Significance
and Innovation
Scott G. Filler, M.D.
Los Angeles Biomedical Research Institute
at Harbor-UCLA Medical Center
Review Criteria
•  Does the application address a
problem of high importance in the
field?
•  Will the results of the work...
Significance
•  Importance of disease
o  1-2 paragraphs
o  Make sure it is factually correct
•  Current gaps in knowledge
...
Goals of Significance Section
•  Emphasize importance of the
research
o In the system under study
o How knowledge gained c...
Key Points
•  Don’t assume the reviewer will read
every word
•  Try to describe broad overall impact
•  Do not directly cr...
Innovation
•  One paragraph
•  Some use bullet points
Innovation
•  Two types of innovation:
o Innovative technology—applying new
tools to an old question
o Innovative hypothes...
Caveats
•  Avoid using standard tools to
answer old questions:
o  Does the calcineurin pathway govern stress
response in o...
Caveats
•  Grants focusing on a process have
higher success rates than ones
focusing on a single protein/gene
o How does m...
Upcoming SlideShare
Loading in …5
×

Filler significance and innovation

263 views

Published on

Published in: Education
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
263
On SlideShare
0
From Embeds
0
Number of Embeds
1
Actions
Shares
0
Downloads
4
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Filler significance and innovation

  1. 1. Significance and Innovation Scott G. Filler, M.D. Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
  2. 2. Review Criteria •  Does the application address a problem of high importance in the field? •  Will the results of the work have a broad, sustained impact?
  3. 3. Significance •  Importance of disease o  1-2 paragraphs o  Make sure it is factually correct •  Current gaps in knowledge •  Description of new technology/ hypotheses •  Importance and impact of proposed work o  What are the deliverables?
  4. 4. Goals of Significance Section •  Emphasize importance of the research o In the system under study o How knowledge gained can be applied to other systems •  Provide essential background information for an uninformed reader •  Get reviewer interested
  5. 5. Key Points •  Don’t assume the reviewer will read every word •  Try to describe broad overall impact •  Do not directly criticize previous work Previous microarray studies were flawed by their inability to detect low abundance transcripts. While microarray studies have provided valuable insight into the transcriptional profile of ..., the frequency of low abundance transcripts remains unknown.
  6. 6. Innovation •  One paragraph •  Some use bullet points
  7. 7. Innovation •  Two types of innovation: o Innovative technology—applying new tools to an old question o Innovative hypothesis—applying standard tools to a new question •  Optimal to have new tools and innovative hypothesis
  8. 8. Caveats •  Avoid using standard tools to answer old questions: o  Does the calcineurin pathway govern stress response in organism X? o  Which of the 3 known signaling pathways are active under these conditions?
  9. 9. Caveats •  Grants focusing on a process have higher success rates than ones focusing on a single protein/gene o How does microorganism X adhere to host cells? (Good) o Is the phosphorylation of tyrosine 234 in protein X necessary for its function? (Bad)

×