Case studies in BioMEMS

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Case studies in BioMEMS

  1. 1. Case studies in
  2. 2. Multiphysics & multi-chemistry solver… Microfludics Fluid Structure Interaction Stochiometry Heat Transfer Electrokinetics Biochemistry Micromixing Electrochemistry Free Surface Flow Newtonian/Non-Newtonian flow
  3. 3. Microscale Fluidics Used for heat transport around a circuit On-Chip IC cooling, micro heat pipes Used to transmit forces Micropumps, diaphragms, Used to create forces Micro thrusters, micro-propulsion Used to transport materials Distribute cells, molecules to sensors Used to react materials Fuel cells, electrochemistry, reaction dynamics 3
  4. 4. Two approaches to Modeling Fluids Continuum models Works when point quantities can be large enough to contain many molecules but still small compared to the scale of the flow Molecular models Must be used when these conditions are not met 4
  5. 5. Continuum Models Navier- Stokes Euler Burnett Stokes Flow
  6. 6. BioMEMS/µFluidics module Highlights 3D Navier-Stokes solver Steady state & Transient Newtonian & non-newtonian Moving wall boundaries (Body fitted co-ordinate mesh for complex geometries) Adsorption & RedOx reactions Galvanostatic/potentiostatic apps Electrokinetics (Electro-osmosis, electrophoresis & dielectrophoresis) Acids, bases and ampholytes
  7. 7. BioMEMS/µFluidics applications Micro Total Analysis Systems Array systems µCapillary Zone Electrophoresis DNA Hybridization µCapillary Isoelectric focusing Proteomics µCapillary Isotachophoresis Protein patterning µ mixers & µ separators MEMS T-sensors Micropumps Reaction chambers Microvalves Drug delivery systems Flow cyclometry Fluid-membrane interaction
  8. 8. Displacement driven flows 8
  9. 9. Principle Flow Flow rectifier Actuator chamber Type: Type: •Piezoelectric •Single chamber •Check valves •Electrostatic •Moving volumes •Fixed geometry •Pneumatic •Peristaltic valves (fluid-structure interaction) •Thermopneumatic •… •… •…
  10. 10. Micro-mixing Valve Concentration gradient Copyright© IntelliSense
  11. 11. Micro-mixing Valve Concentration gradient Copyright© IntelliSense Software 2004
  12. 12. Micro-mixing Valve Concentration gradient Copyright© IntelliSense Software 2004
  13. 13. Micro-mixing Valve Concentration gradient Copyright© IntelliSense Software 2004
  14. 14. Micromixing Hot and cold flows Copyright© IntelliSense Software 2005
  15. 15. Micro-mixing chamber Flow vectors Copyright© IntelliSense Software 2005
  16. 16. Channel Combiner Velocity profile in a y-channel Copyright© IntelliSense
  17. 17. — — shipping product process modeling — Pressure profile Cross sectional velocity profile — VELOCITY VECTORS — transient analysis — micro mixing Agilent Fluidic device for chromatography — In Production in production Copyright© IntelliSense
  18. 18. Cross sectional velocity profile — shipping product — Pressure profile — transient analysis Agilent Fluidic device for chromatography — In Production in production Copyright© IntelliSense
  19. 19. Cross sectional velocity profile — shipping product Agilent Fluidic device for chromatography — In Production in production Copyright© IntelliSense
  20. 20. — shipping product Agilent Fluidic device for chromatography — In Production in production Copyright© IntelliSense
  21. 21. Agilent Fluidic device for chromatography — In Production in production Copyright© IntelliSense
  22. 22. Flow Separation Device • Multiple dead zones • Velocity and Streamline plots Copyright© IntelliSense
  23. 23. Flow Separation Device • Velocity profile across channels • Residence time greater in central paths Copyright© IntelliSense
  24. 24. Slide Velocity Flow Slide Coater • Free surface flow • Stream function plots Copyright© IntelliSense
  25. 25. Slide Coater Pressure distribution Copyright© IntelliSense
  26. 26. Membrane Inlet Fluid-Structure Interaction Deformable pre-tensioned membrane Re = 100 Copyright© IntelliSense
  27. 27. Electric field mediated flow •Static fields Electro osmosis Electrohydrodynamic (EHD) pumping Electrophoresis/Dielectrophoresis •Travelling fields Travelling wave EHD pumping
  28. 28. Electrokinetics Classification Type of movement Electrokinetic Coupling Electrophoresis Charged surface Use an applied moves relative to a electric field to induce stationary liquid movement Electro osmosis Liquid moves relative Use an applied to a stationary electric field to induce charged surface movement
  29. 29. LxWxD = 250x30x10 !m3 1 Ambient Pressure at 3 outlets Variable Voltage Injection Port Waste Port 10 V 0V Separation Channel Variable Voltage Electro-Osmosis Patankar and Hu in Analytical Chemistry, Vol. 70, No. 9, (1998) Copyright© IntelliSense
  30. 30. No external potential 2 Pressure distribution Vector plot Electro-Osmosis Reference model: no external voltage • Equal flow distribution Copyright© IntelliSense
  31. 31. Side reservoirs held at <5 V 3 E E Pressure distribution Vector plot Electro-Osmosis Side reservoirs held at <5 V • Flow into separation channels Copyright© IntelliSense
  32. 32. Side reservoirs held at > 5 V 4 E E Pressure distribution Vector plot Electro-Osmosis Side reservoirs held at > 5V • Flow into injection channel • Sample forced to intersection Copyright© IntelliSense
  33. 33. Sample Voltage varied to obtain desired focusing Focus 2 Focus 1 16 V 16 V Waste 0V Electrokinetic focusing Jacobson & Ramsey in Analytical Chemistry, Vol. 69, No. 16 (1997) Copyright© IntelliSense
  34. 34. 26 V CCD Imaging Electrokinetic focusing Sample forced through the waste channel Rhodamine 6G in buffered solution Copyright© IntelliSense
  35. 35. 19 V CCD Imaging Electrokinetic focusing Tighter focusing of the sample Copyright© IntelliSense
  36. 36. 12 V CCD Imaging Electrokinetic focusing Potential at channel intersection exceeds potential applied to the sample reservoir Copyright© IntelliSense
  37. 37. Focus1 Source1 Focus2 Source2 Focus3 8.1 V8.1 V 3V 15 V 3V 8.1 V 0V 0V Waste1 Waste2 Ambient Pressure at all ports Electro kinetic multiplex focusing Copyright© IntelliSense
  38. 38. 8.1 3 15 3 8.1 Experimental results IntelliSuite results Electro kinetic multiplex focusing Copyright© IntelliSense
  39. 39. Electro kinetic multiplex focusing Flow vectors Copyright© IntelliSense
  40. 40. Electrophoretic Device Layout in IntelliMask™ Copyright© IntelliSense
  41. 41. Electrophoretic Device Etch simulation in AnisE® Copyright© IntelliSense
  42. 42. Electrophoretic Device Flow vectors Copyright© IntelliSense
  43. 43. Electrophoretic Device Pressure distribution in device Copyright© IntelliSense
  44. 44. 20 electrodes channel AC driven flow Electrohydrodynamics (EHD) Travelling wave (ion drag) pumping Copyright© IntelliSense
  45. 45. Electrohydrodynamics Operating principle Copyright© IntelliSense
  46. 46. Travelling wave generation Streamlines across two electrodes Copyright© IntelliSense
  47. 47. Travelling wave generation Streamlines across two electrodes Copyright© IntelliSense
  48. 48. Travelling wave generation Streamlines across two electrodes Copyright© IntelliSense
  49. 49. Measured streamline pattern P.K. Wong et al, Mechatronics Vol 9 (2004) Copyright© IntelliSense
  50. 50. Evolution of fluid velocity Normal velocity profile (100 Hz) Copyright© IntelliSense
  51. 51. 10 KHz 10KHz 1 KHz 1 KHz 100 Hz 100Hz Streamlines as function of frequency Roll size decreases with frequency Copyright© IntelliSense
  52. 52. Other features… 52
  53. 53. PZT actuated membrane Outlet Inlet Flow chamber Example: Valveless piezoelectrically actuated micropump Flow evolution in a piezoelectric membrane micro pump
  54. 54. Concentration skewing Minimized concentration skewing Two reactants meeting at the junction and reacting to form a new analyte. Support for multivalent reactions is new in v 8.5 Enhanced ion drag calculations allows you to optimize elbow turns to minimize concentration skews Enhanced Chemical Reaction Enhanced transport behavior 1 Microfluidics with enhanced transport kinetics 2 Multivalent Ion drag calculations in electrokinetic transport
  55. 55. Droplet moving around a pre-set track (top view) Droplet fission (top view) Electrowetting on dielectric (EWOD) 3 3D Electrowetting calculations
  56. 56. Membrane Inlet Micro-mixing in a valve Flow mixing Fluid Structure Interaction Flow separation device Concentration gradient evolution Y combiner Inlet flow - membrane interaction Microfluidics• Electrokinetics • Transport stochiometry • Heat transfer • Free Surface Flow • Fluid Structure Interaction • Electrochemistry • Micro-mixing • Electrophoresis • Dielectrophoresis • Capillary flow and electro-separation • Electro-osmosis • Electro- hydrodynamics • Flow cyclometry • Micro-pumps and valves Electrokinetics Electro-osmotic driven flow Electrophoresis/Dielectrophoresis Free surface flow Multiplex focusing Electrohydrodynamics for cooling High Frequency Waste separation Slide coater
  57. 57. Thank you • • ध"यवाद • !"‫'&%ا ل‬ Grazie •Merci • Gracias • Danke •Obrigado • Dank U •Terima Kasih www.intellisense.com

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