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“Overview of CTSI Resources”


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Christina Wang, MD “Overview of CTSI Resources”
Associate Director, UCLA Clinical and Translational Science Institute
Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center
Professor of Medicine, David Geffen School of Medicine at UCLA
Division of Endocrinology, Department of Medicine

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“Overview of CTSI Resources”

  1. 1. UCLA CTSIClinical and Translational Science InstituteK Award WorkshopJanuary 10, 2012Los Angeles Biomedical ResearchInstitute at Harbor-UCLA MedicalCenterChristina Wang, MDAssociate Director,UCLA Clinical and Translational Science InstituteHarbor-UCLA Medical Center and Los Angeles Biomedical Research
  2. 2. Purpose of the National CTSA ProgramProviding an infrastructure for clinical and translational research Past Present and Future Inpatient GCRC Outpatient & community based research Individual investigators Transdisciplinary team science Traditional Training in clinical and translational training team science Individual academic Regional and national consortia medical centers linked for collaboration 2
  3. 3. What is translational research? UCLA CTSI translational investigation extends from molecules to societyTranslating knowledge gained from laboratory scienceinto clinical practice to improve health.The aim of translational research is to produce new:• therapeutics• medical devices• tools for diagnosing disease• avenues for community engagement research
  4. 4. Overview of Pilot Grant Programs Pilots Pilots TeamTeam Building Building Proposal Development Proposal Development Proof-of-Concept Proof-of-Concept Catalyst Grants Team Science Awards Prototype GrantsCTSI Scholars Novel Methods Awards & Technologies Award Rapid Response Team
  5. 5. Early Career Awards Opportunity Funds Grant Amount Duration of Award Cycle Application Award (Years) Due Date Pilots Team Building Proposal Development Proof-of-ConceptKL2 Awards: to pursue Up to $125,000 1 year at 75% July 1 Late Februaryinterdisciplinary, mentored research in salary and effort 2013with training research support (renewable for up to 3 years)TL1 Summer Program for Summer stipend The summer June 1 Late March 2013Professional Students: provides plus funding for betweenprofessional students (medical, training-related student’s firstnursing and dental) early exposure to expenses and second yearinterdisciplinary, community- (8 weeks)partnered translational or healthservices researchScholar Awards: for junior faculty in Up to $30,000 Up to 1 year Annual Fall 2013any series within their first threeyears of appointment to supportmentored training in translationalresearch in all areas of investigation.
  6. 6. KL2 Year 1 AwardeesAmira Brown, MS, PhD Assistant Professor, CDU “ Effects of Varenicline on Alcohol and Nicotine Consumption and changes in Dopamine D2-like Receptor Availability in High-Alcohol Preferring Mice”Joshua Zaritsky, MD, PhD Assistant Professor, Pediatric Nephrology, UCLA “ Hepcidin and the Anemia of Chronic Kidney Disease”Gelareh Gabayan, MD, MSHS Assistant Professor of Medicine, UCLA/VA “ Patterns and Predictors of Poor Outcomes Following Emergency Department Discharge in Older Adults”
  7. 7. KL2 Year 2 AwardeesJames McKinnell, MD Assistant Professor, LA-BioMed/Harbor-UCLA “Using Research in Vancomycin-Resistant Enterococcus to Validate an Efficient System of Quantifying Antibiotic Utilization”Mary Sehl, MD, PhD Assistant Professor, UCLA “Modeling of EMT/MET transitions in breast cancer stem cells”David Shackelford, PhD Assistant Professor, UCLA “Development of novel therapeutic strategies to target LKB1/STK11 deficient non-small cell lung cancer” 7
  8. 8. Early Career AwardsCTSI Scholar AwardsFor junior faculty in any series within their first three years ofappointment to support mentored training in translationalresearch.In 2012 12 CTSI scholars: 2 form Cedars, 2 from LA BioMedand 8 from UCLA 8
  9. 9. Funding Opportunities for All Investigators Pilots Team Building Proposal Development Proof-of-Concept Opportunity Funds Grant Duration Award Application Amount of Award Cycle Due Date (Years)Vouchers: Up to 1 Biannual/ Feb 2013for core services at CTSI $10,000 AnnualinstitutionsSeed Grants: to support $1,000 to Up to 1 year Annual Fall 2013research projects encouraging $30,000translational science
  10. 10. Center for Translational Technology Voucher Awards Vouchers of up to $10,000 to utilize core services • RFAs for Voucher Awards will be issued twice a year • Next Voucher RFA will be cross-institutional and announced early 2013 with an award date of March 1, 2013Awardees • Awards prioritized for innovation, translational, and samples and core ready •Junior investigators are ranked separately from established investigators 10
  11. 11. Other Collaborative Funding Opportunities Opportunity Funds Grant Duration Award Application Pilots Team Building Amount ofDevelopment Cycle Proposal Award Proof-of-Concept Due Date (Years)Team Science Awards: Up to 1-2 years Annual Rollingmultidisciplinary, cross- $200,000institutional, translationalscience leading to a proposalunder such team-sciencemechanisms as P01, U54, andcenter grantsCatalyst Awards: to support $1,000 to Up to 1 Quarterly RFA to beseminar series, team-building $5,000 year releasedactivities and pilot studies and August 15,other activities to encourage 2012translational team science
  12. 12. Collaborative Funding Opportunities Catalyst Awards Support team-building activities that advance translational science and promote collaborations across disciplines and CTSI institutions ($100 - $5,000)Cedars Awardees Jonathan Kaye, PhD, for the 2nd Annual Immunology LA conference at the Skirball Center on May 24, 2012. ►The meeting provided a unique opportunity for interactions between immunologists at all partner institutions. 12
  13. 13. Collaborative Funding Opportunities Team Science Awards Support multidisciplinary, cross-institutional, team-based research addressing major health problems (up to $200,000). Partner with other funding organizations to leverage resources. Co-funding is required.2012 Awardee Project: Clinical and Translational Science Institute Prospective Longitudinal Assessment of Co-infected Subjects with HIV/Hepatitis C for endothelial function study (CTSI-PLACE Study). UCLA: Kara Chew and Debika Bhattacharya LA BioMed/Harbor-UCLA: Eric Daar Cedars-Sinai: David Hardy Charles Drew: Wilbert Jordan 13
  14. 14. Upcoming Team Science Award with LA DHS Major focus: How can we improve health care without increasing costs?Anticipated release date: January 2013The UCLA CTSI seeks to expand translational research involving the Los AngelesDepartment of Health Services (LA DHS) delivery system, leading to: (1) system solutions that improve health care, health behaviors, and/or health status of Los Angeles residents without increasing costs (2) submission of extramural grants involving the CTSI and DHSAward: up to $30,000 for a period of one year• Awards are non-renewable• NIH guidelines for annual and end-of-project reporting will apply• Co-funding is required 14
  15. 15. Clinical and Translational Research Centers (CTRC)Ambulatory Clinical Research Facilities at Cedars, Drew, LA BioMed-Harbor, and UCLA-CHS• Private rooms, infusion rooms, procedure rooms• Sleep Research Facilities at LA Biomed-Harbor• Interview and conference rooms• Investigational pharmacy and sample processing• 23 hour capacity at UCLAInpatient Clinical Research Centers at LA Biomed/Harbor and UCLA-Ronald Reagan Medical Center “First in man” clinical pharmacology studies Metabolic Balance Studies Human Physiological Phenotyping Studies
  16. 16. Office of Investigator ServicesResearch Facilitation Contact a FacilitatorProvides across-the-board Cedars-Sinai Medical Centerassistance: (310) 423-2475 Jerlyn Tolentino • research project/grant Charles Drew University of Medicine and proposal development Sciences (323) 357-3645 Hema Ramamurthi • navigating and accessing Los Angeles Biomedical Research Institute at CTSI research support Harbor-UCLA Medical Center resources and services (310) 222-2503 Alla Victoroff and Terry Doherty • expert consultation on all University of California, Los Angeles aspects - from study (310) 794-CTSI concept through regulatory (310) 825-0791 Marisa Briones approval and oversight General Questions Telephone: (310) 794-CTSI (2874) E-mail: 19
  17. 17. CTSA Regional ConsortiaUniversity of California, Los Angeles
  18. 18. UC Biomedical Research Acceleration Integration and Development (UC-BRAID)