Trainee-led Surgical Research        Collaboratives The West Midlands Research Collaborative               experience
The WMRC• Background - why we formed• Aims• Why it works
Project                          Methodology                           & design            Data                           ...
Getting it off the Ground• Enthusiastic Trainees• Senior Support and guidance• Consultant trainer support• Trials Unit(s)•...
Running the WMRC• Regular meetings as a group• Formation of a management committee• Communication      • www.wmresearch.co...
How to set up a collaborativeFormation of a committee   Network Development   Trial Development   Overall organisation...
Committee     Trial 1              Trial 2              Trial 3Chief Investigator   Chief Investigator   Chief Investigato...
How to set up a collaborativeMonthly group meeting    Discuss existing trials    New project presentations and discussi...
Current Research Portfolio3 RCTs           Cohort studies  ROSSINI         CANOES                   CHARMS  DREAMS  ...
Current Progress• Around 45 trainees have GCP accreditation and are  randomising to ROSSINI• Many more (junior) trainees a...
ROSSINI Trial    Reduction Of Surgical Site Infection       using a Novel Intervention A multicentre, prospective randomis...
ROSSINI Trial• Primary Hypothesis:  Use of a wound-edge protection device in  adults undergoing laparotomy will result in ...
Inclusion/Exclusion Criteria• Inclusion criteria  – Any laparotomy  – Any Incision (eg midline, transverse, Kocher’s etc) ...
ROSSINI – ProcessPATIENT       CONSENT        OPERATION          FOLLOW UP A     FOLLOW UP BLISTED              Consent fo...
ROSSINI sites (West Mids)• University Hospital           • University Hospital Coventry  Birmingham                      a...
ROSSINI sites (National)• Royal Derby Hospital     •   St Marks, London• Wrightington,Wigan and   •   Stepping Hill, Stock...
ROSSINI recruitment at 31st March 2011                                               900                                  ...
Spreading the word• RCS support• SARS / ASGBI support• Presentations at ASIT, ASGBI, SARS, ACPGBI• Networking with other g...
Future DevelopmentLSRGSPARCSLeeds groupNational cardiothoracic research collaborative
Contact usWMRC Website:http://www.wmresearch.org.ukE mail committee members:committee@wmresearch.co.uk
Dexamethasone Reduces EmesisAfter Major Gastrointestinal Surgery
TRIAL DESIGN AND PATHWAY• Phase  3, prospective, double-  blind, multicentre, RCT.• Consecutive  unobstructed patients  un...
WHAT YOU NEED TO DO TO           COLLABORATE• Further information at: wmresearch.org.uk• E-mail: dreams@wmresearch.co.uk
The West Midlands Research Collaborative
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The West Midlands Research Collaborative

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Talk given at the Dukes' Club AGM 2011

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  • FIRST PROSPECTIVE, RCT!
  • The West Midlands Research Collaborative

    1. 1. Trainee-led Surgical Research Collaboratives The West Midlands Research Collaborative experience
    2. 2. The WMRC• Background - why we formed• Aims• Why it works
    3. 3. Project Methodology & design Data Collection Team leading & analysis & working Write papers PatientsEnhance CV Trainee Publications Multicentre& Presentations Benefits of Trials Research Transferable Collaborative skills Quality of Research More clinical Region Better surgical trials recruitment
    4. 4. Getting it off the Ground• Enthusiastic Trainees• Senior Support and guidance• Consultant trainer support• Trials Unit(s)• National Support
    5. 5. Running the WMRC• Regular meetings as a group• Formation of a management committee• Communication • www.wmresearch.co.uk • Forums • E-mail
    6. 6. How to set up a collaborativeFormation of a committee  Network Development  Trial Development  Overall organisationCommittee members:  Chairperson  Secretary  Webmaster  A junior surgical liaison  Treasurer  New study manager  Chief Investigator of each study
    7. 7. Committee Trial 1 Trial 2 Trial 3Chief Investigator Chief Investigator Chief Investigator Working Working Working group group group Local Local Local investigators investigators investigators
    8. 8. How to set up a collaborativeMonthly group meeting  Discuss existing trials  New project presentations and discussions  Educational talks Cancer Intelligence Unit Trials Unit Clinical  Journal club Individual trials meetings
    9. 9. Current Research Portfolio3 RCTs  Cohort studies ROSSINI  CANOES  CHARMS DREAMS  ABPI PHAROES  Multicentre Audit  Pancreatitis Study  Qualitative research
    10. 10. Current Progress• Around 45 trainees have GCP accreditation and are randomising to ROSSINI• Many more (junior) trainees are involved in our trials• £232,000 NIHR RfPB grant for ROSSINI• £131,000 BDRF grant for DREAMS• £150,000 company sponsorship for PHAROES• Presentations/Papers• National Meetings
    11. 11. ROSSINI Trial Reduction Of Surgical Site Infection using a Novel Intervention A multicentre, prospective randomised controlled trial of awound-edge protection device to reduce surgical site infection
    12. 12. ROSSINI Trial• Primary Hypothesis: Use of a wound-edge protection device in adults undergoing laparotomy will result in a reduced rate of surgical site infection (SSI) at 30 days.
    13. 13. Inclusion/Exclusion Criteria• Inclusion criteria – Any laparotomy – Any Incision (eg midline, transverse, Kocher’s etc) – Emergency or Elective• Exclusion criteria – Unable to consent – Laparoscopic assisted cases – Previous laparotomy within last 3 months
    14. 14. ROSSINI – ProcessPATIENT CONSENT OPERATION FOLLOW UP A FOLLOW UP BLISTED Consent form Randomised in Day 5-7 wound Day 30-33 woundPatient completed theatre (50:50) review reviewInformationSheet given CRF 1 CRF 2 CRF 3 CRF 4+5 EUROQOL EQ-5D RESOURCE USE Completed at end CRF 6
    15. 15. ROSSINI sites (West Mids)• University Hospital • University Hospital Coventry Birmingham and Warwickshire• Russells Hall Hospital • Royal Shrewsbury Hospital• Walsall Manor Hospital • Princess Royal Hospital Telford• City and Sandwell Hospitals • Hereford County Hospital• Heartlands and Good Hope • Worcester Royal Hospital Hospitals • George Elliot Hospital,• Warwick Hospital Nuneaton• University Hospital North Staffordshire• New Cross Hospital Wolverhampton
    16. 16. ROSSINI sites (National)• Royal Derby Hospital • St Marks, London• Wrightington,Wigan and • Stepping Hill, Stockport Leigh • Bolton• Derriford Hospital, • The Christie, Manchester Plymouth • Wrexham• Hope Hospital, Salford • Glan Clwyd• Royal Devon and Exeter Hospital • Manchester Royal Infirmary• Medway • Yeovil• Maidstone + Tunbridge Wells• The Homerton, London
    17. 17. ROSSINI recruitment at 31st March 2011 900 20 800 18 16 700 Patients recruited 14 600 Sites open 12 500 10 400 8 300 6 200 4 100 2 0 0 Mar-10 May-10 Jul-10 Sep-10 Nov-10 Jan-11 Mar-11 May-11 Jul-11 Sep-11 Nov-11 Jan-12 Mar-12 Apr-10 Jun-10 Aug-10 Oct-10 Dec-10 Feb-11 Apr-11 Jun-11 Aug-11 Oct-11 Dec-11 Feb-12Predicted sites open 0 1 1 2 3 4 5 6 7 9 10 12 13 15 16 18 18 18 19 19 19 19 19 19 19Actual sites open 1 1 1 2 3 5 9 12 12 13 15 17Actual sites recruiting 1 1 1 2 3 4 7 8 9 10 13 13Minimum cumulative recruitment 0 3 6 11 19 30 44 60 78 102 129 161 195 235 277 324 371 418 468 517 567 616 665 715 764 (750)Actual cumulative recruitment 12 17 21 26 44 51 69 82 109 117 157 201 261
    18. 18. Spreading the word• RCS support• SARS / ASGBI support• Presentations at ASIT, ASGBI, SARS, ACPGBI• Networking with other groups of trainees• London / Trent / Southampton / Bristol / Leeds
    19. 19. Future DevelopmentLSRGSPARCSLeeds groupNational cardiothoracic research collaborative
    20. 20. Contact usWMRC Website:http://www.wmresearch.org.ukE mail committee members:committee@wmresearch.co.uk
    21. 21. Dexamethasone Reduces EmesisAfter Major Gastrointestinal Surgery
    22. 22. TRIAL DESIGN AND PATHWAY• Phase 3, prospective, double- blind, multicentre, RCT.• Consecutive unobstructed patients undergoing colorectal surgery (inside and outside of ERAS).• Randomised 1:1
    23. 23. WHAT YOU NEED TO DO TO COLLABORATE• Further information at: wmresearch.org.uk• E-mail: dreams@wmresearch.co.uk

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