Genetics of human blood groups

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Genetics of human blood groups

  1. 1. Human Blood Groups
  2. 2. ABO Blood Group <ul><li>There are 4 blood types in ABO blood group system. </li></ul>Blood Group Antigen A A B B AB A and B O Nil
  3. 3. Inheritance of Blood types <ul><li>Human blood type is determined by co-dominant alleles. </li></ul><ul><li>There are three different alleles. </li></ul><ul><li>I A , I B and i </li></ul><ul><li>I A and I B are the dominant alleles and ‘ i ’ is the recessive allele. </li></ul><ul><ul><li>Allele is one of the variant forms of a gene at a particular location, on a chromosome. </li></ul></ul><ul><ul><li>In an individual, one form of the allele (the dominant one) may be expressed more than another form (the recessive one). </li></ul></ul>
  4. 4. Role of alleles <ul><li>I A produces A antigen </li></ul><ul><li>I B produces B antigen </li></ul><ul><li>i produces no antigen (recessive allele) </li></ul><ul><li>I A and I B are co-dominant. That is, an individual with the genotype I A I B will produce both A and B antigens </li></ul>
  5. 5. Each of us has two blood type alleles. We inherit one blood type allele from our biological mother and one from our biological father. Genotype Blood Group A A B B AB O I A I A I A i I B I B I B i I A I B i i

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