Hinri Labs


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Hinri Labs

  1. 1. Healthcare Institute for Neuro-Recovery and Innovation HINRI Labs © 2009 “ Turning knowledge into practice to transform lives.” Translational
  2. 2. Translational Labs <ul><li>A patient-centered approach to: </li></ul><ul><li>“ Turning knowledge into practice to transform lives.” </li></ul>HINRI Labs © 2009
  3. 3. HINRI Translational Labs Mission <ul><li>Build a nationally recognized nexus for academia, science, medicine, business, philanthropy, and public policy to advance patient-centered research, rehabilitation, restoration, and recovery from neurological impairments due to injury, disease, or congenital causes. </li></ul>HINRI Labs © 2009
  4. 4. HINRI Translational Labs Goals <ul><li>Turn knowledge into practice to transform lives by: </li></ul><ul><ul><li>Creating the nation's leading translational laboratories for spinal cord injury, brain trauma, and neurological disorders with collaboration centers in Atlanta, Palo Alto, and Boston </li></ul></ul><ul><ul><li>Linking knowledge, ideas, and innovation from the scientific, medical, philanthropic, public policy, investment, and patient communities </li></ul></ul><ul><li>Create and support clinical trials to speed times between innovation and application: </li></ul><ul><ul><li>Supporting translational and clinical research </li></ul></ul><ul><ul><li>Promoting promising new technologies and commercial applications </li></ul></ul>HINRI Labs © 2008
  5. 5. HINRI Translational Labs Goals (cont.) <ul><li>Develop patient-centric coordinated care models: </li></ul><ul><ul><li>Collaborate with experts on clinical, physical, emotional, </li></ul></ul><ul><li>lifestyle, financial, family, friends, community, and faith </li></ul><ul><li>for optimum capabilities development </li></ul><ul><li>Engage Venture Philanthropy, Foundations, & Payors: </li></ul><ul><ul><li>Fostering a pre-competitive environment to evaluate and distribute critical intellectual property from research </li></ul></ul><ul><ul><li>Establishing best practices and a model standard of care for rehabilitation and restoration </li></ul></ul><ul><ul><li>Creating economic support and rationalization of care for recovery </li></ul></ul>HINRI Labs © 2008
  6. 6. HINRI Translational Lab The Problem Statement <ul><li>Institute of Medicine – “it takes 18 years for accepted research to become common practice”, because of: </li></ul><ul><li>Inadequately focused research </li></ul><ul><li>Delays in research to trials </li></ul><ul><li>Delays in trials to specialist providers </li></ul><ul><li>Delays in specialist knowledge to common practice </li></ul><ul><li>Delays in treatment applications to help patients </li></ul><ul><li>Lack of patient-centered treatments – traditional focus is on incomplete SCI rather than acute (1 st 30 days) or complete SCI </li></ul><ul><li>Reimbursement and Treatment Limits </li></ul>HINRI Labs © 2008
  7. 7. HINRI Translational Lab The Solution <ul><li>Rapid Dissemination and Translation of Ideas & Best Practices for: </li></ul><ul><li>Research – coordinate and support new ideas </li></ul><ul><li>Rehabilitation – Test and develop new individualized patient-centered physical and emotional approaches to rehabilitation </li></ul><ul><li>Restoration – Promote and conduct clinical trial testing in partnership with researchers, early stage companies and trauma centers </li></ul><ul><li>Recovery – Provide clinical, emotional, & lifestyle education for individual, family, and friends to optimize recovery and capabilities </li></ul>HINRI Labs © 2008
  8. 8. Translational Research HINRI Labs © 2008 Atlanta* Boston* Palo Alto* HINRI LABS Finding Patient Centered Solutions Restoration Rehabilitation Recovery * Academia, Science, Medicine, Business, Philanthropy, and Public Policy
  9. 9. Translational Rehabilitation HINRI Labs HINRI Labs HINRI Labs Activity-Based Electrophysiology Patients Payors Nutrition/Supplements Mental, Spiritual Emotional Health Locomat & Armin Tissue Regeneration Manual Therapy Medical Monitoring Patient Centered Best Practices Improved Functionality Optimum Capabilities Hyperbaric Chamber Collaboration Traditional Rehab Non-Traditional Rehab Assistive Technology Clinical Trials Clinical Practice Academia, Business HINRI Labs © 2008
  10. 10. Translational Restoration HINRI Labs © 2008 Basic Research “ P of P” Research Clinical Research Clinical Practice University Partners HINRI Labs Shepherd Center Trauma Centers “ Proof of Principle” Research – Does the basic science & new ideas hold true for human patients? HINRI Translational Lab’s patient-centered clinical trial platform will foster collaboration between universities and clinical research centers.
  11. 11. Translational Recovery HINRI Labs © 2008 Medication Therapy Physical Health Nutrition Socialization Readiness for Employment Education Spirituality Leisure Activities Family and Friends Patient Centered Goals Normality Functionality Fulfillment Independence
  12. 12. Hinri LABS Areas of Focus <ul><li>Permanent or irreversible </li></ul><ul><li>central nervous system disorders </li></ul><ul><li>Phase 1 - “Complete” Spinal Cord Injury (SCI) </li></ul><ul><li>Phase 2 - Traumatic Brain Injury (TBI) and Stroke </li></ul><ul><li>Phase 3 - Neurological Disorders* </li></ul>HINRI Labs © 2008 *Disease/Degeneration – Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Parkinson’s, and Alzheimer’s
  13. 13. HINRI Labs – Action Plan HINRI Labs © 2008 1A Complete SCI Measurement – Neural Plasticity, Functional Recovery Electrophysiology and Robotics 1B Complete SCI Translation – Bench to Bedside Assistive Technology, Holistic Medicine, Stem Cell Research 2 Brain Injury Measurement and Translation Imaging, Surgery, Pharmaceuticals, Stem Cells, Emerging Therapies 3 Neuro-Disease Neural Injury and Degeneration - Cell death, nerve regeneration and reconnection Basic Research Phase Target Focus Method
  14. 14. HINRI Labs – Rehabilitation Phase 1A and 1B <ul><li>Provide the scientific insights, new technologies and novel treatments to test, train and measure functional recovery (neural activity, muscle pattern activity, spinal reflexes and plasticity) </li></ul><ul><ul><li>Activity-Based Rehabilitation </li></ul></ul><ul><ul><li>New Drugs, Electrical Stimulation and Cell Transplantation Therapies </li></ul></ul><ul><ul><li>Train Reaching and Grasping (to improve upper extremity function) </li></ul></ul><ul><li>Electrophysiology and Robotics (Lokomat and Armin) </li></ul><ul><ul><li>Control experimental conditions </li></ul></ul><ul><ul><li>Generate standardized “training” of motor tasks </li></ul></ul><ul><ul><li>Measure mechanical aspects of functional recovery </li></ul></ul><ul><li>“ Proof of Principle” Studies </li></ul><ul><ul><li>Focus on underserved areas of investigation in SCI research </li></ul></ul><ul><ul><li>Translate animal studies research to human SCI studies </li></ul></ul><ul><ul><li>Neural mechanisms underlying functional recovery and neural connections across the level of injury </li></ul></ul><ul><ul><li>Measure Brain Motor Control Assay (BMCA) </li></ul></ul><ul><ul><li>Functional MRI and diffusion tensor imaging </li></ul></ul>
  15. 15. HINRI Labs Timeline 2009 JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC Atlanta – 1A ($3 MM) Atlanta – 1B ($5 MM) Palo Alto – 1A* ($10 MM) Boston – 1A ($2.5 MM) Atlanta – 2 ($7.5 MM) Atlanta – 3 ($5 MM) Phase HINRI Labs © 2008 *10 MM to be raised for Dr. Gary Steinberg and Dr. Graham Creasey at Stanford
  16. 16. Test & Develop Best Practices Rehabilitation Business Model Promote/Conduct Clinical Trials Restoration Collaborate on Best Practices Rehabilitation Foundations & Charities Common Mission Collaborate on Best Practices Rehabilitation Venture Philanthropy Common Goals Coordinate & Support Research Strategic Partners Collaboration Translational US Military Wounded Veterans Patients Patient Centered Clinical & Lifestyle Recovery Government, VA, Private Insurance Capital
  17. 17. Strategic Partners <ul><li>Location – The Shepherd Center has agreed to provide space on the third floor in their main building </li></ul><ul><li>University Partners - Emory, Stanford and Harvard/MIT </li></ul><ul><li>Media – CNN (Dr. Sanjay Gupta) </li></ul><ul><li>Corporate - Google Health and Microsoft HealthVault </li></ul><ul><li>SHARE Initiative – a $6MM partnership between Humana, Major League Baseball, Bernie Marcus and the McCormick Foundation to assist Wounded Veterans and their Families at Shepherd (100 participants to date) </li></ul>
  18. 18. Venture Philanthropy <ul><li>Corporate Partners </li></ul><ul><li>Dr. Louis Sullivan* – 3M; Bristol, Myers, Squibb; CIGNA </li></ul><ul><li>Bernie Marcus – SHARE Initiative, Home Depot ($300 MM) </li></ul><ul><li>Jeff Arnold – WebMD </li></ul><ul><li>Bill Ide – Former ABA President, East West Institute </li></ul><ul><li>Bob Bozeman – Google Health </li></ul><ul><li>Ron Bachman - Microsoft HealthVault </li></ul><ul><li>John Brandon – Apple </li></ul><ul><li>John Moore – Morgan Stanley (Former Head of Global HC) </li></ul><ul><li>Carter Burton – GE Healthcare Financial Services </li></ul><ul><li>Sanjay Gupta – CNN Medical Director </li></ul><ul><li>Steve Case – Former Vice-Chair CECP </li></ul><ul><li>Anthony Begando – Tenon Consulting </li></ul>* Have agreed to collaborate
  19. 19. Foundations & Charities Initial Prospect List <ul><li>Foundation Partners : </li></ul><ul><li>Woodruff </li></ul><ul><li>Hewlett </li></ul><ul><li>Bill/Melinda Gates </li></ul><ul><li>Omidyar Network </li></ul><ul><li>Google </li></ul><ul><li>Gordon Moore </li></ul><ul><li>Henry Kravitz </li></ul><ul><li>Advisory Panel: </li></ul><ul><li>David Brailer – Health Evolution Partners </li></ul><ul><li>Kleiner Perkins - Brooke Buyers </li></ul><ul><li>Draper Fisher Jurvetson - Steve Jurvetson and Tim Draper </li></ul><ul><li>James Robinson III – RRE Ventures </li></ul><ul><li>Pete G. Peterson – Blackstone </li></ul><ul><li>Silicon Valley Bank – Carlyle Group </li></ul><ul><li>Bono – Elevation Partners </li></ul>
  20. 20. <ul><li>Military Partners </li></ul><ul><li>Armed Forces Service Organization (AFSO) </li></ul><ul><li>United Service Organization (USO) </li></ul><ul><li>Wounded Warrior Project </li></ul><ul><li>Military Foundations (2) – Tenon Consulting Solutions </li></ul><ul><li>Advisory Panel </li></ul><ul><li>Hon. Max Cleland </li></ul><ul><li>Hon. John McCain (Orson Swindle) </li></ul><ul><li>Gen. Norman Schwarzkopf </li></ul><ul><li>Hon. Jeb Bush and/or Hon. Jay Rockefeller </li></ul><ul><li>Tom Hanks – www. welcomebackveterans .org </li></ul><ul><li>Robin Williams - Christopher and Dana Reeve Foundation </li></ul><ul><li>Congressional Service Academy Representatives </li></ul><ul><li>Former Head(s) of VA or VA Hospital System </li></ul><ul><li>Secretary of the Army and/or Joint Chiefs </li></ul>US Military Initial Prospect List
  21. 21. CHT Partnership <ul><li>A CHT “Capabilities” Project </li></ul><ul><li>– Ross Mason, Fellow CHT </li></ul><ul><li>The Center for Health Transformation (CHT) will partner with HINRI Translational Labs (Atlanta, Palo Alto, and Boston) to advise, support, and promote the creation of a national nexus, collaboration, and model of a patient-centered standard of care in research, rehabilitation, restoration, and recovery from “permanent” central nervous system disorders. </li></ul>HINRI Labs © 2008