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Acrolein is an air toxic that laboratory studies suggest may adversely affect neurocognitive function. Although there is strikingly little epidemiology available, US EPA estimates that acrolein is responsible for about 75 percent of non-cancer respiratory health effects attributable to air toxics in the United States, based on the Agency's 2005 National-Scale Air Toxics Assessment (NATA). This data gap was addressed by geographically linking 2005 NATA acrolein exposure estimates at the census tract with residences of subjects in the National Health Interview Survey (NHIS) 2000-2009. The NHIS monitors the health of the civilian, non-institutionalized population of the United States through a comprehensive interview of a nationally representative sample of households. The health outcome was self-reported limitation of activity attributed to senility among adults 55 years and older (n = 21,040). Preliminary results indicate that in the two highest quintiles of acrolein exposure (0.034 - 0.055 and 0.055 - 0.46 ug/m3), there were statistically significant increases in the prevalence of neurocognitive loss (pOR [95% CI]= 1.42 [1.04:1.96] and 1.38 [1.02:1.86], respectively), relative to the lowest exposure quintile and controlling for potential confounders, including smoking status.