Humanity needs a science of intentional cultural change. The only way for us to arrive at a thriving planetary future is through a deliberate, well-designed, collective process. Otherwise the 7.4 billion of us alive today (and our descendants) will not successfully navigate the complexities of 21st Century globalization. The mission of the Culture Design Lab is to monitor, analyze, and design effective patterns of cultural change—using the rigor of academic research to change the trajectory of the real world in practical terms. Accomplishing this will require a collaborative network of researchers and design practitioners helping guide humanity through the paradigm shift that is needed for our collective survival. Humanity is now confronted with a set of wicked problems that are complex interdependent, and global. Examples include human-caused climate change, ocean acidification, resource wars, the breakdown of ecosystems, mass migrations, the rise or fascism, failed nation states, massive wealth inequality, global poverty, and the corrupting influences of money in politics, to name a few. With an exploding population, rising demand, depleted supply, and a political-economic imperative to make profit for a few off the labor of the many we are on a path toward global overshoot-and-collapse. This means the end of everything we value for ourselves, our communities, and all future generations. We must do better.