I am now certain my opinion the three major obstacles to our continued success are reagents
“I am now certain… my opinion the three major obstacles to our continued success arereagents, reagents, and reagents. We must find ways to combat the chilling territorialityof reagent control, because putting together and testing the necessary ingredients for theconstruction of effective vaccines requires crossing all sorts of impenetrable IP andcommercial boundaries.”~Dr. Lloyd J. Old, M.D.~Ludwig Institute for Cancer ResearchThe Cancer Vaccine Collaborative (CVC)We need as a country, in a worldwide collaborative effort to come together and solve thiscancer problem.
The Cancer Vaccine Collaborative (CVC) is a great example on how to approach thisissue. They have setup a structure that is the envy of the medical/research community.They are working with the brightest minds to come up with the right combinatorialprotocol to increase the response rates. Without the cooperation of Big Pharma and theFDA the cure may end up sitting on a shelf of a Drug company or buried in researchpaper. The cure won’t be a mono agent in my opinion; it will be a combination of drugsand or with a vaccine. I believe the hardest part of this therapy is coming up with a wayto shed the right Tumor-specific Antigen for each and every cancer patient. Theresearcher has to come up with the multivalent vaccines, or have a protocol that generatesa self-induced vaccination. This is what has happened to me. But once vaccinated, thecancer patient is going to need help to break the tolerance of the Tregs. This can beapproached in a number of ways. • Anti-CTLA-4 • Anti-PD-1 • Addition of IL-21 • Treg depletion