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Approach
(Basic Science)
Scott G. Filler, M.D.
Los Angeles Biomedical Research Institute
at Harbor-UCLA Medical Center
Approach--Overall Layout
• Preliminary data
• Aim 1
o Rationale and overall approach
o Experimental methods
o Anticipated ...
Approach--Alternate
Layout
• Aim 1
o Preliminary data
o Rationale and overall approach
o Experimental methods
o Anticipate...
Preliminary Data
• Present compelling preliminary
data
o Supports rationale for the work
o Demonstrates feasibility
o Spar...
Approach
• Describe overall approach and
the controls
• Need power calculations for
animal studies
• Many details of anima...
Approach
• Potential pitfalls
o One aim depend on another *
o Excessive detail
• Detracts from overall message
• Target fo...
Anticipated Results and
Potential Pitfalls
• What do you think the results will be?
• Creativity and flexible thinking ver...
Future Directions
• Where is your research going?
• What will be its impact?
• How can the specific
information learn be a...
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K-to-R Workshop: How to Structure the "Approach" Section (Part 1)

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Published on

UCLA CTSI K-to_R Workshop, October 29, 2015

Presenter:
Scott G. Filler, MD
Professor-in-Residence of Medicine at UCLA and Harbor-UCLA Medical Center
Co-leader, CTSI Center for Translational Technologies

Published in: Education
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K-to-R Workshop: How to Structure the "Approach" Section (Part 1)

  1. 1. Approach (Basic Science) Scott G. Filler, M.D. Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
  2. 2. Approach--Overall Layout • Preliminary data • Aim 1 o Rationale and overall approach o Experimental methods o Anticipated results o Alternative outcomes (potential pitfalls) o Future directions • Aim 2 o Rationale and overall approach o Experimental methods o Anticipated results o Alternative outcomes (potential pitfalls) o Future directions
  3. 3. Approach--Alternate Layout • Aim 1 o Preliminary data o Rationale and overall approach o Experimental methods o Anticipated results o Alternative outcomes (potential pitfalls) o Future directions • Aim 2 o Preliminary data o Rationale and overall approach o Experimental methods o Anticipated results o Alternative outcomes (potential pitfalls) o Future directions
  4. 4. Preliminary Data • Present compelling preliminary data o Supports rationale for the work o Demonstrates feasibility o Sparks interest, but leaves reviewer wanting to learn more • Potential pitfalls in prelim data o Clear weaknesses o Supports alternative hypothesis
  5. 5. Approach • Describe overall approach and the controls • Need power calculations for animal studies • Many details of animal studies can be move to Vertebrate Animals section
  6. 6. Approach • Potential pitfalls o One aim depend on another * o Excessive detail • Detracts from overall message • Target for criticism o Densely written prose “If reading a grant gives the reviewer a headache, that grant is unlikely to receive a good score”
  7. 7. Anticipated Results and Potential Pitfalls • What do you think the results will be? • Creativity and flexible thinking very important • Make sure alternative outcomes are also interesting • Never present a potential pitfall for which you don’t have a good solution
  8. 8. Future Directions • Where is your research going? • What will be its impact? • How can the specific information learn be applied to a broader question?

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