Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.
Leukemia Department of Hematology,  the First Affiliated Hospital ,Sun Yat-Sen University   Zhenhai Zhou
   Overview <ul><li>A heterogeneous group of hematopoietic malignancies characterized by infiltration of the blood ,bone m...
<ul><li>Incidence </li></ul><ul><li>2.76/100,00 in China </li></ul><ul><li>More acute leukemia </li></ul><ul><li>Etiology ...
Acute Leukemia <ul><li>classification </li></ul><ul><li>FAB  </li></ul><ul><li>--- Acute myeloid leukemia(AML) </li></ul><...
Clinical feature <ul><li>Decreased production of normal hematopoietic  </li></ul><ul><li>---anemia:pale,tired </li></ul><u...
CT-fungi infection
CT
Laboraory findings <ul><li>Blood test : WBC  ↑ ,  Hb  ↓  , PLT  ↓   </li></ul><ul><li>Bone marrow- morphology </li></ul><u...
<ul><li>Immunophenotypic analysis </li></ul><ul><li>Flow cytometrry-antigen CD </li></ul><ul><li>---Myeloid  lineage  </li...
 
<ul><li>Cytogenetics  : </li></ul><ul><li>Chromosome abnormality </li></ul><ul><li>Molecular genetics:   </li></ul><ul><li...
<ul><li>FISH </li></ul>
Differential diagnosis <ul><li>Myelodysplastic syndrome(MDS) </li></ul><ul><li>Myeloproliferative disorders </li></ul><ul>...
treatment <ul><li>Supporting treatment </li></ul><ul><li>Antimicrobial therapy </li></ul><ul><li>Blood transfusion </li></...
Antileukemic treatment <ul><li>Treatment strategy  --Complete remission(disapperance of all sign of cancer) </li></ul><ul>...
<ul><li>Treatment for AML </li></ul><ul><li>---Induction : DA(DNR,Ara-c) </li></ul><ul><li>---APL:ATRA(all trans-renotic a...
Prognosis <ul><li>Adverse prognostic factors : unfavorable karyotype, age,high WBC,secondary AML… </li></ul>
Chronic myelogenous <ul><li>Incidence   </li></ul><ul><li>Clinical features </li></ul><ul><li>---chronic phase: fatigue, n...
Laboratory findings <ul><li>Blood </li></ul><ul><li>---WBC Moderate-marked increase ,basophils,eosinophils </li></ul><ul><...
<ul><li>Cytogenetic findings </li></ul><ul><li>Philadephia chromosome </li></ul><ul><li>t(9,22)(9q,22q)  Bcr/abl </li></ul>
Treatment <ul><li>Leukophoresis </li></ul><ul><li>Hydroxyurea </li></ul><ul><li>---hematologic remissiom </li></ul><ul><li...
Chronic lymphocytic leukemia <ul><li>Clinical features </li></ul><ul><li>Laboratory findings  </li></ul><ul><li>The majori...
<ul><li>Thank  You ! </li></ul>
Upcoming SlideShare
Loading in …5
×

Foreign students acute leukemia-zhou

2,695 views

Published on

Published in: Education, Health & Medicine
  • Be the first to comment

Foreign students acute leukemia-zhou

  1. 1. Leukemia Department of Hematology, the First Affiliated Hospital ,Sun Yat-Sen University Zhenhai Zhou
  2. 2.   Overview <ul><li>A heterogeneous group of hematopoietic malignancies characterized by infiltration of the blood ,bone marrow,and other tissue by leukemic cells which exhibit differentiation and apoptosis arrest in any stage of maturation. </li></ul><ul><li>Classification: </li></ul><ul><li>acute chronic </li></ul><ul><li>lymphoblastic myloid </li></ul>
  3. 3. <ul><li>Incidence </li></ul><ul><li>2.76/100,00 in China </li></ul><ul><li>More acute leukemia </li></ul><ul><li>Etiology </li></ul><ul><li>---heredity </li></ul><ul><li>---Radiation </li></ul><ul><li>---Chemical and other exposures </li></ul><ul><li>---Drugs </li></ul><ul><li>---virus </li></ul>
  4. 4. Acute Leukemia <ul><li>classification </li></ul><ul><li>FAB </li></ul><ul><li>--- Acute myeloid leukemia(AML) </li></ul><ul><li>M0-M7 </li></ul><ul><li>---Acute lymphoblastic leukemia(ALL) </li></ul><ul><li>L1,L2,L3 </li></ul><ul><li>WHO </li></ul><ul><li>MICM </li></ul>
  5. 5. Clinical feature <ul><li>Decreased production of normal hematopoietic </li></ul><ul><li>---anemia:pale,tired </li></ul><ul><li>---bleeding: PLT, blood vessel wall, DIC </li></ul><ul><li>acute promyelocytic leukemia </li></ul><ul><li>---fever: infection ,or? </li></ul><ul><li>Leukemic cells infiltration </li></ul><ul><li>---Lymph node, liver spleen , Sternum… </li></ul><ul><li>---central nervous system (CNSL) </li></ul>
  6. 6. CT-fungi infection
  7. 7. CT
  8. 8. Laboraory findings <ul><li>Blood test : WBC ↑ , Hb ↓ , PLT ↓ </li></ul><ul><li>Bone marrow- morphology </li></ul><ul><li>Hypercellular </li></ul><ul><li>Cytochemical reactions: POX(aml)PAS(all) NAE(aml) </li></ul>
  9. 9. <ul><li>Immunophenotypic analysis </li></ul><ul><li>Flow cytometrry-antigen CD </li></ul><ul><li>---Myeloid lineage </li></ul><ul><li>MPO,CD117 ,CD33,CD13,CD14,CD15 </li></ul><ul><li>---Lymphoblastic lineage </li></ul><ul><li>B:CD79a,CD19,CD20,CD22… </li></ul><ul><li>T:CD7,CD3,CD5… </li></ul>
  10. 11. <ul><li>Cytogenetics : </li></ul><ul><li>Chromosome abnormality </li></ul><ul><li>Molecular genetics: </li></ul><ul><li>---t(8,21) (q22;q22) AML1-ETO,M2 </li></ul><ul><li>---t(15,17) (q22;q21) PML-RARa M3t() t() </li></ul><ul><li>Low risk, high risk </li></ul>
  11. 12. <ul><li>FISH </li></ul>
  12. 13. Differential diagnosis <ul><li>Myelodysplastic syndrome(MDS) </li></ul><ul><li>Myeloproliferative disorders </li></ul><ul><li>Chronic myelogenous leukemia </li></ul>
  13. 14. treatment <ul><li>Supporting treatment </li></ul><ul><li>Antimicrobial therapy </li></ul><ul><li>Blood transfusion </li></ul><ul><li>Hyperleucocytosis therapy </li></ul><ul><li>Tumor lysis therapy </li></ul><ul><li>oral allopurinol </li></ul>
  14. 15. Antileukemic treatment <ul><li>Treatment strategy --Complete remission(disapperance of all sign of cancer) </li></ul><ul><li>Treatment for ALL </li></ul><ul><li>---Induction : DVLP(DNR,VCR,L-ASP,Prednisone) </li></ul><ul><li>---Postremission therapy :Consolidation and maintain chemotherapy; Allogenetic BMT </li></ul><ul><li>CNS prophylasis :high dose systemic therapy iintrathecal drug </li></ul><ul><li>Relapsed ALL therapy </li></ul>
  15. 16. <ul><li>Treatment for AML </li></ul><ul><li>---Induction : DA(DNR,Ara-c) </li></ul><ul><li>---APL:ATRA(all trans-renotic acid),arsenic trioxide </li></ul><ul><li>---Postremission therapy :Consolidation and maintain chemotherapy; Allogenetic BMT </li></ul><ul><li>Relapsed AML therapy </li></ul>
  16. 17. Prognosis <ul><li>Adverse prognostic factors : unfavorable karyotype, age,high WBC,secondary AML… </li></ul>
  17. 18. Chronic myelogenous <ul><li>Incidence </li></ul><ul><li>Clinical features </li></ul><ul><li>---chronic phase: fatigue, night sweats, </li></ul><ul><li>low-grade fever </li></ul><ul><li>splenomegaly, leukostasis </li></ul><ul><li>---accelerated phrase </li></ul><ul><li>---blast phase </li></ul>
  18. 19. Laboratory findings <ul><li>Blood </li></ul><ul><li>---WBC Moderate-marked increase ,basophils,eosinophils </li></ul><ul><li>---anemia , PLT </li></ul><ul><li>---<5%blast,<10%blast and promyelocytes </li></ul><ul><li>Bone marrow </li></ul><ul><li>---hypercellular, granulocytic </li></ul>
  19. 20. <ul><li>Cytogenetic findings </li></ul><ul><li>Philadephia chromosome </li></ul><ul><li>t(9,22)(9q,22q) Bcr/abl </li></ul>
  20. 21. Treatment <ul><li>Leukophoresis </li></ul><ul><li>Hydroxyurea </li></ul><ul><li>---hematologic remissiom </li></ul><ul><li>Interferon- α </li></ul><ul><li>Imatinb Mesylate </li></ul><ul><li>Stem cell transplantation </li></ul>
  21. 22. Chronic lymphocytic leukemia <ul><li>Clinical features </li></ul><ul><li>Laboratory findings </li></ul><ul><li>The majority of patients with stage A have no symptoms and may be observed for a while to determine treatment. </li></ul>
  22. 23. <ul><li>Thank You ! </li></ul>

×