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Dta use in preformulation study copy

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Dta use in preformulation study copy

  1. 1. GUIDED BY: PRESENTED BY:Dr.R.K.Parikh AHALGAMA JIGNESH VDEPARTMENT OF PHARMACEUTICS ANDPHARMACEUTICAL TECHNOLOGY M.Pharm -1 (2011-12)L.M.COLLEGE OF PHARMACY Roll no :- 09AHMEDABAD-380009
  2. 2.  Thermal analysis Classification of thermal analysis Differential thermal analysis(DTA) Principle InstrumentationAdvantage and Disadvantage Application References Ahalgama Jignesh V. , M-Pharm-1(paper code- 2/25 910102), DTA,LMCP,GTU(2011-12))
  3. 3.  Thermal analysis incorporates those techniques inwhich some physical parameter of the system is derivedand/or recorded as a function of temperature. Matter is heated it undergoes physical and chemicalchanges occur. physical change: melting or boiling ,weight loss,gasevolution. chemical change:decomposition or reaction take place. Ahalgama Jignesh V. , M-Pharm-1(paper code- 910102), DTA,LMCP,GTU(2011-12)) 3/25
  4. 4. Sr no Technique Parameter Instrument Graph measured used1 Thermogravimetry mass thermobalance Mass vs. temp or time2 Derivative dm/dt thermobalance dm/dt vs. thermogravimetry temp.3 Differential thermal Delta T DTA apparatus Delta T vs. analysis temp.4 Differential dH.dt calorimeter dh/dt vs. scanning temp. calorimetry5 Thermometric temperature calorimeter Temp vs. titrimetry titrant volume (Cont…..) Ahalgama Jignesh V. , M-Pharm-1(paper code- 4/25 910102), DTA,LMCP,GTU(2011-12))
  5. 5. 6 Dynamic Reflectance Spectrophot % Reflectance ometer reflectance spectroscopy and temp7 Evolved gas Thermal Thermal T.C vs. detection conductivity conductivity temp. cell8 Thermo Volume or dilatometer Volume or mechanical length length vs. analysis temp.9 Electrical Current or electrometer I or R vs. conductivity resistance temp.10 Emanation Radioactivity ETA E vs. temp. thermal apparatus analysis Ahalgama Jignesh V. , M-Pharm-1(paper code- 910102), DTA,LMCP,GTU(2011-12)) 5/25
  6. 6.  Combination with thermogravimetry 1)for better interpretation a) TG DTA b) TG DSC 2)for identification of gas involved in thermal analysis a) TG MS b) TG GC MSAhalgama Jignesh V. , M-Pharm-1(paper code- 6/25910102), DTA,LMCP,GTU(2011-12))
  7. 7. TG/DTA Simultaneous Measuring InstrumentSimultaneousTG/DTAimproves easeof operation,sensitivity andanalyticalaccuracy . Ahalgama Jignesh V. , M-Pharm-1(paper code- 910102), DTA,LMCP,GTU(2011-12)) 7/25
  8. 8. Principle:A technique in which the temperature differencebetween a substance and a reference(Al2o3) materialis measured as a function of temperature while thesubstance and reference are subjected to a controlledtemperature program. endothermic and exothermic peak. endothermic and exothermic reaction.Ahalgama Jignesh V. , M-Pharm-1(paper code-910102), DTA,LMCP,GTU(2011-12)) 8/25
  9. 9. Δ T vs. temperature ΔT Temp.Ahalgama Jignesh V. , M-Pharm-1(paper code- 9/25910102), DTA,LMCP,GTU(2011-12))
  10. 10. Ahalgama Jignesh V. , M-Pharm-1(Pharmaceutical technology & Pharmaceutics, 10/25DTA,LMCP(2011-12))
  11. 11. a) METALIC : nickel,stainless steel,platinum sharp endothermic peak.a) NON METALIC : glass,silica,sintered alumina sharp exothermic peak. For heating the sample.Material used wire or ribbon wound on refrectorytube. Ahalgama Jignesh V. , M-Pharm-1(paper code- 11/25 910102), DTA,LMCP,GTU(2011-12))
  12. 12. 1) SENSOR 2) CONTROL ELEMENT 3) HEATERAhalgama Jignesh V. , M-Pharm-1(paper code- 12/25910102), DTA,LMCP,GTU(2011-12))
  13. 13. 1) DEFLECTION TYPE: Recording pen is moved directly by the input signal.2) NULL TYPE: Input signal is compared with a reference or standard signal and difference is amplified. Ahalgama Jignesh V. , M-Pharm-1(paper code- 13/25 910102), DTA,LMCP,GTU(2011-12))
  14. 14. Ahalgama Jignesh V. , M-Pharm-1(paper code- 14/25910102), DTA,LMCP,GTU(2011-12))
  15. 15. High resolution and a robust easy to use.  Less satisfactory than dsc with regard to resolution of thermal traces and quantitative data.  Unable to measure the energy associated with each event.Ahalgama Jignesh V. , M-Pharm-1(paper code-910102), DTA,LMCP,GTU(2011-12)) 15/25
  16. 16. 1) Identification of substance: DTA curve of two substance is not identical.2) Identification of product:substance is react with another substance product is identified by their specific DTA curve.3) Melting point: It is an endothermic process in which heat is absorbed by analyte.4) Detection of impurity curves could be compared with the curve of referencestandard. Ahalgama Jignesh V. , M-Pharm-1(paper code- 16/25 910102), DTA,LMCP,GTU(2011-12))
  17. 17. 5) Studying and characterizing polymersThermochimica acta ,vol,4,Aug-1972,page-249-255. thermal transition for a polymer often take place over a extended temp. range because even a pure polymer is a mixture of homologues and not a single chemical. species. Ahalgama Jignesh V. , M-Pharm-1(paper code- 17/25 910102), DTA,LMCP,GTU(2011-12))
  18. 18. 6) Detection of eutectic mixture: binary mixture :two endotherm eutectic mixture : single major endotherm.7) generation of phase diagram andphase transitions In which the peak at 113 c corresponds to the solid phase change from the rhombic to monoclinic form.the peak at 124 c corresponds to the melting point of the element. The peak at 446 c corresponds to the boiling point of sulfur. Ahalgama Jignesh V. , M-Pharm-1(paper code- 18/25 910102), DTA,LMCP,GTU(2011-12))
  19. 19. Ahalgama Jignesh V. , M-Pharm-1(paper code- 19/25910102), DTA,LMCP,GTU(2011-12))
  20. 20. 8) Application of DTA to compatibility and stability problems in penicillin –stearic acid mixturejournal of pharmaceutical science,vol-5,page 631-633,may-1969 Identify stearic acid as the inactivating component in unstable formulation containing sodium dicloxacin and other excipients. Stearic acid + k.penicilin=incompatible Stearic acid+ sodium dicloxacin =incompatible Stearic acid+ ampicilin trihydrates=compatible Ahalgama Jignesh V. , M-Pharm-1(paper code- 20/25 910102), DTA,LMCP,GTU(2011-12))
  21. 21. (9) Comparative physical-chemical charecterization of encapsulated lipid based ISOTRETINOIN product by thermal behavior analysisThermochimica acta 505 ,(2010),73-78. Use in nodular acne. Study the three encapsulated product (1 reference and 2 generic). measure thermal behavior of that product no specific change and more thermostable than isotretinoin. Ahalgama Jignesh V. , M-Pharm-1(paper code- 21/25 910102), DTA,LMCP,GTU(2011-12))
  22. 22. (10) Physiochemical charecterization of edaravonewith hydroxy propyl –B-cyclodextrin.carbohydrate polymer 83(2011),1101-1105. novel free radical scavenger. that preparation for the improve solubility and stability. inclusion complex charecterized by DTA-TG method. inclusion complex more stable than edaravone. Ahalgama Jignesh V. , M-Pharm-1(paper code- 22/25 910102), DTA,LMCP,GTU(2011-12))
  23. 23. Remington’s Pharmaceutical Science,21st edition,2005. Theory and Practice of Industrial Pharmacy by Lachman &Lieberman,third edition. Physical pharmacy, Alfred martin, fourth edition The Science of Dosage form Design M.E Aulton Thermochimica acta ,vol,4,Aug-1972,page-249-255. journal of pharmaceutical science,vol-5,page 631-633,may-1969. Thermochimica acta 505 ,(2010),73-78. carbohydrate polymer 83(2011),1101-1105. Ahalgama Jignesh V. , M-Pharm-1(paper code- 23/25 910102), DTA,LMCP,GTU(2011-12))
  24. 24. Principle and Instrumental analysis, skoog-hollar-nieman, 5th editio.Chemical Abstract vol:146, No:25,June 18 :2007,507180Instrumental methods of chemical analysis,gurdeep r.chatwal,2008. www.linseis.net www.nd.eduwww.shimadzu.lacerta-technology.comwww.wikipedia.com www.ijpsonline.com/article.asp Encyclopedia of pharmaceutical Technology ,Swarbrick & Boylan vol-06 Encyclopedia of pharmaceutical Technology ,Swarbrick & Boylan vol-02 Ahalgama Jignesh V. , M-Pharm-1(paper code- 24/25 910102), DTA,LMCP,GTU(2011-12))
  25. 25. Ahalgama Jignesh V. , M-Pharm-1(paper code- 25/25910102), DTA,LMCP,GTU(2011-12))

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