MENOPAUSE  and   VOIDING TROUBLES   Prof . Abdel karim M. El Hemaly  MRCOG- FRCS
The most common voiding  troubles in  menopausal  women are <ul><li>Increased  frequency   of  micturition.   </li></ul><u...
<ul><li>Less common voiding troubles </li></ul><ul><li>True incontinence : from genitourinary  fistula, resulting from mal...
Menopause Marked drop of  ovarian steroid hormones.   Cumulative effects of trauma from previous childbirth.   Increased t...
Menopause <ul><li>Marked drop of ovarian steroid hormones   will lead to: </li></ul><ul><ul><li>loss of urogenital trophic...
<ul><li>Estrogen deficiency  will lead to  drop in the levels of:  </li></ul><ul><li>Serotonin.  </li></ul><ul><li>Neuro-p...
Menopause Weakness  of the  internal Urethral sphincter Voiding  troubles Cumulative effects from previous childbirth trau...
Recently,  In 1996 we put forward  a new concept, based on evidence  explaining the act of micturition and urinary contine...
Micturition  can be divided into 2 stages: Stage-I :   in Infancy before training of micturition. Stage-II :   in childhoo...
Micturition  <ul><li>Stage-II   : the mother starts to train her infant at the age of 18-24 months  how to control micturi...
Urinary continence depends on <ul><li>1- An acquired behavior gained by learning in early childhood  to keep  a high alpha...
The structure of the internal urethral sphincter  <ul><li>It is mainly  a cylinder  composed of  compact collagenous tissu...
NORMAL INTERNAL URETHRAL SPHINCTER 3-D.  ULTRASONOGRAPHY U.B. U.B. Closed urethra due to a strong, intact int. u.  sphincter
Closed lumen  Intact wall, compact sheet of collagenous tissue with muscle fibers lie on and intermingle with the collagen...
 
Urethra Vagina Urethral lumen Collag. tissue cylinder Muscle layer MRI picture of a normal continent woman
U.B.  Post. Wall of internal urethral sphincter. Uterus Vagina MRI picture of a normal continent woman
<ul><li>Collagen  is  the  most  abundant  protein  in  humans. </li></ul><ul><li>Collagen  fibers  are  usually  found in...
<ul><li>Many  different  types  of  collagen  are  identified  on  the  basis  of  their  molecular  structure. </li></ul>...
<ul><li>In old  age, the  amount  of  intervening  mucopolysacharide decrease.   </li></ul><ul><li>Also  aging, with/ or w...
<ul><li>Important sites of collagen atrophy after menopause: </li></ul><ul><li>-  bone     osteoporosis </li></ul><ul><li>...
<ul><li>Collagen atrophy + mucosal thinning will lead to : </li></ul><ul><ul><li>Frequency </li></ul></ul><ul><ul><li>Dysu...
<ul><li>Weakness of the int. urethral sphincter will lead to:   </li></ul><ul><ul><li>DI, overactive bladder , Urge and Ur...
 
SUI, DI, and  mixed  incontinence are sequel of  a torn weak internal urethral sphincter.   <ul><li>So, we innovated a new...
 
References <ul><li>El Hemaly AKMA, Mousa LA. Micturition and Urinary Continence. Int J Gynecol Obstet 1996:42, 291-2.  </l...
<ul><li>Authors   </li></ul><ul><li>Abdel Karim M. El Hemaly*, Ibrahim M.Kandil, and Bahaa E. El Mohamady M. </li></ul><ul...
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Voiding Troubles

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Voiding Troubles

  1. 1. MENOPAUSE and VOIDING TROUBLES Prof . Abdel karim M. El Hemaly MRCOG- FRCS
  2. 2. The most common voiding troubles in menopausal women are <ul><li>Increased frequency of micturition. </li></ul><ul><li>Polyuria: undiagnosed, uncontrolled diabetes M. </li></ul><ul><li>Dysuria. </li></ul><ul><li>Urgency and urgency incontinence . </li></ul><ul><li>Stress urinary incontinence. </li></ul><ul><li>Mixed type of incontinence. </li></ul>
  3. 3. <ul><li>Less common voiding troubles </li></ul><ul><li>True incontinence : from genitourinary fistula, resulting from malignancy and/or operative trauma. </li></ul><ul><li>Urine retension and retention with overflow resulting from neurologic disease, drugs, pelvic surgery and incarcerated ovarian cyst. </li></ul><ul><li>Haematuria : infection, stone, neoplasm. </li></ul>
  4. 4. Menopause Marked drop of ovarian steroid hormones. Cumulative effects of trauma from previous childbirth. Increased total body weight Diabetes Mellitus and other metabolic disorders Hypertension General conditions e.g.
  5. 5. Menopause <ul><li>Marked drop of ovarian steroid hormones will lead to: </li></ul><ul><ul><li>loss of urogenital trophic support. </li></ul></ul><ul><ul><li>atrophy of urogenital tract. </li></ul></ul><ul><ul><li>atrophy of collagenous tissue of the internal urethral sphincter leading to its weakness </li></ul></ul><ul><ul><li>atrophy of urothelium, this will increase the chance of infection leading to more persistent, recurrent or chronic infection </li></ul></ul>
  6. 6. <ul><li>Estrogen deficiency will lead to drop in the levels of: </li></ul><ul><li>Serotonin. </li></ul><ul><li>Neuro-peptides. </li></ul><ul><li>Nor-epinephrine. </li></ul>Menopause changes in the mood, and Behavior Decrease of the tone of the int, ureth, sphincter.
  7. 7. Menopause Weakness of the internal Urethral sphincter Voiding troubles Cumulative effects from previous childbirth trauma Marked drop of ovarian Steroid hormones infection
  8. 8. Recently, In 1996 we put forward a new concept, based on evidence explaining the act of micturition and urinary continence.
  9. 9. Micturition can be divided into 2 stages: Stage-I : in Infancy before training of micturition. Stage-II : in childhood after training of the act of micturition (how to control).
  10. 10. Micturition <ul><li>Stage-II : the mother starts to train her infant at the age of 18-24 months how to control micturition. This is gained by acquiring high alpha sympathetic tone at the internal sphincter closing it all the time except on need and /or desire. </li></ul>
  11. 11. Urinary continence depends on <ul><li>1- An acquired behavior gained by learning in early childhood to keep a high alpha sympathetic tone in the internal urethral sphincter keeping it closed all the time except on need and/or desire. </li></ul><ul><li>2- An intact and strong internal urethral sphincter. </li></ul>
  12. 12. The structure of the internal urethral sphincter <ul><li>It is mainly a cylinder composed of compact collagenous tissue. It extends from the bladder neck down to the perineal membrane. </li></ul>It is lined by urothelium . The muscle fibers intermingle with the collagenous fibers in the middle part; The muscle layer is controlled by alpha-sympathetic nerves T10-L2.
  13. 13. NORMAL INTERNAL URETHRAL SPHINCTER 3-D. ULTRASONOGRAPHY U.B. U.B. Closed urethra due to a strong, intact int. u. sphincter
  14. 14. Closed lumen Intact wall, compact sheet of collagenous tissue with muscle fibers lie on and intermingle with the collagen fibers In the middle part of the cylinder 3D U.S. Cross section
  15. 16. Urethra Vagina Urethral lumen Collag. tissue cylinder Muscle layer MRI picture of a normal continent woman
  16. 17. U.B. Post. Wall of internal urethral sphincter. Uterus Vagina MRI picture of a normal continent woman
  17. 18. <ul><li>Collagen is the most abundant protein in humans. </li></ul><ul><li>Collagen fibers are usually found in bundles of fibers and provide strength to the tissues. </li></ul><ul><li>Each fiber is made up of fibrils, chemically it has a high content of hydroxy-proline and hydroxy-lysine, </li></ul>
  18. 19. <ul><li>Many different types of collagen are identified on the basis of their molecular structure. </li></ul><ul><li>Type I is the most abundant being found in the dermis, bone, dentin, tendons, fascia, sclera, and organ capsules. </li></ul>
  19. 20. <ul><li>In old age, the amount of intervening mucopolysacharide decrease. </li></ul><ul><li>Also aging, with/ or without infection, cause fibrinoid necrosis of the collagen leading to its weakness </li></ul><ul><li>In addition, marked drop of ovarian hormones leads to loss of urogenital trophic support. </li></ul>
  20. 21. <ul><li>Important sites of collagen atrophy after menopause: </li></ul><ul><li>- bone osteoporosis </li></ul><ul><li>- urethra weakness – voiding troubles </li></ul><ul><li>- skin wrinkling </li></ul><ul><li>- fascia & organs loss of strength, form and shape. </li></ul>
  21. 22. <ul><li>Collagen atrophy + mucosal thinning will lead to : </li></ul><ul><ul><li>Frequency </li></ul></ul><ul><ul><li>Dysuria </li></ul></ul><ul><ul><li>Urgency </li></ul></ul><ul><ul><li>Cystitis </li></ul></ul><ul><ul><li>SUI </li></ul></ul><ul><ul><li>DI </li></ul></ul><ul><ul><li>Mixed type of incontinence. </li></ul></ul>
  22. 23. <ul><li>Weakness of the int. urethral sphincter will lead to: </li></ul><ul><ul><li>DI, overactive bladder , Urge and Urgency incontinence. </li></ul></ul><ul><ul><li>SUI </li></ul></ul><ul><ul><li>Mixed type of incontinence. </li></ul></ul>
  23. 25. SUI, DI, and mixed incontinence are sequel of a torn weak internal urethral sphincter. <ul><li>So, we innovated a new operation , trying to correct such types of urinary incontinence. Mending the torn edges of the internal urethral sphincter together by simple interrupted sutures, will restore the integrity of the internal urethral sphincter, and hence its strength. We called this operation urethro-raphy. </li></ul>
  24. 27. References <ul><li>El Hemaly AKMA, Mousa LA. Micturition and Urinary Continence. Int J Gynecol Obstet 1996:42, 291-2. </li></ul><ul><li>El Hemaly AKMA, Mousa LAE. Stress Urinary Incontinence, a New Concept. Eur J Obstet Gynecol Reprod Biol 1996:68, 129-35. </li></ul><ul><li>El Hemaly AKMA. Nocturnal Enuresis: Pathogenesis and Treatment. Int Urogynecol J Pelvic Floor Dysfunct 1998:9, 129-31. </li></ul><ul><li>Abdel Karim M. El Hemaly, Ibrahim M Kandil, Mohamed M. Radwan. Urethro-raphy a new technique for surgical management of Stress Urinary Incontinence. www.obgyn.net/urogynecology/ urethroraphy </li></ul><ul><li>El hemaly AKMA, Kandil I. M. Stress Urinary Incontinence SUI facts and fiction, Is SUI a puzzle?! www.obgyn.net/ PowerPoint presentations. </li></ul><ul><li>Abdel Karim El Hemaly, Nabil Abdel Maksoud, Laila A. Mousa, Ibrahim M. Kandil, Asem Anwar, M.A.K El Hemaly and Bahaa E. Elmohamady. Evidence based Facts on the pathogenesis and management of SUI. www.obgyn.net/ PowerPoint presentations. </li></ul>
  25. 28. <ul><li>Authors </li></ul><ul><li>Abdel Karim M. El Hemaly*, Ibrahim M.Kandil, and Bahaa E. El Mohamady M. </li></ul><ul><li>Prof. Ob. Gyn. Faculty of medicine Al Azhar University, Cairo, Egypt. </li></ul><ul><li>* corresponding author e mail [email_address] </li></ul>
  26. 29. ThankYou

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