4 Genetics - Gene linkage (by Elizabeth)

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  • Grasshopper gait = alternately kick their legs & lift their legs higher than normal Prune skin = wriggley skin and no hair
  • Grasshopper gait = alternately kick their legs & lift their legs higher than normal Prune skin = wriggley skin and no hair
  • Craniofacial and skeletal malformation
  • Craniofacial and skeletal malformation
  • Craniofacial and skeletal malformation
  • 4 Genetics - Gene linkage (by Elizabeth)

    1. 1. <ul><li>Elizabeth Jeon </li></ul>
    2. 2. <ul><li>Define linkage group (10.2.4) </li></ul><ul><li>Explain an example of a cross between two linked genes. (10.2.5) </li></ul><ul><li>Identify which of the offspring in such dihybrid crosses are the recombinants. (10.2.6) </li></ul>Assessment Statements
    3. 3. Normal Dihybrid Crosses PpGg x ppgg <ul><ul><li>P - normal skin </li></ul></ul><ul><ul><li>p - prune skin </li></ul></ul><ul><ul><li>G - nomral gait </li></ul></ul><ul><ul><li>g - grasshopper gait </li></ul></ul>P P p p G G g g p p g g p p g g
    4. 4. Normal Dihybrid Crosses PpGg x ppgg P P p p G G g g PG pG Pg pg pg PpGg Ppgg ppGg ppgg INDEPENDENT ASSORTMENT p p g g p p g g
    5. 5. Linked Genes <ul><li>Group of genes whose loci are on the same chromosome </li></ul>CcGg x ccgg <ul><ul><li>C- normal skeleton </li></ul></ul><ul><ul><li>c - malformed skeleton (csp) </li></ul></ul><ul><ul><li>G - nomral gait </li></ul></ul><ul><ul><li>g - grasshopper gait </li></ul></ul>C C c c G G g g G C G C c g c g g g c c g g c c CG cg cg CcGg ccgg PARENTAL! CcGg ccgg
    6. 6. YET, crossover C C c c G G g g - @ Prophase I in Meiosis
    7. 7. YET, crossover
    8. 8. YET, crossover Chiasmata
    9. 9. YET, crossover
    10. 10. YET, crossover
    11. 11. YET, crossover C G c g c g C G Frequency of cross over depends on Distance between linked gene Distance between linked gene
    12. 12. Linked Genes <ul><li>Group of genes whose loci are on the same chromosome </li></ul>CcGg x ccgg C C c c G G g g g g c c g g c c CG cg cg CcGg ccgg PARENTAL! C G c g c g C G
    13. 13. Linked Genes <ul><li>Group of genes whose loci are on the same chromosome </li></ul>CcGg x ccgg C C c c G G g g g g c c g g c c CG cg cg CcGg ccgg C G c g c g C G Cg cG Ccgg ccGg RECOMBINENT! Ccgg ccGg 13% 87%
    14. 14. How to distinguish recombiant <ul><li>In test cross of </li></ul>G C G C c g c g C g c G OR !!
    15. 15. Thank you

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