Antibiotics              ALBIO9700/2006JK
• Drugs that are used to treat or cure  infections• Selective toxicity, killing or disabling  pathogen – no effect on host...
• Antibiotics interfere with some aspect of  growth or metabolism of the target  organism such as:   – Synthesis of bacter...
• Broad spectrum antibiotics – effective  against a wide range of bacteria• Narrow spectrum antibiotics – active  only aga...
ALBIO9700/2006JK
Penicillin   • In 1928, bacteriologist     Alexander Fleming made a     chance discovery from an     already discarded,   ...
Penicillin  • Penicillin is a group    of antibiotics derived    from Penicillium fungi.                        ALBIO9700/...
ALBIO9700/2006JK
• Penicillin and other  β-lactam antibiotics  act by inhibiting  penicillin-binding  proteins, which  normally catalyze  c...
• Bacteria that attempt  to divide in the  presence of penicillin  fail to do so and end  up shedding their cell  walls in...
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02 Antibiotics

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02 Antibiotics

  1. 1. Antibiotics ALBIO9700/2006JK
  2. 2. • Drugs that are used to treat or cure infections• Selective toxicity, killing or disabling pathogen – no effect on host cells• Derived from living organisms (isoniazid – synthetic) ALBIO9700/2006JK
  3. 3. • Antibiotics interfere with some aspect of growth or metabolism of the target organism such as: – Synthesis of bacterial walls – Protein synthesis – Plasma membrane function – Enzyme action ALBIO9700/2006JK
  4. 4. • Broad spectrum antibiotics – effective against a wide range of bacteria• Narrow spectrum antibiotics – active only against a few bacteria• Penicillins – prevents the synthesis of the cross-links between the peptidoglycan polymers in the cell walls of bacteria• Antibiotic sensitivity test ALBIO9700/2006JK
  5. 5. ALBIO9700/2006JK
  6. 6. Penicillin • In 1928, bacteriologist Alexander Fleming made a chance discovery from an already discarded, contaminated Petri dish. • The mold that had contaminated the experiment turned out to contain a powerful antibiotic, penicillin. • Though Fleming was credited with the discovery, it was over a decade before someone else turned penicillin into the miracle drug for the 20th centur ALBIO9700/2006JK
  7. 7. Penicillin • Penicillin is a group of antibiotics derived from Penicillium fungi. ALBIO9700/2006JK
  8. 8. ALBIO9700/2006JK
  9. 9. • Penicillin and other β-lactam antibiotics act by inhibiting penicillin-binding proteins, which normally catalyze cross-linking of bacterial cell walls. ALBIO9700/2006JK
  10. 10. • Bacteria that attempt to divide in the presence of penicillin fail to do so and end up shedding their cell walls in the process. ALBIO9700/2006JK

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