collaboration and networking can lead to tunnel vision; innovation opportunities through more distant networks may be overlooked. Knowledge metrics can encourage new and productive networks, by appropriately rewarding contributing network members. 2) Information overload – Information and knowledge are not the same thing. We have too much (unstructured) information and we lack the time required to structure this information into knowledge. Knowledge metrics can encourage the ranking, structuring, and accessing of information on a reward-per-use basis. 3) Data silos – Data silos caused by technical or license hurdles, can reduce the number of efficient collaboration options. Knowledge metrics should clearly reward barrier-breaking and silo-bridging efforts, and favor new and diverse over redundant information…Drug designers, lawyers and computer scientists have a unique opportunity to take on these challenges – drug innovation 2.0!

Published in: Health & Medicine, Education

Drug Innovation 2.0 (Slides)

  1. 1. Drug Innovation 2.0Why we Need Knowledge Metrics for Democratic Action<br />Joerg Kurt Wegner<br />2009<br />Tibotec<br />
  2. 2. J.K. Wegner, 2009, Tibotec<br />information<br />You<br />We want to innovate with novel information<br />
  3. 3. J.K. Wegner, 2009, Tibotec<br />Innovate with … … knowledge = people + information<br />people + information<br />You<br />knowledge you need, but do not have, yet !<br />
  4. 4. J.K. Wegner, 2009, Tibotec<br />For getting knowledge (=people+information) you needknowledge = people + informationEnable this by collaborating with your peers !<br />information<br />people<br />Friend of a Friend<br />You<br />TopicGuru<br />
  5. 5. Use metrics for improving your peer collaboration<br />J.K. Wegner, 2009, Tibotec<br />Knowledge(=people+information) creation cycle<br />
  6. 6. Peers are the metric ! Embrace and use “web 2.0” !<br />J.K. Wegner, 2009, Tibotec<br />Content<br />Filter<br />
  7. 7. Drug Innovation 2.0 challenges<br />Negative group dynamics<br />Information overload<br />Data silos<br />J.K. Wegner, 2009, Tibotec<br />
  8. 8. People are scared ?Use a contribution revision for helping people<br />Ensure compliance<br />Educate contributors<br />J.K. Wegner, 2009, Tibotec<br />§<br />
  9. 9. Are we hiding knowledge (=people+information)?Create knowledge and measure progress!<br />After information makes sense do not hide it in a silo, e.g. eMail<br /> Share content - Three paragraph text <br /> Filter/organize - Hard to find information<br /> Compete – Make contributions transparent<br />J.K. Wegner, 2009, Tibotec<br />
  10. 10. Improve knowledge(people+information) collaboration<br />Stop shouting from skyscrapers,<br />allow “people-centric” feedback.<br />Ensure there is a driving oligarchy, <br />e.g. people with “knowledge sharing” as <br />job objective.<br />J.K. Wegner, 2009, Tibotec<br />
  11. 11. Drug Innovation 2.0 challenges<br />Negative group dynamics<br /><ul><li> Peer cycles are creating innovative knowledge
  12. 12. Support people with revisioning
  13. 13. Improve your knowledge(=people+information) creation factor
  14. 14. Knowledge collaboration must be measured and improved</li></ul>Information overload<br />Data silos<br />J.K. Wegner, 2009, Tibotec<br />
  15. 15. The knowledge gap is increasing,caused by information overload !<br />information<br />knowledge<br />gap<br />Articles<br />knowledge<br />Year<br />J.K. Wegner, 2009, Tibotec<br />source: NCBI PubMed<br />
  16. 16. Information overloadand a knowledgegapare a majorrisk<br />41% / day managing e-mail<br />25% / day finding information<br />This costs ~$900 billion per year in <br />lowered employee productivity and <br />reduced innovation.  <br />J.K. Wegner, 2009, Tibotec<br />
  17. 17. Knowledge workers have too much information, do too little sharing. Stop this ! Leverage !<br />Keeping nothing does not cost anything?<br />But you can not control what you do not know!<br />Keeping is a challenge, but leveraging helps. <br />Which metric helps you optimize?<br />J.K. Wegner, 2009, Tibotec<br />
  18. 18. Drug Innovation 2.0 challenges<br />Negative group dynamics<br />Information overload<br /><ul><li> Too much information/work for a single person
  19. 19. Leverage knowledge collaborations by measuring and improving knowledge(=people+information) growth </li></ul>Data silos<br />J.K. Wegner, 2009, Tibotec<br />
  20. 20. Aspirin was found as drug in 1899. At that time, the puzzle was simple.<br />J.K. Wegner, 2009, Tibotec<br />
  21. 21. Today, information is spread over growing silos.Drug puzzles are complex, collaboration is key!<br />Regulations<br />-OMICS<br />x5from 100k <br />to 500k<br />Last 10 years<br />Patients<br />Literature<br />x1.6from 500k <br />to 800k<br />Last 10 years<br />J.K. Wegner, 2009, Tibotec<br />
  22. 22. Defragmenting data silos is key foraccelerating research<br />Standardization, e.g. for Biobanking data<br /> People must be able to accesspeople silos<br /><ul><li>e.g. Twitter</li></ul> Integration<br />J.K. Wegner, 2009, Tibotec<br />
  23. 23. Legal barriers to data silos ? Get over it, we need to build bridges !<br />Private-Public <br />partnership<br />J.K. Wegner, 2009, Tibotec<br />
  24. 24. Drug Innovation 2.0 challenges<br />Negative group dynamics<br />Information overload<br />Data silos<br /><ul><li> Not using knowledge, does not help patients !
  25. 25. Build legal data silo bridges for knowledge(people+information)
  26. 26. Measure and improve silo bridging efforts (defragmentation)</li></ul>J.K. Wegner, 2009, Tibotec<br />
  27. 27. Drug Innovation 2.0 – Measure and improve !knowledge = people + information<br />Negative group dynamics<br />Encourage people by measuring efficiency and helping them to learn, to compete, to share, and to build trust.<br />Information overload<br />Not keeping is easy! <br />Keeping is a challenge, but crowd-sourcing, “people-need”, and “people-centric” solutions can create knowledge networks.<br />Data silos<br />There are many challenges: standardization, semantics, security, integration, and legal aspects. <br />Helping patients requires building silo bridges !<br />J.K. Wegner, 2009, Tibotec<br />