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3. rifampicin urine


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3. rifampicin urine

  1. 1. Image of The Day 3: Orange Discoloration of Urine Muhamad Na’im B. Ab Razak (MD USM)In approaching patient with urine discoloration, it is very important to distinguish whether theurine discoloration is caused by hematuria or non hematuria urine discoloration.Hematuria could be due to many causes either from systemic, renal, ureter, bladder, prostateor urethra. It signifies a serious condition and need a very serious attention.In a meantime, it is important not to confuse yourself with a non hematuria causes of urinediscoloration which of course less important as compared to haematuria. Urine discolorationcould be due to many things starting from concentrated urine, increase in tissue breakdownthat release myoglobin, dye, diet and drugs.This picture highlight an orange urine discoloration in a patient with TB spine who receiveRifampicin.Rifampicin is a broad spectrum bactericidal antibiotic which inhibit the synthesis of bacterialRNA by binding to the beta subunit of the DNA- dependent RNA polymerase. This will blockthe transcription of the RNA.This traditional antibiotic has been used since ages to treat tuberculosis, leprosy andoppurtunistic mycobacterial infection.