METERED DOSE INHALERS
OVER VIEW: <ul><li>INTRODUCTION </li></ul><ul><li>CONTENTS OF METERED DOSE INHALERS </li></ul><ul><li>EVALUATION OF MDIs <...
INTRODUCTION: <ul><li>Definition: Products in which the Active drug along with  propellant is packed under pressure which ...
 
CONTAINERS : <ul><li>Aluminum is used as material for preparing containers. </li></ul><ul><li>Internally coated with epoxy...
 
<ul><li>It is useful for the easy removal of the drug from the container. </li></ul><ul><li>Used for applying drug on a pa...
PROPELLENT : <ul><li>Propellants in MDIs are liquefied compressed gases that are in the gaseous phase at atmospheric press...
EVALUATION OF MDIs : <ul><li>Dose uniformity over the entire contents. </li></ul><ul><li>Leakage rate. </li></ul><ul><li>T...
<ul><li>MDIs combine the practical benefits of  small size, portability, convenience, and unobtrusiveness, and are relativ...
 
 
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AEROSOLS

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This ppt is regarding the inhalers which are used in asthma conditions.

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AEROSOLS

  1. 1. METERED DOSE INHALERS
  2. 2. OVER VIEW: <ul><li>INTRODUCTION </li></ul><ul><li>CONTENTS OF METERED DOSE INHALERS </li></ul><ul><li>EVALUATION OF MDIs </li></ul><ul><li>ADVANTAGES & LIMITATIONS </li></ul><ul><li>CONCLUTION </li></ul>
  3. 3. INTRODUCTION: <ul><li>Definition: Products in which the Active drug along with propellant is packed under pressure which is released upon application. </li></ul><ul><li>Due to metered valve exact amount of drug is delivered </li></ul><ul><li>Mainly for asthma, COPD & heart diseases . </li></ul>
  4. 5. CONTAINERS : <ul><li>Aluminum is used as material for preparing containers. </li></ul><ul><li>Internally coated with epoxy resin. </li></ul><ul><li>Having 20mm opening at the tip to receive metered valve. </li></ul><ul><li>These are seamless . </li></ul>
  5. 7. <ul><li>It is useful for the easy removal of the drug from the container. </li></ul><ul><li>Used for applying drug on a particular site which we desired . </li></ul>
  6. 8. PROPELLENT : <ul><li>Propellants in MDIs are liquefied compressed gases that are in the gaseous phase at atmospheric pressure, but form liquids when compressed. </li></ul><ul><li>Commonly used propellants. </li></ul><ul><li>Damage to ozone layer. </li></ul>
  7. 9. EVALUATION OF MDIs : <ul><li>Dose uniformity over the entire contents. </li></ul><ul><li>Leakage rate. </li></ul><ul><li>Total number of discharges per container. </li></ul><ul><li>Spray pattern. </li></ul><ul><li>Particle-size distribution. </li></ul><ul><li>Formulation factors. </li></ul><ul><li>Component design. </li></ul>
  8. 10. <ul><li>MDIs combine the practical benefits of small size, portability, convenience, and unobtrusiveness, and are relatively inexpensive. </li></ul><ul><li>The multi-dose capability means that a dose is immediately available when required to treat a wheezing attack. </li></ul><ul><li>Some patients suffer the so-called cold-Freon effect , in which the arrival of the cold propellant spray on the back of the throat causes the patient to stop inhaling. </li></ul>

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